Research Tools | Office of Technology Licensing

Available Technologies by Category
Fourier Light-Field Microscope (FLFM) for Fast, Volumetric, and High-Resolution Imaging of Entire Organoids	Cost-efficient and scalable: Is fully adaptable to epifluorescence protocols resulting in a system that is both cost-efficient and highly scalable Fast: Captures fast cellular and tissue dynamic processes in a simultaneous, volumetric manner (e.g., collective cellular responses at sub-second time scales across whole samples) Validated: Responses to extracellular physical cues such as osmotic and mechanical stresses have been recorded using human induced pluripotent stem cell-derived colon organoids (hCOs).	8844
Recombinant Antibodies for Exclusive Detection of Glaucoma-Associated Myocilin	Exclusive detection: Unlike current myocilin-directed antibodies that do not differentiate among numerous disease-associated states of the protein (e.g., folded, cleaved, and misfolded myocilin), these reagents only detect folded myocilin Authentic and reproducible: Antibodies are produced using recombinant DNA technology, which enables robust precision sequencing of the reagent and maintains fidelity over time High affinity: Antibodies detect both mouse and human myocilin with well-characterized epitopes and high affinity	8055
Antibodies for Glaucoma Research	Precise: Distinguishes between correctly folded and mutated forms from samples, allowing for more precise research and interventions Powerful: Enables a more complete and robust understanding of myocilin antibody targets and their applications in potential glaucoma treatments Enabling: Opens new opportunities for development of pharmaceuticals to treat or prevent damage to the eye caused by glaucoma	8489
High-Throughput MSC Potency Assay to Bring Feasibility to Immune/Inflammatory Therapeutics	Reproducibility: The well-defined cellular environment of the device enables a highly reproducible MSC response not observed in 2D cultures. Scalable: The assay’s simplistic design is amendable to cost-effective scale up. Economical: The low cost of the microfluidic chip and the ease of implementing the assay into existing cell therapy manufacturing practices provide for low costs to enter the market.	8722
Handheld Breath Collection Device for Detecting Disease Biomarkers	Improved diagnosis: Analyzes both the gas and liquid sampled from the patient’s breath for potentially more robust and multifaceted results Enhanced patient experience: Requires a shorter exhalation cycle to get a breath sample, making the test more comfortable for patients Small and portable: Optimizes and miniaturizes the collection process for easy point-of-care applications	8791
Microscale High-Throughput Phenotypic Assay for Fibrosis	Powerful: Provides high-throughput image-based analysis of fibrotic processes as well as fibrinolysis Convenient: Combines label-free readouts for fibrin degradation, collagen synthesis, and cell contraction to evaluate fibrotic tissue remodeling Enabling: Opens new opportunities for understanding fibrosis pathogenesis and for evaluating anti-fibrotic therapeutics	8502
A Biomimetic Nose with Machine Learning for Advanced Threat Detection	Enhanced chemical detection: Reduces proximity issues and enhances detection Functional in air and liquid mediums: Can detect single or multiple chemical agents even when the medium contains both a liquid and a gas. An attachment makes it possible to use the device in liquid with air monitoring sensors. Continuous improvement: Uses machine learning algorithms to continually improve agent characterization	7796
Self-Titrating Bacterial Protease-Activated Prodrug	Effective: Activates an internal dosing mechanism such that the magnitude of an infection locally determines the prodrug dose Robust: Increases the stability of the prodrug form by neutralizing the effective charge of the administered antimicrobial peptide Improves safety: Decreases the potential for off-target effects	8010
Scalable, Low-Cost, Inversion-Free Method of Enabling Automated Underside Cell Seeding	Convenient: Eliminates the need for inversion procedures, which tend to be tedious, difficult to automate, and prone to failure—especially for 96-well inserts due to their limited culture area Generalizable: Developed for screenings that focus on the air-blood barrier, but can also be applied to gut, skin, oral mucosa, and other organ systems Scalable: Employs a simple method that is extensible to automated processes for high-throughput drug screenings and pharmacological tests	8677
Rapid Development of SARS-CoV-2 Monoclonal Antibodies	Powerful: Demonstrates potential to recognize intact SARS-CoV-2 virions with high affinity Highly efficient: Enables researchers to select pairs of high-affinity antibodies that bind to different receptor sites, maximizing the efficiencies of sandwich-style rapid testing methods Enabling: Furthers the development of neutralizing antibodies that can be used as therapeutic agents, delivered either directly or via mRNA for in situ expression	8487
