Available Technologies by Category
Enabling Rapid Detection of Label-Free RNA for Use in COVID-19 Testing
  • Earlier detection: Identifying the viral components themselves—rather than the body’s reaction to the viral presence (i.e., antibodies)—potentially improves early detection in asymptomatic subjects.
  • Simpler process: Use of minimal reagents and fewer preparatory steps is designed to enable more efficient and facile sample preparation. Avoidance of “wash steps” aims to minimize target loss.
  • Fewer disruptions: Avoiding the use of high-demand supplies (e.g., swabs) and reagents potentially reduces supply-chain and contamination issues.
8669
Messenger Ribonucleic Acid (mRNA)–Based Opsin Expression Enables New and Safer Optogenetic Studies
  • Opsin expression using messenger RNA (mRNA) provides an alternative to viral vectors for use in optogenetic studies involving neurons as well as drug testing with cardiomyocytes.
  • Expression with mRNAs has lower toxicity and is usually detectable within 2–24 hours rather than 2–3 weeks.
  • The controllable and temporary nature of mRNA offers improved expression regulation based on the transfection amount.
7534
Microfluidic Device Enables Prediction of T-Cell Ability to Home and Engraft to Disease Tissues
  • Improve the homing capabilities of T cells to increase adoptive cell therapy treatment response and safety while decreasing off-target effects.
  • Enhance tumor-infiltrating capabilities with engineered microfluidic devices that identify optimal subsets of cells.
  • Optimize development pipelines by reducing the number of laborious in vivo studies, while also helping cell therapy companies ensure their products reach the desired tissue.
9052
Soft Wireless Sternal Patch for Detecting Systemic Vasoconstriction Using Photoplethysmography
  • A wireless, soft sternal patch includes integrated skin-like, photolithographically patterned electronics specifically tuned to continuously measure vasoconstriction from the sternum.
  • In overnight trials, the device detected sleep apnea and hypopnea with 95% precision and 100% sensitivity compared to data professionally scored by licensed clinicians.
  • Use of this patch on the chest could improve detection of key markers of numerous harmful health conditions.
9170
Inflatable Balloon Guidewire for Reducing Trauma and Injury in Pediatric and Adult Patient Procedures
  • The soft balloon tip of the guidewire is designed to minimize patient trauma and injury for pediatric and adult procedures. 
  • This versatile design can be used for other pediatric and adult interventions coupled with commercially available systems.
  • Balloon inflation can be symmetric or asymmetric along the length of the guidewire.
9168
Lymphoid Tissue System Harnesses Ex Vivo Immune Reactions for Rapid Antibody Production and Immune Response Prediction
  • This immunocompetent system uniquely accounts for the unexpected activation of various immune cells to allow proper immune cell differentiation, recapitulating an effective immune response.
  • The chemokine gradient is switchable, allowing the immune cell differentiation needed for an appropriate immune reaction.
  • An ex vivo system supports immune response creation in a controlled environment, allowing reproduction of immunologic events for developing improved therapeutics.
9196
Sustained Lymphatic Drug Delivery System Potentially Improves Efficacy and Safety of Immunotherapy and Targeted Therapies
  • This sustained lymphatic drug delivery system guides therapeutics and imaging agents to the injection site, lymphatic vessels, and lymph nodes. 
  • Sustained lymphatic delivery enables lower dosing and fewer administrations to potentially improve therapeutic response while reducing adverse effects and costs.
  • The simplicity of a vaccine-like, sustained drug release injection allows use at less expensive community health centers.
8637
Image-Based Disease Severity Algorithm
  • The technology utilizes an image-based algorithm and automatic methodology to detect biomarkers in disease.
  • It leverages a well-trained neural network on a dataset of healthy instances to learn the feature distribution of the healthy data.
  • Anomaly detection algorithms generate anomaly scores based on properties of the neural network, providing a measure of severity by assessing how anomalous an instance appears compared to the healthy distribution.
9097
Synthetically Generated, Realistic, and Controllable Human Bio-Signals from Participant-Free Data Collection
  • Synthetic data generation system replicates human body signals and uses a deep generative model to create synthetic SCG beats without human participants. 
  • Transformer-based generative model synthesizes SCG beats that are physiologically diverse and realistic. 
  • Clinically relevant feature inputs act as controls for aortic opening (AO) and aortic closing (AC) features of the generated SCG beat.
9081
Universal Transcriptional Programming in a Bacteroides Consortium Creates a Foundation to Advance Living Therapeutics
  • Consortium-based, universal transcriptional programming framework is a biotic decision-making technology using genetic circuit compression in a Bacteroides community.
  • Compressed genetic circuit design shortens circuit-building time, offers a compact circuit footprint that allows more complexity, uses fewer resources, and reduces cell communication time. 
  • Has potential applications in living therapeutics, advanced biomanufacturing, and next-generation biosecurity.
