Life Sciences | Office of Technology Licensing

Available Technologies by Category
Tissue-Selective Anticancer Agents	Tissue-targeted activity: Appended macrocyclic skeletons provide selective tissue distribution. Potent: HDAC inhibitors display stronger in vivo anticancer activity against solid tumors compared to current technology. Lower toxicity: Mice in preclinical experiments did not exhibit significant weight loss, pointing to potentially lower toxicity of these compounds.	4195
Heat-Responsive Programmable T-Cells	Specific: The remote programmable nature of these T-cells allows them to be selectively activated only in the necessary locations. Protective: This focused, genetically engineered immunotherapy is intended to protect patients from the additional harm of the off-target cell death and unnecessary systemic damage that is more common with oncological therapeutics. Non-invasive: With NIR light’s ability to penetrate into multiple layers of biological tissue and be absorbed by AuNRs, this technology removes the need for a light source in the body to trigger the T-cells.	7422
Self-Titrating Bacterial Protease-Activated Prodrug	Effective: Activates an internal dosing mechanism such that the magnitude of an infection locally determines the prodrug dose Robust: Increases the stability of the prodrug form by neutralizing the effective charge of the administered antimicrobial peptide Improves safety: Decreases the potential for off-target effects	8010
Scalable, Low-Cost, Inversion-Free Method of Enabling Automated Underside Cell Seeding	Convenient: Eliminates the need for inversion procedures, which tend to be tedious, difficult to automate, and prone to failure—especially for 96-well inserts due to their limited culture area Generalizable: Developed for screenings that focus on the air-blood barrier, but can also be applied to gut, skin, oral mucosa, and other organ systems Scalable: Employs a simple method that is extensible to automated processes for high-throughput drug screenings and pharmacological tests	8677
Rapid Development of SARS-CoV-2 Monoclonal Antibodies	Powerful: Demonstrates potential to recognize intact SARS-CoV-2 virions with high affinity Highly efficient: Enables researchers to select pairs of high-affinity antibodies that bind to different receptor sites, maximizing the efficiencies of sandwich-style rapid testing methods Enabling: Furthers the development of neutralizing antibodies that can be used as therapeutic agents, delivered either directly or via mRNA for in situ expression	8487
Skin-Conformal Wearable Stress Monitor Delivers Greater Precision and Continuous, Wireless Monitoring with Comfort and Flexibility	All-in-one: The personal adhesive bandage-like single device platform offers wireless, multi-data sensing by simply mounting it on the skin. Disposable: This wearable device is fully disposable after the use and the measured data can be simply sent to the cloud via a tablet or smartphone app. Compact: The unique, thin design of this bioelectric device is one-sixth the volume of current market offerings—weighing less than 7 g, including its rechargeable battery.	8414
Adaptive Broadband Impedance Matching in Ultrasound Front-End Electronics	High performance: Improves power transfer and acoustic reflectivity Flexible: Enables multimodal and tunable operation of CMUTs Efficient: Provides optimal matching for co-design of CMUT electronics	8342
Miniaturized Modular-Array Fluorescence Microscopy	Powerful: Offers high fluorescence sensitivity, efficiency, and spatiotemporal resolution (~3 µm and up to 60 Hz) Configurable: Offers compatibility with conventional cell culture assays and physiological imaging, providing accessibility to upright physiological imaging and integration with biochemical sensors under the cell platform Efficient: Provides effective parallelization of multi-site data acquisition	8580
Drive Belt with Surface Texture to Minimize Vibrations	Effective: Demonstrated significant reduction in vibration compared with flat, untextured belt surfaces in preliminary testing Simple: Provides a straightforward and easy-to-implement solution to a widespread problem Economical: Offers a far less expensive means of maintaining the operation of machinery compared with replacing worn belts or employing complex tension systems	8307
Advancing Mass Spectrometry with Novel Interface	Flexible: Allows for integration with a range of operational modes and analytical workflows for different ESI-MS techniques High performance: Offers enhanced sensitivity and a significantly improved limit of detection Robust and effective: Minimizes charged ion loss and enables sampling of the most analytically “valuable” droplets	4182
