A method for genetic engineering of B Cells with the ability to target highly specific antigens for use in immunotherapy.

Georgia Tech professors have developed a method for creating a biomaterial-based synthetic environment which mimics a lymph node. This environment is able to produce the functions of a germinal center (the site where B cells are able to proliferate, differentiate, and mutate their own genes), without helper cells. The germinal center will be able to create functional B cells from peripheral blood, stem cells, or cord blood.

Solution Advantages
  • Novel – No present technology exists
  • Versatile – Can be adapted to suit a variety of diseases, human and animal
  • Targeted – Antigen-binding qualities within the B cell allow for highly specific therapies
Potential Commercial Applications
  • Ready source for therapeutic antibodies for humans and animals
  • Immunotherapy against cancer, infectious diseases, and autoimmune diseases
  • Further study of B cell biology
Background and More Information

Immunotherapy has become the most transformative therapeutic approach in treating cancer, infectious diseases, and many devastating disorders. To date, cell-based immunotherapy has been restricted to T cells due to lack of robust methods for generating functional, antibody-producing B cells ex vivo. Although treatment of T cells is essential for cancer research, engineering B cells is essential to the future of immunotherapy due to their unique ability to bind to specific antigens.