9006
Single Cell Metabolomics Assay
  • The technology makes it possible to identify single cell resolution of lipids and other small molecules in complex tissue types, as well as metabolism mapping specific to different cell types.
  • The measurements found through this can be used to study metabolomic response to drug exposure.
  • The technology can achieve submicron resolution of lipids and other small molecules at anywhere from 200-1000 depth slices, using spatially resolved metabolic profiling.
9023
Measurement and Modeling System Using Cell Signaling Networks
  • The technology quickly identifies cell signaling pathways from a patient biopsy, allowing for personalized treatment approaches to be identified.
  • Measurements can be used to study potential tumor response to drug treatment, through the use of xenografted cells from the patient.
  • 30-100 potential protein pathways and interactions can be measured using a single sample through multiplexing of rapid immunofluorescence.
9022
Saliva-Based Multiplexed Assay with 25x Higher Sensitivity to SARS-CoV-2 and Influenza A and B
  • New lateral flow assay device achieves enhanced sensitivity with the same sample concentration, significantly reducing the risk of false negatives.
  • Tunable capillary flow allows sample/reagent to be concurrently delivered to multiple regions, enabling multiplexed and repetitive assays on a single device.
  • Transforms a variety of biological assays and tests performed at clinical laboratories into single-use, disposable dipstick tests to be used at the point of care or home.
9149
Quickly and Easily Generate Designer Photopatterned Hydrogel Matrices for Complex Microfluidic Tissue/Organ-on-a-Chip Devices
  • Offers better spatiotemporal control and customization of hydrogel crosslinking and cell patterning
  • Provides a viable alternative to PEG-MAL for culturing primary B cells ex vivo and studying their response to antigens
  • Reduces timing and compatibility issues and offers designer flexibility compared to natural matrices
8986
Foot Ankle Orthotic (FAO) Delivers Real-Time Portable, Discreet Haptic Feedback for Patients and Athletes
  • Providing patients with discreet notifications of real-time plantar pressure to improve rehabilitation of foot-ankle injuries between clinical visits can reduce risk of injury strain and minimize long-term damage.
  • Athletes from various sports (e.g., tennis, football, basketball) could prioritize injury prevention during practice and games because of the discreet haptic notifications that bring attention to foot planting techniques via pressure monitoring.
  • The benefits of measuring plantar pressure from the four zones of this device’s insole (heel, toes, medial, and lateral) extend beyond foot-ankle injuries and can be key to diabetic pressure wound prevention as well as knee osteoarthritis therapy.
8944
Portable, Reusable, Micropower Radiation Monitors Provide Real-Time Assessment of Radiation Risk
  • Innovative radiation detection system provides real-time, on-demand, micropower detection in a versatile design.
  • The device materials offer higher conductivity (mobility) than silicon, resulting in reduced power needs (i.e., requiring power only during read-out).
  • Selection and layering of channel and gate materials enables tuning devices for different radiation types.
8084
Deployable Critical Active Learning (DECAL) System Offers Better Characterization for Improved Diagnostics and Imaging
  • The deployable critical active learning (DECAL) system’s bi-modal interface enables better characterization with large training sets that generate more accurate output for higher precision.
  • The algorithm used during the initialization period creates a framework that can be expanded and generalized to any data method and application.
  •  The DECAL algorithm samples uniquely important, unlabeled data to aid existing active learning systems in generalizing more quickly, providing faster diagnosis statistics.
9099
Paper-Based Multi-Well Depletion Enzyme-Linked Immunosorbent Assay (ELISA) Enables Point-of-Care (POC) Testing
  • Paper-based lateral flow assay automatically performs multi-well ELISA testing for POC titer measurements.
  • Simplifies ELISA testing by eliminating the need for centralized laboratories staffed with trained personnel who perform multiple steps in a specific sequence to execute the assay workflow.
  • Transforms a variety of ELISA-based tests into single-use, disposable dipstick tests to be used at the point of care or at home.
9124
Parametric Resonance Approach for Efficient, Versatile Acoustic Power Transfer for Implantable/Wearable Devices, Sensing, and Communications
  • New class of transducers utilizes parametric resonance to convert acoustic energy from an ultrasonic source to a sustained electrical signal. 
  • Technology powers implantable biomedical devices, small wearable sensors, and other wireless charging applications.
  • Simple yet robust generation of stable electromechanical frequency combs is also possible in both air and liquid environments using a capacitive micro-resonator array.
7635, 9075
Efficiently Generating Complex Hydrogel Structures for Tissue/Organ-on-a-Chip Models
  • Faster: Reduces preparation time from several hours to minutes
  • Simplified: Generates complex patterns, including perfusable channels, using light-triggered polymerization of synthetic hydrogels and photomasks rather than current equipment-intensive methods that use laser-based patterning or ablation techniques
  • Lowers regulatory burdens: Using synthetic rather than biological matrices simplifies regulatory hurdles, increases reproducibility from batch to batch, and increases tunability of the mechanical and biochemical properties of the matrix
8838, 8839