Available Technologies by Category
Quickly and Easily Generate Designer Photopatterned Hydrogel Matrices for Complex Microfluidic Tissue/Organ-on-a-Chip Devices
  • Offers better spatiotemporal control and customization of hydrogel crosslinking and cell patterning
  • Provides a viable alternative to PEG-MAL for culturing primary B cells ex vivo and studying their response to antigens
  • Reduces timing and compatibility issues and offers designer flexibility compared to natural matrices
8986
Foot Ankle Orthotic (FAO) Delivers Real-Time Portable, Discreet Haptic Feedback for Patients and Athletes
  • Providing patients with discreet notifications of real-time plantar pressure to improve rehabilitation of foot-ankle injuries between clinical visits can reduce risk of injury strain and minimize long-term damage.
  • Athletes from various sports (e.g., tennis, football, basketball) could prioritize injury prevention during practice and games because of the discreet haptic notifications that bring attention to foot planting techniques via pressure monitoring.
  • The benefits of measuring plantar pressure from the four zones of this device’s insole (heel, toes, medial, and lateral) extend beyond foot-ankle injuries and can be key to diabetic pressure wound prevention as well as knee osteoarthritis therapy.
8944
Portable, Reusable, Micropower Radiation Monitors Provide Real-Time Assessment of Radiation Risk
  • Innovative radiation detection system provides real-time, on-demand, micropower detection in a versatile design.
  • The device materials offer higher conductivity (mobility) than silicon, resulting in reduced power needs (i.e., requiring power only during read-out).
  • Selection and layering of channel and gate materials enables tuning devices for different radiation types.
8084
Custom-Fit Reusable Respiratory Protective Device (RPD) with Continuous Fit Monitoring Improves Comfort and Protection
  • Vastly improves comfort and protection while bringing peace of mind to wearers through a custom fit and continuous monitoring
  • Reduces pressure injuries caused by extended RPD use through both a customized fit and alerts to the wearer when the RPD should be adjusted or removed
  • Minimizes exposures to workplace hazards by immediately detecting leakage during RPD use and alerting the wearer to adjust the device
8876, 9089, 9090, 9091
Deployable Critical Active Learning (DECAL) System Offers Better Characterization for Improved Diagnostics and Imaging
  • The deployable critical active learning (DECAL) system’s bi-modal interface enables better characterization with large training sets that generate more accurate output for higher precision.
  • The algorithm used during the initialization period creates a framework that can be expanded and generalized to any data method and application.
  •  The DECAL algorithm samples uniquely important, unlabeled data to aid existing active learning systems in generalizing more quickly, providing faster diagnosis statistics.
9099
Sustained Lymphatic Drug Delivery System Potentially Improves Efficacy and Safety of Immunotherapy and Targeted Therapies
  • This sustained lymphatic drug delivery system guides therapeutics and imaging agents to the injection site, lymphatic vessels, and lymph nodes. 
  • Sustained lymphatic delivery enables lower dosing and fewer administrations to potentially improve therapeutic response while reducing adverse effects and costs.
  • The simplicity of a vaccine-like, sustained drug release injection allows use at less expensive community health centers.
8637
“Smart” Feedback-Controlled Bioreactor Platform Enables Consistent High-Yield and High-Quality MSC Products
  • Scaled-down feedback-controlled hollow fiber-based bioreactor enables identifying the critical quality attributes and critical process parameters for high-quantity and high-quality hCT-MSCs for ideal cell growth and efficacy 
  • Provides the controls to maintain optimum conditions and improve expansion yield and cell viability
  • System can be adapted and applied to industrial cell therapy manufacturing and can enable high-yield and high-quality products while minimizing variabilities
8887
Manually Powered Laboratory Mixing Device
  • This manually operated laboratory device mixes and separates solution components at performance levels comparable to existing powered vortexes and centrifuges.
  • The device operates with no external power source, providing labs without access to consistent electrical infrastructure a reliable solution to mixing and separating solution components.
  • This multiuse device is compatible with containers and sample tubes of various sizes and solution amounts.
9096
High-Precision, Hands-Free Remote Control of Complex Robotic Systems Via Eye Movements
  • This two-camera eye-tracking system (TCES) integrates a commercial eye tracker with machine-learning technology for continuous real-time classification of gaze and eye directions for robotic arm control. 
  • The system provides highly accurate classification for four directions of eye movement and has achieved 99.99% accuracy in studies.
  • Using simple eye movement, the TCES offers low-cost, high-precision control of external devices/hardware for people with disabilities, surgery robots, warehouse systems, construction tools, and more. 
9184
Customized 3D-Printed Bioresorbable Heart Valves
  • Resorbable, patient-specific heart valves offer great flexibility for treating a wider range of conditions and patients than traditionally manufactured heart valves. 
  • Customizable valves potentially decrease complications due to poor fit and the need for reinterventions.
  • Selecting materials for optimal mechanical properties, thermodynamic properties, chemical properties, and surface chemistry and morphology reduces mismatch between device and tissue, potentially improving performance and patient outcomes.
