| Artificial Neural Network (ANN) with Unique Input Design that Significantly Reduces Computational Costs of Complex Engineering Systems |
- Neural network’s novel input can utilize first-order schemes and local patches and allows for discontinuities to be reflected accurately and with greater resolution than existing products.
- This adaptable ANN can be adopted by commercial and scientific research as a stand-alone solution or in conjunction with existing software.
- Lower costs for running complex and repetitive computations can be achieved by implementing this neural network with an input system that processes low-cost numerical solution patches arising from two or more converging solutions.
|
8963 |
|
| Improved Electrically Driven Temperature Swing Adsorption (ETSA) System for Faster, More Productive Direct Air Capture of Carbon Dioxide |
- This electrically driven temperature swing adsorption (ETSA) system uses sorbent-coated carbon fibers that exhibit Joule heating and rapid temperature swings for improved CO2 direct air capture (DAC).
- Over ten times faster temperature controls and six times faster CO2 desorption rate in ETSA than temperature swing adsorption (TSA) operation under the same DAC condition
- The dual-layered structure composed of a Joule heating core and CO2 adsorbing coating layer result in a larger amount of CO2 chemisorption.
|
9063 |
|
| Melting Microneedle Patches Extend Drug Delivery Applications, Simplify Manufacturing, and Reduce Costs |
- Melting microneedles enable dispersion of both poorly soluble and water-soluble drugs, which eliminates the need for solvents for improved stabilization and broader applications.
- Melting microneedles shorten manufacturing and drying time, eliminate the need to maintain a cold chain for storage and transportation, and reduce the ultimate cost of the microneedle patch.
- The safe suppository bases are inexpensive and enable control of the drug release timing.
|
8904 |
|
| Quantitative, Performance-Driven Framework for Optimal Desalination Architectures and Energy Subsystems |
- Incorporate and simultaneously compare attributes of multiple types of both desalting systems and energy subsystems for optimal system architectures
- Assess parameters that impact overall cost to discover complete architectures that would not have been discoverable using traditional methods.
- Focus on renewable energy subsystems such as solar, wind, geothermal, hydroelectric, and others to create complete desalination architectures that are cleaner and more water efficient than their conventional counterparts.
|
9055 |
|
| Novel Nanocarriers Strengthen Therapeutic Delivery, Improves Efficacy |
- Greater therapeutic effectiveness is due to the synergistic work of multiple therapeutic agents (hydrophobic/hydrophilic charged) that can be delivered via this dual-loaded biomaterial.
- The risk of immunotoxicity to a vaccine is reduced because an adjuvant, which can induce the body’s anti-inflammatory immune response, may be loaded and simultaneously delivered with the vaccine.
- The novel nanocarrier has broad market application since it can deliver vaccines, gene therapy, small molecule drugs, and even contrast agents.
|
8988 |
|
| Automated Bioreactor Sampling System Can Eliminate Cross-Contamination of Samples |
- Automated bioreactor sampling system maintains sample integrity by changing the syringe between samples
- In addition to savings related to reduced cross-contamination, automated sampling can further lower costs by reducing hands-on time and speeding sampling.
- Flexible platform can be used with any type of collected sample.
|
8886 |
|
| Enhanced Cybersecurity for Networked Motion Control Systems with Somewhat Homomorphic Encryption |
- Increase cybersecurity with expression rewrite rules for encrypted dynamic control schemes that reduce the multiplicative depth of somewhat homomorphic encryption and improve numerical stability.
- New approach generates motion commands to servo systems without creating a security hole.
- Information decryption and control signal calculation can be performed and executed inside the plant, while all sensitive system information outside of the plant is always encrypted.
|
9012 |
|
| Anodically Coloring Molecular Electrochromics (EC) Improve Contrast, Color, and Transitions |
- True black-to-clear transitions with high contrast and color tuning are now possible with anodically coloring electrochromics.
- Broad absorption supports color mixing and color tunability in the charged state, and color tuning is enabled by manipulating the oscillator strengths of radical cation transitions.
- Energy required for practical electrochromic applications is effectively decreased by much lower oxidative potentials, as compared to their corresponding polyamides.
|
7745 |
|
| Cost-Effective Hydra Method Monitors DRAM Memory in Computers |
- Hydra combines the best of SRAM-tracking (low performance overhead) and DRAM-tracking (low SRAM overhead and flexibility) to produce Row-Hammer (RH) mitigation that is effective at ultra-low thresholds.
- Proven results in mitigating the increasing RH security vulnerability issue, Hydra offers a low-cost solution that is widely applicable to all computer systems that use DRAM—over one billion devices.
- Hydra is a hybrid tracker that successfully mitigates RH security issues and does not compromise the functionality of the computer system.
|
8933 |
|
| Efficiently Generating Complex Hydrogel Structures for Tissue/Organ-on-a-Chip Models |
- Faster: Reduces preparation time from several hours to minutes
- Simplified: Generates complex patterns, including perfusable channels, using light-triggered polymerization of synthetic hydrogels and photomasks rather than current equipment-intensive methods that use laser-based patterning or ablation techniques
- Lowers regulatory burdens: Using synthetic rather than biological matrices simplifies regulatory hurdles, increases reproducibility from batch to batch, and increases tunability of the mechanical and biochemical properties of the matrix
|
8838, 8839 |
|
| Electronic Immunoassay Using Enzymatic Metallization on Microparticles |
- Lower cost: Replacing fluorescent markers and readout methods with impedance detection has the potential to significantly decrease the cost of the assay.
