Diagnostics | Office of Technology Licensing

Available Technologies by Category
Adaptive Broadband Impedance Matching in Ultrasound Front-End Electronics	High performance: Improves power transfer and acoustic reflectivity Flexible: Enables multimodal and tunable operation of CMUTs Efficient: Provides optimal matching for co-design of CMUT electronics	8342
Microfluidic CODES with Innovative Machine-Learning Analysis	Scalable: Set-up allows for the integration of multiple microfluidic devices to increase throughput volume. Versatile: Machine learning analysis can be applied to other microfluidic devices integrated with the same Coulter sensor network. Pragmatic: This innovation improves the capabilities of lab-on-a-chip systems to provide an affordable solution for low-resource settings.	7107, 8032
All-Electronic Immunophenotyping Device for Point-of-Care Testing	Convenient: Provides an all-electronic immunophenotyping process with straightforward equipment and techniques Low cost: Performs sophisticated, multistep analyses in a system that is affordable enough for point-of-care settings Flexible: Allows for the easy immobilization of multiple antibodies in the device—a shortcoming of current systems	8045, 8047
Scalable Microfluidic Device with Multiple Constriction Channels for High-Throughput Mechanophenotyping	High throughput: Addresses the low-throughput challenges of other similar technologies by handling a sample volume near that of a Coulter counter Low cost: Eliminates the need for costly equipment, highly trained personnel, and long processing times that come with other measuring processes Scalable: Uses a frequency division scheme so that multiple copies of the system can operate concurrently	8031
Measuring Surface Antigen Expression via Microflow Cytometry	Portable: This innovation uses a disposable, handheld device without bulky or costly equipment, which is expected to be especially useful in low-resource settings. Simple: It is designed to achieve results similar to those from a commercial flow cytometer but without requiring initial purification. Recoverable samples: Unlike commercial systems, the analyzed sample can be recovered for further tests at the end of the analysis.	7913, 8048
High-Tech Infant Suit for Earlier Detection of Cerebral Palsy	Advanced: May allow for earlier detection of motor dysfunctions in order to begin therapeutic interventions as soon as possible Robust: Collects data from three limb segments on the leg for a multifaceted assessment Long-lasting: Uses one power source with regulated voltage in order to prolong the use of the device	7949
Facilitating Ultrasound Penetration of the Skull for Diagnosis and Treatment	Portable: Designed to enable imaging of the brain via small, mobile ultrasound devices, which may offer greater convenience compared with MRI and CT machines Affordable: May be a lower cost modality compared with leading techniques, such as MRI, CT, or positron emission tomography (PET) Robust: Demonstrates energy transmission through the skull on par with that of an aqueous medium in preliminary testing	8340
Near-Real-Time Positioning for Instruments and Tools in Magnetic Resonance Elastography (MRE) and Imaging (MRI)	Precise: Extremely precise positioning mechanism enables orientation and control capable of sub-millimeter motions within the MR environment Rapid: Significantly speeds up procedure time over standard MRI and offers wavefield images in near real time High resolution: Uses high-frequency actuation to enable imaging of small, geometrically difficult targets	8412
Portable Multi-Parameter Cancer Diagnostic Tool	Powerful: Simultaneously measures multiple tissue parameters to determine electro-thermo-mechanical properties Disposable: Uses single-use biochip components to eliminate cross-contamination Versatile: Uses a variety of other micromotion-capable actuators and extends to other manufacturing techniques and different length scales	7619
Assessment of Soluble Cancer Biomarkers for Focused Ultrasound Therapy	Simple: Avoids reliance on magnetic resonance imaging (MRI)-based methods of monitoring and optimizing FUS therapy Safe: Relies on a small amount of fluid collected before/after FUS-targeted drug delivery Robust: Enables a range of new therapeutic interventions for cancerous tumors as well as both delivery and monitoring/optimizing of those therapies	8473
Streamlined Hematology Analysis for Point-of-Care Settings	Streamlined: Enables testing in point-of-care settings without complex procedures and specially trained personnel Highly accurate: Offers a spatial resolution higher than current methods due to the shorter wavelength of UV light Cost-effective: Saves on reagents, complex equipment costs, and time-intensive processes without compromising diagnostic quality	8303
Super-Absorbent Polymer (SAP) Beads for Collection of Biofluid Samples	Fast: Accommodates preloading of specimen collection tubes and completes absorption of analytical targets within a few minutes of fluid collection Low cost: Employs economical materials and eliminates the need for refrigeration of samples while also lowering the weight of samples for transport Easy to use: Avoids the need for filtration, centrifugation, or pipetting and the associated equipment for such tasks	7907
Equipment-Free Quantification in Point-of-Care Diagnostic Assays	Field-deployable robustness: uses reference reactions to accurately measure biomarker levels without expensive or cumbersome equipment Lower cost: quantification does not require expensive technology	7992
Spatial Tracking of Catheters in Interventional MRI	Increased safety — eradicates RF induced heating while providing position of catheters in the body during iMRI procedures Simultaneous measurements — offers temperature measurements, orientation, and other parameters	7952
Wireless Neurovascular Monitoring System	Minimally invasive: minimal impact on hemodynamics (dynamics of blood flow) Flexible and stretchable: able to conform to complex vessel geometry Longer range: improved wireless detection range	7908
A Screening Method to Detect Ovarian Cancer	Early stage detection Highly accurate Minimally invasive	7028
Fluorescence Microscopy with an Ideal sCMOS Camera	Fast – produces fully quantitative sCMOS image restoration up to 100 times faster than the current state-of-the-art Accurate – produces fully quantitative sCMOS image restoration up to two orders of magnitude more accurate than the current state-of-the-art Improved features – allows a broad range of imaging techniques without compromising data reliability	8098
Segmenting Stroke-Like Structures in Images	Computationally efficient User-friendly Operator guidance — correction of errors	4096
Fibrin "Knob" Therapeutics	Simple method Robust production Innate therapeutic potential	4021
New Methods of Fabrication for Biosensor Arrays	Low manufacturing and operating cost Compatible with multiple standard electrochemical techniques Can be used with CMOS detection chips with multiple chemical detection and/or actuation channels or sites	4231

Technologies