| Electronic Immunoassay Using Enzymatic Metallization on Microparticles |
- Lower cost: Replacing fluorescent markers and readout methods with impedance detection has the potential to significantly decrease the cost of the assay.
- Transportable: Impedance measurements in microfluidics can be made transportable, which can potentially enable point-of-care applications, as electronic elements are more durable than optical elements.
- Practical: Identification of COVID-19 antibodies in COVID-positive serum samples has already been demonstrated.
|
8813 |
|
| Wearable Ocular Electronics with Virtual Reality Solution for Effective Home-Based Vision Therapy |
- The first fully portable and wireless ocular electronic system in a VR environment provides an effective, home-based visual therapy program.
- The integrated wearable system has a data classification algorithm to provide high-fidelity, real-time detection of eye vergence to treat eye disorders.
- Running a VR system on a smartphone can create “virtual therapies” that can be used anywhere anytime.
|
7916 |
|
| DetectIV Offers Noninvasive Early IV Infiltration and Extravasation Detection |
- DetectIV provides a continuous, noninvasive, and wireless IV infiltration and extravasation detection system.
- The sensor does not cover the IV site and works well with all skin types—significant improvements over existing detection devices.
- The device detects infiltrations on average 2 hours ahead of nursing standard of care making it an effective early detection system that prevents extended hospital stays.
|
7207 |
|
| Smart, Wireless, Bioelectronic Pacifier for Real-Time Continuous Salivary Electrolyte Monitoring in Infants |
- Smart pacifier offers wireless, real-time, continuous detection of sodium and potassium levels in infants.
- This totally non-invasive monitoring pacifier eliminates the need for blood draws, which can only be done three times each day, and is designed to provide non-invasive neonatal health monitoring.
- Microfluidic channels are designed to efficiently pump optimum quantities and concentration of viscous saliva to the sensor area for quick measurement and to eliminate the need to induce salivary stimulation.
|
8942 |
|
| Quantitative, Multiplexed Electronic Detection of COVID-19 Biomarkers |
- Direct electronic detection: This innovation provides direct detection of biomarkers as a simple electronic readout without the use of any intermediate optics.
- Multiplexed: The device can simultaneously detect multiple biomarkers (e.g., a four-plex chip to detect IgG and IgM antibodies against spike or nucleocapsid antigens).
- Portable: A handheld, cellphone-interfaced reader is designed to enable detection and monitoring of diseases in remote areas for sensitive yet inexpensive point-of-care use.
|
8814 |
|
| Developing Tumor Immune Microenvironments via Engineered Hydrogel |
- Scalable: Enables increased tumor formation rate without sacrificing the dynamic complexity of an in vivo adaptive immune response
- Improved consistency: Demonstrates consistent induction of tumor growth, latency, and immune infiltration in early analyses of the technology
- Cost-effective: Eliminates the repetitive processes of conventional methods and leverages inexpensive hydrogel
|
8785 |
|
| Capillary Flow Control in Lateral Flow Assays (LFAs) via Delaminating Timers |
- ASSURED: LFAs readily satisfy the majority of the ASSURED (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverable to end-users) criteria reported by the World Health Organization to establish capabilities of POC devices.
- Agile: The addition of timers to LFAs provides an opportunity to develop more complex multi-step testing, as well as additional benefits such as built-in signal amplification and POC DNA extraction and purification.
- Automated: The ability to sequentially deliver different reagents into a reaction via programmable timers imprinted on paper makes it possible to automate multi-step assays that otherwise could only be performed in laboratories or with manual intervention.
|
8462, 8634 |
|
| 3D Light-Field Endoscopy for High-Precision Microsurgery |
- Enhanced control and safety: Real time visual navigation enhances guidance and intervention in complex microenvironments, maintaining high spatial resolution while providing quantitative depth information
- Comfortable: System does not require 3D glasses that can cause physician dizziness or headaches after long periods of use
- Streamlined: Technique eliminates the need for other imaging procedures such as micro-CT or MRI to quantify the 3D morphology of tissue
|
8848 |
|
| Cluster-Wells: Isolating Aggressive Tumor Cell Clusters for Improved Cancer Diagnosis and Treatment |
- High performing: Demonstrates superior abilities to isolate CTCs without clogging the system or dissociating the clusters
- Low cost: Shows high potential for large-scale production because it uses simple equipment and a straightforward process
- Versatile: Isolates CTC clusters of any cancer type and uses hardware that can be modified to accommodate various devices
|
8203 |
|
| Cell-free Biosensors to Detect Creatinine, Creatine, and Sarcosine |
- Portable: This technology demonstrates the potential to develop point-of-care screening and monitoring, which is essential to expanding access to care worldwide, including to low- and middle-income countries.
- Inexpensive: CFE-based biosensors can cost as little as a few cents per test and could provide a low-cost alternative to current renal function monitoring and diagnosis, which currently involves laboratory visits, trained phlebotomists, skilled technicians, and expensive, specialized equipment.
