| “Smart” Feedback-Controlled Bioreactor Platform Enables Consistent High-Yield and High-Quality MSC Products |
- Scaled-down feedback-controlled hollow fiber-based bioreactor enables identifying the critical quality attributes and critical process parameters for high-quantity and high-quality hCT-MSCs for ideal cell growth and efficacy
- Provides the controls to maintain optimum conditions and improve expansion yield and cell viability
- System can be adapted and applied to industrial cell therapy manufacturing and can enable high-yield and high-quality products while minimizing variabilities
|
8887 |
|
| Manually Powered Laboratory Mixing Device |
- This manually operated laboratory device mixes and separates solution components at performance levels comparable to existing powered vortexes and centrifuges.
- The device operates with no external power source, providing labs without access to consistent electrical infrastructure a reliable solution to mixing and separating solution components.
- This multiuse device is compatible with containers and sample tubes of various sizes and solution amounts.
|
9096 |
|
| Novel Silicon Radiation Detector Enabled By Tunnel Oxide Passivating Contact |
- The technology passivates the bottom surface well and suppresses electron recombination near the bottom contact, resulting in low leakage current.
- Passivating the silicon surface and decreasing hole recombination near the front contact leads to low recombination current density at the surface and low effective contact resistivity.
- An extremely low J0 for the tunnel oxide passivating contact on both sides yields a higher energy resolution and lower noise level.
|
9227 |
|
| High-Precision, Hands-Free Remote Control of Complex Robotic Systems Via Eye Movements |
- This two-camera eye-tracking system (TCES) integrates a commercial eye tracker with machine-learning technology for continuous real-time classification of gaze and eye directions for robotic arm control.
- The system provides highly accurate classification for four directions of eye movement and has achieved 99.99% accuracy in studies.
- Using simple eye movement, the TCES offers low-cost, high-precision control of external devices/hardware for people with disabilities, surgery robots, warehouse systems, construction tools, and more.
|
9184 |
|
| Customized 3D-Printed Bioresorbable Heart Valves |
- Resorbable, patient-specific heart valves offer great flexibility for treating a wider range of conditions and patients than traditionally manufactured heart valves.
- Customizable valves potentially decrease complications due to poor fit and the need for reinterventions.
- Selecting materials for optimal mechanical properties, thermodynamic properties, chemical properties, and surface chemistry and morphology reduces mismatch between device and tissue, potentially improving performance and patient outcomes.
|
8893 |
|
| Paper-Based Multi-Well Depletion Enzyme-Linked Immunosorbent Assay (ELISA) Enables Point-of-Care (POC) Testing |
- Paper-based lateral flow assay automatically performs multi-well ELISA testing for POC titer measurements.
- Simplifies ELISA testing by eliminating the need for centralized laboratories staffed with trained personnel who perform multiple steps in a specific sequence to execute the assay workflow.
- Transforms a variety of ELISA-based tests into single-use, disposable dipstick tests to be used at the point of care or at home.
|
9124 |
|
| Streamlined Combination Analysis by FORECAST Accurately Predicts and Identifies Pending Malware Attacks |
- Automating the combined techniques of memory forensics and symbolic analysis accelerates how fast an enterprise or government becomes aware of the true extent of malware’s capabilities.
- When countering cyberattacks, FORECAST provides improved accuracy (94%, overall) with its automated analysis, which is crucial to helping cybersecurity efforts to efficiently focus on high-impact solutions.
- FORECAST has the flexibility to be a valuable incidence response tool, even when malware is fileless since it uses the software’s memory image to accurately predict the program’s capabilities.
|
8581 |
|
| Electric Field Treatment Creates Safe, Effective Antimicrobial Surfaces |
- Creates safe, effective antimicrobial surfaces via bacteria inactivation without the use of chemicals
- Targets cell membranes or capsid, is less likely to induce antimicrobial resistance, and should be effective for antibiotic-resistant bacteria
- Requires very short electrical pulses to achieve effective bacteria inactivation, potentially leading to better antifouling performance
|
9130 |
|
| Parametric Resonance Approach for Efficient, Versatile Acoustic Power Transfer for Implantable/Wearable Devices, Sensing, and Communications |
- New class of transducers utilizes parametric resonance to convert acoustic energy from an ultrasonic source to a sustained electrical signal.
- Technology powers implantable biomedical devices, small wearable sensors, and other wireless charging applications.
- Simple yet robust generation of stable electromechanical frequency combs is also possible in both air and liquid environments using a capacitive micro-resonator array.
|
7635, 9075 |
|
| Customizable Smart Charging Solution for Electric Vehicles in Residential Areas |
- This customizable smart charger uses algorithms and a hardware prototype to control electric vehicle charging and optimize benefits to consumers and power grid operators.
- Consumers can charge according to their preference (e.g., minimize cost, maximize carbon-free energy usage, minimize charging time, or minimize battery degradation).
- The smart charger selects charging profiles that delay charging to avoid excessive loads on the power grid.
|
8980 |
|
| Chemically Modified Reduced Graphene Oxides (rGOs) Improve Strength and Qualities of Polymer Composites |
- Chemically modifying rGO creates improved dispersibility and miscibility that can be used in polymer processes as a composite reinforcement or coating material.
