Available Technologies by Category
An Electronic Microfluidic Platform for On-Chip Apoptosis Quantification using Annexin V-Based PS Externalization Detection-GT NEXT
  • This electronic microchip integrates an electrical sensor network with a microfluidic capture chamber to detect phosphatidylserine (PS) externalization, offering a compact, user-friendly, and cost-effective solution for apoptotic analysis.
  • The prototype provides high sensitivity and specificity without the need for prelabeling, making it suitable for diverse applications in clinical diagnostics and biomedical research.
  • It supports drug discovery, toxicity evaluation, and bioprocessing optimizations, enhancing disease mechanism studies and therapeutic target identification.
High Sensitivity Stable Sensors and Methods for Manufacturing
  • This technology introduces dual-gate sensors, separating sensing and amplifying functions for unparalleled stability and sensitivity.
  • The innovation addresses limitations of single-gate sensors, providing high sensitivity, low-voltage operation, and compatibility with diverse substrates.
  • Applications include wearables, IoT, environmental monitoring, with cost-effective large-scale production.
Enabling Rapid Detection of Label-Free RNA for Use in COVID-19 Testing
  • Earlier detection: Identifying the viral components themselves—rather than the body’s reaction to the viral presence (i.e., antibodies)—potentially improves early detection in asymptomatic subjects.
  • Simpler process: Use of minimal reagents and fewer preparatory steps is designed to enable more efficient and facile sample preparation. Avoidance of “wash steps” aims to minimize target loss.
  • Fewer disruptions: Avoiding the use of high-demand supplies (e.g., swabs) and reagents potentially reduces supply-chain and contamination issues.
Messenger Ribonucleic Acid (mRNA)–Based Opsin Expression Enables New and Safer Optogenetic Studies
  • Opsin expression using messenger RNA (mRNA) provides an alternative to viral vectors for use in optogenetic studies involving neurons as well as drug testing with cardiomyocytes.
  • Expression with mRNAs has lower toxicity and is usually detectable within 2–24 hours rather than 2–3 weeks.
  • The controllable and temporary nature of mRNA offers improved expression regulation based on the transfection amount.
Soft Wireless Sternal Patch for Detecting Systemic Vasoconstriction Using Photoplethysmography
  • A wireless, soft sternal patch includes integrated skin-like, photolithographically patterned electronics specifically tuned to continuously measure vasoconstriction from the sternum.
  • In overnight trials, the device detected sleep apnea and hypopnea with 95% precision and 100% sensitivity compared to data professionally scored by licensed clinicians.
  • Use of this patch on the chest could improve detection of key markers of numerous harmful health conditions.
Targeted Single Cell Electroporation for Gene and Cell Therapy
  • The technology enables high efficiency delivery and high post-electroporation cell viability compared to current commercial electroporation systems.
  • The technology performs in-flow single cell measurements integrated with electroporation unlike current commercial electroporation systems which have no single cell measurement capabilities.
  • The technology enables automatic feedback control and real-time optimization of electroporation parameters at the single-cell level unlike current commercial electroporation systems which apply the same parameters to all cells in a batch at a bulk scale.
  • The technology enables selected or targeted electroporation and delivery to selected cells or cell types from a mixture of cells unlike current commercial electroporation systems which require upstream or downstream cell sorting steps.
Universal Transcriptional Programming in a Bacteroides Consortium Creates a Foundation to Advance Living Therapeutics
  • Consortium-based, universal transcriptional programming framework is a biotic decision-making technology using genetic circuit compression in a Bacteroides community.
  • Compressed genetic circuit design shortens circuit-building time, offers a compact circuit footprint that allows more complexity, uses fewer resources, and reduces cell communication time. 
  • Has potential applications in living therapeutics, advanced biomanufacturing, and next-generation biosecurity.
Portable, Reusable, Micropower Radiation Monitors Provide Real-Time Assessment of Radiation Risk
  • Innovative radiation detection system provides real-time, on-demand, micropower detection in a versatile design.
  • The device materials offer higher conductivity (mobility) than silicon, resulting in reduced power needs (i.e., requiring power only during read-out).
  • Selection and layering of channel and gate materials enables tuning devices for different radiation types.
“Smart” Feedback-Controlled Bioreactor Platform Enables Consistent High-Yield and High-Quality MSC Products
  • Scaled-down feedback-controlled hollow fiber-based bioreactor enables identifying the critical quality attributes and critical process parameters for high-quantity and high-quality hCT-MSCs for ideal cell growth and efficacy 
  • Provides the controls to maintain optimum conditions and improve expansion yield and cell viability
  • System can be adapted and applied to industrial cell therapy manufacturing and can enable high-yield and high-quality products while minimizing variabilities
High-Precision, Hands-Free Remote Control of Complex Robotic Systems Via Eye Movements
  • This two-camera eye-tracking system (TCES) integrates a commercial eye tracker with machine-learning technology for continuous real-time classification of gaze and eye directions for robotic arm control. 
  • The system provides highly accurate classification for four directions of eye movement and has achieved 99.99% accuracy in studies.
  • Using simple eye movement, the TCES offers low-cost, high-precision control of external devices/hardware for people with disabilities, surgery robots, warehouse systems, construction tools, and more. 
