| Intracellular Anticancer Delivery |
- Self-assembling: Forms an organized structure in water at room temperature
- Nano-scale: Approximately 35 nm, ideal for intracellular uptake
- Versatile: Can be used with any antibody
|
7174 |
|
| Recirculation System for Aerosol Collectors Maximizes Particle Concentration for Improved Pathogen Detection |
- Enhanced detection: Continuously recirculated collection buffer increases the concentration of targeted particles collected and improves detection of pathogens
- Increased sampled air volume: Recirculating the buffer enables running the system for longer periods of time and with larger volumes of air to improve pathogen detection in entire buildings
- Increased control: Users have active control of the volume of fluid introduced during collection via the system’s recharge pump
|
8903 |
|
| 3D Light-Field Endoscopy for High-Precision Microsurgery |
- Enhanced control and safety: Real time visual navigation enhances guidance and intervention in complex microenvironments, maintaining high spatial resolution while providing quantitative depth information
- Comfortable: System does not require 3D glasses that can cause physician dizziness or headaches after long periods of use
- Streamlined: Technique eliminates the need for other imaging procedures such as micro-CT or MRI to quantify the 3D morphology of tissue
|
8848 |
|
| Cell-free Biosensors to Detect Creatinine, Creatine, and Sarcosine |
- Portable: This technology demonstrates the potential to develop point-of-care screening and monitoring, which is essential to expanding access to care worldwide, including to low- and middle-income countries.
- Inexpensive: CFE-based biosensors can cost as little as a few cents per test and could provide a low-cost alternative to current renal function monitoring and diagnosis, which currently involves laboratory visits, trained phlebotomists, skilled technicians, and expensive, specialized equipment.
- Cell-free: The use of a cell-free expression system could enable easier-to-read quantitative output that is less susceptible to matrix effects.
|
8776 |
|
| New Methods for Skin Tissue Engineering: Textile-Based Sandwich Scaffold and CNT-based Electrospun Polymer Composite Yarns |
- Biocompatible: Exhibits good biocompatibility of the yarns fabricated using a wet electrospinning technique (results shown within a limited range of CNT concentration in the bath)
- Purposeful: Mimics the strain-stiffening behavior of human tissue, unlike other scaffolds that exhibit strain-softening of their synthetic materials
- Demonstrated: Exhibits the ability to guide cell anisotropic arrangement as well as support cell proliferation and infiltration in in vitro biological tests
|
8751, 8752 |
|
| Wearable Device for Evaluating Post-Injury Ankle Health During Ambulation |
- Better decisions: Helps clinicians more easily determine the best course for ankle rehabilitation and improves compliance with physical therapy
- Faster recovery: Enables improved rehabilitation guidance based on collected telehealth data that may speed the time to recovery
- Fewer re-injuries: Supports clinicians in making better decisions regarding appropriate activity levels and readiness to return to activities to avoid re-injury
|
8513 |
|
| Transcatheter Heart Valve with Multi-Arm Mechanism |
- Reduced flow stasis: This mechanism displaces the native valve leaflets away from the THV stent frame, essentially removing its “cover” and allowing blood to move freely through the open stent cells. This can help to significantly reduce flow stasis in the neo-sinus region, thereby reducing thrombus initiation/progression.
- Prevention of coronary artery obstruction: Coronary artery obstruction following TAVR is a rare but often fatal complication. In rare cases in patients with unusually large native leaflets or small aortic roots, the large leaflets block the flow of blood to the coronary arteries as the new valve’s scaffolding opens. Georgia Tech’s design displaces the native valve leaflets away from the THV stent frame, which can help to reduce this risk.
- Optimized THV deployment: The innovation offers dual feedback to aid clinicians in determining optimal THV deployment height—a key factor in optimizing patient outcomes. As the device’s “arms” extend against the native vessel wall, they create both tactile feedback during THV positioning as well as visual feedback via fluoroscopy. In addition to deployment height, the multi-arm design supports axial alignment of the THV with respect to the native vessel wall—a factor shown to impact valve performance.
