Available Technologies by Category
Customized 3D-Printed Bioresorbable Heart Valves
  • Resorbable, patient-specific heart valves offer great flexibility for treating a wider range of conditions and patients than traditionally manufactured heart valves. 
  • Customizable valves potentially decrease complications due to poor fit and the need for reinterventions.
  • Selecting materials for optimal mechanical properties, thermodynamic properties, chemical properties, and surface chemistry and morphology reduces mismatch between device and tissue, potentially improving performance and patient outcomes.
8893
Tunable Membrane-Based Wastewater Treatment and Resource Recovery
  • Customizable membrane structure and surface properties provide selective removal of contaminants of emerging concerns (CEC) and recovery of valuable components.
  • An enlarged membrane surface area, combined with a gutter effect from the interlayer, results in nearly double the water permeability of current filtration membranes.
  • Achieves high-performance recovery of essential nutrients/fertilizers that are free of CECs.
8633
Scalable Manufacturing Approach of Graded Polymer Thin Film Has Potential for Widespread Use
  • Combines slot die coating with a custom roll-to-roll imaging system to allow for efficient, rapid, and scalable fabrication of high-quality gradient thin films.
  • An improved manufacturing process over existing techniques because it uses broad material combinations and yields higher quality patterned thin films.
  • Incorporates multiple materials to increase the application of patterned thin films across industries, including microelectronics, energy technologies, and environmental systems.
8994
Overvoltage Surge Protection System for Distributed Energy Resources
  • iMOV is a dynamic system capable of achieving voltage surge clamping within 20% of the system’s nominal voltage. This effectively provides protection for highly sensitive semiconductors present in DER-associated power converters. 
  • This system is built upon a metal oxide varistors (MOV) foundation, whose material composition inherently allows rapid device connection of 500 picoseconds for quicker response times. 
  • iMOV uses integrated microprocessors and sensors in a cloud-based architecture that provides protection against cyberattacks, reduces system cost, and allows system and power grid monitoring.
9190
AI-Designed High Energy–Density High-Temperature Polymers
  • The present materials are capable of withstanding enormous electric fields at very high temperatures.
  • The materials produced are extremely lightweight.
  • Vehicles making use of these materials will be lightweight, and lighter vehicles consume less energy.
9101
Microgeodes Enable Tunable Optical Response for Advanced Coatings/Paint
  • Microgeodes have a programmable structure of nanowires that allows their optical response to be engineered precisely over multiple spectral bands, from UV through mid-IR. 
  • Microgeodes combine the tunability and versatility of nanowires with the processability of microspheres to provide a photonic materials platform for a wide range of applications. 
  • Microgeode paints could reduce building surface temperatures by as much as 25°C, offering the potential for significant consumer savings while retaining aesthetically pleasing colors.
8866
Lymphoid Tissue System Harnesses Ex Vivo Immune Reactions for Rapid Antibody Production and Immune Response Prediction
  • This immunocompetent system uniquely accounts for the unexpected activation of various immune cells to allow proper immune cell differentiation, recapitulating an effective immune response.
  • The chemokine gradient is switchable, allowing the immune cell differentiation needed for an appropriate immune reaction.
  • An ex vivo system supports immune response creation in a controlled environment, allowing reproduction of immunologic events for developing improved therapeutics.
9196
Solar Cell Manufacturing Technique Increases Efficiency and Lowers Costs
  • This double-side polysilicon/silicon oxide TOPCon (tunnel oxide passivated contact) solar cell concept provides a simple and low-cost way to passivate front and back surfaces of silicon wafers to enhance efficiency.
  • Provides current and voltage comparable to full-area double-side TOPCon but with no appreciable absorption in front polysilicon and without compromising short circuit current density
  • Includes a novel and fast way to pattern polysilicon using laser-induced selective oxidation
8888
Bioabsorbable, Permeable, and Flexible 3D Auxetic Implants Offer Large-Volume Soft Tissue Reconstruction
  • A novel 3D auxetic architecture offers enhanced compressive flexibility, permeability, and nonlinear mechanical behavior.  
  • This high-performance technology has the potential to generate implants with soft tissue-mimetic biomechanical properties and high mass transfer capacity.
  • Implants can be customized for patients by adjusting the strut width and intervals and by fitting the complex anatomic geometry of the defect based on patient medical data.  
8821
Tunable MEMs Gas Sensor Improves Selectivity and Sensitivity
  • Versatile: Customizes MEMS chemical sensors, compatible with a variety of sensing materials, allowing for the detection of numerous gas-phase analytes
  • Easy to manufacture: Uses batch-fabricated sensors compatible with COTS electronics
  • Highly sensitive: Offers sub parts-per-million detection limits for volatile organic compounds
  • Enhanced selectivity: Combines gravimetric and impedimetric responses to demonstrate enhanced discrimination between multiple VOCs
  • Powerful: Enables the simultaneous observation of both mass loading and dielectric changes in polymeric sensing films upon sorption of an analyte
  • Innovative: Uses the transient response characteristics of a sensor response to a gated exposure event, rather than steady-state sensor data
8269, 8987
Sustained Lymphatic Drug Delivery System Potentially Improves Efficacy and Safety of Immunotherapy and Targeted Therapies
  • This sustained lymphatic drug delivery system guides therapeutics and imaging agents to the injection site, lymphatic vessels, and lymph nodes. 
