Biological | Office of Technology Licensing

Available Technologies by Category
Handheld Breath Collection Device for Detecting Disease Biomarkers	Improved diagnosis: Analyzes both the gas and liquid sampled from the patient’s breath for potentially more robust and multifaceted results Enhanced patient experience: Requires a shorter exhalation cycle to get a breath sample, making the test more comfortable for patients Small and portable: Optimizes and miniaturizes the collection process for easy point-of-care applications	8791
Increasing Medium-Chain Fatty Acid (MCFA) Yield in Bacterial Host with Engineered Enzyme	High performance: Increases the yield of MCFAs during chemical and biopolymer synthesis Enabling: Improves the microbial production of chemicals that require the expression of heterologous enzymes Adaptable: Potentially applies to methods of engineering other heterologous enzymes to interact with endogenous proteins in order to produce molecules of interest in a bacterial host	7595
Skin-Conformal Wearable Stress Monitor Delivers Greater Precision and Continuous, Wireless Monitoring with Comfort and Flexibility	All-in-one: The personal adhesive bandage-like single device platform offers wireless, multi-data sensing by simply mounting it on the skin. Disposable: This wearable device is fully disposable after the use and the measured data can be simply sent to the cloud via a tablet or smartphone app. Compact: The unique, thin design of this bioelectric device is one-sixth the volume of current market offerings—weighing less than 7 g, including its rechargeable battery.	8414
Adaptive Broadband Impedance Matching in Ultrasound Front-End Electronics	High performance: Improves power transfer and acoustic reflectivity Flexible: Enables multimodal and tunable operation of CMUTs Efficient: Provides optimal matching for co-design of CMUT electronics	8342
Miniaturized Modular-Array Fluorescence Microscopy	Powerful: Offers high fluorescence sensitivity, efficiency, and spatiotemporal resolution (~3 µm and up to 60 Hz) Configurable: Offers compatibility with conventional cell culture assays and physiological imaging, providing accessibility to upright physiological imaging and integration with biochemical sensors under the cell platform Efficient: Provides effective parallelization of multi-site data acquisition	8580
Advancing Mass Spectrometry with Novel Interface	Flexible: Allows for integration with a range of operational modes and analytical workflows for different ESI-MS techniques High performance: Offers enhanced sensitivity and a significantly improved limit of detection Robust and effective: Minimizes charged ion loss and enables sampling of the most analytically “valuable” droplets	4182
All-Electronic Immunophenotyping Device for Point-of-Care Testing	Convenient: Provides an all-electronic immunophenotyping process with straightforward equipment and techniques Low cost: Performs sophisticated, multistep analyses in a system that is affordable enough for point-of-care settings Flexible: Allows for the easy immobilization of multiple antibodies in the device—a shortcoming of current systems	8045, 8047
Scalable Microfluidic Device with Multiple Constriction Channels for High-Throughput Mechanophenotyping	High throughput: Addresses the low-throughput challenges of other similar technologies by handling a sample volume near that of a Coulter counter Low cost: Eliminates the need for costly equipment, highly trained personnel, and long processing times that come with other measuring processes Scalable: Uses a frequency division scheme so that multiple copies of the system can operate concurrently	8031
Measuring Surface Antigen Expression via Microflow Cytometry	Portable: This innovation uses a disposable, handheld device without bulky or costly equipment, which is expected to be especially useful in low-resource settings. Simple: It is designed to achieve results similar to those from a commercial flow cytometer but without requiring initial purification. Recoverable samples: Unlike commercial systems, the analyzed sample can be recovered for further tests at the end of the analysis.	7913, 8048
Facilitating Ultrasound Penetration of the Skull for Diagnosis and Treatment	Portable: Designed to enable imaging of the brain via small, mobile ultrasound devices, which may offer greater convenience compared with MRI and CT machines Affordable: May be a lower cost modality compared with leading techniques, such as MRI, CT, or positron emission tomography (PET) Robust: Demonstrates energy transmission through the skull on par with that of an aqueous medium in preliminary testing	8340
Portable Multi-Parameter Cancer Diagnostic Tool	Powerful: Simultaneously measures multiple tissue parameters to determine electro-thermo-mechanical properties Disposable: Uses single-use biochip components to eliminate cross-contamination Versatile: Uses a variety of other micromotion-capable actuators and extends to other manufacturing techniques and different length scales	7619
Optical Architecture Enables High-Performance Chips	High performance: Provides efficient, practical, and manufacturable optical computing solutions for a variety of platforms Efficient: Permits a new way of designing high-performance computing and decision-making tasks using manufacturable solutions with high-speed processing, despite fabrication imperfections Flexible: Offers photonic chips in a variety of material platforms (i.e., silicon, silicon nitride) and meta-surface arrays implemented in hybrid platforms that combine dielectrics and nonlinear/reconfigurable materials	8437
Hybrid Meta-Surfaces for Active, Non-Volatile Light Manipulation	Fast: Enables highly dense pixels with fast (nanosecond) switching capability Scalable: Can be fabricated with features down to nanometer sizes; the overall device can incorporate several meta-surfaces with different features over a large-size wafer Agile: Offers high switching robustness (up to 1012 cycles)	8530
Powered Bilateral Knee Exoskeleton for Rehabilitation of Children and Adults	Lightweight: Uses one of the lightest available electromechanical actuators—just 0.5 kg—along with a mere 1.5 kg for the exoskeleton assembly Back-drivable: Lowers the mechanical effort involved in back driving with a single-stage actuator Efficient: Reduces battery consumption compared with existing systems	8369
Multi-Functional Sparse Phased Arrays for Guiding Focused Ultrasound Therapies	Robust: Provides sensitivity of detection down to a single microbubble for FUS-induced microbubble activity Precise: Offers broadband B-mode imaging capabilities to improve workflow and efficacy of FUS-based therapies Scalable: Enables the formation of large CMUT arrays and subarrays with appropriate element spacing	8493
Streamlined Hematology Analysis for Point-of-Care Settings	Streamlined: Enables testing in point-of-care settings without complex procedures and specially trained personnel Highly accurate: Offers a spatial resolution higher than current methods due to the shorter wavelength of UV light Cost-effective: Saves on reagents, complex equipment costs, and time-intensive processes without compromising diagnostic quality	8303
Airy-beam Tomographic Microscopy for Biological Imaging	Streamlined: Offers a scan-free method of obtaining 3D-resolution images Volumetric imaging: Generates and resolves images of tissues and cells in the 3D space High resolution and image depth: Provides 3D diffraction-limited resolution	8381
Wireless Neurovascular Monitoring System	Minimally invasive: minimal impact on hemodynamics (dynamics of blood flow) Flexible and stretchable: able to conform to complex vessel geometry Longer range: improved wireless detection range	7908
Detecting Change of Dielectric Constant	Enables detection of materials based on changes to the effective dielectric constant of a circular resonator Measures the index of refraction to detect the change in optical wavelength that is occurring Able to detect the power of the electromagnetic wave in the circular resonator at resonance condition and/or during build-up stage	2839
New Methods of Fabrication for Biosensor Arrays	Low manufacturing and operating cost Compatible with multiple standard electrochemical techniques Can be used with CMOS detection chips with multiple chemical detection and/or actuation channels or sites	4231

Technologies