Biotechnology | Office of Technology Licensing

Available Technologies by Category
Reducing Intraocular Pressure in Glaucoma Patients Without Drugs or Surgery via a Simple Hydrogel Injection	Hydrogel injections alleviate elevated intraocular pressure (IOP) with fast results and extended impact. Surgery-free approach eliminates the risk of tissue damage caused by a surgical incision or laser application. Simplified and effective treatment process from standard daily drug intake to a brief office visit only once every 4-6 months.	8467
Synthetic Hydrogel for Satellite Cell Delivery in Dystrophic Skeletal Muscle	Addresses the critical need for a viable treatment for deterioration of the diaphragm, which is a leading cause of respiratory failure and death in Duchenne Muscular Dystrophy patients Engineered hydrogels comprised of synthetic polymers and peptides are designed to enable successful muscle satellite cell (MuSC) transplantation to the diaphragm or other dystrophic skeletal muscle tissue Shown to support MuSC survival, proliferation, and differentiation, which can enable restoration of dystrophin – a protein absent in DMD and critical to strengthening and repairing muscle fibers	7841
Synthetic Hydrogels for Human Organoid (HO) Generation and Transplantation	Synthetic hydrogel exhibits high cytocompatibility and minimal toxicity and inflammation in vivo for improved human organoid viability Injectable delivery vehicle supports localized HO engraftment in mucosal wounds to potentially enhance wound closure and repair Modular design and delivery via endoscopic techniques enables the translational potential of this delivery platform for regenerative medicine and overcomes limitations associated with the use of commercially available matrices for hPSC-based organoid technologies	7536
Hybrid Molecular Catalysts: A New Blueprint for Catalyst Design, Preparation, and Testing	Attachment of molecular catalysts to solid supports can lead to new reactivity not seen under homogeneous conditions At an optimal atomic layer deposition (ALD) layer thickness, the molecular catalyst remains highly active while still being resistant to surface detachment and subsequent deactivation Catalyst separation and recovery achieved via a simple filtering and washing process rather than energy- and time-intensive distillation or re-crystallization processes In addition to the simple filter-and-wash process mentioned above, encapsulation requires only about 10 reaction cycles, making this process technologically and economically viable for large-scale manufacturing	8537
Advanced Manufacturing of Biodegradable Shape Memory Polymers Increases In Vivo Success	Faster healing: Improvements catalyze the regeneration of tissue for a faster recovery Increased efficacy: Decreases the likelihood of rejection because the polymers are manufactured in such a way to increase tissue ingrowth and cell attachment Reduced healthcare resource utilization: When initial implantation is successful, it reduces the need for secondary procedures or advanced clinical care for infection	8658
Hydrogels for Controlled Delivery of Lysostaphin to Treat Staphylococcus aureus Infections	Injectable (or surgically applied) hydrogel formulation conforms and adheres to the fracture and surrounding tissue, ensuring efficient, local delivery of lysostaphin Localized treatments enable higher relative doses to be given at the site of infection, and enhanced stability from the hydrogel carrier may reduce the number of overall doses needed Tunable nature of the material provides control over the amount and time over which lysostaphin is delivered	7729
New Methods for Skin Tissue Engineering: Textile-Based Sandwich Scaffold and CNT-based Electrospun Polymer Composite Yarns	Biocompatible: Exhibits good biocompatibility of the yarns fabricated using a wet electrospinning technique (results shown within a limited range of CNT concentration in the bath) Purposeful: Mimics the strain-stiffening behavior of human tissue, unlike other scaffolds that exhibit strain-softening of their synthetic materials Demonstrated: Exhibits the ability to guide cell anisotropic arrangement as well as support cell proliferation and infiltration in in vitro biological tests	8751, 8752
A Biological Computing Framework for Living Systems	Innovative: Builds on probabilistic computing principles to construct analog biological bits, enabling an entirely new set of logic gates and algorithms and potentially allowing users to solve previously intractable problems Robust: Can sense every extracellular protease encoded in the human genome, for which there is a known peptide substrate, enabling a simple plug-and-play framework for communicating with a variety of biological activities and offering performance competitive with DNA-based computers but with increased processing speed Relevant: Provides a framework based on biological activity and constructed from biological materials, which enables a direct interface with and understanding of living materials and systems	8009
