Available Technologies by Category
Smart Nanosensor-Embedded Stent System for Wireless Surveillance of Restenosis in Coronary Artery Disease
  • An electronic stent that incorporates an ultrathin stretchable wireless sensor for continuous surveillance of restenosis along with neointimal proliferation and plaque deposition.
  • There is no existing system that offers a clinically practical solution for continuous, real- time detection of both restenosis incidence and progression.
  • This device will profoundly decrease the number of healthcare dollars spent on repeated revascularization due to restenosis in CAD.
8542
Systems and Methods for Flexible Sheath Locking with Integrated Shape Sensing
  • This technology aims to become a new steerable device to reduce the invasiveness of traditional methods for delivering drugs and diagnostic devices inside the body.
  • There are no known existing methods of delivering radiotherapy without the potential of adversely affecting healthy cells.
  • This device and method will enable drastic improvements in the quality of life of patients having to undergo radiotherapy treatment. 
9264
Customized 3D-Printed Bioresorbable Heart Valves
  • Resorbable, patient-specific heart valves offer great flexibility for treating a wider range of conditions and patients than traditionally manufactured heart valves. 
  • Customizable valves potentially decrease complications due to poor fit and the need for reinterventions.
  • Selecting materials for optimal mechanical properties, thermodynamic properties, chemical properties, and surface chemistry and morphology reduces mismatch between device and tissue, potentially improving performance and patient outcomes.
8893
Messenger Ribonucleic Acid (mRNA)–Based Opsin Expression Enables New and Safer Optogenetic Studies
  • Opsin expression using messenger RNA (mRNA) provides an alternative to viral vectors for use in optogenetic studies involving neurons as well as drug testing with cardiomyocytes.
  • Expression with mRNAs has lower toxicity and is usually detectable within 2–24 hours rather than 2–3 weeks.
  • The controllable and temporary nature of mRNA offers improved expression regulation based on the transfection amount.
7534
Microfluidic Device Enables Prediction of T-Cell Ability to Home and Engraft to Disease Tissues
  • Improve the homing capabilities of T cells to increase adoptive cell therapy treatment response and safety while decreasing off-target effects.
  • Enhance tumor-infiltrating capabilities with engineered microfluidic devices that identify optimal subsets of cells.
  • Optimize development pipelines by reducing the number of laborious in vivo studies, while also helping cell therapy companies ensure their products reach the desired tissue.
9052
High-Precision, Hands-Free Remote Control of Complex Robotic Systems Via Eye Movements
  • This two-camera eye-tracking system (TCES) integrates a commercial eye tracker with machine-learning technology for continuous real-time classification of gaze and eye directions for robotic arm control. 
  • The system provides highly accurate classification for four directions of eye movement and has achieved 99.99% accuracy in studies.
  • Using simple eye movement, the TCES offers low-cost, high-precision control of external devices/hardware for people with disabilities, surgery robots, warehouse systems, construction tools, and more. 
9184
Bi-Channel Needle for Injection
  • The injection fluids are completely separated until the tip of the needle, preventing their mixing until they have reached the syringe’s distal tip. 
  • Since the specific volumes of each drug required will be added to the channels of the syringe, this device reduces the amount of fluid left in the syringe after injection.
  • The needle allows the clinician to inject with syringes that are parallel to each other, as opposed to at some oblique angle.
  • The length of the device is not limited to the current 1-inch syringe. It can be longer (even greater than 1 meter) for catheter-based procedures.
9028
Soft Wireless Sternal Patch for Detecting Systemic Vasoconstriction Using Photoplethysmography
  • A wireless, soft sternal patch includes integrated skin-like, photolithographically patterned electronics specifically tuned to continuously measure vasoconstriction from the sternum.
  • In overnight trials, the device detected sleep apnea and hypopnea with 95% precision and 100% sensitivity compared to data professionally scored by licensed clinicians.
  • Use of this patch on the chest could improve detection of key markers of numerous harmful health conditions.
9170
Inflatable Balloon Guidewire for Reducing Trauma and Injury in Pediatric and Adult Patient Procedures
  • The soft balloon tip of the guidewire is designed to minimize patient trauma and injury for pediatric and adult procedures. 
  • This versatile design can be used for other pediatric and adult interventions coupled with commercially available systems.
  • Balloon inflation can be symmetric or asymmetric along the length of the guidewire.
9168
Bioabsorbable, Permeable, and Flexible 3D Auxetic Implants Offer Large-Volume Soft Tissue Reconstruction
  • A novel 3D auxetic architecture offers enhanced compressive flexibility, permeability, and nonlinear mechanical behavior.  
  • This high-performance technology has the potential to generate implants with soft tissue-mimetic biomechanical properties and high mass transfer capacity.
  • Implants can be customized for patients by adjusting the strut width and intervals and by fitting the complex anatomic geometry of the defect based on patient medical data.  