|
8140 |
|
| Low-Power Real-Time Ionizing Radiation Detector |
- Sensitive: Detects the charge generated from the interactions of ionizing radiation within matter with a high level of precision and discerns X-ray pulses of varying dose
- Scalable: Covers a significantly larger detection area than other methods, ranging from 60,000 square micrometers to one square millimeter
- Responsive: Responds within microseconds and proportionately with the overall radiation dose when exposed to X-rays of varying tube voltage (energy) and tube current (number of particles)
|
8780 |
|
| Steerable and Flexible Robotic Endoscopic Tool with Instrument-Changing System |
- Flexible: Offers multiple tendon-driven degrees of freedom and is designed to enable the surgeon to avoid obstacles within the workspace
- Simplifies instrument changes: Includes three instrument stations with a motorized shaft to allow insertion into or retraction from the working channel(s) without leaving the surgical field
- Reduces procedure time: Demonstrates potential to improve procedure efficiency and patient safety by reducing procedure time
|
8118 |
|
| Wearable Health Monitoring Device Improves Data Quality and Accuracy |
- High performance: Captures real-time, real-world data of multiple physiological signals with a significant reduction in MA interference
- Chest-mounted: Provides more accurate ECG, heart rate, respiratory rate, and activity detection than existing wrist-worn commercial monitors
- Comfortable: Adheres securely and discretely to the skin using a breathable soft membrane for continuous conformal contact, eliminating excessive sweating and skin irritation
|
8691 |
|
| Robotically Steerable Guidewire for Improved Vascular Intervention |
- Robotic: Provides operational improvement of guidewire navigation to facilitate catheter placement by employing robotics, while most other commercially available guidewires lack active steering capability
- Versatile: Controls the guidewire bending angle and also adjusts the bending length of the joint, increasing the capabilities of the guidewire and accommodating varied vasculature geometries
- Flexible: Can be extended to multiple bending sections and degrees of freedom, in stark contrast to passive guidewires that offer clinicians very limited degrees of freedom
|
8451 |
|
| Handheld Breath Collection Device for Detecting Disease Biomarkers |
- Improved diagnosis: Analyzes both the gas and liquid sampled from the patient’s breath for potentially more robust and multifaceted results
- Enhanced patient experience: Requires a shorter exhalation cycle to get a breath sample, making the test more comfortable for patients
- Small and portable: Optimizes and miniaturizes the collection process for easy point-of-care applications
|
8791 |
|
| Adaptive Broadband Impedance Matching in Ultrasound Front-End Electronics |
- High performance: Improves power transfer and acoustic reflectivity
- Flexible: Enables multimodal and tunable operation of CMUTs
- Efficient: Provides optimal matching for co-design of CMUT electronics
|
8342 |
|
| Drive Belt with Surface Texture to Minimize Vibrations |
- Effective: Demonstrated significant reduction in vibration compared with flat, untextured belt surfaces in preliminary testing
- Simple: Provides a straightforward and easy-to-implement solution to a widespread problem
- Economical: Offers a far less expensive means of maintaining the operation of machinery compared with replacing worn belts or employing complex tension systems
|
8307 |
|
| High-Tech Infant Suit for Earlier Detection of Cerebral Palsy |
- Advanced: May allow for earlier detection of motor dysfunctions in order to begin therapeutic interventions as soon as possible
- Robust: Collects data from three limb segments on the leg for a multifaceted assessment
- Long-lasting: Uses one power source with regulated voltage in order to prolong the use of the device
|
7949 |
|
| LoCHAid: An Ultra-Low-Cost and Self-Fitting Hearing Aid |
- Low cost: Uses widely available components that cost 98 cents when purchased in bulk quantities
- User friendly: Easier to fit—and keep track of—than conventional behind- and in-the-ear hearing aids
- Accessible: Designed for easy manufacture and repair in locations where conventional hearing aids are priced beyond the reach of most citizens
|
7876 |
|
| Facilitating Ultrasound Penetration of the Skull for Diagnosis and Treatment |
- Portable: Designed to enable imaging of the brain via small, mobile ultrasound devices, which may offer greater convenience compared with MRI and CT machines
- Affordable: May be a lower cost modality compared with leading techniques, such as MRI, CT, or positron emission tomography (PET)
- Robust: Demonstrates energy transmission through the skull on par with that of an aqueous medium in preliminary testing
|
8340 |
|
| Near-Real-Time Positioning for Instruments and Tools in Magnetic Resonance Elastography (MRE) and Imaging (MRI) |
- Precise: Extremely precise positioning mechanism enables orientation and control capable of sub-millimeter motions within the MR environment
- Rapid: Significantly speeds up procedure time over standard MRI and offers wavefield images in near real time
- High resolution: Uses high-frequency actuation to enable imaging of small, geometrically difficult targets
|
8412 |
|
| A Partial-Hand Prosthesis Simulator |
- Specific: Designed to maintain limb length by placing artificial fingers in positions similar to where they would be in an intact hand performing grasping actions (rather than extending the length of the limb as many prostheses do)
- User friendly: Features rubber-capped fingertips that may provide a more lifelike representation of grasp and enhance usability
- Nuanced: Designed to limit tactile sensation and feedback from immobilized fingers, which may allow better evaluation of how the device is functioning for the patient in comparison to an actual prosthesis
|
8534 |
|
| Portable Multi-Parameter Cancer Diagnostic Tool |
- Powerful: Simultaneously measures multiple tissue parameters to determine electro-thermo-mechanical properties
- Disposable: Uses single-use biochip components to eliminate cross-contamination
- Versatile: Uses a variety of other micromotion-capable actuators and extends to other manufacturing techniques and different length scales
|
7619 |
|
