| DetectIV Offers Noninvasive Early IV Infiltration and Extravasation Detection |
- DetectIV provides a continuous, noninvasive, and wireless IV infiltration and extravasation detection system.
- The sensor does not cover the IV site and works well with all skin types—significant improvements over existing detection devices.
- The device detects infiltrations on average 2 hours ahead of nursing standard of care making it an effective early detection system that prevents extended hospital stays.
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Life Sciences |
| Cluster-Wells: Isolating Aggressive Tumor Cell Clusters for Improved Cancer Diagnosis and Treatment |
- High performing: Demonstrates superior abilities to isolate CTCs without clogging the system or dissociating the clusters
- Low cost: Shows high potential for large-scale production because it uses simple equipment and a straightforward process
- Versatile: Isolates CTC clusters of any cancer type and uses hardware that can be modified to accommodate various devices
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Life Sciences |
| Recombinant Antibodies for Exclusive Detection of Glaucoma-Associated Myocilin |
- Exclusive detection: Unlike current myocilin-directed antibodies that do not differentiate among numerous disease-associated states of the protein (e.g., folded, cleaved, and misfolded myocilin), these reagents only detect folded myocilin
- Authentic and reproducible: Antibodies are produced using recombinant DNA technology, which enables robust precision sequencing of the reagent and maintains fidelity over time
- High affinity: Antibodies detect both mouse and human myocilin with well-characterized epitopes and high affinity
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Life Sciences |
| Transcatheter Heart Valve with Multi-Arm Mechanism |
- Reduced flow stasis: This mechanism displaces the native valve leaflets away from the THV stent frame, essentially removing its “cover” and allowing blood to move freely through the open stent cells. This can help to significantly reduce flow stasis in the neo-sinus region, thereby reducing thrombus initiation/progression.
- Prevention of coronary artery obstruction: Coronary artery obstruction following TAVR is a rare but often fatal complication. In rare cases in patients with unusually large native leaflets or small aortic roots, the large leaflets block the flow of blood to the coronary arteries as the new valve’s scaffolding opens. Georgia Tech’s design displaces the native valve leaflets away from the THV stent frame, which can help to reduce this risk.
- Optimized THV deployment: The innovation offers dual feedback to aid clinicians in determining optimal THV deployment height—a key factor in optimizing patient outcomes. As the device’s “arms” extend against the native vessel wall, they create both tactile feedback during THV positioning as well as visual feedback via fluoroscopy. In addition to deployment height, the multi-arm design supports axial alignment of the THV with respect to the native vessel wall—a factor shown to impact valve performance.
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Life Sciences |
| Low-Power Real-Time Ionizing Radiation Detector |
- Sensitive: Detects the charge generated from the interactions of ionizing radiation within matter with a high level of precision and discerns X-ray pulses of varying dose
- Scalable: Covers a significantly larger detection area than other methods, ranging from 60,000 square micrometers to one square millimeter
- Responsive: Responds within microseconds and proportionately with the overall radiation dose when exposed to X-rays of varying tube voltage (energy) and tube current (number of particles)
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Life Sciences |
| Antibodies for Glaucoma Research |
- Precise: Distinguishes between correctly folded and mutated forms from samples, allowing for more precise research and interventions
- Powerful: Enables a more complete and robust understanding of myocilin antibody targets and their applications in potential glaucoma treatments
- Enabling: Opens new opportunities for development of pharmaceuticals to treat or prevent damage to the eye caused by glaucoma
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Life Sciences |
| A Biological Computing Framework for Living Systems |
- Innovative: Builds on probabilistic computing principles to construct analog biological bits, enabling an entirely new set of logic gates and algorithms and potentially allowing users to solve previously intractable problems
- Robust: Can sense every extracellular protease encoded in the human genome, for which there is a known peptide substrate, enabling a simple plug-and-play framework for communicating with a variety of biological activities and offering performance competitive with DNA-based computers but with increased processing speed
- Relevant: Provides a framework based on biological activity and constructed from biological materials, which enables a direct interface with and understanding of living materials and systems
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Life Sciences |
| High-Throughput MSC Potency Assay to Bring Feasibility to Immune/Inflammatory Therapeutics |
- Reproducibility: The well-defined cellular environment of the device enables a highly reproducible MSC response not observed in 2D cultures.
- Scalable: The assay’s simplistic design is amendable to cost-effective scale up.
- Economical: The low cost of the microfluidic chip and the ease of implementing the assay into existing cell therapy manufacturing practices provide for low costs to enter the market.
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Life Sciences |
| Steerable and Flexible Robotic Endoscopic Tool with Instrument-Changing System |
- Flexible: Offers multiple tendon-driven degrees of freedom and is designed to enable the surgeon to avoid obstacles within the workspace
- Simplifies instrument changes: Includes three instrument stations with a motorized shaft to allow insertion into or retraction from the working channel(s) without leaving the surgical field
- Reduces procedure time: Demonstrates potential to improve procedure efficiency and patient safety by reducing procedure time
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Life Sciences |
| Wearable Health Monitoring Device Improves Data Quality and Accuracy |
- High performance: Captures real-time, real-world data of multiple physiological signals with a significant reduction in MA interference
- Chest-mounted: Provides more accurate ECG, heart rate, respiratory rate, and activity detection than existing wrist-worn commercial monitors
- Comfortable: Adheres securely and discretely to the skin using a breathable soft membrane for continuous conformal contact, eliminating excessive sweating and skin irritation
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Life Sciences |
| Smart Porous Hydrogels to Increase Cold Supply Chain Efficacy of Biologics and Pharmaceuticals |
- Preservation: With the ability to adjust the pore size of the SMH, researchers may be able to increase the rejection rate of bacteria, thereby protecting the medicine by slowing down biodegradation.
