| DetectIV Offers Noninvasive Early IV Infiltration and Extravasation Detection |
- DetectIV provides a continuous, noninvasive, and wireless IV infiltration and extravasation detection system.
- The sensor does not cover the IV site and works well with all skin types—significant improvements over existing detection devices.
- The device detects infiltrations on average 2 hours ahead of nursing standard of care making it an effective early detection system that prevents extended hospital stays.
|
7207 |
|
| Biodegradable Shape Memory Polymer for 3D-Printed Tissue and Biomedical Devices |
- New synthesis reaction produces novel biomaterials for soft tissue treatment combines shape memory and biodegradability with custom 3D printing for patient-specific, minimally invasive solutions
- Customizable to patient needs by varying the formulation and molecular architecture to alter the mechanical properties
- Improves safety and efficacy by providing a much-needed middle range to existing “too hard/too soft” tissue repair options, while also being biodegradable and bioresorbable
|
8655 |
|
| Synthetic Hydrogel for Satellite Cell Delivery in Dystrophic Skeletal Muscle |
- Addresses the critical need for a viable treatment for deterioration of the diaphragm, which is a leading cause of respiratory failure and death in Duchenne Muscular Dystrophy patients
- Engineered hydrogels comprised of synthetic polymers and peptides are designed to enable successful muscle satellite cell (MuSC) transplantation to the diaphragm or other dystrophic skeletal muscle tissue
- Shown to support MuSC survival, proliferation, and differentiation, which can enable restoration of dystrophin – a protein absent in DMD and critical to strengthening and repairing muscle fibers
|
7841 |
|
| Microrobots for Neurosurgery Applications |
- Minimally invasive: Significantly reduces invasiveness of procedures in comparison to current macroscale, neurosurgical robots
- Precise control: Uses 3D position data of the microrobots on the brain surface in a closed-loop system to adjust the magnetic field parameters (i.e., magnitude, frequency, phase, and direct current [DC] offset of each coil) as well as the forces the robots exert to the biopsy tissue
- Facilitates movement: Employs microfabricated shapes that dictate the microrobot's movements, limits their contact with the brain surface to reduce adhesion, and may also provide a means for the robot to propel itself in fluid
|
8749 |
|
| Eco-Method Mordant that Improves Natural Dye Adhesion to Synthetic Fabrics |
- Eco-friendly: An improved industrial dyeing process because it reduces excessive heat and water contamination during manufacturing.
- Wide applicability: Demonstrated to be successful with other materials beyond polyester, including Kevlar and polyacrylonitrile (PAN).
- Improved quality: Improving commercial dye methods without losing the desired properties of polyester such as flexibility is beneficial to industries like medical supply.
|
9048 |
|
| Advanced Manufacturing of Biodegradable Shape Memory Polymers Increases In Vivo Success |
- Faster healing: Improvements catalyze the regeneration of tissue for a faster recovery
- Increased efficacy: Decreases the likelihood of rejection because the polymers are manufactured in such a way to increase tissue ingrowth and cell attachment
- Reduced healthcare resource utilization: When initial implantation is successful, it reduces the need for secondary procedures or advanced clinical care for infection
|
8658 |
|
| Hydrogels for Controlled Delivery of Lysostaphin to Treat Staphylococcus aureus Infections |
- Injectable (or surgically applied) hydrogel formulation conforms and adheres to the fracture and surrounding tissue, ensuring efficient, local delivery of lysostaphin
- Localized treatments enable higher relative doses to be given at the site of infection, and enhanced stability from the hydrogel carrier may reduce the number of overall doses needed
- Tunable nature of the material provides control over the amount and time over which lysostaphin is delivered
|
7729 |
|
| Smart, Wireless, Bioelectronic Pacifier for Real-Time Continuous Salivary Electrolyte Monitoring in Infants |
- Smart pacifier offers wireless, real-time, continuous detection of sodium and potassium levels in infants.
- This totally non-invasive monitoring pacifier eliminates the need for blood draws, which can only be done three times each day, and is designed to provide non-invasive neonatal health monitoring.
- Microfluidic channels are designed to efficiently pump optimum quantities and concentration of viscous saliva to the sensor area for quick measurement and to eliminate the need to induce salivary stimulation.
|
8942 |
|
| Quantitative, Multiplexed Electronic Detection of COVID-19 Biomarkers |
- Direct electronic detection: This innovation provides direct detection of biomarkers as a simple electronic readout without the use of any intermediate optics.
- Multiplexed: The device can simultaneously detect multiple biomarkers (e.g., a four-plex chip to detect IgG and IgM antibodies against spike or nucleocapsid antigens).
