Available Technologies by Category
Systems and Methods for Flexible Sheath Locking with Integrated Shape Sensing
  • This technology aims to become a new steerable device to reduce the invasiveness of traditional methods for delivering drugs and diagnostic devices inside the body.
  • There are no known existing methods of delivering radiotherapy without the potential of adversely affecting healthy cells.
  • This device and method will enable drastic improvements in the quality of life of patients having to undergo radiotherapy treatment. 
9264
Smart Nanosensor-Embedded Stent System for Wireless Surveillance of Restenosis in Coronary Artery Disease
  • An electronic stent that incorporates an ultrathin stretchable wireless sensor for continuous surveillance of restenosis along with neointimal proliferation and plaque deposition.
  • There is no existing system that offers a clinically practical solution for continuous, real- time detection of both restenosis incidence and progression.
  • This device will profoundly decrease the number of healthcare dollars spent on repeated revascularization due to restenosis in CAD.
8542
Enhanced Diversifying Base Editors for Directed Evolution in S. cerevisiae
  • This invention presents an optimized and integrated CRISPR diversifying base editor for use in yeast and demonstrate its ability to rapidly improve the affinity of an antibody through yeast display. 
  • The innovation has enhanced the base editor mutation rate up has been increased to 27-fold by characterizing an improved key variant and by optimizing the structure of the CRISPR guide RNAs.
  • The technology has attained a rate roughly 10-fold higher than state-of-art systems and facilitates ultra-rapid antibody diversification.
9111
Novel Repressor Proteins for Gene Regulation and CRISPRi
  • The new CRISPRi platform uses novel fusion proteins to specifically inhibit target genes of interest and overcome the off-target issues with existing CRISPR platforms already on the market.
  • The technology can be used as a life science tool and/or for diagnostics and therapeutics.
  • The platform aims to limit off-target editing, circumvent incomplete gene knockdown sgRNA sequence-dependent repression activity, and variable performance across human cancer cell lines.
9106
Microfluidic Device Enables Prediction of T-Cell Ability to Home and Engraft to Disease Tissues
  • Improve the homing capabilities of T cells to increase adoptive cell therapy treatment response and safety while decreasing off-target effects.
  • Enhance tumor-infiltrating capabilities with engineered microfluidic devices that identify optimal subsets of cells.
  • Optimize development pipelines by reducing the number of laborious in vivo studies, while also helping cell therapy companies ensure their products reach the desired tissue.
9052
mRNA Therapeutic Delivery System Offers Targeted, Sustained HIV Pre-Exposure Protection in the Female Reproductive Tract
  • This system delivers messenger RNA that encodes neutralizing antibodies, which anchor to the female reproductive tract ensuring adequate, sustained tissue concentration for HIV prophylaxis.
  • This HIV prevention therapy targets the female reproductive tract and offers month-long protection to reduce office visit frequency and potentially lower medical costs.
  • This safe, water-based technology offers ease of administration to enhance patient compliance and prevent systemic complications. 
8324
Scalable Manufacturing Approach of Graded Polymer Thin Film Has Potential for Widespread Use
  • Combines slot die coating with a custom roll-to-roll imaging system to allow for efficient, rapid, and scalable fabrication of high-quality gradient thin films.
  • An improved manufacturing process over existing techniques because it uses broad material combinations and yields higher quality patterned thin films.
  • Incorporates multiple materials to increase the application of patterned thin films across industries, including microelectronics, energy technologies, and environmental systems.
8994
Lymphatic System-Specific Lipid Nanoparticles
  • This platform technology improves current targeting to lymphatic tissues and specifically lymphatic endothelial cells.
  • Provides superior tissue targeting and functional delivery of mRNA to lymphatics via loco-regional dermal or subcutaneous avenues.
  • mRNA-based platforms offer a transient and less immunogenic method of delivery compared to protein therapeutics or adeno-associated virus-based platforms.
9056
Soft Wireless Sternal Patch for Detecting Systemic Vasoconstriction Using Photoplethysmography
  • A wireless, soft sternal patch includes integrated skin-like, photolithographically patterned electronics specifically tuned to continuously measure vasoconstriction from the sternum.
  • In overnight trials, the device detected sleep apnea and hypopnea with 95% precision and 100% sensitivity compared to data professionally scored by licensed clinicians.
  • Use of this patch on the chest could improve detection of key markers of numerous harmful health conditions.
9170
Lymphoid Tissue System Harnesses Ex Vivo Immune Reactions for Rapid Antibody Production and Immune Response Prediction
  • This immunocompetent system uniquely accounts for the unexpected activation of various immune cells to allow proper immune cell differentiation, recapitulating an effective immune response.
  • The chemokine gradient is switchable, allowing the immune cell differentiation needed for an appropriate immune reaction.
  • An ex vivo system supports immune response creation in a controlled environment, allowing reproduction of immunologic events for developing improved therapeutics.
