Available Technologies by Category
Smart, Wireless, Bioelectronic Pacifier for Real-Time Continuous Salivary Electrolyte Monitoring in Infants
  • Smart pacifier offers wireless, real-time, continuous detection of sodium and potassium levels in infants.
  • This totally non-invasive monitoring pacifier eliminates the need for blood draws, which can only be done three times each day, and is designed to provide non-invasive neonatal health monitoring.
  • Microfluidic channels are designed to efficiently pump optimum quantities and concentration of viscous saliva to the sensor area for quick measurement and to eliminate the need to induce salivary stimulation.
Quantitative, Multiplexed Electronic Detection of COVID-19 Biomarkers
  • Direct electronic detection: This innovation provides direct detection of biomarkers as a simple electronic readout without the use of any intermediate optics.
  • Multiplexed: The device can simultaneously detect multiple biomarkers (e.g., a four-plex chip to detect IgG and IgM antibodies against spike or nucleocapsid antigens).
  • Portable: A handheld, cellphone-interfaced reader is designed to enable detection and monitoring of diseases in remote areas for sensitive yet inexpensive point-of-care use.
Intracellular Anticancer Delivery
  • Self-assembling: Forms an organized structure in water at room temperature
  • Nano-scale: Approximately 35 nm, ideal for intracellular uptake
  • Versatile: Can be used with any antibody
Developing Tumor Immune Microenvironments via Engineered Hydrogel
  • Scalable: Enables increased tumor formation rate without sacrificing the dynamic complexity of an in vivo adaptive immune response
  • Improved consistency: Demonstrates consistent induction of tumor growth, latency, and immune infiltration in early analyses of the technology
  • Cost-effective: Eliminates the repetitive processes of conventional methods and leverages inexpensive hydrogel
Biologically Inspired Connected Advanced Driver Assistance System
  • Cost-effective: Leverages existing vehicle infrastructure (e.g., sensors, lights) along with an affordable software upgrade to provide enhanced collision avoidance capabilities, typically for less than $500
  • Safety-enhancing: Designed to help prevent up to 94% of automotive crashes by providing reduced lag time and enabling faster driver reaction rates 
  • Convenient: Aims to optimize vehicle travel speeds and reduce traffic congestion and travel times
Atomic Metal Catalysts
  • Innovative: Generates new isomers by changing the order in which atoms are added in a hetero-atomic cluster (can maximize available catalytic sites)
  • Efficient: Creates and optimizes active isomers of atomic metals such as Au and Pd, increasing the catalytic efficiency of these high-demand metals (requires minimal precious catalytic metal)
  • Scalable: Provides a scalable process resulting in theoretically predictable catalytic properties
6451, 5217
Capillary Flow Control in Lateral Flow Assays (LFAs) via Delaminating Timers
  • ASSURED: LFAs readily satisfy the majority of the ASSURED (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverable to end-users) criteria reported by the World Health Organization to establish capabilities of POC devices.
  • Agile: The addition of timers to LFAs provides an opportunity to develop more complex multi-step testing, as well as additional benefits such as built-in signal amplification and POC DNA extraction and purification.
  • Automated: The ability to sequentially deliver different reagents into a reaction via programmable timers imprinted on paper makes it possible to automate multi-step assays that otherwise could only be performed in laboratories or with manual intervention.
8462, 8634
Recirculation System for Aerosol Collectors Maximizes Particle Concentration for Improved Pathogen Detection
  • Enhanced detection: Continuously recirculated collection buffer increases the concentration of targeted particles collected and improves detection of pathogens 
  • Increased sampled air volume: Recirculating the buffer enables running the system for longer periods of time and with larger volumes of air to improve pathogen detection in entire buildings
  • Increased control: Users have active control of the volume of fluid introduced during collection via the system’s recharge pump
3D Light-Field Endoscopy for High-Precision Microsurgery
  • Enhanced control and safety: Real time visual navigation enhances guidance and intervention in complex microenvironments, maintaining high spatial resolution while providing quantitative depth information
  • Comfortable: System does not require 3D glasses that can cause physician dizziness or headaches after long periods of use
  • Streamlined: Technique eliminates the need for other imaging procedures such as micro-CT or MRI to quantify the 3D morphology of tissue
Cluster-Wells: Isolating Aggressive Tumor Cell Clusters for Improved Cancer Diagnosis and Treatment
  • High performing: Demonstrates superior abilities to isolate CTCs without clogging the system or dissociating the clusters
  • Low cost: Shows high potential for large-scale production because it uses simple equipment and a straightforward process
  • Versatile: Isolates CTC clusters of any cancer type and uses hardware that can be modified to accommodate various devices
Fourier Light-Field Microscope (FLFM) for Fast, Volumetric, and High-Resolution Imaging of Entire Organoids
  • Cost-efficient and scalable: Is fully adaptable to epifluorescence protocols resulting in a system that is both cost-efficient and highly scalable
  • Fast: Captures fast cellular and tissue dynamic processes in a simultaneous, volumetric manner (e.g., collective cellular responses at sub-second time scales across whole samples)
  • Validated: Responses to extracellular physical cues such as osmotic and mechanical stresses have been recorded using human induced pluripotent stem cell-derived colon organoids (hCOs).
