| Enabling Rapid Detection of Label-Free RNA for Use in COVID-19 Testing |
- Earlier detection: Identifying the viral components themselves—rather than the body’s reaction to the viral presence (i.e., antibodies)—potentially improves early detection in asymptomatic subjects.
- Simpler process: Use of minimal reagents and fewer preparatory steps is designed to enable more efficient and facile sample preparation. Avoidance of “wash steps” aims to minimize target loss.
- Fewer disruptions: Avoiding the use of high-demand supplies (e.g., swabs) and reagents potentially reduces supply-chain and contamination issues.
|
8669 |
|
| Customized 3D-Printed Bioresorbable Heart Valves |
- Resorbable, patient-specific heart valves offer great flexibility for treating a wider range of conditions and patients than traditionally manufactured heart valves.
- Customizable valves potentially decrease complications due to poor fit and the need for reinterventions.
- Selecting materials for optimal mechanical properties, thermodynamic properties, chemical properties, and surface chemistry and morphology reduces mismatch between device and tissue, potentially improving performance and patient outcomes.
|
8893 |
|
| Systems and Methods for Flexible Sheath Locking with Integrated Shape Sensing |
- This technology aims to become a new steerable device to reduce the invasiveness of traditional methods for delivering drugs and diagnostic devices inside the body.
- There are no known existing methods of delivering radiotherapy without the potential of adversely affecting healthy cells.
- This device and method will enable drastic improvements in the quality of life of patients having to undergo radiotherapy treatment.
|
9264 |
|
| Smart Nanosensor-Embedded Stent System for Wireless Surveillance of Restenosis in Coronary Artery Disease |
- An electronic stent that incorporates an ultrathin stretchable wireless sensor for continuous surveillance of restenosis along with neointimal proliferation and plaque deposition.
- There is no existing system that offers a clinically practical solution for continuous, real- time detection of both restenosis incidence and progression.
- This device will profoundly decrease the number of healthcare dollars spent on repeated revascularization due to restenosis in CAD.
|
8542 |
|
| Enhanced Diversifying Base Editors for Directed Evolution in S. cerevisiae |
- This invention presents an optimized and integrated CRISPR diversifying base editor for use in yeast and demonstrate its ability to rapidly improve the affinity of an antibody through yeast display.
- The innovation has enhanced the base editor mutation rate up has been increased to 27-fold by characterizing an improved key variant and by optimizing the structure of the CRISPR guide RNAs.
- The technology has attained a rate roughly 10-fold higher than state-of-art systems and facilitates ultra-rapid antibody diversification.
|
9111 |
|
| Novel Repressor Proteins for Gene Regulation and CRISPRi |
- The new CRISPRi platform uses novel fusion proteins to specifically inhibit target genes of interest and overcome the off-target issues with existing CRISPR platforms already on the market.
- The technology can be used as a life science tool and/or for diagnostics and therapeutics.
- The platform aims to limit off-target editing, circumvent incomplete gene knockdown sgRNA sequence-dependent repression activity, and variable performance across human cancer cell lines.
|
9106 |
|
| Messenger Ribonucleic Acid (mRNA)–Based Opsin Expression Enables New and Safer Optogenetic Studies |
- Opsin expression using messenger RNA (mRNA) provides an alternative to viral vectors for use in optogenetic studies involving neurons as well as drug testing with cardiomyocytes.
- Expression with mRNAs has lower toxicity and is usually detectable within 2–24 hours rather than 2–3 weeks.
- The controllable and temporary nature of mRNA offers improved expression regulation based on the transfection amount.
|
7534 |
|
| Microfluidic Device Enables Prediction of T-Cell Ability to Home and Engraft to Disease Tissues |
- Improve the homing capabilities of T cells to increase adoptive cell therapy treatment response and safety while decreasing off-target effects.
- Enhance tumor-infiltrating capabilities with engineered microfluidic devices that identify optimal subsets of cells.
- Optimize development pipelines by reducing the number of laborious in vivo studies, while also helping cell therapy companies ensure their products reach the desired tissue.
|
9052 |
|
| mRNA Therapeutic Delivery System Offers Targeted, Sustained HIV Pre-Exposure Protection in the Female Reproductive Tract |
- This system delivers messenger RNA that encodes neutralizing antibodies, which anchor to the female reproductive tract ensuring adequate, sustained tissue concentration for HIV prophylaxis.
- This HIV prevention therapy targets the female reproductive tract and offers month-long protection to reduce office visit frequency and potentially lower medical costs.
- This safe, water-based technology offers ease of administration to enhance patient compliance and prevent systemic complications.
|
8324 |
|
| Scalable Manufacturing Approach of Graded Polymer Thin Film Has Potential for Widespread Use |
- Combines slot die coating with a custom roll-to-roll imaging system to allow for efficient, rapid, and scalable fabrication of high-quality gradient thin films.
- An improved manufacturing process over existing techniques because it uses broad material combinations and yields higher quality patterned thin films.
- Incorporates multiple materials to increase the application of patterned thin films across industries, including microelectronics, energy technologies, and environmental systems.
|
8994 |
|
| High-Precision, Hands-Free Remote Control of Complex Robotic Systems Via Eye Movements |
- This two-camera eye-tracking system (TCES) integrates a commercial eye tracker with machine-learning technology for continuous real-time classification of gaze and eye directions for robotic arm control.