- Cell-free: The use of a cell-free expression system could enable easier-to-read quantitative output that is less susceptible to matrix effects.
|
8776 |
|
| Recombinant Antibodies for Exclusive Detection of Glaucoma-Associated Myocilin |
- Exclusive detection: Unlike current myocilin-directed antibodies that do not differentiate among numerous disease-associated states of the protein (e.g., folded, cleaved, and misfolded myocilin), these reagents only detect folded myocilin
- Authentic and reproducible: Antibodies are produced using recombinant DNA technology, which enables robust precision sequencing of the reagent and maintains fidelity over time
- High affinity: Antibodies detect both mouse and human myocilin with well-characterized epitopes and high affinity
|
8055 |
|
| Antibodies for Glaucoma Research |
- Precise: Distinguishes between correctly folded and mutated forms from samples, allowing for more precise research and interventions
- Powerful: Enables a more complete and robust understanding of myocilin antibody targets and their applications in potential glaucoma treatments
- Enabling: Opens new opportunities for development of pharmaceuticals to treat or prevent damage to the eye caused by glaucoma
|
8489 |
|
| High-Throughput MSC Potency Assay to Bring Feasibility to Immune/Inflammatory Therapeutics |
- Reproducibility: The well-defined cellular environment of the device enables a highly reproducible MSC response not observed in 2D cultures.
- Scalable: The assay’s simplistic design is amendable to cost-effective scale up.
- Economical: The low cost of the microfluidic chip and the ease of implementing the assay into existing cell therapy manufacturing practices provide for low costs to enter the market.
|
8722 |
|
| Wearable Health Monitoring Device Improves Data Quality and Accuracy |
- High performance: Captures real-time, real-world data of multiple physiological signals with a significant reduction in MA interference
- Chest-mounted: Provides more accurate ECG, heart rate, respiratory rate, and activity detection than existing wrist-worn commercial monitors
- Comfortable: Adheres securely and discretely to the skin using a breathable soft membrane for continuous conformal contact, eliminating excessive sweating and skin irritation
|
8691 |
|
| Generative Causal Explanations for Black-Box Classifiers |
- Increased trust: Has the potential to improve the transparency and fairness of machine learning systems and increase the level of trust users place in their decisions
- Flexible explanation vocabulary: Provides a rich and flexible vocabulary for explanation that is more expressive than feature selection or saliency map–based methods
- Deeper insights: Offers visualizations that can be much more descriptive than saliency maps, particularly in vision applications, leading to better user understanding
|
8507 |
|
| Handheld Breath Collection Device for Detecting Disease Biomarkers |
- Improved diagnosis: Analyzes both the gas and liquid sampled from the patient’s breath for potentially more robust and multifaceted results
- Enhanced patient experience: Requires a shorter exhalation cycle to get a breath sample, making the test more comfortable for patients
- Small and portable: Optimizes and miniaturizes the collection process for easy point-of-care applications
|
8791 |
|
| Microscale High-Throughput Phenotypic Assay for Fibrosis |
- Powerful: Provides high-throughput image-based analysis of fibrotic processes as well as fibrinolysis
- Convenient: Combines label-free readouts for fibrin degradation, collagen synthesis, and cell contraction to evaluate fibrotic tissue remodeling
- Enabling: Opens new opportunities for understanding fibrosis pathogenesis and for evaluating anti-fibrotic therapeutics
|
8502 |
|
| Heat-Responsive Programmable T-Cells |
- Specific: The remote programmable nature of these T-cells allows them to be selectively activated only in the necessary locations.
- Protective: This focused, genetically engineered immunotherapy is intended to protect patients from the additional harm of the off-target cell death and unnecessary systemic damage that is more common with oncological therapeutics.
- Non-invasive: With NIR light’s ability to penetrate into multiple layers of biological tissue and be absorbed by AuNRs, this technology removes the need for a light source in the body to trigger the T-cells.
|
7422 |
|
| Rapid Development of SARS-CoV-2 Monoclonal Antibodies |
- Powerful: Demonstrates potential to recognize intact SARS-CoV-2 virions with high affinity
- Highly efficient: Enables researchers to select pairs of high-affinity antibodies that bind to different receptor sites, maximizing the efficiencies of sandwich-style rapid testing methods
- Enabling: Furthers the development of neutralizing antibodies that can be used as therapeutic agents, delivered either directly or via mRNA for in situ expression
|
8487 |
|
| Skin-Conformal Wearable Stress Monitor Delivers Greater Precision and Continuous, Wireless Monitoring with Comfort and Flexibility |
- All-in-one: The personal adhesive bandage-like single device platform offers wireless, multi-data sensing by simply mounting it on the skin.
- Disposable: This wearable device is fully disposable after the use and the measured data can be simply sent to the cloud via a tablet or smartphone app.
- Compact: The unique, thin design of this bioelectric device is one-sixth the volume of current market offerings—weighing less than 7 g, including its rechargeable battery.
|
8414 |
|
