| Messenger RNA based expression of cardiomyocyte phenotype sensors and differentiating genes for in vitro correction of cardiac disorders |
- This invention uses a gene therapy as a direct treatment for symptomatic bradyarrhythmia and removes the needs for implantation of electronic pacemakers.
- The innovation does not lead to spillover to the liver, spleen and lungs; allows for mRNA gene transfer to stay focal to the injection site; and does not have danger of integration into the host’s DNA.
- The new gene therapy could be used as first-line treatment of arrhythmias and consequent ailments and to circumvent the need for major surgical interventions.
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7526 |
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| Enabling Rapid Detection of Label-Free RNA for Use in COVID-19 Testing |
- Earlier detection: Identifying the viral components themselves—rather than the body’s reaction to the viral presence (i.e., antibodies)—potentially improves early detection in asymptomatic subjects.
- Simpler process: Use of minimal reagents and fewer preparatory steps is designed to enable more efficient and facile sample preparation. Avoidance of “wash steps” aims to minimize target loss.
- Fewer disruptions: Avoiding the use of high-demand supplies (e.g., swabs) and reagents potentially reduces supply-chain and contamination issues.
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8669 |
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| Dominance Based Wireless Communication and Associated Solutions |
- A new method of wireless communication has lessened the need for multiple channels and time durations, by creating a system where many transmitters can simultaneously transmit and increase network throughput.
- This new system yields higher spatial reuse, reduces the latency of data reception, and improves loss performance and can be used in most wireless network scenarios.
- The dominance based technique uses collection of information coding, and other supporting mechanisms in order to prevent the waste of communication resources.
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4713 |
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| Customized 3D-Printed Bioresorbable Heart Valves |
- Resorbable, patient-specific heart valves offer great flexibility for treating a wider range of conditions and patients than traditionally manufactured heart valves.
- Customizable valves potentially decrease complications due to poor fit and the need for reinterventions.
- Selecting materials for optimal mechanical properties, thermodynamic properties, chemical properties, and surface chemistry and morphology reduces mismatch between device and tissue, potentially improving performance and patient outcomes.
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8893 |
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| Tunable Membrane-Based Wastewater Treatment and Resource Recovery |
- Customizable membrane structure and surface properties provide selective removal of contaminants of emerging concerns (CEC) and recovery of valuable components.
- An enlarged membrane surface area, combined with a gutter effect from the interlayer, results in nearly double the water permeability of current filtration membranes.
- Achieves high-performance recovery of essential nutrients/fertilizers that are free of CECs.
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8633 |
|
| Magnetohydrodynamic Pumped Liquid Metal Loops for Spacecraft Thermal Control |
- The absence of moving parts and low vapor pressure of the liquid result in enhanced reliability and minimum power consumption.
- The near-zero vapor pressure of the liquid metal reduces leaks and minimizes the pressure difference between the loop and the external environment, which reduces the mass of the pipes and enables the use of non-metallic lightweight fluid handling materials.
- With thermal conductivity values two orders of magnitude above standard refrigerants, the volume and mass of heat exchangers are reduced proportionally.
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9251 |
|
| Systems and Methods for Flexible Sheath Locking with Integrated Shape Sensing |
- This technology aims to become a new steerable device to reduce the invasiveness of traditional methods for delivering drugs and diagnostic devices inside the body.
- There are no known existing methods of delivering radiotherapy without the potential of adversely affecting healthy cells.
- This device and method will enable drastic improvements in the quality of life of patients having to undergo radiotherapy treatment.
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9264 |
|
| Smart Nanosensor-Embedded Stent System for Wireless Surveillance of Restenosis in Coronary Artery Disease |
- An electronic stent that incorporates an ultrathin stretchable wireless sensor for continuous surveillance of restenosis along with neointimal proliferation and plaque deposition.
- There is no existing system that offers a clinically practical solution for continuous, real- time detection of both restenosis incidence and progression.
- This device will profoundly decrease the number of healthcare dollars spent on repeated revascularization due to restenosis in CAD.
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8542 |
|
| Back-Illuminated, Modified Silicon Photomultipliers with Largely Enhanced Efficiency for Multiple Applications |
- A novel photomultiplier device has been created that minimizes photon losses, and greatly enhances the efficiency of the device.
- The photomultiplier may improve the fill factor to 100% from 75% for the current SiPM and increases the usable wavelength range to cover the entire UV-Vis spectrum.
- The technology contains a texturized photoelectric surface and at least one coating layer and can be produced using standard manufacturing processes and low extinction coefficient materials.
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8965 |
|
| Enhanced Diversifying Base Editors for Directed Evolution in S. cerevisiae |
- This invention presents an optimized and integrated CRISPR diversifying base editor for use in yeast and demonstrate its ability to rapidly improve the affinity of an antibody through yeast display.
- The innovation has enhanced the base editor mutation rate up has been increased to 27-fold by characterizing an improved key variant and by optimizing the structure of the CRISPR guide RNAs.
