Available Technologies by Category
Microscale High-Throughput Phenotypic Assay for Fibrosis
  • Powerful: Provides high-throughput image-based analysis of fibrotic processes as well as fibrinolysis
  • Convenient: Combines label-free readouts for fibrin degradation, collagen synthesis, and cell contraction to evaluate fibrotic tissue remodeling
  • Enabling: Opens new opportunities for understanding fibrosis pathogenesis and for evaluating anti-fibrotic therapeutics
8502
A Chip-Scale Linear Ion Trap to Enable Portable Mass Spectrometers
  • Enabling: Can be used in the development of much smaller mass spectrometers than are currently available—from benchtop devices to handheld or even smaller instruments—which would extend their use to applications in which they are not currently cost effective
  • High-performance: Provides better than unit-mass resolution and high detection efficiency, and operates at much higher pressures than larger mass analyzers, as shown during lab-based simulations
  • Multi-modal: Allows for several different modes of operation and enables tandem(MS/MS or MS2) or multi-stage/sequential (MSn) mass spectrometry, greatly improving capability compared with other analyzers
8137
Increasing Medium-Chain Fatty Acid (MCFA) Yield in Bacterial Host with Engineered Enzyme
  • High performance: Increases the yield of MCFAs during chemical and biopolymer synthesis
  • Enabling:  Improves the microbial production of chemicals that require the expression of heterologous enzymes
  • Adaptable:  Potentially applies to methods of engineering other heterologous enzymes to interact with endogenous proteins in order to produce molecules of interest in a bacterial host
7595
A Biomimetic Nose with Machine Learning for Advanced Threat Detection
  • Enhanced chemical detection: Reduces proximity issues and enhances detection
  • Functional in air and liquid mediums: Can detect single or multiple chemical agents even when the medium contains both a liquid and a gas. An attachment makes it possible to use the device in liquid with air monitoring sensors.
  • Continuous improvement: Uses machine learning algorithms to continually improve agent characterization
7796
Tissue-Selective Anticancer Agents
  • Tissue-targeted activity: Appended macrocyclic skeletons provide selective tissue distribution.
  • Potent: HDAC inhibitors display stronger in vivo anticancer activity against solid tumors compared to current technology.
  • Lower toxicity: Mice in preclinical experiments did not exhibit significant weight loss, pointing to potentially lower toxicity of these compounds.
4195
Heat-Responsive Programmable T-Cells
  • Specific: The remote programmable nature of these T-cells allows them to be selectively activated only in the necessary locations.
  • Protective: This focused, genetically engineered immunotherapy is intended to protect patients from the additional harm of the off-target cell death and unnecessary systemic damage that is more common with oncological therapeutics.
  • Non-invasive: With NIR light’s ability to penetrate into multiple layers of biological tissue and be absorbed by AuNRs, this technology removes the need for a light source in the body to trigger the T-cells.
7422
Self-Titrating Bacterial Protease-Activated Prodrug
  • Effective: Activates an internal dosing mechanism such that the magnitude of an infection locally determines the prodrug dose
  • Robust: Increases the stability of the prodrug form by neutralizing the effective charge of the administered antimicrobial peptide
  • Improves safety: Decreases the potential for off-target effects
8010
Scalable, Low-Cost, Inversion-Free Method of Enabling Automated Underside Cell Seeding
  • Convenient: Eliminates the need for inversion procedures, which tend to be tedious, difficult to automate, and prone to failure—especially for 96-well inserts due to their limited culture area
  • Generalizable: Developed for screenings that focus on the air-blood barrier, but can also be  applied to gut, skin, oral mucosa, and other organ systems
  • Scalable: Employs a simple method that is extensible to automated processes for high-throughput drug screenings and pharmacological tests
8677
Rapid Development of SARS-CoV-2 Monoclonal Antibodies
  • Powerful: Demonstrates potential to recognize intact SARS-CoV-2 virions with high affinity
  • Highly efficient: Enables researchers to select pairs of high-affinity antibodies that bind to different receptor sites, maximizing the efficiencies of sandwich-style rapid testing methods
  • Enabling: Furthers the development of neutralizing antibodies that can be used as therapeutic agents, delivered either directly or via mRNA for in situ expression
8487
Skin-Conformal Wearable Stress Monitor Delivers Greater Precision and Continuous, Wireless Monitoring with Comfort and Flexibility
  • All-in-one: The personal adhesive bandage-like single device platform offers wireless, multi-data sensing by simply mounting it on the skin.
