Technologies | Technology Licensing

Available Technologies by Category

Paper-Based Multi-Well Depletion Enzyme-Linked Immunosorbent Assay (ELISA) Enables Point-of-Care (POC) Testing Paper-based lateral flow assay automatically performs multi-well ELISA testing for POC titer measurements. Simplifies ELISA testing by eliminating the need for centralized laboratories staffed with trained personnel who perform multiple steps in a specific sequence to execute the assay workflow. Transforms a variety of ELISA-based tests into single-use, disposable dipstick tests to be used at the point of care or at home.	9124
Streamlined Combination Analysis by FORECAST Accurately Predicts and Identifies Pending Malware Attacks Automating the combined techniques of memory forensics and symbolic analysis accelerates how fast an enterprise or government becomes aware of the true extent of malware’s capabilities. When countering cyberattacks, FORECAST provides improved accuracy (94%, overall) with its automated analysis, which is crucial to helping cybersecurity efforts to efficiently focus on high-impact solutions. FORECAST has the flexibility to be a valuable incidence response tool, even when malware is fileless since it uses the software’s memory image to accurately predict the program’s capabilities.	8581
Electric Field Treatment Creates Safe, Effective Antimicrobial Surfaces Creates safe, effective antimicrobial surfaces via bacteria inactivation without the use of chemicals Targets cell membranes or capsid, is less likely to induce antimicrobial resistance, and should be effective for antibiotic-resistant bacteria Requires very short electrical pulses to achieve effective bacteria inactivation, potentially leading to better antifouling performance	9130
Customized 3D-Printed Bioresorbable Heart Valves Resorbable, patient-specific heart valves offer great flexibility for treating a wider range of conditions and patients than traditionally manufactured heart valves. Customizable valves potentially decrease complications due to poor fit and the need for reinterventions. Selecting materials for optimal mechanical properties, thermodynamic properties, chemical properties, and surface chemistry and morphology reduces mismatch between device and tissue, potentially improving performance and patient outcomes.	8893
Parametric Resonance Approach for Efficient, Versatile Acoustic Power Transfer for Implantable/Wearable Devices, Sensing, and Communications New class of transducers utilizes parametric resonance to convert acoustic energy from an ultrasonic source to a sustained electrical signal. Technology powers implantable biomedical devices, small wearable sensors, and other wireless charging applications. Simple yet robust generation of stable electromechanical frequency combs is also possible in both air and liquid environments using a capacitive micro-resonator array.	7635, 9075
Customizable Smart Charging Solution for Electric Vehicles in Residential Areas This customizable smart charger uses algorithms and a hardware prototype to control electric vehicle charging and optimize benefits to consumers and power grid operators. Consumers can charge according to their preference (e.g., minimize cost, maximize carbon-free energy usage, minimize charging time, or minimize battery degradation). The smart charger selects charging profiles that delay charging to avoid excessive loads on the power grid.	8980
Chemically Modified Reduced Graphene Oxides (rGOs) Improve Strength and Qualities of Polymer Composites Chemically modifying rGO creates improved dispersibility and miscibility that can be used in polymer processes as a composite reinforcement or coating material. Easily scalable solution chemistry and purification/filtration makes the process economically feasible, resulting in a commercially viable material for many applications. Melt lamination results in a robust conductive coating that is more durable than comparable polymer-based coatings and enables many electronically active device designs.	8297
Artificial Neural Network (ANN) with Unique Input Design That Significantly Reduces Computational Costs of Complex Engineering Systems Neural network’s novel input can utilize first-order schemes and local patches and allows for discontinuities to be reflected accurately and with greater resolution than existing products. This adaptable ANN can be adopted by commercial and scientific research as a stand-alone solution or in conjunction with existing software. Lower costs for running complex and repetitive computations can be achieved by implementing this neural network with an input system that processes low-cost numerical solution patches arising from two or more converging solutions.	8963
Improved Electrically Driven Temperature Swing Adsorption (ETSA) System for Faster, More Productive Direct Air Capture of Carbon Dioxide This electrically driven temperature swing adsorption (ETSA) system uses sorbent-coated carbon fibers that exhibit Joule heating and rapid temperature swings for improved CO₂ direct air capture (DAC). Over ten times faster temperature controls and six times faster CO₂ desorption rate in ETSA than temperature swing adsorption (TSA) operation under the same DAC condition The dual-layered structure composed of a Joule heating core and CO₂adsorbing coating layer result in a larger amount of CO₂ chemisorption.	9063
Melting Microneedle Patches Extend Drug Delivery Applications, Simplify Manufacturing, and Reduce Costs Melting microneedles enable dispersion of both poorly soluble and water-soluble drugs, which eliminates the need for solvents for improved stabilization and broader applications. Melting microneedles shorten manufacturing and drying time, eliminate the need to maintain a cold chain for storage and transportation, and reduce the ultimate cost of the microneedle patch. The safe suppository bases are inexpensive and enable control of the drug release timing.	8904
