| Deployable Critical Active Learning (DECAL) System Offers Better Characterization for Improved Diagnostics and Imaging |
- The deployable critical active learning (DECAL) system’s bi-modal interface enables better characterization with large training sets that generate more accurate output for higher precision.
- The algorithm used during the initialization period creates a framework that can be expanded and generalized to any data method and application.
- The DECAL algorithm samples uniquely important, unlabeled data to aid existing active learning systems in generalizing more quickly, providing faster diagnosis statistics.
|
9099 |
|
| Sustained Lymphatic Drug Delivery System Potentially Improves Efficacy and Safety of Immunotherapy and Targeted Therapies |
- This sustained lymphatic drug delivery system guides therapeutics and imaging agents to the injection site, lymphatic vessels, and lymph nodes.
- Sustained lymphatic delivery enables lower dosing and fewer administrations to potentially improve therapeutic response while reducing adverse effects and costs.
- The simplicity of a vaccine-like, sustained drug release injection allows use at less expensive community health centers.
|
8637 |
|
| Paper-Based Multi-Well Depletion Enzyme-Linked Immunosorbent Assay (ELISA) Enables Point-of-Care (POC) Testing |
- Paper-based lateral flow assay automatically performs multi-well ELISA testing for POC titer measurements.
- Simplifies ELISA testing by eliminating the need for centralized laboratories staffed with trained personnel who perform multiple steps in a specific sequence to execute the assay workflow.
- Transforms a variety of ELISA-based tests into single-use, disposable dipstick tests to be used at the point of care or at home.
|
9124 |
|
| Parametric Resonance Approach for Efficient, Versatile Acoustic Power Transfer for Implantable/Wearable Devices, Sensing, and Communications |
- New class of transducers utilizes parametric resonance to convert acoustic energy from an ultrasonic source to a sustained electrical signal.
- Technology powers implantable biomedical devices, small wearable sensors, and other wireless charging applications.
- Simple yet robust generation of stable electromechanical frequency combs is also possible in both air and liquid environments using a capacitive micro-resonator array.
|
7635, 9075 |
|
| Efficiently Generating Complex Hydrogel Structures for Tissue/Organ-on-a-Chip Models |
- Faster: Reduces preparation time from several hours to minutes
- Simplified: Generates complex patterns, including perfusable channels, using light-triggered polymerization of synthetic hydrogels and photomasks rather than current equipment-intensive methods that use laser-based patterning or ablation techniques
- Lowers regulatory burdens: Using synthetic rather than biological matrices simplifies regulatory hurdles, increases reproducibility from batch to batch, and increases tunability of the mechanical and biochemical properties of the matrix
|
8838, 8839 |
|
| Electronic Immunoassay Using Enzymatic Metallization on Microparticles |
- Lower cost: Replacing fluorescent markers and readout methods with impedance detection has the potential to significantly decrease the cost of the assay.
- Transportable: Impedance measurements in microfluidics can be made transportable, which can potentially enable point-of-care applications, as electronic elements are more durable than optical elements.
- Practical: Identification of COVID-19 antibodies in COVID-positive serum samples has already been demonstrated.
|
8813 |
|
| Wearable Ocular Electronics with Virtual Reality Solution for Effective Home-Based Vision Therapy |
- The first fully portable and wireless ocular electronic system in a VR environment provides an effective, home-based visual therapy program.
- The integrated wearable system has a data classification algorithm to provide high-fidelity, real-time detection of eye vergence to treat eye disorders.
- Running a VR system on a smartphone can create “virtual therapies” that can be used anywhere anytime.
|
7916 |
|
| DetectIV Offers Noninvasive Early IV Infiltration and Extravasation Detection |
- DetectIV provides a continuous, noninvasive, and wireless IV infiltration and extravasation detection system.
- The sensor does not cover the IV site and works well with all skin types—significant improvements over existing detection devices.
- The device detects infiltrations on average 2 hours ahead of nursing standard of care making it an effective early detection system that prevents extended hospital stays.
|
7207 |
|
| Smart, Wireless, Bioelectronic Pacifier for Real-Time Continuous Salivary Electrolyte Monitoring in Infants |
- Smart pacifier offers wireless, real-time, continuous detection of sodium and potassium levels in infants.
- This totally non-invasive monitoring pacifier eliminates the need for blood draws, which can only be done three times each day, and is designed to provide non-invasive neonatal health monitoring.
- Microfluidic channels are designed to efficiently pump optimum quantities and concentration of viscous saliva to the sensor area for quick measurement and to eliminate the need to induce salivary stimulation.
|
8942 |
|
| Quantitative, Multiplexed Electronic Detection of COVID-19 Biomarkers |
- Direct electronic detection: This innovation provides direct detection of biomarkers as a simple electronic readout without the use of any intermediate optics.
- Multiplexed: The device can simultaneously detect multiple biomarkers (e.g., a four-plex chip to detect IgG and IgM antibodies against spike or nucleocapsid antigens).