8821
Synthetically Generated, Realistic, and Controllable Human Bio-Signals from Participant-Free Data Collection
  • Synthetic data generation system replicates human body signals and uses a deep generative model to create synthetic SCG beats without human participants. 
  • Transformer-based generative model synthesizes SCG beats that are physiologically diverse and realistic. 
  • Clinically relevant feature inputs act as controls for aortic opening (AO) and aortic closing (AC) features of the generated SCG beat.
9081
Superluminescent Light Projection (SLP) System Decreases Nanoscale Printing Costs by 10–50 Times
  • This superluminescent light projection (SLP) system decreases overall nanoscale printing costs by 10–50 times. 
  • A parallel writing mechanism supports higher throughput speeds: up to 100 times higher than existing metal printing methods and four times higher than existing polymer printing methods. 
  • SLP creates sharp-edged images with minimal speckling patterns, resulting in high-resolution images and structures on both polymer and metal-based films. 
9066
Versatile Continuum Robots with Variable Stiffness Control for Improved Positioning and Manipulation
  • Continuum robot design offers stiffness control continuously along the length of a guidewire or at variable discrete locations along the structure’s length. 
  • Versatile design is not restricted to one actuator type along the length of the guidewire, and elements can be placed along any section of the guidewire body.
  • With better control of the wire positioning within a patient’s anatomy, it may be possible to improve treatment outcomes.
9166
Patient-Centered Biofeedback Headset Can Isolate, Monitor, and Analyze Vocal Output in Real Time for Optimal Voice Modulation in Patients with Parkinson’s Disease
  • Innovative headset offers real-time haptic feedback for vocal improvement and increased patient autonomy.
  • Device stores easily accessible data for therapist review and fine-tuning of preset therapeutic thresholds to continually improve vocal output.
  • Lightweight, low-profile, battery-powered headset are favorable for all-day wear and use omnidirectional microphones for optimal comfort.
9134
Microfluidic System Enables Scalable, High-Throughput Separation for High-Purity Human Induced Pluripotent Stem Cells (hiPSCs)
  • Simple, tunable high-throughput process separates hiPSCs quickly and efficiently according to the degree to which they adhere to a substrate inside the microfluidic device. 
  • Separation of intact cell colonies enables this simple system to avoid damaging and adversely affecting the pluripotency of the cells.
  • The approach is fast, does not rely on labeling technologies, supports greatly enriched cells, and results in a cell survival rate greater than 80%.
5685
Hydrogel-Based Artificial Ligaments Offer Substantial Improvements for ACL Reconstruction Therapies
  • This biocompatible hydrogel-based device is designed to reproduce natural ligament/tendon function to decrease the incidence of immune responses that lead to chronic inflammation.
  • An alternative to standard artificial ligaments and tendons, the device is designed to be placed via non-invasive techniques, making it a safer alternative to current, invasive surgical methods.
  • Non-biodegradable hydrogels are highly durable, potentially increasing the lifespan of the prostheses.
5386
Thermoformed Polymeric Valved Conduits Offer a Biocompatible, Customizable Heart Valve Replacement Treatment
  • This biocompatible device may reduce adverse events resulting in a lower incidence of post-surgical adverse events for better long-term outcomes.
  • Customizable valve conduits allow patient-specific device creation for potentially easier surgical placement and optimal post-surgical valve function.
  • This unique device may offer a safer treatment option by providing a biocompatible, patient-specific intervention, resulting in fewer undesirable adverse events.
9003
Fully Bioresorbable Heart Valve Scaffold Supports Native Neovalve Growth to Reduce Future Procedures
  • Replacing a stenotic fetal heart valve with a living autologous valve could possibly cure the complex cardiac anomalies that cause single ventricle physiology.
  • With this approach, the valve has the potential to accommodate patient growth and eliminate the need for multiple heart valve replacements during the patient’s lifetime.
  • The transcatheter nature of this valve deployment makes the procedure similar in risk to a traditional fetal valvuloplasty.
8868
Saliva-Based Multiplexed Assay with 25x Higher Sensitivity to SARS-CoV-2 and Influenza A and B
  • New lateral flow assay device achieves enhanced sensitivity with the same sample concentration, significantly reducing the risk of false negatives.
  • Tunable capillary flow allows sample/reagent to be concurrently delivered to multiple regions, enabling multiplexed and repetitive assays on a single device.
  • Transforms a variety of biological assays and tests performed at clinical laboratories into single-use, disposable dipstick tests to be used at the point of care or home.
9149
Patterned Implantable Devices for Improved Reconstruction of Tubular Tissue Passageway Defects
  • This innovation improves patterned airway stents for passageways or tubular tissues to potentially enable long-passageway reconstructions. 
  • Extrusion-based 3D bioprinting produces a patterned implantable device with higher mechanical strength without increasing the wall thickness of the device.
  • Incorporating auxetic-patterning creates an implantable splinting device for supporting passageway defects in growing patients, such as infants or children.
8831