9196
Bioabsorbable, Permeable, and Flexible 3D Auxetic Implants Offer Large-Volume Soft Tissue Reconstruction
  • A novel 3D auxetic architecture offers enhanced compressive flexibility, permeability, and nonlinear mechanical behavior.  
  • This high-performance technology has the potential to generate implants with soft tissue-mimetic biomechanical properties and high mass transfer capacity.
  • Implants can be customized for patients by adjusting the strut width and intervals and by fitting the complex anatomic geometry of the defect based on patient medical data.  
8821
Sustained Lymphatic Drug Delivery System Potentially Improves Efficacy and Safety of Immunotherapy and Targeted Therapies
  • This sustained lymphatic drug delivery system guides therapeutics and imaging agents to the injection site, lymphatic vessels, and lymph nodes. 
  • Sustained lymphatic delivery enables lower dosing and fewer administrations to potentially improve therapeutic response while reducing adverse effects and costs.
  • The simplicity of a vaccine-like, sustained drug release injection allows use at less expensive community health centers.
8637
Device Continuously Separates Functionalized Magnetic Microparticles from Solids to Yield Benefits for the Pharmaceutical Industry and More
  • Magnetic force is used to enhance traditional solid-solid separation techniques to yield a high-purity product stream and continuously return catalyst to a reactor.
  • The device is capable of continuous separation for multiple hours and can be parallelized or ran in series to improve solids throughput and separation efficiency.
  • This technology could help accelerate the adoption of continuous, heterogeneously catalyzed reactive crystallizations and, more generally, expand the chemistries and processes fit for continuous manufacturing. 
8806
Synthetically Generated, Realistic, and Controllable Human Bio-Signals from Participant-Free Data Collection
  • Synthetic data generation system replicates human body signals and uses a deep generative model to create synthetic SCG beats without human participants. 
  • Transformer-based generative model synthesizes SCG beats that are physiologically diverse and realistic. 
  • Clinically relevant feature inputs act as controls for aortic opening (AO) and aortic closing (AC) features of the generated SCG beat.
9081
Improving Quantitative Phase Imaging to Enhance Reliability and Broaden Applications
  • Universal application of an OBM/qOBM optical phase imaging device is made possible by the optimized SNR that identifies configurations with fewer limitations (e.g., conditions, tissue).
  • The simulated SNR can identify non-intuitive geometries for optical phase imaging devices that previously may not have been identified by the arduous experimental optimization process. 
  • Optimized SNR when OBM/qOBM devices take in-vivo and in-situ measurements have been proven reliable across multiple types of tissue.
8936
Versatile Continuum Robots with Variable Stiffness Control for Improved Positioning and Manipulation
  • Continuum robot design offers stiffness control continuously along the length of a guidewire or at variable discrete locations along the structure’s length. 
  • Versatile design is not restricted to one actuator type along the length of the guidewire, and elements can be placed along any section of the guidewire body.
  • With better control of the wire positioning within a patient’s anatomy, it may be possible to improve treatment outcomes.
9166
Microfluidic System Enables Scalable, High-Throughput Separation for High-Purity Human Induced Pluripotent Stem Cells (hiPSCs)
  • Simple, tunable high-throughput process separates hiPSCs quickly and efficiently according to the degree to which they adhere to a substrate inside the microfluidic device. 
  • Separation of intact cell colonies enables this simple system to avoid damaging and adversely affecting the pluripotency of the cells.
  • The approach is fast, does not rely on labeling technologies, supports greatly enriched cells, and results in a cell survival rate greater than 80%.
5685
Hydrogel-Based Artificial Ligaments Offer Substantial Improvements for ACL Reconstruction Therapies
  • This biocompatible hydrogel-based device is designed to reproduce natural ligament/tendon function to decrease the incidence of immune responses that lead to chronic inflammation.
  • An alternative to standard artificial ligaments and tendons, the device is designed to be placed via non-invasive techniques, making it a safer alternative to current, invasive surgical methods.
  • Non-biodegradable hydrogels are highly durable, potentially increasing the lifespan of the prostheses.
5386
Universal Transcriptional Programming in a Bacteroides Consortium Creates a Foundation to Advance Living Therapeutics
  • Consortium-based, universal transcriptional programming framework is a biotic decision-making technology using genetic circuit compression in a Bacteroides community.
  • Compressed genetic circuit design shortens circuit-building time, offers a compact circuit footprint that allows more complexity, uses fewer resources, and reduces cell communication time. 
  • Has potential applications in living therapeutics, advanced biomanufacturing, and next-generation biosecurity.
9006
Fast, Effective Thrombolytic Agent for Arterial Blood Clots
  • The disulfide dimer of the amino acid cystine, has the potential to be a highly efficient thrombolytic agent for treating dangerous arterial blood clots.
  • During in vitro testing DiNAC dissolved thrombi in as quickly as 90 seconds and reduced the diameter and surface area of certain thrombi by 50–95 percent.
  • DiNAC has the potential to treat multiple conditions associated with arterial thrombus formation and to mitigate life-threatening side effects. 
8007