- Portable: A handheld, cellphone-interfaced reader is designed to enable detection and monitoring of diseases in remote areas for sensitive yet inexpensive point-of-care use.
|
8814 |
|
| Developing Tumor Immune Microenvironments via Engineered Hydrogel |
- Scalable: Enables increased tumor formation rate without sacrificing the dynamic complexity of an in vivo adaptive immune response
- Improved consistency: Demonstrates consistent induction of tumor growth, latency, and immune infiltration in early analyses of the technology
- Cost-effective: Eliminates the repetitive processes of conventional methods and leverages inexpensive hydrogel
|
8785 |
|
| Capillary Flow Control in Lateral Flow Assays (LFAs) via Delaminating Timers |
- ASSURED: LFAs readily satisfy the majority of the ASSURED (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverable to end-users) criteria reported by the World Health Organization to establish capabilities of POC devices.
- Agile: The addition of timers to LFAs provides an opportunity to develop more complex multi-step testing, as well as additional benefits such as built-in signal amplification and POC DNA extraction and purification.
- Automated: The ability to sequentially deliver different reagents into a reaction via programmable timers imprinted on paper makes it possible to automate multi-step assays that otherwise could only be performed in laboratories or with manual intervention.
|
8462, 8634 |
|
| 3D Light-Field Endoscopy for High-Precision Microsurgery |
- Enhanced control and safety: Real time visual navigation enhances guidance and intervention in complex microenvironments, maintaining high spatial resolution while providing quantitative depth information
- Comfortable: System does not require 3D glasses that can cause physician dizziness or headaches after long periods of use
- Streamlined: Technique eliminates the need for other imaging procedures such as micro-CT or MRI to quantify the 3D morphology of tissue
|
8848 |
|
| Cluster-Wells: Isolating Aggressive Tumor Cell Clusters for Improved Cancer Diagnosis and Treatment |
- High performing: Demonstrates superior abilities to isolate CTCs without clogging the system or dissociating the clusters
- Low cost: Shows high potential for large-scale production because it uses simple equipment and a straightforward process
- Versatile: Isolates CTC clusters of any cancer type and uses hardware that can be modified to accommodate various devices
|
8203 |
|
| Cell-free Biosensors to Detect Creatinine, Creatine, and Sarcosine |
- Portable: This technology demonstrates the potential to develop point-of-care screening and monitoring, which is essential to expanding access to care worldwide, including to low- and middle-income countries.
- Inexpensive: CFE-based biosensors can cost as little as a few cents per test and could provide a low-cost alternative to current renal function monitoring and diagnosis, which currently involves laboratory visits, trained phlebotomists, skilled technicians, and expensive, specialized equipment.
- Cell-free: The use of a cell-free expression system could enable easier-to-read quantitative output that is less susceptible to matrix effects.
|
8776 |
|
| Recombinant Antibodies for Exclusive Detection of Glaucoma-Associated Myocilin |
- Exclusive detection: Unlike current myocilin-directed antibodies that do not differentiate among numerous disease-associated states of the protein (e.g., folded, cleaved, and misfolded myocilin), these reagents only detect folded myocilin
- Authentic and reproducible: Antibodies are produced using recombinant DNA technology, which enables robust precision sequencing of the reagent and maintains fidelity over time
- High affinity: Antibodies detect both mouse and human myocilin with well-characterized epitopes and high affinity
|
8055 |
|
| Antibodies for Glaucoma Research |
- Precise: Distinguishes between correctly folded and mutated forms from samples, allowing for more precise research and interventions
- Powerful: Enables a more complete and robust understanding of myocilin antibody targets and their applications in potential glaucoma treatments
- Enabling: Opens new opportunities for development of pharmaceuticals to treat or prevent damage to the eye caused by glaucoma
|
8489 |
|
| High-Throughput MSC Potency Assay to Bring Feasibility to Immune/Inflammatory Therapeutics |
- Reproducibility: The well-defined cellular environment of the device enables a highly reproducible MSC response not observed in 2D cultures.
- Scalable: The assay’s simplistic design is amendable to cost-effective scale up.
- Economical: The low cost of the microfluidic chip and the ease of implementing the assay into existing cell therapy manufacturing practices provide for low costs to enter the market.
|
8722 |
|
| Wearable Health Monitoring Device Improves Data Quality and Accuracy |
- High performance: Captures real-time, real-world data of multiple physiological signals with a significant reduction in MA interference
- Chest-mounted: Provides more accurate ECG, heart rate, respiratory rate, and activity detection than existing wrist-worn commercial monitors
- Comfortable: Adheres securely and discretely to the skin using a breathable soft membrane for continuous conformal contact, eliminating excessive sweating and skin irritation
|
8691 |
|
| Generative Causal Explanations for Black-Box Classifiers |
- Increased trust: Has the potential to improve the transparency and fairness of machine learning systems and increase the level of trust users place in their decisions
- Flexible explanation vocabulary: Provides a rich and flexible vocabulary for explanation that is more expressive than feature selection or saliency map–based methods
- Deeper insights: Offers visualizations that can be much more descriptive than saliency maps, particularly in vision applications, leading to better user understanding
|
8507 |
|
