Apoptosis detection can be limited by costs and complexities
The problem with current apoptosis detection methods is their reliance on complex, expensive, and space-consuming equipment, and the need for prelabeling samples, which is not always feasible. These limitations hinder rapid, cost-effective, and accessible apoptotic analysis, particularly in smaller clinics and point-of-care settings.
This innovative electronic microchip integrates an electrical sensor network with a microfluidic capture chamber to detect phosphatidylserine (PS) externalization, a hallmark of apoptosis. It offers a compact, user-friendly, and cost-effective solution, providing high sensitivity and specificity without the need for prelabeling. This adaptable platform enables autonomous, label-free, real-time apoptotic analysis, suitable for diverse applications including clinical diagnostics.
A novel microchip allows for a compact and cost-effective way to detect apoptosis
This electronic microchip integrates an electrical sensor network with a microfluidic capture chamber to detect phosphatidylserine (PS) externalization, a hallmark of apoptosis. It surpasses traditional methods by providing a compact, user-friendly, and cost-effective solution for the analysis of apoptotic events, with applications extending to cell differentiation, signaling, and clinical diagnostics.
- High sensitivity and specificity for PS detection
- Eliminates the need for prelabeling cells, reducing assay time and complexity.
- Integration with microfluidics ensures efficient sample processing and reduced volume requirements.
- Low-cost
- Adaptable platform suitable for field-deployed analysis tools
- Compact and user-friendly design
• Biomedical research for studying disease mechanisms, drug responses, and therapeutic target identification.
• Pharmaceutical industry for drug discovery, candidate screening, and toxicity evaluation.
• Bioprocessing and cell manufacturing for optimizing production processes and ensuring product quality