  • Disposable: This wearable device is fully disposable after the use and the measured data can be simply sent to the cloud via a tablet or smartphone app.
  • Compact: The unique, thin design of this bioelectric device is one-sixth the volume of current market offerings—weighing less than 7 g, including its rechargeable battery.
8414
Adaptive Broadband Impedance Matching in Ultrasound Front-End Electronics
  • High performance: Improves power transfer and acoustic reflectivity
  • Flexible: Enables multimodal and tunable operation of CMUTs
  • Efficient: Provides optimal matching for co-design of CMUT electronics
8342
Miniaturized Modular-Array Fluorescence Microscopy
  • Powerful: Offers high fluorescence sensitivity, efficiency, and spatiotemporal resolution (~3 µm and up to 60 Hz)
  • Configurable: Offers compatibility with conventional cell culture assays and physiological imaging, providing accessibility to upright physiological imaging and integration with biochemical sensors under the cell platform
  • Efficient: Provides effective parallelization of multi-site data acquisition
8580
Drive Belt with Surface Texture to Minimize Vibrations
  • Effective: Demonstrated significant reduction in vibration compared with flat, untextured belt surfaces in preliminary testing 
  • Simple: Provides a straightforward and easy-to-implement solution to a widespread problem 
  • Economical: Offers a far less expensive means of maintaining the operation of machinery compared with replacing worn belts or employing complex tension systems
8307
Advancing Mass Spectrometry with Novel Interface
  • Flexible: Allows for integration with a range of operational modes and analytical workflows for different ESI-MS techniques
  • High performance: Offers enhanced sensitivity and a significantly improved limit of detection
  • Robust and effective: Minimizes charged ion loss and enables sampling of the most analytically “valuable” droplets
4182
Integrating Electrical Sensors into Soft-Lithography Microfluidic Devices
  • Sophisticated: Advances the integration of electrical sensors on microfluidic devices with a simple, approachable solution
  • Sensitive: Demonstrates a higher signal sensitivity than electrodes in a typical coplanar arrangement
  • Adaptable: Allows for greater layout flexibility because of its straightforward fabrication process
7769
Microfluidic CODES with Innovative Machine-Learning Analysis
  • Scalable: Set-up allows for the integration of multiple microfluidic devices to increase throughput volume.
  • Versatile: Machine learning analysis can be applied to other microfluidic devices integrated with the same Coulter sensor network.
  • Pragmatic: This innovation improves the capabilities of lab-on-a-chip systems to provide an affordable solution for low-resource settings.
7107, 8032
Utilizing Impedance Spectroscopy for Advanced Characterization of Particles
  • Comprehensive: Simultaneously measures both spatial and dielectric properties of particles
  • Streamlined: Helps resolve signal interference from coincident cells—a challenge of other assessment techniques
  • Precise: Offers complex impedance as a new level of particle feature assessment, integrating it with other measurements such as elasticity and size for more predictive analyses
8049
All-Electronic Immunophenotyping Device for Point-of-Care Testing
  • Convenient: Provides an all-electronic immunophenotyping process with straightforward equipment and techniques
  • Low cost: Performs sophisticated, multistep analyses in a system that is affordable enough for point-of-care settings
  • Flexible: Allows for the easy immobilization of multiple antibodies in the device—a shortcoming of current systems
8045, 8047
Scalable Microfluidic Device with Multiple Constriction Channels for High-Throughput Mechanophenotyping
  • High throughput: Addresses the low-throughput challenges of other similar technologies by handling a sample volume near that of a Coulter counter
  • Low cost: Eliminates the need for costly equipment, highly trained personnel, and long processing times that come with other measuring processes
  • Scalable: Uses a frequency division scheme so that multiple copies of the system can operate concurrently
8031
Measuring Surface Antigen Expression via Microflow Cytometry
  • Portable: This innovation uses a disposable, handheld device without bulky or costly equipment, which is expected to be especially useful in low-resource settings.
  • Simple: It is designed to achieve results similar to those from a commercial flow cytometer but without requiring initial purification.
  • Recoverable samples: Unlike commercial systems, the analyzed sample can be recovered for further tests at the end of the analysis.
7913, 8048