- The system provides highly accurate classification for four directions of eye movement and has achieved 99.99% accuracy in studies.
- Using simple eye movement, the TCES offers low-cost, high-precision control of external devices/hardware for people with disabilities, surgery robots, warehouse systems, construction tools, and more.
|
9184 |
|
| Bi-Channel Needle for Injection |
- The injection fluids are completely separated until the tip of the needle, preventing their mixing until they have reached the syringe’s distal tip.
- Since the specific volumes of each drug required will be added to the channels of the syringe, this device reduces the amount of fluid left in the syringe after injection.
- The needle allows the clinician to inject with syringes that are parallel to each other, as opposed to at some oblique angle.
- The length of the device is not limited to the current 1-inch syringe. It can be longer (even greater than 1 meter) for catheter-based procedures.
|
9028 |
|
| Lymphatic System-Specific Lipid Nanoparticles |
- This platform technology improves current targeting to lymphatic tissues and specifically lymphatic endothelial cells.
- Provides superior tissue targeting and functional delivery of mRNA to lymphatics via loco-regional dermal or subcutaneous avenues.
- mRNA-based platforms offer a transient and less immunogenic method of delivery compared to protein therapeutics or adeno-associated virus-based platforms.
|
9056 |
|
| Soft Wireless Sternal Patch for Detecting Systemic Vasoconstriction Using Photoplethysmography |
- A wireless, soft sternal patch includes integrated skin-like, photolithographically patterned electronics specifically tuned to continuously measure vasoconstriction from the sternum.
- In overnight trials, the device detected sleep apnea and hypopnea with 95% precision and 100% sensitivity compared to data professionally scored by licensed clinicians.
- Use of this patch on the chest could improve detection of key markers of numerous harmful health conditions.
|
9170 |
|
| Inflatable Balloon Guidewire for Reducing Trauma and Injury in Pediatric and Adult Patient Procedures |
- The soft balloon tip of the guidewire is designed to minimize patient trauma and injury for pediatric and adult procedures.
- This versatile design can be used for other pediatric and adult interventions coupled with commercially available systems.
- Balloon inflation can be symmetric or asymmetric along the length of the guidewire.
|
9168 |
|
| Targeted Single Cell Electroporation for Gene and Cell Therapy |
- The technology enables high efficiency delivery and high post-electroporation cell viability compared to current commercial electroporation systems.
- The technology performs in-flow single cell measurements integrated with electroporation unlike current commercial electroporation systems which have no single cell measurement capabilities.
- The technology enables automatic feedback control and real-time optimization of electroporation parameters at the single-cell level unlike current commercial electroporation systems which apply the same parameters to all cells in a batch at a bulk scale.
- The technology enables selected or targeted electroporation and delivery to selected cells or cell types from a mixture of cells unlike current commercial electroporation systems which require upstream or downstream cell sorting steps.
|
9086 |
|
| Lymphoid Tissue System Harnesses Ex Vivo Immune Reactions for Rapid Antibody Production and Immune Response Prediction |
- This immunocompetent system uniquely accounts for the unexpected activation of various immune cells to allow proper immune cell differentiation, recapitulating an effective immune response.
- The chemokine gradient is switchable, allowing the immune cell differentiation needed for an appropriate immune reaction.
- An ex vivo system supports immune response creation in a controlled environment, allowing reproduction of immunologic events for developing improved therapeutics.
|
9196 |
|
| Bioabsorbable, Permeable, and Flexible 3D Auxetic Implants Offer Large-Volume Soft Tissue Reconstruction |
- A novel 3D auxetic architecture offers enhanced compressive flexibility, permeability, and nonlinear mechanical behavior.
- This high-performance technology has the potential to generate implants with soft tissue-mimetic biomechanical properties and high mass transfer capacity.
- Implants can be customized for patients by adjusting the strut width and intervals and by fitting the complex anatomic geometry of the defect based on patient medical data.
|
8821 |
|
| Sustained Lymphatic Drug Delivery System Potentially Improves Efficacy and Safety of Immunotherapy and Targeted Therapies |
- This sustained lymphatic drug delivery system guides therapeutics and imaging agents to the injection site, lymphatic vessels, and lymph nodes.
- Sustained lymphatic delivery enables lower dosing and fewer administrations to potentially improve therapeutic response while reducing adverse effects and costs.
- The simplicity of a vaccine-like, sustained drug release injection allows use at less expensive community health centers.
|
8637 |
|
| Device Continuously Separates Functionalized Magnetic Microparticles from Solids to Yield Benefits for the Pharmaceutical Industry and More |
- Magnetic force is used to enhance traditional solid-solid separation techniques to yield a high-purity product stream and continuously return catalyst to a reactor.
- The device is capable of continuous separation for multiple hours and can be parallelized or ran in series to improve solids throughput and separation efficiency.
- This technology could help accelerate the adoption of continuous, heterogeneously catalyzed reactive crystallizations and, more generally, expand the chemistries and processes fit for continuous manufacturing.
|
8806 |
|