Improved Discrimination Performance in MEMS-Based Gas Sensors Enhanced selectivity: Combines gravimetric and impedimetric responses to demonstrate enhanced discrimination between multiple VOCs Powerful: Enables the simultaneous observation of both mass loading and dielectric changes in polymeric sensing films upon sorption of an analyte Innovative: Uses the transient response characteristics of a sensor response to a gated exposure event, rather than steady-state sensor data	8987
Microgeodes Enable Tunable Optical Response for Advanced Coatings/Paint Microgeodes have a programmable structure of nanowires that allows their optical response to be engineered precisely over multiple spectral bands, from UV through mid-IR. Microgeodes combine the tunability and versatility of nanowires with the processability of microspheres to provide a photonic materials platform for a wide range of applications. Microgeode paints could reduce building surface temperatures by as much as 25°C, offering the potential for significant consumer savings while retaining aesthetically pleasing colors.	8866
Quantitative, Performance-Driven Framework for Optimal Desalination Architectures and Energy Subsystems Incorporate and simultaneously compare attributes of multiple types of both desalting systems and energy subsystems for optimal system architectures Assess parameters that impact overall cost to discover complete architectures that would not have been discoverable using traditional methods. Focus on renewable energy subsystems such as solar, wind, geothermal, hydroelectric, and others to create complete desalination architectures that are cleaner and more water efficient than their conventional counterparts.	9055
Novel Nanocarriers Strengthen Therapeutic Delivery, Improves Efficacy Greater therapeutic effectiveness is due to the synergistic work of multiple therapeutic agents (hydrophobic/hydrophilic charged) that can be delivered via this dual-loaded biomaterial. The risk of immunotoxicity to a vaccine is reduced because an adjuvant, which can induce the body’s anti-inflammatory immune response, may be loaded and simultaneously delivered with the vaccine. The novel nanocarrier has broad market application since it can deliver vaccines, gene therapy, small molecule drugs, and even contrast agents.	8988
Automated Bioreactor Sampling System Can Eliminate Cross-Contamination of Samples Automated bioreactor sampling system maintains sample integrity by changing the syringe between samples In addition to savings related to reduced cross-contamination, automated sampling can further lower costs by reducing hands-on time and speeding sampling. Flexible platform can be used with any type of collected sample.	8886
Enhanced Cybersecurity for Networked Motion Control Systems with Somewhat Homomorphic Encryption Increase cybersecurity with expression rewrite rules for encrypted dynamic control schemes that reduce the multiplicative depth of somewhat homomorphic encryption and improve numerical stability. New approach generates motion commands to servo systems without creating a security hole. Information decryption and control signal calculation can be performed and executed inside the plant, while all sensitive system information outside of the plant is always encrypted.	9012
Reducing Traffic Congestion and Achieving Driver Anticipation in Autonomous Vehicles Leverages existing sensing technologies to reduce congestion through ACC software changes Using history trajectories to achieve anticipative driving and reduce congestion requires significantly less processing power than machine learning As automated driving systems advance by adding additional sensors, this data can be added via software to produce more history trajectory data, which can further improve driver anticipation capabilities	9033, 9039
Efficiently Generating Complex Hydrogel Structures for Tissue/Organ-on-a-Chip Models Faster: Reduces preparation time from several hours to minutes Simplified: Generates complex patterns, including perfusable channels, using light-triggered polymerization of synthetic hydrogels and photomasks rather than current equipment-intensive methods that use laser-based patterning or ablation techniques Lowers regulatory burdens: Using synthetic rather than biological matrices simplifies regulatory hurdles, increases reproducibility from batch to batch, and increases tunability of the mechanical and biochemical properties of the matrix	8838, 8839
Electronic Immunoassay Using Enzymatic Metallization on Microparticles Lower cost: Replacing fluorescent markers and readout methods with impedance detection has the potential to significantly decrease the cost of the assay. Transportable: Impedance measurements in microfluidics can be made transportable, which can potentially enable point-of-care applications, as electronic elements are more durable than optical elements. Practical: Identification of COVID-19 antibodies in COVID-positive serum samples has already been demonstrated.	8813
patcherBotPHARMA Automated Intracellular Pharmacological Electrophysiology Robot Increased efficiency: Autonomous operation ensures accurate placement of components and creates high success rates for experiment completion. Decreased human effort: Performs typical ligand-gated ionotropic receptor experimentation protocols autonomously for up to a tenfold reduction in operator interaction time over the duration of the experiment Higher experiment yield: Rapidly replicates previous datasets, reducing the time to produce an 8-point concentration response curve from weeks of recording to ~13 hours of recording	8717
