Medical Devices | Office of Technology Licensing

Available Technologies by Category
Quickly and Easily Generate Designer Photopatterned Hydrogel Matrices for Complex Microfluidic Tissue/Organ-on-a-Chip Devices	Offers better spatiotemporal control and customization of hydrogel crosslinking and cell patterning Provides a viable alternative to PEG-MAL for culturing primary B cells ex vivo and studying their response to antigens Reduces timing and compatibility issues and offers designer flexibility compared to natural matrices	8986
Foot Ankle Orthotic (FAO) Delivers Real-Time Portable, Discreet Haptic Feedback for Patients and Athletes	Providing patients with discreet notifications of real-time plantar pressure to improve rehabilitation of foot-ankle injuries between clinical visits can reduce risk of injury strain and minimize long-term damage. Athletes from various sports (e.g., tennis, football, basketball) could prioritize injury prevention during practice and games because of the discreet haptic notifications that bring attention to foot planting techniques via pressure monitoring. The benefits of measuring plantar pressure from the four zones of this device’s insole (heel, toes, medial, and lateral) extend beyond foot-ankle injuries and can be key to diabetic pressure wound prevention as well as knee osteoarthritis therapy.	8944
Portable, Reusable, Micropower Radiation Monitors Provide Real-Time Assessment of Radiation Risk	Innovative radiation detection system provides real-time, on-demand, micropower detection in a versatile design. The device materials offer higher conductivity (mobility) than silicon, resulting in reduced power needs (i.e., requiring power only during read-out). Selection and layering of channel and gate materials enables tuning devices for different radiation types.	8084
Custom-Fit Reusable Respiratory Protective Device (RPD) with Continuous Fit Monitoring Improves Comfort and Protection	Vastly improves comfort and protection while bringing peace of mind to wearers through a custom fit and continuous monitoring Reduces pressure injuries caused by extended RPD use through both a customized fit and alerts to the wearer when the RPD should be adjusted or removed Minimizes exposures to workplace hazards by immediately detecting leakage during RPD use and alerting the wearer to adjust the device	8876, 9089, 9090, 9091
High-Precision, Hands-Free Remote Control of Complex Robotic Systems Via Eye Movements	This two-camera eye-tracking system (TCES) integrates a commercial eye tracker with machine-learning technology for continuous real-time classification of gaze and eye directions for robotic arm control. The system provides highly accurate classification for four directions of eye movement and has achieved 99.99% accuracy in studies. Using simple eye movement, the TCES offers low-cost, high-precision control of external devices/hardware for people with disabilities, surgery robots, warehouse systems, construction tools, and more.	9184
Customized 3D-Printed Bioresorbable Heart Valves	Resorbable, patient-specific heart valves offer great flexibility for treating a wider range of conditions and patients than traditionally manufactured heart valves. Customizable valves potentially decrease complications due to poor fit and the need for reinterventions. Selecting materials for optimal mechanical properties, thermodynamic properties, chemical properties, and surface chemistry and morphology reduces mismatch between device and tissue, potentially improving performance and patient outcomes.	8893
Paper-Based Multi-Well Depletion Enzyme-Linked Immunosorbent Assay (ELISA) Enables Point-of-Care (POC) Testing	Paper-based lateral flow assay automatically performs multi-well ELISA testing for POC titer measurements. Simplifies ELISA testing by eliminating the need for centralized laboratories staffed with trained personnel who perform multiple steps in a specific sequence to execute the assay workflow. Transforms a variety of ELISA-based tests into single-use, disposable dipstick tests to be used at the point of care or at home.	9124
Electric Field Treatment Creates Safe, Effective Antimicrobial Surfaces	Creates safe, effective antimicrobial surfaces via bacteria inactivation without the use of chemicals Targets cell membranes or capsid, is less likely to induce antimicrobial resistance, and should be effective for antibiotic-resistant bacteria Requires very short electrical pulses to achieve effective bacteria inactivation, potentially leading to better antifouling performance	9130
Parametric Resonance Approach for Efficient, Versatile Acoustic Power Transfer for Implantable/Wearable Devices, Sensing, and Communications	New class of transducers utilizes parametric resonance to convert acoustic energy from an ultrasonic source to a sustained electrical signal. Technology powers implantable biomedical devices, small wearable sensors, and other wireless charging applications. Simple yet robust generation of stable electromechanical frequency combs is also possible in both air and liquid environments using a capacitive micro-resonator array.	7635, 9075
Wearable Ocular Electronics with Virtual Reality Solution for Effective Home-Based Vision Therapy	The first fully portable and wireless ocular electronic system in a VR environment provides an effective, home-based visual therapy program. The integrated wearable system has a data classification algorithm to provide high-fidelity, real-time detection of eye vergence to treat eye disorders. Running a VR system on a smartphone can create “virtual therapies” that can be used anywhere anytime.	7916
