Available Technologies by Category
Adaptive Medical Image Recognition System with Limited Data Transfer Learning
  • Adaptive medical image recognition system that utilizes transfer learning to overcome limitations caused by minimal amounts of data.
  • Novel innovation transforms generic models into application-specific ones and overcomes the limitations of traditional systems that are often tailored to specific domains or imaging devices.
  • New image recognition system can be used for diagnostics and analysis as well as medical condition monitoring.
8168
Low-Cost, Efficient Intracellular Delivery of Proteins and Nucleic Acids via Hydrophobic Ion Pairing
  • Safe and efficient approach of delivering therapeutics to disease by mixing cargo and charged hydrophobic ions with cells.
  • Applications in therapeutic/drug delivery, protein transduction reagent, and gene transduction reagent.
  • Enables efficacious delivery of a wide range of protein and nucleic acid therapeutics.
9178
Scalable Manufacturing Approach of Graded Polymer Thin Film Has Potential for Widespread Use
  • Combines slot die coating with a custom roll-to-roll imaging system to allow for efficient, rapid, and scalable fabrication of high-quality gradient thin films.
  • An improved manufacturing process over existing techniques because it uses broad material combinations and yields higher quality patterned thin films.
  • Incorporates multiple materials to increase the application of patterned thin films across industries, including microelectronics, energy technologies, and environmental systems.
8994
Improving Quantitative Phase Imaging to Enhance Reliability and Broaden Applications
  • Universal application of an OBM/qOBM optical phase imaging device is made possible by the optimized SNR that identifies configurations with fewer limitations (e.g., conditions, tissue).
  • The simulated SNR can identify non-intuitive geometries for optical phase imaging devices that previously may not have been identified by the arduous experimental optimization process. 
  • Optimized SNR when OBM/qOBM devices take in-vivo and in-situ measurements have been proven reliable across multiple types of tissue.
8936
Messenger RNA–Based Expression of Cardiomyocyte Phenotype Sensors and Differentiating Genes for In Vitro Correction of Cardiac Disorders
  • This invention uses a gene therapy as a direct treatment for symptomatic bradyarrhythmia and removes the needs for implantation of electronic pacemakers.
  • The innovation does not lead to spillover to the liver, spleen and lungs; allows for mRNA gene transfer to stay focal to the injection site; and does not have danger of integration into the host’s DNA.
  • The new gene therapy could be used as first-line treatment of arrhythmias and consequent ailments and to circumvent the need for major surgical interventions.
7526
Smart Nanosensor-Embedded Stent System for Wireless Surveillance of Restenosis in Coronary Artery Disease
  • An electronic stent that incorporates an ultrathin stretchable wireless sensor for continuous surveillance of restenosis along with neointimal proliferation and plaque deposition.
  • There is no existing system that offers a clinically practical solution for continuous, real- time detection of both restenosis incidence and progression.
  • This device will profoundly decrease the number of healthcare dollars spent on repeated revascularization due to restenosis in CAD.
8542
Systems and Methods for Flexible Sheath Locking with Integrated Shape Sensing
  • This technology aims to become a new steerable device to reduce the invasiveness of traditional methods for delivering drugs and diagnostic devices inside the body.
  • There are no known existing methods of delivering radiotherapy without the potential of adversely affecting healthy cells.
  • This device and method will enable drastic improvements in the quality of life of patients having to undergo radiotherapy treatment. 
9264
Enhanced Diversifying Base Editors for Directed Evolution in S. cerevisiae
  • This invention presents an optimized and integrated CRISPR diversifying base editor for use in yeast and demonstrate its ability to rapidly improve the affinity of an antibody through yeast display. 
  • The innovation has enhanced the base editor mutation rate up has been increased to 27-fold by characterizing an improved key variant and by optimizing the structure of the CRISPR guide RNAs.
  • The technology has attained a rate roughly 10-fold higher than state-of-art systems and facilitates ultra-rapid antibody diversification.
9111
Novel Repressor Proteins for Gene Regulation and CRISPRi
  • The new CRISPRi platform uses novel fusion proteins to specifically inhibit target genes of interest and overcome the off-target issues with existing CRISPR platforms already on the market.
  • The technology can be used as a life science tool and/or for diagnostics and therapeutics.
  • The platform aims to limit off-target editing, circumvent incomplete gene knockdown sgRNA sequence-dependent repression activity, and variable performance across human cancer cell lines.
9106
Enabling Rapid Detection of Label-Free RNA for Use in COVID-19 Testing
  • Earlier detection: Identifying the viral components themselves—rather than the body’s reaction to the viral presence (i.e., antibodies)—potentially improves early detection in asymptomatic subjects.
  • Simpler process: Use of minimal reagents and fewer preparatory steps is designed to enable more efficient and facile sample preparation. Avoidance of “wash steps” aims to minimize target loss.
  • Fewer disruptions: Avoiding the use of high-demand supplies (e.g., swabs) and reagents potentially reduces supply-chain and contamination issues.
