| Methods and Markers for Ovarian Cancer Diagnosis and Stratification |
- This technology utilizes advanced machine learning algorithms and lipid panels to distinguish high-grade serous ovarian cancer from other reproductive system cancers, enhancing diagnostic accuracy and early detection capabilities.
- The prototype improves treatment decision-making and patient monitoring, particularly for individuals with genetic predispositions to ovarian cancer.
- It serves as a diagnostic tool for ovarian cancer detection, either standalone or alongside existing tests like CA125 and HE4, offering precise diagnosis and aiding in treatment planning.
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9366 |
|
| Capillary Driven Microneedle Patch for Blood Biomarker Analysis |
- This bioresorbable thermoplastic microneedle platform accurately collects capillary blood and quantifies biomarkers on-chip, supported by a smartphone attachment for easy read-out.
- The prototype integrates hollow microneedles with microfluidic patterns and crossflow filtration, providing low-cost, reliable, and sensitive point-of-care blood testing.
- It enables point-of-care personalized diagnostics and blood biomarker analysis in clinical and remote settings without expensive peripheral equipment.
|
9292 |
|
| Inline manipulation of cells and cell clusters |
- This extracorporeal circulation system enriches CTC clusters from large blood volumes, enabling detailed longitudinal screening and analysis of metastasis.
- The prototype improves detection rates and facilitates continuous monitoring and in vitro analysis of CTC clusters, aiding early cancer detection and treatment.
- It supports in-line dialysis systems for pathogenic cells, enhances cancer diagnosis, and provides research tools for studying tumor biology and developing treatments.
|
9125 |
|
| Activity-based synthetic liquid biopsy of solid tumors |
- Activatable biosensors injected into tumors capture dynamic biological activity and immune responses, allowing non-invasive monitoring of tumor responses through bodily fluids.
- The prototype offers real-time insights into tumor behavior and treatment effectiveness, providing a less invasive alternative to traditional biopsies.
- This method enhances sensitivity and specificity for tumor-specific biomarkers, improving monitoring of drug responses and cancer progression.
|
9387 |
|
| Lymphoid Tissues with Switchable Protein Gradients |
- Technology Overview: Georgia Tech's hydrogel-based immune organoids mimic lymphoid tissue, enabling ex vivo differentiation of B cells and studying immune responses to infections and vaccinations.
- Advantages: This non-invasive method supports long-term B and T cell survival, mimics antibody production processes, and offers insights into diseases like lymphoma.
- Commercial Applications: Useful for drug discovery, clinical research on immune disorders, personalized medicine, and academic studies in immunology.
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2024-116 |
|
| Adaptive Medical Image Recognition System with Limited Data Transfer Learning |
- Adaptive medical image recognition system that utilizes transfer learning to overcome limitations caused by minimal amounts of data.
- Novel innovation transforms generic models into application-specific ones and overcomes the limitations of traditional systems that are often tailored to specific domains or imaging devices.
- New image recognition system can be used for diagnostics and analysis as well as medical condition monitoring.
|
8168 |
|
| Enabling Rapid Detection of Label-Free RNA for Use in COVID-19 Testing |
- Earlier detection: Identifying the viral components themselves—rather than the body’s reaction to the viral presence (i.e., antibodies)—potentially improves early detection in asymptomatic subjects.
- Simpler process: Use of minimal reagents and fewer preparatory steps is designed to enable more efficient and facile sample preparation. Avoidance of “wash steps” aims to minimize target loss.
- Fewer disruptions: Avoiding the use of high-demand supplies (e.g., swabs) and reagents potentially reduces supply-chain and contamination issues.
|
8669 |
|
| Messenger Ribonucleic Acid (mRNA)–Based Opsin Expression Enables New and Safer Optogenetic Studies |
- Opsin expression using messenger RNA (mRNA) provides an alternative to viral vectors for use in optogenetic studies involving neurons as well as drug testing with cardiomyocytes.
- Expression with mRNAs has lower toxicity and is usually detectable within 2–24 hours rather than 2–3 weeks.
- The controllable and temporary nature of mRNA offers improved expression regulation based on the transfection amount.
|
7534 |
|
| Microfluidic Device Enables Prediction of T-Cell Ability to Home and Engraft to Disease Tissues |
- Improve the homing capabilities of T cells to increase adoptive cell therapy treatment response and safety while decreasing off-target effects.
- Enhance tumor-infiltrating capabilities with engineered microfluidic devices that identify optimal subsets of cells.
- Optimize development pipelines by reducing the number of laborious in vivo studies, while also helping cell therapy companies ensure their products reach the desired tissue.
|
9052 |
|
| Soft Wireless Sternal Patch for Detecting Systemic Vasoconstriction Using Photoplethysmography |
- A wireless, soft sternal patch includes integrated skin-like, photolithographically patterned electronics specifically tuned to continuously measure vasoconstriction from the sternum.
- In overnight trials, the device detected sleep apnea and hypopnea with 95% precision and 100% sensitivity compared to data professionally scored by licensed clinicians.