Airborne Acoustic Sensing System for “Ear in the Sky” Capabilities on Unmanned Aerial Vehicles (UAVs)
  • Optimizes speech clarity: Uses acquired empirical data and iteratively refines the processing capability until the optimal signal to noise ratio (SNR) is achieved
  • Improves covert detection: Enables acquisition of a live voice signal from a person of interest without detection by using UAS platforms to remotely acquire acoustic signals and using digital signal processing algorithms to filter, enhance, and localize the speech signal of interest
  • Enhances warfare tools: Provides increased situational awareness, enhanced ISR capabilities, and helps identify potential security threats to deployed assets
6985, 7223
Reprocessing, Recycling, and Repairing Covalent Adaptable Network Polymers
  • Environmentally friendly: Recycles fibers and polymers without the use of supercritical chemicals (e.g., acids) 
  • Effective: Allows for pressure-free surface repair and welding 
  • Efficient: Reclaims fibers and polymer with the same mechanical properties as fresh material for use in new products
TabAccess: A Wireless Controller for Tablet Accessibility
  • Enabling: Provides an alternative interface to touchscreen-based devices for people with limited fine motor control, potentially enabling them to interact with applications that could improve their quality of life or even create employment opportunities
  • Reconfigurable: Sensor modules can be interconnected as well as separated and mounted anywhere (e.g., on the human body or on a table, floor, wheelchair, etc.), enabling adaptation of the device based on the capability, range of access, and the individual’s range of motion.
  • Adjustable: Uses an adjustable Velcro strap so one size fits the majority of forearms
Cell-free Biosensors to Detect Creatinine, Creatine, and Sarcosine
  • Portable: This technology demonstrates the potential to develop point-of-care screening and monitoring, which is essential to expanding access to care worldwide, including to low- and middle-income countries.
  • Inexpensive: CFE-based biosensors can cost as little as a few cents per test and could provide a low-cost alternative to current renal function monitoring and diagnosis, which currently involves laboratory visits, trained phlebotomists, skilled technicians, and expensive, specialized equipment.
  • Cell-free: The use of a cell-free expression system could enable easier-to-read quantitative output that is less susceptible to matrix effects.
Chip-Scale Atomic Beam System
  • Precision timekeeping (e.g., chip-scale atomic clocks primarily used in cell phone base stations) 
  • Navigation (e.g., interferometers used in underwater oil and gas exploration)
  • Robotics
New Methods for Skin Tissue Engineering: Textile-Based Sandwich Scaffold and CNT-based Electrospun Polymer Composite Yarns
  • Biocompatible: Exhibits good biocompatibility of the yarns fabricated using a wet electrospinning technique (results shown within a limited range of CNT concentration in the bath)
  • Purposeful: Mimics the strain-stiffening behavior of human tissue, unlike other scaffolds that exhibit strain-softening of their synthetic materials
  • Demonstrated: Exhibits the ability to guide cell anisotropic arrangement as well as support cell proliferation and infiltration in in vitro biological tests
8751, 8752
Versatile Retroreflective Metastructures for Enhanced Electromagnetic Response
  • Improved steep angle performance: Increases the angular range of reflectivity to greatly reduce the precision needed to produce a retroreflective response
  • Increased bandwidth: Combines multiple periodic metasurfaces into a hybrid metastructure for greater bandwidth
  • Versatile design: Can be designed for either single- or dual-polarized retroreflection, with metasurfaces of different periodicities combined for varying angles
Small Beamformer for Simultaneous Spatial and Channel Diversity Communications
  • Scalable: Improves capacity by increasing the number of arrays and increasing the gain of each interpenetrating array
  • Small formfactor: Contains nine interpenetrating arrays in the same area as a single legacy array capable of carrying only one bandwidth
  • Efficient: Demonstrates that each antenna array can spatially scan at least nine independent interpenetrating arrays simultaneously, each carrying its assigned information channel within the assigned bandwidth
Small Molecule Glycosylated Histone Deacetylase Inhibitors (HDACi)
  • Targeted: The compounds were particularly cytotoxic to liver or hepatocellular cancer cells (HCC) during in vivo murine model laboratory studies.
  • Enhanced potency: The compounds’ hepatocellular carcinoma selectivity observed in laboratory studies potentially increases their efficacy on liver cancer and possibly other cancers.
  • Many formulations: A number of formulation methods are potentially available, including tablets, beads, granules, microparticle, or nanoparticles that provide a variety of drug release profiles.