Wearable Ocular Electronics with Virtual Reality Solution for Effective Home-Based Vision Therapy The first fully portable and wireless ocular electronic system in a VR environment provides an effective, home-based visual therapy program. The integrated wearable system has a data classification algorithm to provide high-fidelity, real-time detection of eye vergence to treat eye disorders. Running a VR system on a smartphone can create “virtual therapies” that can be used anywhere anytime.	7916
Self-Driven, Reusable, Scalable Technique for Harvesting Microalgae with Porous Superabsorbent Polymer Fast: The optimized pore structure of the PSAP beads allows fast and selective absorption of water, greatly reducing standard processing time. Cost effective: Microalgae harvesting with PSAP beads cuts costs, as it does not require any complex instrument and little training is needed to operate the harvesting procedures. Scalable: PSAP beads can be produced in large quantities at a significantly lower cost than conventional harvesting tools.	8849
Simulated Synovial Fluid Offers Potential for Effective Treatment of Knee Osteoarthritis Osteoarthritis (OA)-simulated synovial fluid (simSF) provides the opportunity to evaluate how different cell therapies respond to an OA-like environment. By analyzing OA patient-derived synovial fluid (pdSF) and developing potency assays, researchers created a simSF comparable to pdSF that overcomes patient variability. The simSF allows for the investigation of OA biology with greater reproducibility of predictive outcomes and could advance effective treatment of knee OA.	8956
“Smart” Feedback-Controlled Bioreactor Platform Enables Consistent High-Yield and High-Quality MSC Products Scaled-down feedback-controlled hollow fiber-based bioreactor enables identifying the critical quality attributes and critical process parameters for high-quantity and high-quality hCT-MSCs for ideal cell growth and efficacy Provides the controls to maintain optimum conditions and improve expansion yield and cell viability System can be adapted and applied to industrial cell therapy manufacturing and can enable high-yield and high-quality products while minimizing variabilities	8887
Buoyant Platform Assembly Improves PCM Thermal Management Enhances solidification: Incorporating highly localized agitation via a stirring whip rod, this technology seeds solidification to improve this often-arduous phase of PCM thermal cycling. Prevents scale build-up: This technology reduces the instance of sheets of solid PCM forming on the heat sink. The high-frequency, extensible whip rod orbits around the passageway to facilitate nucleation (creating improved solidification), while preventing scale build-up on the interior passageway surfaces. Customizable: The structural design allows the platform to be tailored to the effective density of the PCM material, enabling it to stay between the liquid and solid phases.	8835
Reducing Intraocular Pressure in Glaucoma Patients Without Drugs or Surgery via a Simple Hydrogel Injection Hydrogel injections alleviate elevated intraocular pressure (IOP) with fast results and extended impact. Surgery-free approach eliminates the risk of tissue damage caused by a surgical incision or laser application. Simplified and effective treatment process from standard daily drug intake to a brief office visit only once every 4-6 months.	8467
Lightweight, Versatile Cryogenic Conductors Lithium exhibits lower atomic mass, higher power density, and lower losses under cryogenic conditions Conductors such as lithium become even more power-dense at lower temperatures, exhibiting improved electrical performance Cladding with copper enables lithium to be drawn using standard wire-drawing techniques and tools	8729
DetectIV Offers Noninvasive Early IV Infiltration and Extravasation Detection DetectIV provides a continuous, noninvasive, and wireless IV infiltration and extravasation detection system. The sensor does not cover the IV site and works well with all skin types—significant improvements over existing detection devices. The device detects infiltrations on average 2 hours ahead of nursing standard of care making it an effective early detection system that prevents extended hospital stays.	7207
Biodegradable Shape Memory Polymer for 3D-Printed Tissue and Biomedical Devices New synthesis reaction produces novel biomaterials for soft tissue treatment combines shape memory and biodegradability with custom 3D printing for patient-specific, minimally invasive solutions Customizable to patient needs by varying the formulation and molecular architecture to alter the mechanical properties Improves safety and efficacy by providing a much-needed middle range to existing “too hard/too soft” tissue repair options, while also being biodegradable and bioresorbable	8655
Synthetic Hydrogel for Satellite Cell Delivery in Dystrophic Skeletal Muscle Addresses the critical need for a viable treatment for deterioration of the diaphragm, which is a leading cause of respiratory failure and death in Duchenne Muscular Dystrophy patients Engineered hydrogels comprised of synthetic polymers and peptides are designed to enable successful muscle satellite cell (MuSC) transplantation to the diaphragm or other dystrophic skeletal muscle tissue Shown to support MuSC survival, proliferation, and differentiation, which can enable restoration of dystrophin – a protein absent in DMD and critical to strengthening and repairing muscle fibers	7841
