Pharmaceuticals | Office of Technology Licensing

Available Technologies by Category
Synthetic Hydrogels for Human Organoid (HO) Generation and Transplantation	Synthetic hydrogel exhibits high cytocompatibility and minimal toxicity and inflammation in vivo for improved human organoid viability Injectable delivery vehicle supports localized HO engraftment in mucosal wounds to potentially enhance wound closure and repair Modular design and delivery via endoscopic techniques enables the translational potential of this delivery platform for regenerative medicine and overcomes limitations associated with the use of commercially available matrices for hPSC-based organoid technologies	7536
Hybrid Molecular Catalysts: A New Blueprint for Catalyst Design, Preparation, and Testing	Attachment of molecular catalysts to solid supports can lead to new reactivity not seen under homogeneous conditions At an optimal atomic layer deposition (ALD) layer thickness, the molecular catalyst remains highly active while still being resistant to surface detachment and subsequent deactivation Catalyst separation and recovery achieved via a simple filtering and washing process rather than energy- and time-intensive distillation or re-crystallization processes In addition to the simple filter-and-wash process mentioned above, encapsulation requires only about 10 reaction cycles, making this process technologically and economically viable for large-scale manufacturing	8537
Hydrogels for Controlled Delivery of Lysostaphin to Treat Staphylococcus aureus Infections	Injectable (or surgically applied) hydrogel formulation conforms and adheres to the fracture and surrounding tissue, ensuring efficient, local delivery of lysostaphin Localized treatments enable higher relative doses to be given at the site of infection, and enhanced stability from the hydrogel carrier may reduce the number of overall doses needed Tunable nature of the material provides control over the amount and time over which lysostaphin is delivered	7729
Intracellular Anticancer Delivery	Self-assembling: Forms an organized structure in water at room temperature Nano-scale: Approximately 35 nm, ideal for intracellular uptake Versatile: Can be used with any antibody	7174
Developing Tumor Immune Microenvironments via Engineered Hydrogel	Scalable: Enables increased tumor formation rate without sacrificing the dynamic complexity of an in vivo adaptive immune response Improved consistency: Demonstrates consistent induction of tumor growth, latency, and immune infiltration in early analyses of the technology Cost-effective: Eliminates the repetitive processes of conventional methods and leverages inexpensive hydrogel	8785
TabAccess: A Wireless Controller for Tablet Accessibility	Enabling: Provides an alternative interface to touchscreen-based devices for people with limited fine motor control, potentially enabling them to interact with applications that could improve their quality of life or even create employment opportunities Reconfigurable: Sensor modules can be interconnected as well as separated and mounted anywhere (e.g., on the human body or on a table, floor, wheelchair, etc.), enabling adaptation of the device based on the capability, range of access, and the individual’s range of motion. Adjustable: Uses an adjustable Velcro strap so one size fits the majority of forearms	5946
Small Molecule Glycosylated Histone Deacetylase Inhibitors (HDACi)	Targeted: The compounds were particularly cytotoxic to liver or hepatocellular cancer cells (HCC) during in vivo murine model laboratory studies. Enhanced potency: The compounds’ hepatocellular carcinoma selectivity observed in laboratory studies potentially increases their efficacy on liver cancer and possibly other cancers. Many formulations: A number of formulation methods are potentially available, including tablets, beads, granules, microparticle, or nanoparticles that provide a variety of drug release profiles.	8373
Wearable Device for Evaluating Post-Injury Ankle Health During Ambulation	Better decisions: Helps clinicians more easily determine the best course for ankle rehabilitation and improves compliance with physical therapy Faster recovery: Enables improved rehabilitation guidance based on collected telehealth data that may speed the time to recovery Fewer re-injuries: Supports clinicians in making better decisions regarding appropriate activity levels and readiness to return to activities to avoid re-injury	8513
New Class of Tissue-Targeting Agents Inhibits Fibrosis, Inflammation, and Cancer Growth	Potent: Candidates among these agents are 1,000 times more potent than pirfenidone, the standard treatment of IPF. Specific: The compounds may potentially exhibit tissue-targeting properties for sustained levels at disease sites. Minimal toxicity: Enhanced tissue specificity inhibits inflammation and growth of targeted cancer cells while minimizing off-target effects and toxicity.	8374