Reducing Intraocular Pressure in Glaucoma Patients Without Drugs or Surgery via a Simple Hydrogel Injection	Hydrogel injections alleviate elevated intraocular pressure (IOP) with fast results and extended impact. Surgery-free approach eliminates the risk of tissue damage caused by a surgical incision or laser application. Simplified and effective treatment process from standard daily drug intake to a brief office visit only once every 4-6 months.	8467
DetectIV Offers Noninvasive Early IV Infiltration and Extravasation Detection	DetectIV provides a continuous, noninvasive, and wireless IV infiltration and extravasation detection system. The sensor does not cover the IV site and works well with all skin types—significant improvements over existing detection devices. The device detects infiltrations on average 2 hours ahead of nursing standard of care making it an effective early detection system that prevents extended hospital stays.	7207
Biodegradable Shape Memory Polymer for 3D-Printed Tissue and Biomedical Devices	New synthesis reaction produces novel biomaterials for soft tissue treatment combines shape memory and biodegradability with custom 3D printing for patient-specific, minimally invasive solutions Customizable to patient needs by varying the formulation and molecular architecture to alter the mechanical properties Improves safety and efficacy by providing a much-needed middle range to existing “too hard/too soft” tissue repair options, while also being biodegradable and bioresorbable	8655
Synthetic Hydrogel for Satellite Cell Delivery in Dystrophic Skeletal Muscle	Addresses the critical need for a viable treatment for deterioration of the diaphragm, which is a leading cause of respiratory failure and death in Duchenne Muscular Dystrophy patients Engineered hydrogels comprised of synthetic polymers and peptides are designed to enable successful muscle satellite cell (MuSC) transplantation to the diaphragm or other dystrophic skeletal muscle tissue Shown to support MuSC survival, proliferation, and differentiation, which can enable restoration of dystrophin – a protein absent in DMD and critical to strengthening and repairing muscle fibers	7841
Microrobots for Neurosurgery Applications	Minimally invasive: Significantly reduces invasiveness of procedures in comparison to current macroscale, neurosurgical robots Precise control: Uses 3D position data of the microrobots on the brain surface in a closed-loop system to adjust the magnetic field parameters (i.e., magnitude, frequency, phase, and direct current [DC] offset of each coil) as well as the forces the robots exert to the biopsy tissue Facilitates movement: Employs microfabricated shapes that dictate the microrobot's movements, limits their contact with the brain surface to reduce adhesion, and may also provide a means for the robot to propel itself in fluid	8749
Eco-Method Mordant that Improves Natural Dye Adhesion to Synthetic Fabrics	Eco-friendly: An improved industrial dyeing process because it reduces excessive heat and water contamination during manufacturing. Wide applicability: Demonstrated to be successful with other materials beyond polyester, including Kevlar and polyacrylonitrile (PAN). Improved quality: Improving commercial dye methods without losing the desired properties of polyester such as flexibility is beneficial to industries like medical supply.	9048
Advanced Manufacturing of Biodegradable Shape Memory Polymers Increases In Vivo Success	Faster healing: Improvements catalyze the regeneration of tissue for a faster recovery Increased efficacy: Decreases the likelihood of rejection because the polymers are manufactured in such a way to increase tissue ingrowth and cell attachment Reduced healthcare resource utilization: When initial implantation is successful, it reduces the need for secondary procedures or advanced clinical care for infection	8658
Hydrogels for Controlled Delivery of Lysostaphin to Treat Staphylococcus aureus Infections	Injectable (or surgically applied) hydrogel formulation conforms and adheres to the fracture and surrounding tissue, ensuring efficient, local delivery of lysostaphin Localized treatments enable higher relative doses to be given at the site of infection, and enhanced stability from the hydrogel carrier may reduce the number of overall doses needed Tunable nature of the material provides control over the amount and time over which lysostaphin is delivered	7729
Smart, Wireless, Bioelectronic Pacifier for Real-Time Continuous Salivary Electrolyte Monitoring in Infants	Smart pacifier offers wireless, real-time, continuous detection of sodium and potassium levels in infants. This totally non-invasive monitoring pacifier eliminates the need for blood draws, which can only be done three times each day, and is designed to provide non-invasive neonatal health monitoring. Microfluidic channels are designed to efficiently pump optimum quantities and concentration of viscous saliva to the sensor area for quick measurement and to eliminate the need to induce salivary stimulation.	8942
Quantitative, Multiplexed Electronic Detection of COVID-19 Biomarkers	Direct electronic detection: This innovation provides direct detection of biomarkers as a simple electronic readout without the use of any intermediate optics. Multiplexed: The device can simultaneously detect multiple biomarkers (e.g., a four-plex chip to detect IgG and IgM antibodies against spike or nucleocapsid antigens). Portable: A handheld, cellphone-interfaced reader is designed to enable detection and monitoring of diseases in remote areas for sensitive yet inexpensive point-of-care use.	8814

Technologies