- The technology has attained a rate roughly 10-fold higher than state-of-art systems and facilitates ultra-rapid antibody diversification.
|
9111 |
|
| Novel Repressor Proteins for Gene Regulation and CRISPRi |
- The new CRISPRi platform uses novel fusion proteins to specifically inhibit target genes of interest and overcome the off-target issues with existing CRISPR platforms already on the market.
- The technology can be used as a life science tool and/or for diagnostics and therapeutics.
- The platform aims to limit off-target editing, circumvent incomplete gene knockdown sgRNA sequence-dependent repression activity, and variable performance across human cancer cell lines.
|
9106 |
|
| A Brayton Electrochemical Refrigerator/Air-Conditioner |
- The Brayton Electrochemical Refrigerator/AC is a new, electrochemistry-based method of highly efficient cooling.
- Based on the Brayton cycle, the process provides continuous cooling while also providing near-zero global warming potential (GWP) refrigeration.
- This technology is highly efficient with a measured coefficient of performance that exceeds 8 as well as a non-flammable and non-toxic technology.
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8711 |
|
| Messenger Ribonucleic Acid (mRNA)–Based Opsin Expression Enables New and Safer Optogenetic Studies |
- Opsin expression using messenger RNA (mRNA) provides an alternative to viral vectors for use in optogenetic studies involving neurons as well as drug testing with cardiomyocytes.
- Expression with mRNAs has lower toxicity and is usually detectable within 2–24 hours rather than 2–3 weeks.
- The controllable and temporary nature of mRNA offers improved expression regulation based on the transfection amount.
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7534 |
|
| Microfluidic Device Enables Prediction of T-Cell Ability to Home and Engraft to Disease Tissues |
- Improve the homing capabilities of T cells to increase adoptive cell therapy treatment response and safety while decreasing off-target effects.
- Enhance tumor-infiltrating capabilities with engineered microfluidic devices that identify optimal subsets of cells.
- Optimize development pipelines by reducing the number of laborious in vivo studies, while also helping cell therapy companies ensure their products reach the desired tissue.
|
9052 |
|
| mRNA Therapeutic Delivery System Offers Targeted, Sustained HIV Pre-Exposure Protection in the Female Reproductive Tract |
- This system delivers messenger RNA that encodes neutralizing antibodies, which anchor to the female reproductive tract ensuring adequate, sustained tissue concentration for HIV prophylaxis.
- This HIV prevention therapy targets the female reproductive tract and offers month-long protection to reduce office visit frequency and potentially lower medical costs.
- This safe, water-based technology offers ease of administration to enhance patient compliance and prevent systemic complications.
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8324 |
|
| Scalable Manufacturing Approach of Graded Polymer Thin Film Has Potential for Widespread Use |
- Combines slot die coating with a custom roll-to-roll imaging system to allow for efficient, rapid, and scalable fabrication of high-quality gradient thin films.
- An improved manufacturing process over existing techniques because it uses broad material combinations and yields higher quality patterned thin films.
- Incorporates multiple materials to increase the application of patterned thin films across industries, including microelectronics, energy technologies, and environmental systems.
|
8994 |
|
| New Light Detection and Ranging (LIDAR) Technique’s Unprecedented Time and Space Resolution Improves Understanding of Atmospheric Optical Covariances for Forecasting |
- Optimizing free-space optical communications tools with enhanced optical turbulence strength measurements as a function of time and range enables path for development of first of their kind tracebility standards.
- Quantitative measurements of optical turbulence with unprecedented spatial and temporal coverage offer improved performance for long-range FSO applications.
- Singular measurement of optical turbulence results from combination LIDAR measurements of wind, temperature, and water vapor, which enables better weather forecasting and models to be built.
|
9016 |
|
| Predictive Maintenance System for Large-Scale Operations Offers Potential for Significant Cost Savings |
- Consistent workflow improvements: Offers repeatable and consistent enterprise-level improvements to the maintenance workflow.
- Proactive readiness: Improves maintenance scheduling, allowing for improved logistics, scheduling, virtual kitting, and part/component availability.
- Customizable: Customers can build and tailor their PMx solutions according to their needs, providing increased data control and an alternative to costly and limited solutions.
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8793 |
|
| High-Precision, Hands-Free Remote Control of Complex Robotic Systems Via Eye Movements |
- This two-camera eye-tracking system (TCES) integrates a commercial eye tracker with machine-learning technology for continuous real-time classification of gaze and eye directions for robotic arm control.
- The system provides highly accurate classification for four directions of eye movement and has achieved 99.99% accuracy in studies.
- Using simple eye movement, the TCES offers low-cost, high-precision control of external devices/hardware for people with disabilities, surgery robots, warehouse systems, construction tools, and more.
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9184 |
|
| High-Accuracy, Low-Cost, Low-Power Wireless Tracking Tags |
- Low-cost, ultra-low power wireless tag for real-time asset tracking
- Passive wireless tag costs less than $1 to manufacture and can operate for several years with maintenance-free operation
- Compatible with off-the-shelf devices, making it ideal for efficient inventory control in multiple industries
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8943 |
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