- Transportable: Impedance measurements in microfluidics can be made transportable, which can potentially enable point-of-care applications, as electronic elements are more durable than optical elements.
- Practical: Identification of COVID-19 antibodies in COVID-positive serum samples has already been demonstrated.
|
8813 |
|
| patcherBotPHARMA Automated Intracellular Pharmacological Electrophysiology Robot |
- Increased efficiency: Autonomous operation ensures accurate placement of components and creates high success rates for experiment completion.
- Decreased human effort: Performs typical ligand-gated ionotropic receptor experimentation protocols autonomously for up to a tenfold reduction in operator interaction time over the duration of the experiment
- Higher experiment yield: Rapidly replicates previous datasets, reducing the time to produce an 8-point concentration response curve from weeks of recording to ~13 hours of recording
|
8717 |
|
| Wearable Ocular Electronics with Virtual Reality Solution for Effective Home-Based Vision Therapy |
- The first fully portable and wireless ocular electronic system in a VR environment provides an effective, home-based visual therapy program.
- The integrated wearable system has a data classification algorithm to provide high-fidelity, real-time detection of eye vergence to treat eye disorders.
- Running a VR system on a smartphone can create “virtual therapies” that can be used anywhere anytime.
|
7916 |
|
| Self-Driven, Reusable, Scalable Technique for Harvesting Microalgae with Porous Superabsorbent Polymer |
- Fast: The optimized pore structure of the PSAP beads allows fast and selective absorption of water, greatly reducing standard processing time.
- Cost effective: Microalgae harvesting with PSAP beads cuts costs, as it does not require any complex instrument and little training is needed to operate the harvesting procedures.
- Scalable: PSAP beads can be produced in large quantities at a significantly lower cost than conventional harvesting tools.
|
8849 |
|
| Simulated Synovial Fluid Offers Potential for Effective Treatment of Knee Osteoarthritis |
- Osteoarthritis (OA)-simulated synovial fluid (simSF) provides the opportunity to evaluate how different cell therapies respond to an OA-like environment.
- By analyzing OA patient-derived synovial fluid (pdSF) and developing potency assays, researchers created a simSF comparable to pdSF that overcomes patient variability.
- The simSF allows for the investigation of OA biology with greater reproducibility of predictive outcomes and could advance effective treatment of knee OA.
|
8956 |
|
| Buoyant Platform Assembly Improves PCM Thermal Management |
- Enhances solidification: Incorporating highly localized agitation via a stirring whip rod, this technology seeds solidification to improve this often-arduous phase of PCM thermal cycling.
- Prevents scale build-up: This technology reduces the instance of sheets of solid PCM forming on the heat sink. The high-frequency, extensible whip rod orbits around the passageway to facilitate nucleation (creating improved solidification), while preventing scale build-up on the interior passageway surfaces.
- Customizable: The structural design allows the platform to be tailored to the effective density of the PCM material, enabling it to stay between the liquid and solid phases.
|
8835 |
|
| Reducing Intraocular Pressure in Glaucoma Patients Without Drugs or Surgery via a Simple Hydrogel Injection |
- Hydrogel injections alleviate elevated intraocular pressure (IOP) with fast results and extended impact.
- Surgery-free approach eliminates the risk of tissue damage caused by a surgical incision or laser application.
- Simplified and effective treatment process from standard daily drug intake to a brief office visit only once every 4-6 months.
|
8467 |
|
| Lightweight, Versatile Cryogenic Conductors |
- Lithium exhibits lower atomic mass, higher power density, and lower losses under cryogenic conditions
- Conductors such as lithium become even more power-dense at lower temperatures, exhibiting improved electrical performance
- Cladding with copper enables lithium to be drawn using standard wire-drawing techniques and tools
|
8729 |
|
| DetectIV Offers Noninvasive Early IV Infiltration and Extravasation Detection |
- DetectIV provides a continuous, noninvasive, and wireless IV infiltration and extravasation detection system.
- The sensor does not cover the IV site and works well with all skin types—significant improvements over existing detection devices.
- The device detects infiltrations on average 2 hours ahead of nursing standard of care making it an effective early detection system that prevents extended hospital stays.
|
7207 |
|
| Biodegradable Shape Memory Polymer for 3D-Printed Tissue and Biomedical Devices |
- New synthesis reaction produces novel biomaterials for soft tissue treatment combines shape memory and biodegradability with custom 3D printing for patient-specific, minimally invasive solutions
- Customizable to patient needs by varying the formulation and molecular architecture to alter the mechanical properties
- Improves safety and efficacy by providing a much-needed middle range to existing “too hard/too soft” tissue repair options, while also being biodegradable and bioresorbable
|
8655 |
|
