Available Technologies by Category
Antigen-specific Cell Programming Using non-viral Approaches
  • This innovative technology uses synthetic nanoparticles to deliver gene modulators and engineered MHC molecules directly to antigen-specific T cells in vivo, enhancing T cell functions and bypassing ex vivo processes.
  • The prototype improves T cell specificity and reduces off-target toxicity, significantly lowering costs and manufacturing time for effective T cell therapies.
  • It has applications in cancer therapy, immune therapy, autoimmune disease therapy, and infectious disease therapy.
8703
Inline manipulation of cells and cell clusters
  • This extracorporeal circulation system enriches CTC clusters from large blood volumes, enabling detailed longitudinal screening and analysis of metastasis.
  • The prototype improves detection rates and facilitates continuous monitoring and in vitro analysis of CTC clusters, aiding early cancer detection and treatment.
  • It supports in-line dialysis systems for pathogenic cells, enhances cancer diagnosis, and provides research tools for studying tumor biology and developing treatments.
9125
Scarless isolation of antigen-specific T cells for CAR T cell manufacturing via DNA-gated sorting
  • This technology introduces DNA-gated sorting (DGS) for label-free isolation of antigen-specific CD8+ T cells, improving CAR T cell therapy.
  • The prototype enhances CAR T cell scalability and therapeutic effectiveness against solid tumors by using a DNA gate mechanism for targeted T cell capture and release.
  • DGS improves in vivo persistence and specificity of CAR T cells, offering better treatment outcomes for solid tumors and other cancers.
9388
Activity-based synthetic liquid biopsy of solid tumors
  • Activatable biosensors injected into tumors capture dynamic biological activity and immune responses, allowing non-invasive monitoring of tumor responses through bodily fluids.
  • The prototype offers real-time insights into tumor behavior and treatment effectiveness, providing a less invasive alternative to traditional biopsies.
  • This method enhances sensitivity and specificity for tumor-specific biomarkers, improving monitoring of drug responses and cancer progression.
9387
Needle-like Nanostructures to Deliver Multi-scale Biomolecules to Non-activated Immune Cells
  • This functionalized nanowire platform delivers multiple genetic materials to naïve T and B cells without pre-activation, enhancing their efficacy in adoptive cell therapy.
  • The prototype improves gene delivery efficiency while preserving the naïve state of immune cells, increasing cell viability and immune response modulation.
  • It offers superior protection against intracellular pathogens and serves as a research tool for immune cell manipulation across various species, ages, and subtypes.
9431
Multi-Niche Human Bone Marrow-On-A-Chip for Plasma Cell Survival and Differentiation
  • This novel microfluidic chip simulates the human bone marrow environment, incorporating multiple niches and supporting long-term plasma cell culture and study.
  • The prototype enables comprehensive study of plasma cell maturation, aiding the development of targeted therapies for plasma cell-related disorders.
  • It overcomes limitations in traditional plasma cell culture, facilitating vaccine development, antibody production research, and immune response modulation.
9246
Lymphoid-Lymphatics-Integrated Organ-on-Chip Device and Method
  • This innovative organ-on-chip system combines vascularized lung and lymphoid tissues, aiding studies on airway infections.
  • The prototype supports diverse cell cultures, making it useful for screening treatments and vaccines.
  • It enhances current lung-on-chip models by accurately simulating lung tissue and immune responses.
9349
A Multi-Stage Cascade Air Conditioning and Refrigeration System Using Thermally Responsive Liquids
  • Innovative technology using thermally responsive liquids in multiple stages enhances air conditioning and refrigeration systems.
  • Currently at proof-of-concept stage, it aims to improve temperature and humidity control efficiency.
  • Offers eco-friendly cooling and dehumidification with zero global warming potential, targeting residential, commercial, and data center applications.
9284
T cell Secretion of Engineered Enzymatic Weapons for Solid Tumor Translation
  • This innovation involves genetically modifying human cells to secrete an enzyme that breaks down adenosine, enhancing CAR-T and other T cell therapies' effectiveness against solid tumors.
  • The prototype addresses adenosine-mediated immunosuppression, improving therapy specificity and efficacy in treating solid tumors.
  • It has commercial applications in enhancing CAR-T cell therapies and other immunotherapy treatments for various cancers, marking a significant advancement in cancer care.
8854
Methods and Markers for Ovarian Cancer Diagnosis and Stratification
  • This technology utilizes advanced machine learning algorithms and lipid panels to distinguish high-grade serous ovarian cancer from other reproductive system cancers, enhancing diagnostic accuracy and early detection capabilities.
  • The prototype improves treatment decision-making and patient monitoring, particularly for individuals with genetic predispositions to ovarian cancer.
  • It serves as a diagnostic tool for ovarian cancer detection, either standalone or alongside existing tests like CA125 and HE4, offering precise diagnosis and aiding in treatment planning.
9366
An Electronic Microfluidic Platform for On-Chip Apoptosis Quantification using Annexin V-Based PS Externalization Detection-GT NEXT
  • This electronic microchip integrates an electrical sensor network with a microfluidic capture chamber to detect phosphatidylserine (PS) externalization, offering a compact, user-friendly, and cost-effective solution for apoptotic analysis.
  • The prototype provides high sensitivity and specificity without the need for prelabeling, making it suitable for diverse applications in clinical diagnostics and biomedical research.
  • It supports drug discovery, toxicity evaluation, and bioprocessing optimizations, enhancing disease mechanism studies and therapeutic target identification.
9306
Capillary Driven Microneedle Patch for Blood Biomarker Analysis
  • This bioresorbable thermoplastic microneedle platform accurately collects capillary blood and quantifies biomarkers on-chip, supported by a smartphone attachment for easy read-out.
  • The prototype integrates hollow microneedles with microfluidic patterns and crossflow filtration, providing low-cost, reliable, and sensitive point-of-care blood testing.
  • It enables point-of-care personalized diagnostics and blood biomarker analysis in clinical and remote settings without expensive peripheral equipment.
9292
BiCMOS Process Integrated Silicon-Germanium Avalanche Photodiode
  • The invention introduces a novel semiconductor photodetector design, leveraging the principle of avalanche multiplication to detect light signals effectively.
  • It enables cost-effective high-volume production through the utilization of existing semiconductor foundry processes, bypassing traditional constraints.
  • This innovative design supports the integration of a complete optical receiver subsystem onto a single chip, thereby enhancing performance and streamlining production processes.
8741
Functionalized Nanowires for miRNA-mediated Programming of Naive T Cells
  • Technology Overview: Georgia Tech's functionalized nanowires deliver genetic materials like miRNAs and CRISPR directly to naive T cells, enhancing their therapeutic potential without pre-activation.
  • Advantages: This method preserves the naive state of T cells, allowing for better viability and functionality, reduced exhaustion, and delivery of both small and large biomolecules, including lentiviral particles.
  • Commercial Applications: The technology can be used in adoptive T cell therapy for cancer and infectious diseases, therapeutic delivery of biomolecules, and as a research tool for immune cell manipulation.
9341
Lymphoid Tissues with Switchable Protein Gradients
  • Technology Overview: Georgia Tech's hydrogel-based immune organoids mimic lymphoid tissue, enabling ex vivo differentiation of B cells and studying immune responses to infections and vaccinations.
  • Advantages: This non-invasive method supports long-term B and T cell survival, mimics antibody production processes, and offers insights into diseases like lymphoma.
  • Commercial Applications: Useful for drug discovery, clinical research on immune disorders, personalized medicine, and academic studies in immunology.
2024-116
Engineering Antigen-Specific T Cells for CAR T Cell Therapy via Antigen-Presenting Lipid Nanoparticles
  • Technology Overview: Georgia Tech's new CAR T cell therapy uses lipid nanoparticles (LNPs) to program antigen-specific T cells in vivo, potentially reducing costs and production time.

