| Thermoformed Polymeric Valved Conduits Offer a Biocompatible, Customizable Heart Valve Replacement Treatment |
- This biocompatible device may reduce adverse events resulting in a lower incidence of post-surgical adverse events for better long-term outcomes.
- Customizable valve conduits allow patient-specific device creation for potentially easier surgical placement and optimal post-surgical valve function.
- This unique device may offer a safer treatment option by providing a biocompatible, patient-specific intervention, resulting in fewer undesirable adverse events.
|
9003 |
|
| Fully Bioresorbable Heart Valve Scaffold Supports Native Neovalve Growth to Reduce Future Procedures |
- Replacing a stenotic fetal heart valve with a living autologous valve could possibly cure the complex cardiac anomalies that cause single ventricle physiology.
- With this approach, the valve has the potential to accommodate patient growth and eliminate the need for multiple heart valve replacements during the patient’s lifetime.
- The transcatheter nature of this valve deployment makes the procedure similar in risk to a traditional fetal valvuloplasty.
|
8868 |
|
| Patterned Implantable Devices for Improved Reconstruction of Tubular Tissue Passageway Defects |
- This innovation improves patterned airway stents for passageways or tubular tissues to potentially enable long-passageway reconstructions.
- Extrusion-based 3D bioprinting produces a patterned implantable device with higher mechanical strength without increasing the wall thickness of the device.
- Incorporating auxetic-patterning creates an implantable splinting device for supporting passageway defects in growing patients, such as infants or children.
|
8831 |
|
| Quickly and Easily Generate Designer Photopatterned Hydrogel Matrices for Complex Microfluidic Tissue/Organ-on-a-Chip Devices |
- Offers better spatiotemporal control and customization of hydrogel crosslinking and cell patterning
- Provides a viable alternative to PEG-MAL for culturing primary B cells ex vivo and studying their response to antigens
- Reduces timing and compatibility issues and offers designer flexibility compared to natural matrices
|
8986 |
|
| Plasma-Activated Catalytic Air Purifier Cleans Enclosed Spaces |
- This plasma-activated catalytic air purifier can be used to clean enclosed spaces, such as aircraft, hospitals, and classrooms, while mitigating hazardous gas-phase byproducts.
- The air purifier can be used synergistically with UV diode lasers and UV lamps, providing additional contaminant destruction pathways while lowering the potential for dielectric breakdown and plasma formation.
- This comprehensive technology is effective for germicide and sterilization activities as well as for hydroxyl-radical production and ozone removal in a wide variety of indoor environments.
|
8536 |
|
| Custom-Fit Reusable Respiratory Protective Device (RPD) with Continuous Fit Monitoring Improves Comfort and Protection |
- Vastly improves comfort and protection while bringing peace of mind to wearers through a custom fit and continuous monitoring
- Reduces pressure injuries caused by extended RPD use through both a customized fit and alerts to the wearer when the RPD should be adjusted or removed
- Minimizes exposures to workplace hazards by immediately detecting leakage during RPD use and alerting the wearer to adjust the device
|
8876, 9089, 9090, 9091 |
|
| Sustained Lymphatic Drug Delivery System Potentially Improves Efficacy and Safety of Immunotherapy and Targeted Therapies |
- This sustained lymphatic drug delivery system guides therapeutics and imaging agents to the injection site, lymphatic vessels, and lymph nodes.
- Sustained lymphatic delivery enables lower dosing and fewer administrations to potentially improve therapeutic response while reducing adverse effects and costs.
- The simplicity of a vaccine-like, sustained drug release injection allows use at less expensive community health centers.
|
8637 |
|
| Customized 3D-Printed Bioresorbable Heart Valves |
- Resorbable, patient-specific heart valves offer great flexibility for treating a wider range of conditions and patients than traditionally manufactured heart valves.
- Customizable valves potentially decrease complications due to poor fit and the need for reinterventions.
- Selecting materials for optimal mechanical properties, thermodynamic properties, chemical properties, and surface chemistry and morphology reduces mismatch between device and tissue, potentially improving performance and patient outcomes.
|
8893 |
|
| Electric Field Treatment Creates Safe, Effective Antimicrobial Surfaces |
- Creates safe, effective antimicrobial surfaces via bacteria inactivation without the use of chemicals
- Targets cell membranes or capsid, is less likely to induce antimicrobial resistance, and should be effective for antibiotic-resistant bacteria
- Requires very short electrical pulses to achieve effective bacteria inactivation, potentially leading to better antifouling performance
|
9130 |
|
| Chemically Modified Reduced Graphene Oxides (rGOs) Improve Strength and Qualities of Polymer Composites |
- Chemically modifying rGO creates improved dispersibility and miscibility that can be used in polymer processes as a composite reinforcement or coating material.
- Easily scalable solution chemistry and purification/filtration makes the process economically feasible, resulting in a commercially viable material for many applications.
- Melt lamination results in a robust conductive coating that is more durable than comparable polymer-based coatings and enables many electronically active device designs.
|
8297 |
|
| Artificial Neural Network (ANN) with Unique Input Design that Significantly Reduces Computational Costs of Complex Engineering Systems |
- Neural network’s novel input can utilize first-order schemes and local patches and allows for discontinuities to be reflected accurately and with greater resolution than existing products.
