Life Sciences | Office of Technology Licensing

Available Technologies by Category
Novel Chemical Compounds Support Excess Copper Removal in Biological Systems	Powerful: Displays an affinity for copper that is unprecedented among synthetic ligands, with a complex stability constant of logK = 20.0 Specific: Functions without interference by other metals in the body Effective: Possesses a strong copper coordinating ability, even in the complex chemical environments of different biological systems	8151
Airy-beam Tomographic Microscopy for Biological Imaging	Streamlined: Offers a scan-free method of obtaining 3D-resolution images Volumetric imaging: Generates and resolves images of tissues and cells in the 3D space High resolution and image depth: Provides 3D diffraction-limited resolution	8381
A Semiconductor Particle Detector Based on Work Function Modulation	Small: Can be used as a portable radiation detector Versatile: Can be implemented in current particle detectors for accuracy testing and experimental verification Scalable: Offers the potential to be used in creating an array of devices for implementation in larger research experiments	8410
High-Precision Cell Membrane Tracking for Automated Electrophysiology	Highly accurate: Overcomes the challenges of tissue interference and movement for precise membrane tracking that can be used for automation Instantaneous: Surpasses earlier attempts at automating this process by effectively identifying and tracking cell boundaries in real time High fidelity: Operates efficiently and precisely even in dynamic, high-interference environments	7467
Voice-Activated Robotic Exoskeleton for Rehabilitation and Assistance	Voice-activated movement controlled by the patient Integrated smartphone application to recommend exercises and schedules Quantitative performance metrics and analysis sent to the physical therapist	8130
Ultra-High Resolution Multimodal Imaging System	Integrative perspective imaging - topological and chemical imaging of complex biological samples and heterogeneous nanomaterial interfaces with sub-micrometric resolution Improved spatial resolution - system provides chemical imaging resolution of ~ 250 nm and electron microscopy topological resolution of ~ 50 nm. Accuracy in analytics - analysis at the level of a single cell or with subcellular resolution has been seen as a next frontier in innovative approaches to discovery	8300
2D Array Device	Simple – does not require microstructure fabrication or periphery equipment, such as pressure-driven pumps to operate Unique – loading method enables rapid sample loading and high-percentage sample isolation simultaneously Cheaper – improvements in efficiency and robustness reduce complexity and overhead expenses	8253
Disposable Impedance Biosensor for Cell Manufacturing	Multi-point measurements- provide tempo-spatial profiles of culture attributes and can print a wide range of conductive and insulating materials on both rigid and flexible substrates with non-planar surfaces Wireless - collects the signal wirelessly via printed antennas to simplify the integration to different types of existing bioreactor technologies Safe - system does not apply contact, and minimizes any chance of harm or contamination to affect the cell culture	8270
Equipment-Free Quantification in Point-of-Care Diagnostic Assays	Field-deployable robustness: uses reference reactions to accurately measure biomarker levels without expensive or cumbersome equipment Lower cost: quantification does not require expensive technology	7992
3D Light-Field Endoscopy Using a Gradient Index Lens Array	Measurements: system achieves 'true quantitative' 3D information Imaging and visualization: system brings a great potential for fast 3D quantitative imaging, visualization, and synthesis of the focal stacks Material: method is glass-free	8283
Precision Needle Positioning Robotic System for MRI Guided Injection	Increased accuracy — robot capable of less than 100 micron accuracy Increased speed — faster targeting of injection locations	8246
Spatial Tracking of Catheters in Interventional MRI	Increased safety — eradicates RF induced heating while providing position of catheters in the body during iMRI procedures Simultaneous measurements — offers temperature measurements, orientation, and other parameters	7952
Guided Injection of Charged Cargo for Intracellular Delivery	Novelty – use of an electrically-charged liquid beam of electrospray Improved control – control of action on the scale of single cell/single pores Diversity – arbitrary diverse set of cargo	8275
Instrumented Ankle-foot Orthosis	User friendly – fully wearable and portable Objective data – enhances patient outcomes	7547
Wireless Neurovascular Monitoring System	Minimally invasive: minimal impact on hemodynamics (dynamics of blood flow) Flexible and stretchable: able to conform to complex vessel geometry Longer range: improved wireless detection range	7908
Water-Soluble Mold for Sample Analysis	Inexpensive: difference in materials used from existing practices, lowers manufacturing costs Universal adoption: no requirement of expensive cleanrooms facilities and associated personnel Environmentally: conscious- non-toxic process eliminates need for organic solvent and waste treatment	8138
A Technique for Integrating Photographs for Medical Imaging Examinations	Prevents the application of incorrect patient identification at the time of medical image generation Allows the correlation of serial imaging studies by ensuring that all studies are from the same patient Avoids the generation of incorrect reports	6402
Constellation Diagrams to Model Biomolecules’ Electrostatic Properties	Low computational cost – reduces algorithm run-time via reduction in complexity of computing molecular electrostatic properties Digitally encoded molecular electrostatic properties – utilizes orthogonal basis functions Visual toolsets- to analyze molecular electrostatic properties and generates 4D plots of molecular electrostatic properties	8245
Storage Media for Determining Optimal Respiratory Treatment	Automatically determines optimal radiation therapy treatment phase Enables higher, more effective radiation dosage amounts Minimizes unnecessary radiation to normal surrounding tissues	6926
Self-Assembling Peptides for Cell and Notch-Ligand Delivery	Hydrogels are biocompatible, easy to modify and biodegradable Could be applied in a more platform-like manner by incorporating other peptides to repair cardiac or other tissues The peptide sequence activates signaling of pathways improving the growth or replication of tissue or cells	6480

Technologies