Antibodies for Glaucoma Research	Precise: Distinguishes between correctly folded and mutated forms from samples, allowing for more precise research and interventions Powerful: Enables a more complete and robust understanding of myocilin antibody targets and their applications in potential glaucoma treatments Enabling: Opens new opportunities for development of pharmaceuticals to treat or prevent damage to the eye caused by glaucoma	8489
High-Throughput MSC Potency Assay to Bring Feasibility to Immune/Inflammatory Therapeutics	Reproducibility: The well-defined cellular environment of the device enables a highly reproducible MSC response not observed in 2D cultures. Scalable: The assay’s simplistic design is amendable to cost-effective scale up. Economical: The low cost of the microfluidic chip and the ease of implementing the assay into existing cell therapy manufacturing practices provide for low costs to enter the market.	8722
Microscale High-Throughput Phenotypic Assay for Fibrosis	Powerful: Provides high-throughput image-based analysis of fibrotic processes as well as fibrinolysis Convenient: Combines label-free readouts for fibrin degradation, collagen synthesis, and cell contraction to evaluate fibrotic tissue remodeling Enabling: Opens new opportunities for understanding fibrosis pathogenesis and for evaluating anti-fibrotic therapeutics	8502
Tissue-Selective Anticancer Agents	Tissue-targeted activity: Appended macrocyclic skeletons provide selective tissue distribution. Potent: HDAC inhibitors display stronger in vivo anticancer activity against solid tumors compared to current technology. Lower toxicity: Mice in preclinical experiments did not exhibit significant weight loss, pointing to potentially lower toxicity of these compounds.	4195
Heat-Responsive Programmable T-Cells	Specific: The remote programmable nature of these T-cells allows them to be selectively activated only in the necessary locations. Protective: This focused, genetically engineered immunotherapy is intended to protect patients from the additional harm of the off-target cell death and unnecessary systemic damage that is more common with oncological therapeutics. Non-invasive: With NIR light’s ability to penetrate into multiple layers of biological tissue and be absorbed by AuNRs, this technology removes the need for a light source in the body to trigger the T-cells.	7422
Self-Titrating Bacterial Protease-Activated Prodrug	Effective: Activates an internal dosing mechanism such that the magnitude of an infection locally determines the prodrug dose Robust: Increases the stability of the prodrug form by neutralizing the effective charge of the administered antimicrobial peptide Improves safety: Decreases the potential for off-target effects	8010
Rapid Development of SARS-CoV-2 Monoclonal Antibodies	Powerful: Demonstrates potential to recognize intact SARS-CoV-2 virions with high affinity Highly efficient: Enables researchers to select pairs of high-affinity antibodies that bind to different receptor sites, maximizing the efficiencies of sandwich-style rapid testing methods Enabling: Furthers the development of neutralizing antibodies that can be used as therapeutic agents, delivered either directly or via mRNA for in situ expression	8487
Scalable Microfluidic Device with Multiple Constriction Channels for High-Throughput Mechanophenotyping	High throughput: Addresses the low-throughput challenges of other similar technologies by handling a sample volume near that of a Coulter counter Low cost: Eliminates the need for costly equipment, highly trained personnel, and long processing times that come with other measuring processes Scalable: Uses a frequency division scheme so that multiple copies of the system can operate concurrently	8031
Facilitating Ultrasound Penetration of the Skull for Diagnosis and Treatment	Portable: Designed to enable imaging of the brain via small, mobile ultrasound devices, which may offer greater convenience compared with MRI and CT machines Affordable: May be a lower cost modality compared with leading techniques, such as MRI, CT, or positron emission tomography (PET) Robust: Demonstrates energy transmission through the skull on par with that of an aqueous medium in preliminary testing	8340
Near-Real-Time Positioning for Instruments and Tools in Magnetic Resonance Elastography (MRE) and Imaging (MRI)	Precise: Extremely precise positioning mechanism enables orientation and control capable of sub-millimeter motions within the MR environment Rapid: Significantly speeds up procedure time over standard MRI and offers wavefield images in near real time High resolution: Uses high-frequency actuation to enable imaging of small, geometrically difficult targets	8412
Novel Crosslinked Hydrogel Improves Efficacy and Side Effects of Cancer Treatment	Versatile: Can integrate with all types of immune checkpoint blockade antibodies and respond to various types of cancers Improved tolerability via local delivery: Limits side effects on nonmalignant tissues and organs—a challenge of other immunotherapies Innovative: Leverages the body’s natural immune response to reduce the likelihood of cancer recurrence	8505

Technologies