| Synthetic Hydrogel for Satellite Cell Delivery in Dystrophic Skeletal Muscle |
- Addresses the critical need for a viable treatment for deterioration of the diaphragm, which is a leading cause of respiratory failure and death in Duchenne Muscular Dystrophy patients
- Engineered hydrogels comprised of synthetic polymers and peptides are designed to enable successful muscle satellite cell (MuSC) transplantation to the diaphragm or other dystrophic skeletal muscle tissue
- Shown to support MuSC survival, proliferation, and differentiation, which can enable restoration of dystrophin – a protein absent in DMD and critical to strengthening and repairing muscle fibers
|
7841 |
|
| Microrobots for Neurosurgery Applications |
- Minimally invasive: Significantly reduces invasiveness of procedures in comparison to current macroscale, neurosurgical robots
- Precise control: Uses 3D position data of the microrobots on the brain surface in a closed-loop system to adjust the magnetic field parameters (i.e., magnitude, frequency, phase, and direct current [DC] offset of each coil) as well as the forces the robots exert to the biopsy tissue
- Facilitates movement: Employs microfabricated shapes that dictate the microrobot's movements, limits their contact with the brain surface to reduce adhesion, and may also provide a means for the robot to propel itself in fluid
|
8749 |
|
| Synthetic Hydrogels for Human Organoid (HO) Generation and Transplantation |
- Synthetic hydrogel exhibits high cytocompatibility and minimal toxicity and inflammation in vivo for improved human organoid viability
- Injectable delivery vehicle supports localized HO engraftment in mucosal wounds to potentially enhance wound closure and repair
- Modular design and delivery via endoscopic techniques enables the translational potential of this delivery platform for regenerative medicine and overcomes limitations associated with the use of commercially available matrices for hPSC-based organoid technologies
|
7536 |
|
| Hybrid Molecular Catalysts: A New Blueprint for Catalyst Design, Preparation, and Testing |
- Attachment of molecular catalysts to solid supports can lead to new reactivity not seen under homogeneous conditions
- At an optimal atomic layer deposition (ALD) layer thickness, the molecular catalyst remains highly active while still being resistant to surface detachment and subsequent deactivation
- Catalyst separation and recovery achieved via a simple filtering and washing process rather than energy- and time-intensive distillation or re-crystallization processes
- In addition to the simple filter-and-wash process mentioned above, encapsulation requires only about 10 reaction cycles, making this process technologically and economically viable for large-scale manufacturing
|
8537 |
|
| Eco-Method Mordant that Improves Natural Dye Adhesion to Synthetic Fabrics |
- Eco-friendly: An improved industrial dyeing process because it reduces excessive heat and water contamination during manufacturing.
- Wide applicability: Demonstrated to be successful with other materials beyond polyester, including Kevlar and polyacrylonitrile (PAN).
- Improved quality: Improving commercial dye methods without losing the desired properties of polyester such as flexibility is beneficial to industries like medical supply.
|
9048 |
|
| Advanced Manufacturing of Biodegradable Shape Memory Polymers Increases In Vivo Success |
- Faster healing: Improvements catalyze the regeneration of tissue for a faster recovery
- Increased efficacy: Decreases the likelihood of rejection because the polymers are manufactured in such a way to increase tissue ingrowth and cell attachment
- Reduced healthcare resource utilization: When initial implantation is successful, it reduces the need for secondary procedures or advanced clinical care for infection
|
8658 |
|
| Hydrogels for Controlled Delivery of Lysostaphin to Treat Staphylococcus aureus Infections |
- Injectable (or surgically applied) hydrogel formulation conforms and adheres to the fracture and surrounding tissue, ensuring efficient, local delivery of lysostaphin
- Localized treatments enable higher relative doses to be given at the site of infection, and enhanced stability from the hydrogel carrier may reduce the number of overall doses needed
- Tunable nature of the material provides control over the amount and time over which lysostaphin is delivered
|
7729 |
|
| Vapor Phase Infiltration Produces Solar Cells with Greater Thermal Stability |
- Stability: Decreasing spiro-OMeTAD crystallization improves thermal stability of hole transport layers within perovskite solar cells (PSCs)
- Longevity: Eliminating the main cause of PSCs’ operational degradation increases the overall product lifespan
- Efficiency: Preventing the delamination of the layers transporting electronic charge has doubled the power conversion efficiency of modified PSCs
|
9034 |
|
| Submersible Water Activity Meter (SWAM) |
- Submersion allows rapid determination of water activity (aw) levels onsite, without returning samples to a bench-top aw system in a lab
- In-situ measurement capabilities can inform other kinds of sampling decisions very rapidly, allowing discretionary sample collection
- Membrane is permeable to water vapor but not liquid water, preventing liquid (or other media) from entering the sample volume, reducing contamination and protecting the electronics
|
8902 |
|
| Smart, Wireless, Bioelectronic Pacifier for Real-Time Continuous Salivary Electrolyte Monitoring in Infants |
- Smart pacifier offers wireless, real-time, continuous detection of sodium and potassium levels in infants.