- Use of this patch on the chest could improve detection of key markers of numerous harmful health conditions.
|
9170 |
|
| Lymphoid Tissue System Harnesses Ex Vivo Immune Reactions for Rapid Antibody Production and Immune Response Prediction |
- This immunocompetent system uniquely accounts for the unexpected activation of various immune cells to allow proper immune cell differentiation, recapitulating an effective immune response.
- The chemokine gradient is switchable, allowing the immune cell differentiation needed for an appropriate immune reaction.
- An ex vivo system supports immune response creation in a controlled environment, allowing reproduction of immunologic events for developing improved therapeutics.
|
9196 |
|
| Image-Based Disease Severity Algorithm |
- The technology utilizes an image-based algorithm and automatic methodology to detect biomarkers in disease.
- It leverages a well-trained neural network on a dataset of healthy instances to learn the feature distribution of the healthy data.
- Anomaly detection algorithms generate anomaly scores based on properties of the neural network, providing a measure of severity by assessing how anomalous an instance appears compared to the healthy distribution.
|
9097 |
|
| Synthetically Generated, Realistic, and Controllable Human Bio-Signals from Participant-Free Data Collection |
- Synthetic data generation system replicates human body signals and uses a deep generative model to create synthetic SCG beats without human participants.
- Transformer-based generative model synthesizes SCG beats that are physiologically diverse and realistic.
- Clinically relevant feature inputs act as controls for aortic opening (AO) and aortic closing (AC) features of the generated SCG beat.
|
9081 |
|
| Universal Transcriptional Programming in a Bacteroides Consortium Creates a Foundation to Advance Living Therapeutics |
- Consortium-based, universal transcriptional programming framework is a biotic decision-making technology using genetic circuit compression in a Bacteroides community.
- Compressed genetic circuit design shortens circuit-building time, offers a compact circuit footprint that allows more complexity, uses fewer resources, and reduces cell communication time.
- Has potential applications in living therapeutics, advanced biomanufacturing, and next-generation biosecurity.
|
9006 |
|
| Single Cell Metabolomics Assay |
- The technology makes it possible to identify single cell resolution of lipids and other small molecules in complex tissue types, as well as metabolism mapping specific to different cell types.
- The measurements found through this can be used to study metabolomic response to drug exposure.
- The technology can achieve submicron resolution of lipids and other small molecules at anywhere from 200-1000 depth slices, using spatially resolved metabolic profiling.
|
9023 |
|
| Measurement and Modeling System Using Cell Signaling Networks |
- The technology quickly identifies cell signaling pathways from a patient biopsy, allowing for personalized treatment approaches to be identified.
- Measurements can be used to study potential tumor response to drug treatment, through the use of xenografted cells from the patient.
- 30-100 potential protein pathways and interactions can be measured using a single sample through multiplexing of rapid immunofluorescence.
|
9022 |
|
| Saliva-Based Multiplexed Assay with 25x Higher Sensitivity to SARS-CoV-2 and Influenza A and B |
- New lateral flow assay device achieves enhanced sensitivity with the same sample concentration, significantly reducing the risk of false negatives.
- Tunable capillary flow allows sample/reagent to be concurrently delivered to multiple regions, enabling multiplexed and repetitive assays on a single device.
- Transforms a variety of biological assays and tests performed at clinical laboratories into single-use, disposable dipstick tests to be used at the point of care or home.
|
9149 |
|
| Quickly and Easily Generate Designer Photopatterned Hydrogel Matrices for Complex Microfluidic Tissue/Organ-on-a-Chip Devices |
- Offers better spatiotemporal control and customization of hydrogel crosslinking and cell patterning
- Provides a viable alternative to PEG-MAL for culturing primary B cells ex vivo and studying their response to antigens
- Reduces timing and compatibility issues and offers designer flexibility compared to natural matrices
|
8986 |
|
| Foot Ankle Orthotic (FAO) Delivers Real-Time Portable, Discreet Haptic Feedback for Patients and Athletes |
- Providing patients with discreet notifications of real-time plantar pressure to improve rehabilitation of foot-ankle injuries between clinical visits can reduce risk of injury strain and minimize long-term damage.
- Athletes from various sports (e.g., tennis, football, basketball) could prioritize injury prevention during practice and games because of the discreet haptic notifications that bring attention to foot planting techniques via pressure monitoring.
- The benefits of measuring plantar pressure from the four zones of this device’s insole (heel, toes, medial, and lateral) extend beyond foot-ankle injuries and can be key to diabetic pressure wound prevention as well as knee osteoarthritis therapy.
|
8944 |
|
| Portable, Reusable, Micropower Radiation Monitors Provide Real-Time Assessment of Radiation Risk |
- Innovative radiation detection system provides real-time, on-demand, micropower detection in a versatile design.
- The device materials offer higher conductivity (mobility) than silicon, resulting in reduced power needs (i.e., requiring power only during read-out).
- Selection and layering of channel and gate materials enables tuning devices for different radiation types.
|
8084 |
|