- This adaptable ANN can be adopted by commercial and scientific research as a stand-alone solution or in conjunction with existing software.
- Lower costs for running complex and repetitive computations can be achieved by implementing this neural network with an input system that processes low-cost numerical solution patches arising from two or more converging solutions.
|
8963 |
|
| Novel Nanocarriers Strengthen Therapeutic Delivery, Improves Efficacy |
- Greater therapeutic effectiveness is due to the synergistic work of multiple therapeutic agents (hydrophobic/hydrophilic charged) that can be delivered via this dual-loaded biomaterial.
- The risk of immunotoxicity to a vaccine is reduced because an adjuvant, which can induce the body’s anti-inflammatory immune response, may be loaded and simultaneously delivered with the vaccine.
- The novel nanocarrier has broad market application since it can deliver vaccines, gene therapy, small molecule drugs, and even contrast agents.
|
8988 |
|
| Anodically Coloring Molecular Electrochromics (EC) Improve Contrast, Color, and Transitions |
- True black-to-clear transitions with high contrast and color tuning are now possible with anodically coloring electrochromics.
- Broad absorption supports color mixing and color tunability in the charged state, and color tuning is enabled by manipulating the oscillator strengths of radical cation transitions.
- Energy required for practical electrochromic applications is effectively decreased by much lower oxidative potentials, as compared to their corresponding polyamides.
|
7745 |
|
| Efficiently Generating Complex Hydrogel Structures for Tissue/Organ-on-a-Chip Models |
- Faster: Reduces preparation time from several hours to minutes
- Simplified: Generates complex patterns, including perfusable channels, using light-triggered polymerization of synthetic hydrogels and photomasks rather than current equipment-intensive methods that use laser-based patterning or ablation techniques
- Lowers regulatory burdens: Using synthetic rather than biological matrices simplifies regulatory hurdles, increases reproducibility from batch to batch, and increases tunability of the mechanical and biochemical properties of the matrix
|
8838, 8839 |
|
| Wearable Ocular Electronics with Virtual Reality Solution for Effective Home-Based Vision Therapy |
- The first fully portable and wireless ocular electronic system in a VR environment provides an effective, home-based visual therapy program.
- The integrated wearable system has a data classification algorithm to provide high-fidelity, real-time detection of eye vergence to treat eye disorders.
- Running a VR system on a smartphone can create “virtual therapies” that can be used anywhere anytime.
|
7916 |
|
| Self-Driven, Reusable, Scalable Technique for Harvesting Microalgae with Porous Superabsorbent Polymer |
- Fast: The optimized pore structure of the PSAP beads allows fast and selective absorption of water, greatly reducing standard processing time.
- Cost effective: Microalgae harvesting with PSAP beads cuts costs, as it does not require any complex instrument and little training is needed to operate the harvesting procedures.
- Scalable: PSAP beads can be produced in large quantities at a significantly lower cost than conventional harvesting tools.
|
8849 |
|
| Buoyant Platform Assembly Improves PCM Thermal Management |
- Enhances solidification: Incorporating highly localized agitation via a stirring whip rod, this technology seeds solidification to improve this often-arduous phase of PCM thermal cycling.
- Prevents scale build-up: This technology reduces the instance of sheets of solid PCM forming on the heat sink. The high-frequency, extensible whip rod orbits around the passageway to facilitate nucleation (creating improved solidification), while preventing scale build-up on the interior passageway surfaces.
- Customizable: The structural design allows the platform to be tailored to the effective density of the PCM material, enabling it to stay between the liquid and solid phases.
|
8835 |
|
| Lightweight, Versatile Cryogenic Conductors |
- Lithium exhibits lower atomic mass, higher power density, and lower losses under cryogenic conditions
- Conductors such as lithium become even more power-dense at lower temperatures, exhibiting improved electrical performance
- Cladding with copper enables lithium to be drawn using standard wire-drawing techniques and tools
|
8729 |
|
| Biodegradable Shape Memory Polymer for 3D-Printed Tissue and Biomedical Devices |
- New synthesis reaction produces novel biomaterials for soft tissue treatment combines shape memory and biodegradability with custom 3D printing for patient-specific, minimally invasive solutions
- Customizable to patient needs by varying the formulation and molecular architecture to alter the mechanical properties
- Improves safety and efficacy by providing a much-needed middle range to existing “too hard/too soft” tissue repair options, while also being biodegradable and bioresorbable
|
8655 |
|
| Synthetic Hydrogel for Satellite Cell Delivery in Dystrophic Skeletal Muscle |
- Addresses the critical need for a viable treatment for deterioration of the diaphragm, which is a leading cause of respiratory failure and death in Duchenne Muscular Dystrophy patients
- Engineered hydrogels comprised of synthetic polymers and peptides are designed to enable successful muscle satellite cell (MuSC) transplantation to the diaphragm or other dystrophic skeletal muscle tissue
- Shown to support MuSC survival, proliferation, and differentiation, which can enable restoration of dystrophin – a protein absent in DMD and critical to strengthening and repairing muscle fibers
|
7841 |
|