- This totally non-invasive monitoring pacifier eliminates the need for blood draws, which can only be done three times each day, and is designed to provide non-invasive neonatal health monitoring.
- Microfluidic channels are designed to efficiently pump optimum quantities and concentration of viscous saliva to the sensor area for quick measurement and to eliminate the need to induce salivary stimulation.
|
8942 |
|
| Quantitative, Multiplexed Electronic Detection of COVID-19 Biomarkers |
- Direct electronic detection: This innovation provides direct detection of biomarkers as a simple electronic readout without the use of any intermediate optics.
- Multiplexed: The device can simultaneously detect multiple biomarkers (e.g., a four-plex chip to detect IgG and IgM antibodies against spike or nucleocapsid antigens).
- Portable: A handheld, cellphone-interfaced reader is designed to enable detection and monitoring of diseases in remote areas for sensitive yet inexpensive point-of-care use.
|
8814 |
|
| Intracellular Anticancer Delivery |
- Self-assembling: Forms an organized structure in water at room temperature
- Nano-scale: Approximately 35 nm, ideal for intracellular uptake
- Versatile: Can be used with any antibody
|
7174 |
|
| Developing Tumor Immune Microenvironments via Engineered Hydrogel |
- Scalable: Enables increased tumor formation rate without sacrificing the dynamic complexity of an in vivo adaptive immune response
- Improved consistency: Demonstrates consistent induction of tumor growth, latency, and immune infiltration in early analyses of the technology
- Cost-effective: Eliminates the repetitive processes of conventional methods and leverages inexpensive hydrogel
|
8785 |
|
| Biologically Inspired Connected Advanced Driver Assistance System |
- Cost-effective: Leverages existing vehicle infrastructure (e.g., sensors, lights) along with an affordable software upgrade to provide enhanced collision avoidance capabilities, typically for less than $500
- Safety-enhancing: Designed to help prevent up to 94% of automotive crashes by providing reduced lag time and enabling faster driver reaction rates
- Convenient: Aims to optimize vehicle travel speeds and reduce traffic congestion and travel times
|
8918 |
|
| Atomic Metal Catalysts |
- Innovative: Generates new isomers by changing the order in which atoms are added in a hetero-atomic cluster (can maximize available catalytic sites)
- Efficient: Creates and optimizes active isomers of atomic metals such as Au and Pd, increasing the catalytic efficiency of these high-demand metals (requires minimal precious catalytic metal)
- Scalable: Provides a scalable process resulting in theoretically predictable catalytic properties
|
6451, 5217 |
|
| Capillary Flow Control in Lateral Flow Assays (LFAs) via Delaminating Timers |
- ASSURED: LFAs readily satisfy the majority of the ASSURED (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverable to end-users) criteria reported by the World Health Organization to establish capabilities of POC devices.
- Agile: The addition of timers to LFAs provides an opportunity to develop more complex multi-step testing, as well as additional benefits such as built-in signal amplification and POC DNA extraction and purification.
- Automated: The ability to sequentially deliver different reagents into a reaction via programmable timers imprinted on paper makes it possible to automate multi-step assays that otherwise could only be performed in laboratories or with manual intervention.
|
8462, 8634 |
|
| Recirculation System for Aerosol Collectors Maximizes Particle Concentration for Improved Pathogen Detection |
- Enhanced detection: Continuously recirculated collection buffer increases the concentration of targeted particles collected and improves detection of pathogens
- Increased sampled air volume: Recirculating the buffer enables running the system for longer periods of time and with larger volumes of air to improve pathogen detection in entire buildings
- Increased control: Users have active control of the volume of fluid introduced during collection via the system’s recharge pump
|
8903 |
|
| 3D Light-Field Endoscopy for High-Precision Microsurgery |
- Enhanced control and safety: Real time visual navigation enhances guidance and intervention in complex microenvironments, maintaining high spatial resolution while providing quantitative depth information
- Comfortable: System does not require 3D glasses that can cause physician dizziness or headaches after long periods of use
- Streamlined: Technique eliminates the need for other imaging procedures such as micro-CT or MRI to quantify the 3D morphology of tissue
|
8848 |
|
| Cluster-Wells: Isolating Aggressive Tumor Cell Clusters for Improved Cancer Diagnosis and Treatment |
- High performing: Demonstrates superior abilities to isolate CTCs without clogging the system or dissociating the clusters
- Low cost: Shows high potential for large-scale production because it uses simple equipment and a straightforward process
- Versatile: Isolates CTC clusters of any cancer type and uses hardware that can be modified to accommodate various devices
|
8203 |
|
| Fourier Light-Field Microscope (FLFM) for Fast, Volumetric, and High-Resolution Imaging of Entire Organoids |
- Cost-efficient and scalable: Is fully adaptable to epifluorescence protocols resulting in a system that is both cost-efficient and highly scalable
- Fast: Captures fast cellular and tissue dynamic processes in a simultaneous, volumetric manner (e.g., collective cellular responses at sub-second time scales across whole samples)
- Validated: Responses to extracellular physical cues such as osmotic and mechanical stresses have been recorded using human induced pluripotent stem cell-derived colon organoids (hCOs).
|
8844 |
|
