| T cell Secretion of Engineered Enzymatic Weapons for Solid Tumor Translation |
- This innovation involves genetically modifying human cells to secrete an enzyme that breaks down adenosine, enhancing CAR-T and other T cell therapies' effectiveness against solid tumors.
- The prototype addresses adenosine-mediated immunosuppression, improving therapy specificity and efficacy in treating solid tumors.
- It has commercial applications in enhancing CAR-T cell therapies and other immunotherapy treatments for various cancers, marking a significant advancement in cancer care.
|
8854 |
|
| An Electronic Microfluidic Platform for On-Chip Apoptosis Quantification using Annexin V-Based PS Externalization Detection-GT NEXT |
- This electronic microchip integrates an electrical sensor network with a microfluidic capture chamber to detect phosphatidylserine (PS) externalization, offering a compact, user-friendly, and cost-effective solution for apoptotic analysis.
- The prototype provides high sensitivity and specificity without the need for prelabeling, making it suitable for diverse applications in clinical diagnostics and biomedical research.
- It supports drug discovery, toxicity evaluation, and bioprocessing optimizations, enhancing disease mechanism studies and therapeutic target identification.
|
9306 |
|
| Antigen-specific Cell Programming Using non-viral Approaches |
- This innovative technology uses synthetic nanoparticles to deliver gene modulators and engineered MHC molecules directly to antigen-specific T cells in vivo, enhancing T cell functions and bypassing ex vivo processes.
- The prototype improves T cell specificity and reduces off-target toxicity, significantly lowering costs and manufacturing time for effective T cell therapies.
- It has applications in cancer therapy, immune therapy, autoimmune disease therapy, and infectious disease therapy.
|
8703 |
|
| Scarless isolation of antigen-specific T cells for CAR T cell manufacturing via DNA-gated sorting |
- This technology introduces DNA-gated sorting (DGS) for label-free isolation of antigen-specific CD8+ T cells, improving CAR T cell therapy.
- The prototype enhances CAR T cell scalability and therapeutic effectiveness against solid tumors by using a DNA gate mechanism for targeted T cell capture and release.
- DGS improves in vivo persistence and specificity of CAR T cells, offering better treatment outcomes for solid tumors and other cancers.
|
9388 |
|
| Activity-based synthetic liquid biopsy of solid tumors |
- Activatable biosensors injected into tumors capture dynamic biological activity and immune responses, allowing non-invasive monitoring of tumor responses through bodily fluids.
- The prototype offers real-time insights into tumor behavior and treatment effectiveness, providing a less invasive alternative to traditional biopsies.
- This method enhances sensitivity and specificity for tumor-specific biomarkers, improving monitoring of drug responses and cancer progression.
|
9387 |
|
| Needle-like Nanostructures to Deliver Multi-scale Biomolecules to Non-activated Immune Cells |
- This functionalized nanowire platform delivers multiple genetic materials to naïve T and B cells without pre-activation, enhancing their efficacy in adoptive cell therapy.
- The prototype improves gene delivery efficiency while preserving the naïve state of immune cells, increasing cell viability and immune response modulation.
- It offers superior protection against intracellular pathogens and serves as a research tool for immune cell manipulation across various species, ages, and subtypes.
|
9431 |
|
| Multi-Niche Human Bone Marrow-On-A-Chip for Plasma Cell Survival and Differentiation |
- This novel microfluidic chip simulates the human bone marrow environment, incorporating multiple niches and supporting long-term plasma cell culture and study.
- The prototype enables comprehensive study of plasma cell maturation, aiding the development of targeted therapies for plasma cell-related disorders.
- It overcomes limitations in traditional plasma cell culture, facilitating vaccine development, antibody production research, and immune response modulation.
|
9246 |
|
| Lymphoid-Lymphatics-Integrated Organ-on-Chip Device and Method |
- This innovative organ-on-chip system combines vascularized lung and lymphoid tissues, aiding studies on airway infections.
- The prototype supports diverse cell cultures, making it useful for screening treatments and vaccines.
- It enhances current lung-on-chip models by accurately simulating lung tissue and immune responses.
|
9349 |
|
| Functionalized Nanowires for miRNA-mediated Programming of Naive T Cells |
- Technology Overview: Georgia Tech's functionalized nanowires deliver genetic materials like miRNAs and CRISPR directly to naive T cells, enhancing their therapeutic potential without pre-activation.
- Advantages: This method preserves the naive state of T cells, allowing for better viability and functionality, reduced exhaustion, and delivery of both small and large biomolecules, including lentiviral particles.
- Commercial Applications: The technology can be used in adoptive T cell therapy for cancer and infectious diseases, therapeutic delivery of biomolecules, and as a research tool for immune cell manipulation.
|
9341 |
|
| Lymphoid Tissues with Switchable Protein Gradients |
- Technology Overview: Georgia Tech's hydrogel-based immune organoids mimic lymphoid tissue, enabling ex vivo differentiation of B cells and studying immune responses to infections and vaccinations.
- Advantages: This non-invasive method supports long-term B and T cell survival, mimics antibody production processes, and offers insights into diseases like lymphoma.