8669
Messenger Ribonucleic Acid (mRNA)–Based Opsin Expression Enables New and Safer Optogenetic Studies
  • Opsin expression using messenger RNA (mRNA) provides an alternative to viral vectors for use in optogenetic studies involving neurons as well as drug testing with cardiomyocytes.
  • Expression with mRNAs has lower toxicity and is usually detectable within 2–24 hours rather than 2–3 weeks.
  • The controllable and temporary nature of mRNA offers improved expression regulation based on the transfection amount.
7534
Microfluidic Device Enables Prediction of T-Cell Ability to Home and Engraft to Disease Tissues
  • Improve the homing capabilities of T cells to increase adoptive cell therapy treatment response and safety while decreasing off-target effects.
  • Enhance tumor-infiltrating capabilities with engineered microfluidic devices that identify optimal subsets of cells.
  • Optimize development pipelines by reducing the number of laborious in vivo studies, while also helping cell therapy companies ensure their products reach the desired tissue.
9052
mRNA Therapeutic Delivery System Offers Targeted, Sustained HIV Pre-Exposure Protection in the Female Reproductive Tract
  • This system delivers messenger RNA that encodes neutralizing antibodies, which anchor to the female reproductive tract ensuring adequate, sustained tissue concentration for HIV prophylaxis.
  • This HIV prevention therapy targets the female reproductive tract and offers month-long protection to reduce office visit frequency and potentially lower medical costs.
  • This safe, water-based technology offers ease of administration to enhance patient compliance and prevent systemic complications. 
8324
Bi-Channel Needle for Injection
  • The injection fluids are completely separated until the tip of the needle, preventing their mixing until they have reached the syringe’s distal tip. 
  • Since the specific volumes of each drug required will be added to the channels of the syringe, this device reduces the amount of fluid left in the syringe after injection.
  • The needle allows the clinician to inject with syringes that are parallel to each other, as opposed to at some oblique angle.
  • The length of the device is not limited to the current 1-inch syringe. It can be longer (even greater than 1 meter) for catheter-based procedures.
9028
Lymphatic System-Specific Lipid Nanoparticles
  • This platform technology improves current targeting to lymphatic tissues and specifically lymphatic endothelial cells.
  • Provides superior tissue targeting and functional delivery of mRNA to lymphatics via loco-regional dermal or subcutaneous avenues.
  • mRNA-based platforms offer a transient and less immunogenic method of delivery compared to protein therapeutics or adeno-associated virus-based platforms.
9056
Soft Wireless Sternal Patch for Detecting Systemic Vasoconstriction Using Photoplethysmography
  • A wireless, soft sternal patch includes integrated skin-like, photolithographically patterned electronics specifically tuned to continuously measure vasoconstriction from the sternum.
  • In overnight trials, the device detected sleep apnea and hypopnea with 95% precision and 100% sensitivity compared to data professionally scored by licensed clinicians.
  • Use of this patch on the chest could improve detection of key markers of numerous harmful health conditions.
9170
Targeted Single Cell Electroporation for Gene and Cell Therapy
  • The technology enables high efficiency delivery and high post-electroporation cell viability compared to current commercial electroporation systems.
  • The technology performs in-flow single cell measurements integrated with electroporation unlike current commercial electroporation systems which have no single cell measurement capabilities.
  • The technology enables automatic feedback control and real-time optimization of electroporation parameters at the single-cell level unlike current commercial electroporation systems which apply the same parameters to all cells in a batch at a bulk scale.
  • The technology enables selected or targeted electroporation and delivery to selected cells or cell types from a mixture of cells unlike current commercial electroporation systems which require upstream or downstream cell sorting steps.
9086
Lymphoid Tissue System Harnesses Ex Vivo Immune Reactions for Rapid Antibody Production and Immune Response Prediction
  • This immunocompetent system uniquely accounts for the unexpected activation of various immune cells to allow proper immune cell differentiation, recapitulating an effective immune response.
  • The chemokine gradient is switchable, allowing the immune cell differentiation needed for an appropriate immune reaction.
  • An ex vivo system supports immune response creation in a controlled environment, allowing reproduction of immunologic events for developing improved therapeutics.
9196
Bioabsorbable, Permeable, and Flexible 3D Auxetic Implants Offer Large-Volume Soft Tissue Reconstruction
  • A novel 3D auxetic architecture offers enhanced compressive flexibility, permeability, and nonlinear mechanical behavior.  
  • This high-performance technology has the potential to generate implants with soft tissue-mimetic biomechanical properties and high mass transfer capacity.
  • Implants can be customized for patients by adjusting the strut width and intervals and by fitting the complex anatomic geometry of the defect based on patient medical data.  
8821
Device Continuously Separates Functionalized Magnetic Microparticles from Solids to Yield Benefits for the Pharmaceutical Industry and More
  • Magnetic force is used to enhance traditional solid-solid separation techniques to yield a high-purity product stream and continuously return catalyst to a reactor.
  • The device is capable of continuous separation for multiple hours and can be parallelized or ran in series to improve solids throughput and separation efficiency.
  • This technology could help accelerate the adoption of continuous, heterogeneously catalyzed reactive crystallizations and, more generally, expand the chemistries and processes fit for continuous manufacturing. 
8806