Integrating Electrical Sensors into Soft-Lithography Microfluidic Devices	Sophisticated: Advances the integration of electrical sensors on microfluidic devices with a simple, approachable solution Sensitive: Demonstrates a higher signal sensitivity than electrodes in a typical coplanar arrangement Adaptable: Allows for greater layout flexibility because of its straightforward fabrication process	7769
Microfluidic CODES with Innovative Machine-Learning Analysis	Scalable: Set-up allows for the integration of multiple microfluidic devices to increase throughput volume. Versatile: Machine learning analysis can be applied to other microfluidic devices integrated with the same Coulter sensor network. Pragmatic: This innovation improves the capabilities of lab-on-a-chip systems to provide an affordable solution for low-resource settings.	7107, 8032
Utilizing Impedance Spectroscopy for Advanced Characterization of Particles	Comprehensive: Simultaneously measures both spatial and dielectric properties of particles Streamlined: Helps resolve signal interference from coincident cells—a challenge of other assessment techniques Precise: Offers complex impedance as a new level of particle feature assessment, integrating it with other measurements such as elasticity and size for more predictive analyses	8049
All-Electronic Immunophenotyping Device for Point-of-Care Testing	Convenient: Provides an all-electronic immunophenotyping process with straightforward equipment and techniques Low cost: Performs sophisticated, multistep analyses in a system that is affordable enough for point-of-care settings Flexible: Allows for the easy immobilization of multiple antibodies in the device—a shortcoming of current systems	8045, 8047
Scalable Microfluidic Device with Multiple Constriction Channels for High-Throughput Mechanophenotyping	High throughput: Addresses the low-throughput challenges of other similar technologies by handling a sample volume near that of a Coulter counter Low cost: Eliminates the need for costly equipment, highly trained personnel, and long processing times that come with other measuring processes Scalable: Uses a frequency division scheme so that multiple copies of the system can operate concurrently	8031
Measuring Surface Antigen Expression via Microflow Cytometry	Portable: This innovation uses a disposable, handheld device without bulky or costly equipment, which is expected to be especially useful in low-resource settings. Simple: It is designed to achieve results similar to those from a commercial flow cytometer but without requiring initial purification. Recoverable samples: Unlike commercial systems, the analyzed sample can be recovered for further tests at the end of the analysis.	7913, 8048
Innovative Ion Mobility Spectrometry with Open-Air Assembly	Protective: Potentially helps protect the technician against contact with ionic hazards Rapid: Separates ions through fast detection of differences in their mass, charge, and cross-section Convenient: Leverages an open-air arrangement that significantly reduces time for experiment setup and sample preparation	4885
High-Tech Infant Suit for Earlier Detection of Cerebral Palsy	Advanced: May allow for earlier detection of motor dysfunctions in order to begin therapeutic interventions as soon as possible Robust: Collects data from three limb segments on the leg for a multifaceted assessment Long-lasting: Uses one power source with regulated voltage in order to prolong the use of the device	7949
LoCHAid: An Ultra-Low-Cost and Self-Fitting Hearing Aid	Low cost: Uses widely available components that cost 98 cents when purchased in bulk quantities User friendly: Easier to fit—and keep track of—than conventional behind- and in-the-ear hearing aids Accessible: Designed for easy manufacture and repair in locations where conventional hearing aids are priced beyond the reach of most citizens	7876
Facilitating Ultrasound Penetration of the Skull for Diagnosis and Treatment	Portable: Designed to enable imaging of the brain via small, mobile ultrasound devices, which may offer greater convenience compared with MRI and CT machines Affordable: May be a lower cost modality compared with leading techniques, such as MRI, CT, or positron emission tomography (PET) Robust: Demonstrates energy transmission through the skull on par with that of an aqueous medium in preliminary testing	8340

Technologies