Available Technologies by Category
Synthesis of Alkaloids

This technology can be used in the development of yeast-based syntheses of plant alkaloids, or any other biosynthetic pathway that uses 5-hydroxytryptohan or L-DOPA as precursors. It can be used for the synthesis of compound monoterpene indole alkaloids derived from strictosidine (e.g. quinine, camptothecin, ajmalicine, serpentine, vinblastine and vincristine) or benzylisoquinoline alkaloids derived from dopamine (e.g. berberine and morphine).

6817
GPCR-Based Biosensors for Medium-Chain Fatty Acids
  • Innovative – first medium-chain fatty acid biosensor
  • Cost Saving – enables more rapid production
  • Diverse applications – applications that require different dynamic and linear ranges
6767
Aptamer-Driven Gene Targeting
  • Apatamers have unique secondary structure, allowing them to bind with high specificity and affinity to a specific target
  • Utilizes intrinsic double stranded DNA break (DSB) and repair system, enabling targeted delivery of exogenous DNA in all eukaryotic cell types
  • AGT development could lead to enhancement of gene editing technologies and ultimately disease-targeted therapy
6757
Glucose Regulation Via Electrical Stimulation Of Nerves
  • Needle-free blood glucose control.
  • Potential to either eliminate or decrease use of blood glucose control medications.
  • First demonstrated use of electrical stimulation to inhibit nerve activity to cause a decrease in measured blood glucose levels
6745
Sampling Interstitial Fluid Using Microneedle Patches
  • Novel biomarkers – access biomarkers found only in ISF
  • Continuous monitoring – lack of clotting allows continuous ISF collection
  • Minimally invasive – no hypodermic needles or large instrumentation needed
7766
Lithography-Free Nanowire Transistors
  • Scalable – Eliminating the cost and time associated with top-down patterning enables large-scale manufacturing
  • High Performance – Achieves switching speeds well beyond 1 GHz at supply voltages near 0.5 V
  • Adaptable – Device dimensions can be readily scaled as transistor fabrication techniques advance
7737
Wearable Technology for Joint Health Assessment
  • Sensitive bio-markers of knee healing process 
  • Can be used outside of clinical settings 
  • Provides quantitative measurements as opposed to qualitative ones
7000
Method for Making Thermally Conductive Materials
  • Property tuning capability
  • Improved surface wettability and electrical conductivity which improved alignment of polymer chains
  • Increased thermal capability
6725
Wearable Technology for Cardiovascular Activity
  • Non-invasive measure of cardiac function through wearable ballistocardiography
  • Regular measurements of systolic time intervals during normal daily activities
  • Could be used in harsh environmental conditions including underwater
6714
Chemotaxis Bacterial Cell Separation and Preconcentration
  • Ease-to-use – Sensor design is simple and device is self-powered
  • Versatile – Allows detection of: NOx, SOx, H2S, CH4, CO, CO2, H2O, HCL, NH3, PH3, toluene, and mercaptons
  • Reliable – Design allows analysis with low power consumption at high temperatures
6535
Ribonucleotide-Capture Method
  • Enables the mapping of precise-genome wide positions of rNMPs incorporated in genomic DNA
  • Results in sensitive and specific identification and mapping of rNMPs
  • Could be used for further understanding of the biological implication and consequences of rNMP incorporation in DNA
6522
A Method for Exhaustive CRISPR Off-Target Analysis
  • Provides exhaustive genomic searches for off-target sites due to mismatches, deletions, and insertions
  • Provides primers for experimental validation of predicted off-target sites
  • Facilitates experimental testing using assays or deep sequencing of potential off-target sites given in the output
6478
Microfluidic Device for Cell Aggregates
  • Control - Precise control over the cell culture environment
  • High content assays – Multiple types of imaging-based assays can be done on the same sample, both during live culture and at end-point
  • High throughput – Greater number of experiments
7720
Embedded Wireless Temperature Sensor for Orthopedic Implants
  • Utilizes temperature as indication of deep tissue infection
  • Deep tissue measurement vs. only reaching skin surface
  • Non-invasive monitoring
7682
Cancer Diagnosis Using Nanotechnology
  • Can be used with a simple microscope
  • More sensitive and cost-effective
  • Non-toxic
3424
Microfluidic Droplet for Drug Delivery and Therapeutic Applications
  • Viable, cellular micro-environments requiring precise control are achieved using hydrogel microspheres with diameter sizes ranging from 10-1000 micrometers
  • A protective, semi-permeable capsule encases the cells and biomolecules
  • Release rates of encapsulated biomolecules or drugs are controlled by adjusting the polymer parameters used to fabricate hydrogel microspheres
6467
Disease Progression Modeling
  • Accurate - Provides continuous time modeling, which is more appropriate for medical data due to patients being monitored at irregular intervals
  • Multipurpose - Could be used for disease staging, characteristic progression pattern discovery, prediction of the future state of disease, fast local progression detection, and to enable understanding of disease progression
6466
New Imaging Tool to Compare Healthy and Diseased Cells
  • Discrimination between healthy & diseased cell biology
  • Personalized medicine – specific treatment for an individual
  • Diagnosis of a disease prior to symptoms
6458
Assistive Stairs Utilizing Energy-Recycling Technology
  • ERAS are the only energy-recycling device tailored for assistance during stair movement.
  • The modular design of ERAS allow for quick and easy installation (and removal, if necessary) on top of an existing staircase without expensive remodeling.
  • The low-cost and low-power design allow ERAS to be more affordable and practical to people with limited financial resources.
7596
Synthetic Nano-Antibodies for Immunotherapy
  • Cheaper and faster to manufacture- production only involves synthesis of ligands, nanoparticles, and nano-antibodies; it does not involve cell-lines or animal work
  • More effective- better accumulation and penetration is achieved due to the nanoparticle design
  • Better for patients- dosage to achieve therapeutic efficacy is reduced and can lower the price, duration, and frequency of treatment
7554