Pharmaceuticals | Office of Technology Licensing

Available Technologies by Category
Novel Pharmaceutical Compounds Based on Tumor-Selective KDM Inhibitors	Selective: Can be used to target specific types of tumors Proven efficacy in vitro: Can be used to inhibit proliferation of cells (e.g., cancer or tumor cells), reducing tumor burden, inhibiting tumor growth, or both Enhanced potency: Displayed a 65-fold increase in cytotoxic potency against tested triple negative breast cancer cell lines	7880
Assessment of Soluble Cancer Biomarkers for Focused Ultrasound Therapy	Simple: Avoids reliance on magnetic resonance imaging (MRI)-based methods of monitoring and optimizing FUS therapy Safe: Relies on a small amount of fluid collected before/after FUS-targeted drug delivery Robust: Enables a range of new therapeutic interventions for cancerous tumors as well as both delivery and monitoring/optimizing of those therapies	8473
Novel Chemical Compounds Support Excess Copper Removal in Biological Systems	Powerful: Displays an affinity for copper that is unprecedented among synthetic ligands, with a complex stability constant of logK = 20.0 Specific: Functions without interference by other metals in the body Effective: Possesses a strong copper coordinating ability, even in the complex chemical environments of different biological systems	8151
Precision Needle Positioning Robotic System for MRI Guided Injection	Increased accuracy — robot capable of less than 100 micron accuracy Increased speed — faster targeting of injection locations	8246
Guided Injection of Charged Cargo for Intracellular Delivery	Novelty – use of an electrically-charged liquid beam of electrospray Improved control – control of action on the scale of single cell/single pores Diversity – arbitrary diverse set of cargo	8275
Constellation Diagrams to Model Biomolecules’ Electrostatic Properties	Low computational cost – reduces algorithm run-time via reduction in complexity of computing molecular electrostatic properties Digitally encoded molecular electrostatic properties – utilizes orthogonal basis functions Visual toolsets- to analyze molecular electrostatic properties and generates 4D plots of molecular electrostatic properties	8245
Storage Media for Determining Optimal Respiratory Treatment	Automatically determines optimal radiation therapy treatment phase Enables higher, more effective radiation dosage amounts Minimizes unnecessary radiation to normal surrounding tissues	6926
Self-Assembling Peptides for Cell and Notch-Ligand Delivery	Hydrogels are biocompatible, easy to modify and biodegradable Could be applied in a more platform-like manner by incorporating other peptides to repair cardiac or other tissues The peptide sequence activates signaling of pathways improving the growth or replication of tissue or cells	6480
Method for Treatment of Pathologies	Fast - activity is immediate (within 2 hours) Easy to use - applied to nasal sprays or skin patches Safe – less immunogenic	7878
Fibrin "Knob" Therapeutics	Simple method Robust production Innate therapeutic potential	4021
Biomolecular Coating for Implants	Simple, one-step surface modification without chemical cross-linking agents Modification at the time of surgery in the operation room Straight forward sterilization	3967
Therapeutic Compounds for Prostate Cancer Treatment	Prostate specific: This technology is a targeted approach for androgen receptor malignancies. More effective: It offers a new treatment for tumors that have progressed to the hormone refractory stage. Less toxic: Compounds are highly selective for targeted receptors.	5394
System for Bone Regeneration	Provides superior retention and release of osteoinductive protein Reduces necessary dose of osteoinductive protein Reduced cost of procedure	4660
Improved AZA-peptide Epoxides	Versatile: able to treat multiple diseases Can be administered with or without other protease inhibitors	3738
Core-Shell Nanogel Cellular Delivery Vehicles	Delivery of a broad range of various materials to cells Higher payloads and faster and more sustained RNA interference than non-targeted commercial siRNA delivery vehicle Less toxic than commercial liposomal formulations	4480
Carbon Nanotube Electrode Array for Neural Prosthetics	Densely packed CNT arrays allow for better bio-incorporation, prevention of glial scarring, chronic inflammation, and neuronal cell loss Readily functionalized to promote neuronal growth and tissue-electrode adhesion, enhancing electrode performance and quality of read-out signals Inherent mechanical stiffness enhances the rigidity of adjacent CNTs preventing buckling as in other high-aspect probe systems.	4434
Cell-Free Biomaterial for Tissue Regeneration and Repair	Simple — does not require difficult or extensive preparation Regenerative — provides unique molecular cues similar to early embryogenesis, enabling directing of cell differentiation and tissue morphogenesis Compatible and customizable — can be tailored for specific tissue applications by directing the differentiation of the ES cells prior to acellularization	3662
Microneedle Coating	Alternative method for hypodermic needles Coating uniformity Spatial control on coating length	3526
Devices, Systems, and Methods for Excavating Cancer Cells	Tumors are able to migrate on manufactured fibers or films instead of healthy brain tissue Minimally invasive- the device can be deployed directly or using a catheter The device is size and shape variable- films can range from nano- to micron- scale	5057
Pterin-Based Hydroxylation of Aromatic Monomers	Could provide substantial high value intermediates Enzymatic catalysis is more energy efficient, yields less (industrial type) waste than chemically based methods Higher level of precision than most chemical reactions	6943

Technologies