Cost-Effective Hydra Method Monitors DRAM Memory in Computers Hydra combines the best of SRAM-tracking (low performance overhead) and DRAM-tracking (low SRAM overhead and flexibility) to produce Row-Hammer (RH) mitigation that is effective at ultra-low thresholds. Proven results in mitigating the increasing RH security vulnerability issue, Hydra offers a low-cost solution that is widely applicable to all computer systems that use DRAM—over one billion devices. Hydra is a hybrid tracker that successfully mitigates RH security issues and does not compromise the functionality of the computer system.	8933
Microrobots for Neurosurgery Applications Minimally invasive: Significantly reduces invasiveness of procedures in comparison to current macroscale, neurosurgical robots Precise control: Uses 3D position data of the microrobots on the brain surface in a closed-loop system to adjust the magnetic field parameters (i.e., magnitude, frequency, phase, and direct current [DC] offset of each coil) as well as the forces the robots exert to the biopsy tissue Facilitates movement: Employs microfabricated shapes that dictate the microrobot's movements, limits their contact with the brain surface to reduce adhesion, and may also provide a means for the robot to propel itself in fluid	8749
Synthetic Hydrogels for Human Organoid (HO) Generation and Transplantation Synthetic hydrogel exhibits high cytocompatibility and minimal toxicity and inflammation in vivo for improved human organoid viability Injectable delivery vehicle supports localized HO engraftment in mucosal wounds to potentially enhance wound closure and repair Modular design and delivery via endoscopic techniques enables the translational potential of this delivery platform for regenerative medicine and overcomes limitations associated with the use of commercially available matrices for hPSC-based organoid technologies	7536
Hybrid Molecular Catalysts: A New Blueprint for Catalyst Design, Preparation, and Testing Attachment of molecular catalysts to solid supports can lead to new reactivity not seen under homogeneous conditions At an optimal atomic layer deposition (ALD) layer thickness, the molecular catalyst remains highly active while still being resistant to surface detachment and subsequent deactivation Catalyst separation and recovery achieved via a simple filtering and washing process rather than energy- and time-intensive distillation or re-crystallization processes In addition to the simple filter-and-wash process mentioned above, encapsulation requires only about 10 reaction cycles, making this process technologically and economically viable for large-scale manufacturing	8537
Eco-Method Mordant that Improves Natural Dye Adhesion to Synthetic Fabrics Eco-friendly: An improved industrial dyeing process because it reduces excessive heat and water contamination during manufacturing. Wide applicability: Demonstrated to be successful with other materials beyond polyester, including Kevlar and polyacrylonitrile (PAN). Improved quality: Improving commercial dye methods without losing the desired properties of polyester such as flexibility is beneficial to industries like medical supply.	9048
Advanced Manufacturing of Biodegradable Shape Memory Polymers Increases In Vivo Success Faster healing: Improvements catalyze the regeneration of tissue for a faster recovery Increased efficacy: Decreases the likelihood of rejection because the polymers are manufactured in such a way to increase tissue ingrowth and cell attachment Reduced healthcare resource utilization: When initial implantation is successful, it reduces the need for secondary procedures or advanced clinical care for infection	8658
Hydrogels for Controlled Delivery of Lysostaphin to Treat Staphylococcus aureus Infections Injectable (or surgically applied) hydrogel formulation conforms and adheres to the fracture and surrounding tissue, ensuring efficient, local delivery of lysostaphin Localized treatments enable higher relative doses to be given at the site of infection, and enhanced stability from the hydrogel carrier may reduce the number of overall doses needed Tunable nature of the material provides control over the amount and time over which lysostaphin is delivered	7729
Innovative Polymeric Bipolar Membrane Design Provides Wide Industrial Applications This innovative bipolar membrane design dissociates water at a low voltage and provides a tunable membrane with a green method for large-scale manufacturing. Polyvinyl alcohol-based bipolar membrane designs reduce energy costs, maintenance, and toxic chemical usage. This polymeric bipolar membrane is widely applicable across industries, including fuel cells, hydrogen production, carbon capture/conversion, wastewater treatment, and battery-based technologies.	9044
Vapor Phase Infiltration Produces Solar Cells with Greater Thermal Stability Stability: Decreasing spiro-OMeTAD crystallization improves thermal stability of hole transport layers within perovskite solar cells (PSCs) Longevity: Eliminating the main cause of PSCs’ operational degradation increases the overall product lifespan Efficiency: Preventing the delamination of the layers transporting electronic charge has doubled the power conversion efficiency of modified PSCs	9034
Scalable Manufacturing Approach of Graded Polymer Thin Film Has Potential for Widespread Use Combines slot die coating with a custom roll-to-roll imaging system to allow for efficient, rapid, and scalable fabrication of high-quality gradient thin films. An improved manufacturing process over existing techniques because it uses broad material combinations and yields higher quality patterned thin films. Incorporates multiple materials to increase the application of patterned thin films across industries, including microelectronics, energy technologies, and environmental systems.	8994

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