Skin-Conformal Wearable Stress Monitor Delivers Greater Precision and Continuous, Wireless Monitoring with Comfort and Flexibility	All-in-one: The personal adhesive bandage-like single device platform offers wireless, multi-data sensing by simply mounting it on the skin. Disposable: This wearable device is fully disposable after the use and the measured data can be simply sent to the cloud via a tablet or smartphone app. Compact: The unique, thin design of this bioelectric device is one-sixth the volume of current market offerings—weighing less than 7 g, including its rechargeable battery.	8414
Miniaturized Modular-Array Fluorescence Microscopy	Powerful: Offers high fluorescence sensitivity, efficiency, and spatiotemporal resolution (~3 µm and up to 60 Hz) Configurable: Offers compatibility with conventional cell culture assays and physiological imaging, providing accessibility to upright physiological imaging and integration with biochemical sensors under the cell platform Efficient: Provides effective parallelization of multi-site data acquisition	8580
Integrating Electrical Sensors into Soft-Lithography Microfluidic Devices	Sophisticated: Advances the integration of electrical sensors on microfluidic devices with a simple, approachable solution Sensitive: Demonstrates a higher signal sensitivity than electrodes in a typical coplanar arrangement Adaptable: Allows for greater layout flexibility because of its straightforward fabrication process	7769
Microfluidic CODES with Innovative Machine-Learning Analysis	Scalable: Set-up allows for the integration of multiple microfluidic devices to increase throughput volume. Versatile: Machine learning analysis can be applied to other microfluidic devices integrated with the same Coulter sensor network. Pragmatic: This innovation improves the capabilities of lab-on-a-chip systems to provide an affordable solution for low-resource settings.	7107, 8032
Utilizing Impedance Spectroscopy for Advanced Characterization of Particles	Comprehensive: Simultaneously measures both spatial and dielectric properties of particles Streamlined: Helps resolve signal interference from coincident cells—a challenge of other assessment techniques Precise: Offers complex impedance as a new level of particle feature assessment, integrating it with other measurements such as elasticity and size for more predictive analyses	8049
All-Electronic Immunophenotyping Device for Point-of-Care Testing	Convenient: Provides an all-electronic immunophenotyping process with straightforward equipment and techniques Low cost: Performs sophisticated, multistep analyses in a system that is affordable enough for point-of-care settings Flexible: Allows for the easy immobilization of multiple antibodies in the device—a shortcoming of current systems	8045, 8047
Scalable Microfluidic Device with Multiple Constriction Channels for High-Throughput Mechanophenotyping	High throughput: Addresses the low-throughput challenges of other similar technologies by handling a sample volume near that of a Coulter counter Low cost: Eliminates the need for costly equipment, highly trained personnel, and long processing times that come with other measuring processes Scalable: Uses a frequency division scheme so that multiple copies of the system can operate concurrently	8031
Measuring Surface Antigen Expression via Microflow Cytometry	Portable: This innovation uses a disposable, handheld device without bulky or costly equipment, which is expected to be especially useful in low-resource settings. Simple: It is designed to achieve results similar to those from a commercial flow cytometer but without requiring initial purification. Recoverable samples: Unlike commercial systems, the analyzed sample can be recovered for further tests at the end of the analysis.	7913, 8048
Innovative Ion Mobility Spectrometry with Open-Air Assembly	Protective: Potentially helps protect the technician against contact with ionic hazards Rapid: Separates ions through fast detection of differences in their mass, charge, and cross-section Convenient: Leverages an open-air arrangement that significantly reduces time for experiment setup and sample preparation	4885
High-Tech Infant Suit for Earlier Detection of Cerebral Palsy	Advanced: May allow for earlier detection of motor dysfunctions in order to begin therapeutic interventions as soon as possible Robust: Collects data from three limb segments on the leg for a multifaceted assessment Long-lasting: Uses one power source with regulated voltage in order to prolong the use of the device	7949

Technologies