- Extended use: Preserving the potency of the transported and stored biologic or pharmaceutical should allow for an improved shelf-life (regardless of the cold supply chain) and an increase in the supply accessible to patients.
- Lower cost: Using Georgia Tech’s SMH for the storage and handling of biologics or pharmaceuticals should minimize the dependence on a cold supply chain, which utilizes freezers that cost between $10,000-$15,000.
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Life Sciences |
| Robotically Steerable Guidewire for Improved Vascular Intervention |
- Robotic: Provides operational improvement of guidewire navigation to facilitate catheter placement by employing robotics, while most other commercially available guidewires lack active steering capability
- Versatile: Controls the guidewire bending angle and also adjusts the bending length of the joint, increasing the capabilities of the guidewire and accommodating varied vasculature geometries
- Flexible: Can be extended to multiple bending sections and degrees of freedom, in stark contrast to passive guidewires that offer clinicians very limited degrees of freedom
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Life Sciences |
| Scalable, Low-Cost, Inversion-Free Method of Enabling Automated Underside Cell Seeding |
- Convenient: Eliminates the need for inversion procedures, which tend to be tedious, difficult to automate, and prone to failure—especially for 96-well inserts due to their limited culture area
- Generalizable: Developed for screenings that focus on the air-blood barrier, but can also be applied to gut, skin, oral mucosa, and other organ systems
- Scalable: Employs a simple method that is extensible to automated processes for high-throughput drug screenings and pharmacological tests
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Life Sciences |
| Rapid Development of SARS-CoV-2 Monoclonal Antibodies |
- Powerful: Demonstrates potential to recognize intact SARS-CoV-2 virions with high affinity
- Highly efficient: Enables researchers to select pairs of high-affinity antibodies that bind to different receptor sites, maximizing the efficiencies of sandwich-style rapid testing methods
- Enabling: Furthers the development of neutralizing antibodies that can be used as therapeutic agents, delivered either directly or via mRNA for in situ expression
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Life Sciences |
| Skin-Conformal Wearable Stress Monitor Delivers Greater Precision and Continuous, Wireless Monitoring with Comfort and Flexibility |
- All-in-one: The personal adhesive bandage-like single device platform offers wireless, multi-data sensing by simply mounting it on the skin.
- Disposable: This wearable device is fully disposable after the use and the measured data can be simply sent to the cloud via a tablet or smartphone app.
- Compact: The unique, thin design of this bioelectric device is one-sixth the volume of current market offerings—weighing less than 7 g, including its rechargeable battery.
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Life Sciences |
| Miniaturized Modular-Array Fluorescence Microscopy |
- Powerful: Offers high fluorescence sensitivity, efficiency, and spatiotemporal resolution (~3 µm and up to 60 Hz)
- Configurable: Offers compatibility with conventional cell culture assays and physiological imaging, providing accessibility to upright physiological imaging and integration with biochemical sensors under the cell platform
- Efficient: Provides effective parallelization of multi-site data acquisition
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Life Sciences |
| Scalable Microfluidic Device with Multiple Constriction Channels for High-Throughput Mechanophenotyping |
- High throughput: Addresses the low-throughput challenges of other similar technologies by handling a sample volume near that of a Coulter counter
- Low cost: Eliminates the need for costly equipment, highly trained personnel, and long processing times that come with other measuring processes
- Scalable: Uses a frequency division scheme so that multiple copies of the system can operate concurrently
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Life Sciences |
| LoCHAid: An Ultra-Low-Cost and Self-Fitting Hearing Aid |
- Low cost: Uses widely available components that cost 98 cents when purchased in bulk quantities
- User friendly: Easier to fit—and keep track of—than conventional behind- and in-the-ear hearing aids
- Accessible: Designed for easy manufacture and repair in locations where conventional hearing aids are priced beyond the reach of most citizens
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Life Sciences |
| Vest-Style Device Assists Ventilation and Perfusion (V/Q) to Help Prevent Respiratory Failure |
- Powerful: Designed to optimize oxygenation for patients in acute hypoxic respiratory failure
- Supportive therapy: Non-invasively complements mechanical ventilator support
- Low cost: Significantly less expensive than technologies that increase oxygenation (e.g., ventilators, oxygen systems)
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Life Sciences |
| Novel Pharmaceutical Compounds Based on Tumor-Selective KDM Inhibitors |
- Selective: Can be used to target specific types of tumors
- Proven efficacy in vitro: Can be used to inhibit proliferation of cells (e.g., cancer or tumor cells), reducing tumor burden, inhibiting tumor growth, or both
- Enhanced potency: Displayed a 65-fold increase in cytotoxic potency against tested triple negative breast cancer cell lines
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Life Sciences |