Parametric Resonance Approach for Efficient, Versatile Acoustic Power Transfer for Implantable/Wearable Devices, Sensing, and Communications
  • New class of transducers utilizes parametric resonance to convert acoustic energy from an ultrasonic source to a sustained electrical signal. 
  • Technology powers implantable biomedical devices, small wearable sensors, and other wireless charging applications.
  • Simple yet robust generation of stable electromechanical frequency combs is also possible in both air and liquid environments using a capacitive micro-resonator array.
7635, 9075
Efficiently Generating Complex Hydrogel Structures for Tissue/Organ-on-a-Chip Models
  • Faster: Reduces preparation time from several hours to minutes
  • Simplified: Generates complex patterns, including perfusable channels, using light-triggered polymerization of synthetic hydrogels and photomasks rather than current equipment-intensive methods that use laser-based patterning or ablation techniques
  • Lowers regulatory burdens: Using synthetic rather than biological matrices simplifies regulatory hurdles, increases reproducibility from batch to batch, and increases tunability of the mechanical and biochemical properties of the matrix
8838, 8839
patcherBotPHARMA Automated Intracellular Pharmacological Electrophysiology Robot
  • Increased efficiency: Autonomous operation ensures accurate placement of components and creates high success rates for experiment completion.
  • Decreased human effort: Performs typical ligand-gated ionotropic receptor experimentation protocols autonomously for up to a tenfold reduction in operator interaction time over the duration of the experiment
  • Higher experiment yield: Rapidly replicates previous datasets, reducing the time to produce an 8-point concentration response curve from weeks of recording to ~13 hours of recording


DetectIV Offers Noninvasive Early IV Infiltration and Extravasation Detection
  • DetectIV provides a continuous, noninvasive, and wireless IV infiltration and extravasation detection system. 
  • The sensor does not cover the IV site and works well with all skin types—significant improvements over existing detection devices. 
  • The device detects infiltrations on average 2 hours ahead of nursing standard of care making it an effective early detection system that prevents extended hospital stays. 
Microrobots for Neurosurgery Applications
  • Minimally invasive: Significantly reduces invasiveness of procedures in comparison to current macroscale, neurosurgical robots 
  • Precise control: Uses 3D position data of the microrobots on the brain surface in a closed-loop system to adjust the magnetic field parameters (i.e., magnitude, frequency, phase, and direct current [DC] offset of each coil) as well as the forces the robots exert to the biopsy tissue
  • Facilitates movement: Employs microfabricated shapes that dictate the microrobot's movements, limits their contact with the brain surface to reduce adhesion, and may also provide a means for the robot to propel itself in fluid
Smart, Wireless, Bioelectronic Pacifier for Real-Time Continuous Salivary Electrolyte Monitoring in Infants
  • Smart pacifier offers wireless, real-time, continuous detection of sodium and potassium levels in infants.
  • This totally non-invasive monitoring pacifier eliminates the need for blood draws, which can only be done three times each day, and is designed to provide non-invasive neonatal health monitoring.
  • Microfluidic channels are designed to efficiently pump optimum quantities and concentration of viscous saliva to the sensor area for quick measurement and to eliminate the need to induce salivary stimulation.
Quantitative, Multiplexed Electronic Detection of COVID-19 Biomarkers
  • Direct electronic detection: This innovation provides direct detection of biomarkers as a simple electronic readout without the use of any intermediate optics.
  • Multiplexed: The device can simultaneously detect multiple biomarkers (e.g., a four-plex chip to detect IgG and IgM antibodies against spike or nucleocapsid antigens).
  • Portable: A handheld, cellphone-interfaced reader is designed to enable detection and monitoring of diseases in remote areas for sensitive yet inexpensive point-of-care use.
Recirculation System for Aerosol Collectors Maximizes Particle Concentration for Improved Pathogen Detection
  • Enhanced detection: Continuously recirculated collection buffer increases the concentration of targeted particles collected and improves detection of pathogens 
  • Increased sampled air volume: Recirculating the buffer enables running the system for longer periods of time and with larger volumes of air to improve pathogen detection in entire buildings
  • Increased control: Users have active control of the volume of fluid introduced during collection via the system’s recharge pump
Fourier Light-Field Microscope (FLFM) for Fast, Volumetric, and High-Resolution Imaging of Entire Organoids
  • Cost-efficient and scalable: Is fully adaptable to epifluorescence protocols resulting in a system that is both cost-efficient and highly scalable
  • Fast: Captures fast cellular and tissue dynamic processes in a simultaneous, volumetric manner (e.g., collective cellular responses at sub-second time scales across whole samples)
  • Validated: Responses to extracellular physical cues such as osmotic and mechanical stresses have been recorded using human induced pluripotent stem cell-derived colon organoids (hCOs).
Cell-free Biosensors to Detect Creatinine, Creatine, and Sarcosine
  • Portable: This technology demonstrates the potential to develop point-of-care screening and monitoring, which is essential to expanding access to care worldwide, including to low- and middle-income countries.
  • Inexpensive: CFE-based biosensors can cost as little as a few cents per test and could provide a low-cost alternative to current renal function monitoring and diagnosis, which currently involves laboratory visits, trained phlebotomists, skilled technicians, and expensive, specialized equipment.
  • Cell-free: The use of a cell-free expression system could enable easier-to-read quantitative output that is less susceptible to matrix effects.