- Easily scalable solution chemistry and purification/filtration makes the process economically feasible, resulting in a commercially viable material for many applications.
- Melt lamination results in a robust conductive coating that is more durable than comparable polymer-based coatings and enables many electronically active device designs.
|
8297 |
|
| Artificial Neural Network (ANN) with Unique Input Design that Significantly Reduces Computational Costs of Complex Engineering Systems |
- Neural network’s novel input can utilize first-order schemes and local patches and allows for discontinuities to be reflected accurately and with greater resolution than existing products.
- This adaptable ANN can be adopted by commercial and scientific research as a stand-alone solution or in conjunction with existing software.
- Lower costs for running complex and repetitive computations can be achieved by implementing this neural network with an input system that processes low-cost numerical solution patches arising from two or more converging solutions.
|
8963 |
|
| Improved Electrically Driven Temperature Swing Adsorption (ETSA) System for Faster, More Productive Direct Air Capture of Carbon Dioxide |
- This electrically driven temperature swing adsorption (ETSA) system uses sorbent-coated carbon fibers that exhibit Joule heating and rapid temperature swings for improved CO2 direct air capture (DAC).
- Over ten times faster temperature controls and six times faster CO2 desorption rate in ETSA than temperature swing adsorption (TSA) operation under the same DAC condition
- The dual-layered structure composed of a Joule heating core and CO2 adsorbing coating layer result in a larger amount of CO2 chemisorption.
|
9063 |
|
| Melting Microneedle Patches Extend Drug Delivery Applications, Simplify Manufacturing, and Reduce Costs |
- Melting microneedles enable dispersion of both poorly soluble and water-soluble drugs, which eliminates the need for solvents for improved stabilization and broader applications.
- Melting microneedles shorten manufacturing and drying time, eliminate the need to maintain a cold chain for storage and transportation, and reduce the ultimate cost of the microneedle patch.
- The safe suppository bases are inexpensive and enable control of the drug release timing.
|
8904 |
|
| Quantitative, Performance-Driven Framework for Optimal Desalination Architectures and Energy Subsystems |
- Incorporate and simultaneously compare attributes of multiple types of both desalting systems and energy subsystems for optimal system architectures
- Assess parameters that impact overall cost to discover complete architectures that would not have been discoverable using traditional methods.
- Focus on renewable energy subsystems such as solar, wind, geothermal, hydroelectric, and others to create complete desalination architectures that are cleaner and more water efficient than their conventional counterparts.
|
9055 |
|
| Novel Nanocarriers Strengthen Therapeutic Delivery, Improves Efficacy |
- Greater therapeutic effectiveness is due to the synergistic work of multiple therapeutic agents (hydrophobic/hydrophilic charged) that can be delivered via this dual-loaded biomaterial.
- The risk of immunotoxicity to a vaccine is reduced because an adjuvant, which can induce the body’s anti-inflammatory immune response, may be loaded and simultaneously delivered with the vaccine.
- The novel nanocarrier has broad market application since it can deliver vaccines, gene therapy, small molecule drugs, and even contrast agents.
|
8988 |
|
| Automated Bioreactor Sampling System Can Eliminate Cross-Contamination of Samples |
- Automated bioreactor sampling system maintains sample integrity by changing the syringe between samples
- In addition to savings related to reduced cross-contamination, automated sampling can further lower costs by reducing hands-on time and speeding sampling.
- Flexible platform can be used with any type of collected sample.
|
8886 |
|
| Enhanced Cybersecurity for Networked Motion Control Systems with Somewhat Homomorphic Encryption |
- Increase cybersecurity with expression rewrite rules for encrypted dynamic control schemes that reduce the multiplicative depth of somewhat homomorphic encryption and improve numerical stability.
- New approach generates motion commands to servo systems without creating a security hole.
- Information decryption and control signal calculation can be performed and executed inside the plant, while all sensitive system information outside of the plant is always encrypted.
|
9012 |
|
| Anodically Coloring Molecular Electrochromics (EC) Improve Contrast, Color, and Transitions |
- True black-to-clear transitions with high contrast and color tuning are now possible with anodically coloring electrochromics.
- Broad absorption supports color mixing and color tunability in the charged state, and color tuning is enabled by manipulating the oscillator strengths of radical cation transitions.
- Energy required for practical electrochromic applications is effectively decreased by much lower oxidative potentials, as compared to their corresponding polyamides.
|
7745 |
|
| Cost-Effective Hydra Method Monitors DRAM Memory in Computers |
- Hydra combines the best of SRAM-tracking (low performance overhead) and DRAM-tracking (low SRAM overhead and flexibility) to produce Row-Hammer (RH) mitigation that is effective at ultra-low thresholds.
- Proven results in mitigating the increasing RH security vulnerability issue, Hydra offers a low-cost solution that is widely applicable to all computer systems that use DRAM—over one billion devices.
- Hydra is a hybrid tracker that successfully mitigates RH security issues and does not compromise the functionality of the computer system.
|
8933 |
|