8893
Paper-Based Multi-Well Depletion Enzyme-Linked Immunosorbent Assay (ELISA) Enables Point-of-Care (POC) Testing
  • Paper-based lateral flow assay automatically performs multi-well ELISA testing for POC titer measurements.
  • Simplifies ELISA testing by eliminating the need for centralized laboratories staffed with trained personnel who perform multiple steps in a specific sequence to execute the assay workflow.
  • Transforms a variety of ELISA-based tests into single-use, disposable dipstick tests to be used at the point of care or at home.
9124
Electric Field Treatment Creates Safe, Effective Antimicrobial Surfaces
  • Creates safe, effective antimicrobial surfaces via bacteria inactivation without the use of chemicals
  • Targets cell membranes or capsid, is less likely to induce antimicrobial resistance, and should be effective for antibiotic-resistant bacteria
  • Requires very short electrical pulses to achieve effective bacteria inactivation, potentially leading to better antifouling performance
9130
Parametric Resonance Approach for Efficient, Versatile Acoustic Power Transfer for Implantable/Wearable Devices, Sensing, and Communications
  • New class of transducers utilizes parametric resonance to convert acoustic energy from an ultrasonic source to a sustained electrical signal. 
  • Technology powers implantable biomedical devices, small wearable sensors, and other wireless charging applications.
  • Simple yet robust generation of stable electromechanical frequency combs is also possible in both air and liquid environments using a capacitive micro-resonator array.
7635, 9075
Artificial Neural Network (ANN) with Unique Input Design that Significantly Reduces Computational Costs of Complex Engineering Systems
  • Neural network’s novel input can utilize first-order schemes and local patches and allows for discontinuities to be reflected accurately and with greater resolution than existing products.
  • This adaptable ANN can be adopted by commercial and scientific research as a stand-alone solution or in conjunction with existing software. 
  • Lower costs for running complex and repetitive computations can be achieved by implementing this neural network with an input system that processes low-cost numerical solution patches arising from two or more converging solutions.
8963
Melting Microneedle Patches Extend Drug Delivery Applications, Simplify Manufacturing, and Reduce Costs
  • Melting microneedles enable dispersion of both poorly soluble and water-soluble drugs, which eliminates the need for solvents for improved stabilization and broader applications.
  • Melting microneedles shorten manufacturing and drying time, eliminate the need to maintain a cold chain for storage and transportation, and reduce the ultimate cost of the microneedle patch.
  • The safe suppository bases are inexpensive and enable control of the drug release timing.
8904
Quantitative, Performance-Driven Framework for Optimal Desalination Architectures and Energy Subsystems
  • Incorporate and simultaneously compare attributes of multiple types of both desalting systems and energy subsystems for optimal system architectures
  • Assess parameters that impact overall cost to discover complete architectures that would not have been discoverable using traditional methods.
  • Focus on renewable energy subsystems such as solar, wind, geothermal, hydroelectric, and others to create complete desalination architectures that are cleaner and more water efficient than their conventional counterparts. 
9055
Novel Nanocarriers Strengthen Therapeutic Delivery, Improves Efficacy
  • Greater therapeutic effectiveness is due to the synergistic work of multiple therapeutic agents (hydrophobic/hydrophilic charged) that can be delivered via this dual-loaded biomaterial.
  • The risk of immunotoxicity to a vaccine is reduced because an adjuvant, which can induce the body’s anti-inflammatory immune response, may be loaded and simultaneously delivered with the vaccine. 
  • The novel nanocarrier has broad market application since it can deliver vaccines, gene therapy, small molecule drugs, and even contrast agents.
8988
Automated Bioreactor Sampling System Can Eliminate Cross-Contamination of Samples
  • Automated bioreactor sampling system maintains sample integrity by changing the syringe between samples
  • In addition to savings related to reduced cross-contamination, automated sampling can further lower costs by reducing hands-on time and speeding sampling.
  • Flexible platform can be used with any type of collected sample.
8886
Efficiently Generating Complex Hydrogel Structures for Tissue/Organ-on-a-Chip Models
  • Faster: Reduces preparation time from several hours to minutes
  • Simplified: Generates complex patterns, including perfusable channels, using light-triggered polymerization of synthetic hydrogels and photomasks rather than current equipment-intensive methods that use laser-based patterning or ablation techniques
  • Lowers regulatory burdens: Using synthetic rather than biological matrices simplifies regulatory hurdles, increases reproducibility from batch to batch, and increases tunability of the mechanical and biochemical properties of the matrix
8838, 8839
Electronic Immunoassay Using Enzymatic Metallization on Microparticles
  • Lower cost: Replacing fluorescent markers and readout methods with impedance detection has the potential to significantly decrease the cost of the assay. 
  • Transportable: Impedance measurements in microfluidics can be made transportable, which can potentially enable point-of-care applications, as electronic elements are more durable than optical elements.
  • Practical: Identification of COVID-19 antibodies in COVID-positive serum samples has already been demonstrated.
8813