- Portable: A handheld, cellphone-interfaced reader is designed to enable detection and monitoring of diseases in remote areas for sensitive yet inexpensive point-of-care use.
|
8814 |
|
| Intracellular Anticancer Delivery |
- Self-assembling: Forms an organized structure in water at room temperature
- Nano-scale: Approximately 35 nm, ideal for intracellular uptake
- Versatile: Can be used with any antibody
|
7174 |
|
| Recirculation System for Aerosol Collectors Maximizes Particle Concentration for Improved Pathogen Detection |
- Enhanced detection: Continuously recirculated collection buffer increases the concentration of targeted particles collected and improves detection of pathogens
- Increased sampled air volume: Recirculating the buffer enables running the system for longer periods of time and with larger volumes of air to improve pathogen detection in entire buildings
- Increased control: Users have active control of the volume of fluid introduced during collection via the system’s recharge pump
|
8903 |
|
| 3D Light-Field Endoscopy for High-Precision Microsurgery |
- Enhanced control and safety: Real time visual navigation enhances guidance and intervention in complex microenvironments, maintaining high spatial resolution while providing quantitative depth information
- Comfortable: System does not require 3D glasses that can cause physician dizziness or headaches after long periods of use
- Streamlined: Technique eliminates the need for other imaging procedures such as micro-CT or MRI to quantify the 3D morphology of tissue
|
8848 |
|
| Cell-free Biosensors to Detect Creatinine, Creatine, and Sarcosine |
- Portable: This technology demonstrates the potential to develop point-of-care screening and monitoring, which is essential to expanding access to care worldwide, including to low- and middle-income countries.
- Inexpensive: CFE-based biosensors can cost as little as a few cents per test and could provide a low-cost alternative to current renal function monitoring and diagnosis, which currently involves laboratory visits, trained phlebotomists, skilled technicians, and expensive, specialized equipment.
- Cell-free: The use of a cell-free expression system could enable easier-to-read quantitative output that is less susceptible to matrix effects.
|
8776 |
|
| New Methods for Skin Tissue Engineering: Textile-Based Sandwich Scaffold and CNT-based Electrospun Polymer Composite Yarns |
- Biocompatible: Exhibits good biocompatibility of the yarns fabricated using a wet electrospinning technique (results shown within a limited range of CNT concentration in the bath)
- Purposeful: Mimics the strain-stiffening behavior of human tissue, unlike other scaffolds that exhibit strain-softening of their synthetic materials
- Demonstrated: Exhibits the ability to guide cell anisotropic arrangement as well as support cell proliferation and infiltration in in vitro biological tests
|
8751, 8752 |
|
| Wearable Device for Evaluating Post-Injury Ankle Health During Ambulation |
- Better decisions: Helps clinicians more easily determine the best course for ankle rehabilitation and improves compliance with physical therapy
- Faster recovery: Enables improved rehabilitation guidance based on collected telehealth data that may speed the time to recovery
- Fewer re-injuries: Supports clinicians in making better decisions regarding appropriate activity levels and readiness to return to activities to avoid re-injury
|
8513 |
|
| Transcatheter Heart Valve with Multi-Arm Mechanism |
- Reduced flow stasis: This mechanism displaces the native valve leaflets away from the THV stent frame, essentially removing its “cover” and allowing blood to move freely through the open stent cells. This can help to significantly reduce flow stasis in the neo-sinus region, thereby reducing thrombus initiation/progression.
- Prevention of coronary artery obstruction: Coronary artery obstruction following TAVR is a rare but often fatal complication. In rare cases in patients with unusually large native leaflets or small aortic roots, the large leaflets block the flow of blood to the coronary arteries as the new valve’s scaffolding opens. Georgia Tech’s design displaces the native valve leaflets away from the THV stent frame, which can help to reduce this risk.
- Optimized THV deployment: The innovation offers dual feedback to aid clinicians in determining optimal THV deployment height—a key factor in optimizing patient outcomes. As the device’s “arms” extend against the native vessel wall, they create both tactile feedback during THV positioning as well as visual feedback via fluoroscopy. In addition to deployment height, the multi-arm design supports axial alignment of the THV with respect to the native vessel wall—a factor shown to impact valve performance.
|
8140 |
|
| Low-Power Real-Time Ionizing Radiation Detector |
- Sensitive: Detects the charge generated from the interactions of ionizing radiation within matter with a high level of precision and discerns X-ray pulses of varying dose
- Scalable: Covers a significantly larger detection area than other methods, ranging from 60,000 square micrometers to one square millimeter
- Responsive: Responds within microseconds and proportionately with the overall radiation dose when exposed to X-rays of varying tube voltage (energy) and tube current (number of particles)
|
8780 |
|
| Steerable and Flexible Robotic Endoscopic Tool with Instrument-Changing System |
- Flexible: Offers multiple tendon-driven degrees of freedom and is designed to enable the surgeon to avoid obstacles within the workspace
- Simplifies instrument changes: Includes three instrument stations with a motorized shaft to allow insertion into or retraction from the working channel(s) without leaving the surgical field
- Reduces procedure time: Demonstrates potential to improve procedure efficiency and patient safety by reducing procedure time
|
8118 |
|
| Wearable Health Monitoring Device Improves Data Quality and Accuracy |
- High performance: Captures real-time, real-world data of multiple physiological signals with a significant reduction in MA interference
- Chest-mounted: Provides more accurate ECG, heart rate, respiratory rate, and activity detection than existing wrist-worn commercial monitors
- Comfortable: Adheres securely and discretely to the skin using a breathable soft membrane for continuous conformal contact, eliminating excessive sweating and skin irritation
|
8691 |
|
| Robotically Steerable Guidewire for Improved Vascular Intervention |
- Robotic: Provides operational improvement of guidewire navigation to facilitate catheter placement by employing robotics, while most other commercially available guidewires lack active steering capability
- Versatile: Controls the guidewire bending angle and also adjusts the bending length of the joint, increasing the capabilities of the guidewire and accommodating varied vasculature geometries
- Flexible: Can be extended to multiple bending sections and degrees of freedom, in stark contrast to passive guidewires that offer clinicians very limited degrees of freedom
|
8451 |
|