Smart Porous Hydrogels to Increase Cold Supply Chain Efficacy of Biologics and Pharmaceuticals	Preservation: With the ability to adjust the pore size of the SMH, researchers may be able to increase the rejection rate of bacteria, thereby protecting the medicine by slowing down biodegradation. Extended use: Preserving the potency of the transported and stored biologic or pharmaceutical should allow for an improved shelf-life (regardless of the cold supply chain) and an increase in the supply accessible to patients. Lower cost: Using Georgia Tech’s SMH for the storage and handling of biologics or pharmaceuticals should minimize the dependence on a cold supply chain, which utilizes freezers that cost between $10,000-$15,000.	8685
A Chip-Scale Linear Ion Trap to Enable Portable Mass Spectrometers	Enabling: Can be used in the development of much smaller mass spectrometers than are currently available—from benchtop devices to handheld or even smaller instruments—which would extend their use to applications in which they are not currently cost effective High-performance: Provides better than unit-mass resolution and high detection efficiency, and operates at much higher pressures than larger mass analyzers, as shown during lab-based simulations Multi-modal: Allows for several different modes of operation and enables tandem(MS/MS or MS2) or multi-stage/sequential (MSn) mass spectrometry, greatly improving capability compared with other analyzers	8137
Increasing Medium-Chain Fatty Acid (MCFA) Yield in Bacterial Host with Engineered Enzyme	High performance: Increases the yield of MCFAs during chemical and biopolymer synthesis Enabling: Improves the microbial production of chemicals that require the expression of heterologous enzymes Adaptable: Potentially applies to methods of engineering other heterologous enzymes to interact with endogenous proteins in order to produce molecules of interest in a bacterial host	7595
Scalable, Low-Cost, Inversion-Free Method of Enabling Automated Underside Cell Seeding	Convenient: Eliminates the need for inversion procedures, which tend to be tedious, difficult to automate, and prone to failure—especially for 96-well inserts due to their limited culture area Generalizable: Developed for screenings that focus on the air-blood barrier, but can also be applied to gut, skin, oral mucosa, and other organ systems Scalable: Employs a simple method that is extensible to automated processes for high-throughput drug screenings and pharmacological tests	8677
Advancing Mass Spectrometry with Novel Interface	Flexible: Allows for integration with a range of operational modes and analytical workflows for different ESI-MS techniques High performance: Offers enhanced sensitivity and a significantly improved limit of detection Robust and effective: Minimizes charged ion loss and enables sampling of the most analytically “valuable” droplets	4182
2D Array Device	Simple – does not require microstructure fabrication or periphery equipment, such as pressure-driven pumps to operate Unique – loading method enables rapid sample loading and high-percentage sample isolation simultaneously Cheaper – improvements in efficiency and robustness reduce complexity and overhead expenses	8253
Disposable Impedance Biosensor for Cell Manufacturing	Multi-point measurements- provide tempo-spatial profiles of culture attributes and can print a wide range of conductive and insulating materials on both rigid and flexible substrates with non-planar surfaces Wireless - collects the signal wirelessly via printed antennas to simplify the integration to different types of existing bioreactor technologies Safe - system does not apply contact, and minimizes any chance of harm or contamination to affect the cell culture	8270
A Technique for Integrating Photographs for Medical Imaging Examinations	Prevents the application of incorrect patient identification at the time of medical image generation Allows the correlation of serial imaging studies by ensuring that all studies are from the same patient Avoids the generation of incorrect reports	6402
Microfluidic Platform for Phase Separation of Aqueous Solutions	Efficient workflow- sample removal and analysis can be performed without manual oversight Smaller sample size- less sample volume required alleviating dilution of low concentration solutions that is common in alternative sample preparation workflows Faster process- thermoelectric cooling can induce separation in a matter of seconds with precision and tunability	8247
Method for Treatment of Pathologies	Fast - activity is immediate (within 2 hours) Easy to use - applied to nasal sprays or skin patches Safe – less immunogenic	7878
Organ Transplant Decision Aid	Simple – easy-to-use interface for entering patient and donor characteristics Flexible – separate survival models use different variables which enhance the performance of each model Multifaceted – calculates survival probabilities for multiple organs where current technologies only determine survival probability for kidneys	8001
Pterin-Based Hydroxylation of Aromatic Monomers	Could provide substantial high value intermediates Enzymatic catalysis is more energy efficient, yields less (industrial type) waste than chemically based methods Higher level of precision than most chemical reactions	6943

Technologies