  • Advantages: This approach avoids expensive and time-consuming ex vivo manufacturing, minimizes off-target effects, can adapt to various CAR constructs and cancer types, and promises rapid scaling and reduced costs.

  • Commercial Applications: Applicable to multiple myeloma, CD19+ cancers, and a wide range of other cancers, this technology streamlines CAR T cell therapy manufacturing for faster, more affordable treatments.

9386
Driving Neural Activity to Rapidly Control Inflammation, Protein, and Gene Expression in the Brain
  • Novel non-invasive method utilizing neural activity to swiftly control inflammation, protein, and gene expression in the brain.
  • The technology enables rapid and precise modulation of brain functions, potentially revolutionizing treatment for various neurological conditions.
  • Commercial applications include treating Alzheimer's, schizophrenia, autism, epilepsy, and more, offering faster, non-invasive, and targeted therapeutic options.
7773
Lipid Nanoparticle-Mediated Delivery of mRNA Encoded Synthetic Antigens for CAR T Cell Therapy
  • Georgia Tech's novel CAR T cell therapy uses lipid nanoparticles (LNPs) to deliver mRNA-encoded synthetic antigens, improving targeting of solid tumors and reducing off-target effects.

  • The technology ensures efficient mRNA delivery, prompting tumor cells to express unique antigens, enhancing immune recognition and destruction of cancer cells.

  • This approach broadens CAR T cell therapy applicability, allows repeat dosing, and minimizes off-tumor toxicity, offering significant advantages over traditional methods.

9385
Organic Molecules with Delayed Fluorescence for Human-Centric Lighting and Radiation Detectors
  • Innovative light converter tech mimics natural daylight using organic molecules with delayed fluorescence, surpassing current solutions.
  • The technology addresses health issues caused by artificial lighting, offering stable, energy-efficient human-centric lighting.
  • It has versatile applications include indoor lighting, therapy for mood disorders, and smart lighting systems.
2024-080
Controlling the Solubility and Electrical Conductivity of Organic Semiconductor Films by Reversible Doping
  • This innovation introduces a novel approach for achieving precise p-type doping and reversible solubility control in organic semiconductor layers, thereby enhancing their conductivity and stability.
  • It provides solution processability and minimal dopant diffusion, leading to improved performance and versatility for a wide range of electronic devices.
  • This technology finds applications in printed electronics, organic solar cells, LEDs, transistors, and sensors, facilitating the production of thin, flexible components with enduring performance.
7017