- Commercial Applications: Useful for drug discovery, clinical research on immune disorders, personalized medicine, and academic studies in immunology.
|
2024-116 |
|
| Engineering Antigen-Specific T Cells for CAR T Cell Therapy via Antigen-Presenting Lipid Nanoparticles |
Technology Overview: Georgia Tech's new CAR T cell therapy uses lipid nanoparticles (LNPs) to program antigen-specific T cells in vivo, potentially reducing costs and production time. Advantages: This approach avoids expensive and time-consuming ex vivo manufacturing, minimizes off-target effects, can adapt to various CAR constructs and cancer types, and promises rapid scaling and reduced costs. Commercial Applications: Applicable to multiple myeloma, CD19+ cancers, and a wide range of other cancers, this technology streamlines CAR T cell therapy manufacturing for faster, more affordable treatments.
|
9386 |
|
| Driving Neural Activity to Rapidly Control Inflammation, Protein, and Gene Expression in the Brain |
- Novel non-invasive method utilizing neural activity to swiftly control inflammation, protein, and gene expression in the brain.
- The technology enables rapid and precise modulation of brain functions, potentially revolutionizing treatment for various neurological conditions.
- Commercial applications include treating Alzheimer's, schizophrenia, autism, epilepsy, and more, offering faster, non-invasive, and targeted therapeutic options.
|
7773 |
|
| Lipid Nanoparticle-Mediated Delivery of mRNA Encoded Synthetic Antigens for CAR T Cell Therapy |
Georgia Tech's novel CAR T cell therapy uses lipid nanoparticles (LNPs) to deliver mRNA-encoded synthetic antigens, improving targeting of solid tumors and reducing off-target effects. The technology ensures efficient mRNA delivery, prompting tumor cells to express unique antigens, enhancing immune recognition and destruction of cancer cells. This approach broadens CAR T cell therapy applicability, allows repeat dosing, and minimizes off-tumor toxicity, offering significant advantages over traditional methods.
|
9385 |
|
| Acousto-Optical Sensors for MRI Safety Evaluation |
- The invention is an acousto-optical sensor that can measure the SAR (specific absorption rate) in its environment through temperature and the radio frequency (RF) field.
- The innovation can be used to improve patient safety during MRI scans and to ensure MRI-compatibility for medical implants.
- The solution is more compact and flexible than market alternatives
|
7953 |
|
| Novel Hydrogels for Encapsulation, Vascularization, and Transplantation of Cells |
- This hydrolytically degradable poly(ethylene glycol) (PEG) hydrogel leverages ester linkages combined at various ratios with non-degradable macromers to enable tunable degradation kinetics.
- Potential applications include controlled release and delivery of drugs or proteins as well as cell encapsulation. It can also be used as a delivery vehicle and adhesive for cells in transplantation settings.
- These innovative hydrogels allow for rapid hydrolytic cleavage in vivo but remain stable in vitro for weeks at neural pH 7 to support regenerative medicine techniques.
|
9019 |
|
| Low-Cost, Efficient Intracellular Delivery of Proteins and Nucleic Acids via Hydrophobic Ion Pairing |
- Safe and efficient approach of delivering therapeutics to disease by mixing cargo and charged hydrophobic ions with cells.
- Applications in therapeutic/drug delivery, protein transduction reagent, and gene transduction reagent.
- Enables efficacious delivery of a wide range of protein and nucleic acid therapeutics.
|
9178 |
|
| Scalable Manufacturing Approach of Graded Polymer Thin Film Has Potential for Widespread Use |
- Combines slot die coating with a custom roll-to-roll imaging system to allow for efficient, rapid, and scalable fabrication of high-quality gradient thin films.
- An improved manufacturing process over existing techniques because it uses broad material combinations and yields higher quality patterned thin films.
- Incorporates multiple materials to increase the application of patterned thin films across industries, including microelectronics, energy technologies, and environmental systems.
|
8994 |
|
| Improving Quantitative Phase Imaging to Enhance Reliability and Broaden Applications |
- Universal application of an OBM/qOBM optical phase imaging device is made possible by the optimized SNR that identifies configurations with fewer limitations (e.g., conditions, tissue).
- The simulated SNR can identify non-intuitive geometries for optical phase imaging devices that previously may not have been identified by the arduous experimental optimization process.
- Optimized SNR when OBM/qOBM devices take in-vivo and in-situ measurements have been proven reliable across multiple types of tissue.
|
8936 |
|
| Messenger RNA–Based Expression of Cardiomyocyte Phenotype Sensors and Differentiating Genes for In Vitro Correction of Cardiac Disorders |
- This invention uses a gene therapy as a direct treatment for symptomatic bradyarrhythmia and removes the needs for implantation of electronic pacemakers.
- The innovation does not lead to spillover to the liver, spleen and lungs; allows for mRNA gene transfer to stay focal to the injection site; and does not have danger of integration into the host’s DNA.
- The new gene therapy could be used as first-line treatment of arrhythmias and consequent ailments and to circumvent the need for major surgical interventions.
|
7526 |
|
| Smart Nanosensor-Embedded Stent System for Wireless Surveillance of Restenosis in Coronary Artery Disease |
- An electronic stent that incorporates an ultrathin stretchable wireless sensor for continuous surveillance of restenosis along with neointimal proliferation and plaque deposition.
- There is no existing system that offers a clinically practical solution for continuous, real- time detection of both restenosis incidence and progression.
- This device will profoundly decrease the number of healthcare dollars spent on repeated revascularization due to restenosis in CAD.
|
8542 |
|