  • Sustained lymphatic delivery enables lower dosing and fewer administrations to potentially improve therapeutic response while reducing adverse effects and costs.
  • The simplicity of a vaccine-like, sustained drug release injection allows use at less expensive community health centers.
8637
Catalyst for Degradation of Traditional PET
  • Degradation of PET products lead to less landfill waste.
  • The technology has applications in bio-based packaging to eliminate single-use plastics.
  • Degradation does not give rise to microplastics, which are hazardous.
8960
Superluminescent Light Projection (SLP) System Decreases Nanoscale Printing Costs by 10–50 Times
  • This superluminescent light projection (SLP) system decreases overall nanoscale printing costs by 10–50 times. 
  • A parallel writing mechanism supports higher throughput speeds: up to 100 times higher than existing metal printing methods and four times higher than existing polymer printing methods. 
  • SLP creates sharp-edged images with minimal speckling patterns, resulting in high-resolution images and structures on both polymer and metal-based films. 
9066
Patient-Centered Biofeedback Headset Can Isolate, Monitor, and Analyze Vocal Output in Real Time for Optimal Voice Modulation in Patients with Parkinson’s Disease
  • Innovative headset offers real-time haptic feedback for vocal improvement and increased patient autonomy.
  • Device stores easily accessible data for therapist review and fine-tuning of preset therapeutic thresholds to continually improve vocal output.
  • Lightweight, low-profile, battery-powered headset are favorable for all-day wear and use omnidirectional microphones for optimal comfort.
9134
Hydrogel-Based Artificial Ligaments Offer Substantial Improvements for ACL Reconstruction Therapies
  • This biocompatible hydrogel-based device is designed to reproduce natural ligament/tendon function to decrease the incidence of immune responses that lead to chronic inflammation.
  • An alternative to standard artificial ligaments and tendons, the device is designed to be placed via non-invasive techniques, making it a safer alternative to current, invasive surgical methods.
  • Non-biodegradable hydrogels are highly durable, potentially increasing the lifespan of the prostheses.
5386
Thermoformed Polymeric Valved Conduits Offer a Biocompatible, Customizable Heart Valve Replacement Treatment
  • This biocompatible device may reduce adverse events resulting in a lower incidence of post-surgical adverse events for better long-term outcomes.
  • Customizable valve conduits allow patient-specific device creation for potentially easier surgical placement and optimal post-surgical valve function.
  • This unique device may offer a safer treatment option by providing a biocompatible, patient-specific intervention, resulting in fewer undesirable adverse events.
9003
Fully Bioresorbable Heart Valve Scaffold Supports Native Neovalve Growth to Reduce Future Procedures
  • Replacing a stenotic fetal heart valve with a living autologous valve could possibly cure the complex cardiac anomalies that cause single ventricle physiology.
  • With this approach, the valve has the potential to accommodate patient growth and eliminate the need for multiple heart valve replacements during the patient’s lifetime.
  • The transcatheter nature of this valve deployment makes the procedure similar in risk to a traditional fetal valvuloplasty.
8868
Patterned Implantable Devices for Improved Reconstruction of Tubular Tissue Passageway Defects
  • This innovation improves patterned airway stents for passageways or tubular tissues to potentially enable long-passageway reconstructions. 
  • Extrusion-based 3D bioprinting produces a patterned implantable device with higher mechanical strength without increasing the wall thickness of the device.
  • Incorporating auxetic-patterning creates an implantable splinting device for supporting passageway defects in growing patients, such as infants or children.
8831
Novel Hydrogels for Encapsulation, Vascularization, and Transplantation of Cells
  • This hydrolytically degradable poly(ethylene glycol) (PEG) hydrogel leverages ester linkages combined at various ratios with non-degradable macromers to enable tunable degradation kinetics.
  • Potential applications include controlled release and delivery of drugs or proteins as well as cell encapsulation. It can also be used as a delivery vehicle and adhesive for cells in transplantation settings.
  • These innovative hydrogels allow for rapid hydrolytic cleavage in vivo but remain stable in vitro for weeks at neural pH 7 to support regenerative medicine techniques.
9019
Quickly and Easily Generate Designer Photopatterned Hydrogel Matrices for Complex Microfluidic Tissue/Organ-on-a-Chip Devices
  • Offers better spatiotemporal control and customization of hydrogel crosslinking and cell patterning
  • Provides a viable alternative to PEG-MAL for culturing primary B cells ex vivo and studying their response to antigens
  • Reduces timing and compatibility issues and offers designer flexibility compared to natural matrices
8986