| Novel Hydrogels for Encapsulation, Vascularization, and Transplantation of Cells |
- This hydrolytically degradable poly(ethylene glycol) (PEG) hydrogel leverages ester linkages combined at various ratios with non-degradable macromers to enable tunable degradation kinetics.
- Potential applications include controlled release and delivery of drugs or proteins as well as cell encapsulation. It can also be used as a delivery vehicle and adhesive for cells in transplantation settings.
- These innovative hydrogels allow for rapid hydrolytic cleavage in vivo but remain stable in vitro for weeks at neural pH 7 to support regenerative medicine techniques.
|
9019 |
|
| High-Performance Analog Processor Offers Potential to Expand Capabilities of Radio Frequency (RF) Systems |
- TRAFFIC is the first generalized, high-performance analog finite impulse response processor technology that enables direct throughput processing of RF signals within the RF and microwave spectrums.
- The device enables multiple-function RF capabilities and significantly reduces the size, weight, and power requirements of RF technologies.
- TRAFFIC has unique performance benefits that allow it to operate reliably in extreme environments, including high performance across wide temperature ranges and radiation-intense applications.
|
8143 |
|
| Quickly and Easily Generate Designer Photopatterned Hydrogel Matrices for Complex Microfluidic Tissue/Organ-on-a-Chip Devices |
- Offers better spatiotemporal control and customization of hydrogel crosslinking and cell patterning
- Provides a viable alternative to PEG-MAL for culturing primary B cells ex vivo and studying their response to antigens
- Reduces timing and compatibility issues and offers designer flexibility compared to natural matrices
|
8986 |
|
| Foot Ankle Orthotic (FAO) Delivers Real-Time Portable, Discreet Haptic Feedback for Patients and Athletes |
- Providing patients with discreet notifications of real-time plantar pressure to improve rehabilitation of foot-ankle injuries between clinical visits can reduce risk of injury strain and minimize long-term damage.
- Athletes from various sports (e.g., tennis, football, basketball) could prioritize injury prevention during practice and games because of the discreet haptic notifications that bring attention to foot planting techniques via pressure monitoring.
- The benefits of measuring plantar pressure from the four zones of this device’s insole (heel, toes, medial, and lateral) extend beyond foot-ankle injuries and can be key to diabetic pressure wound prevention as well as knee osteoarthritis therapy.
|
8944 |
|
| Portable, Reusable, Micropower Radiation Monitors Provide Real-Time Assessment of Radiation Risk |
- Innovative radiation detection system provides real-time, on-demand, micropower detection in a versatile design.
- The device materials offer higher conductivity (mobility) than silicon, resulting in reduced power needs (i.e., requiring power only during read-out).
- Selection and layering of channel and gate materials enables tuning devices for different radiation types.
|
8084 |
|
| Plasma-Activated Catalytic Air Purifier Cleans Enclosed Spaces |
- This plasma-activated catalytic air purifier can be used to clean enclosed spaces, such as aircraft, hospitals, and classrooms, while mitigating hazardous gas-phase byproducts.
- The air purifier can be used synergistically with UV diode lasers and UV lamps, providing additional contaminant destruction pathways while lowering the potential for dielectric breakdown and plasma formation.
- This comprehensive technology is effective for germicide and sterilization activities as well as for hydroxyl-radical production and ozone removal in a wide variety of indoor environments.
|
8536 |
|
| Custom-Fit Reusable Respiratory Protective Device (RPD) with Continuous Fit Monitoring Improves Comfort and Protection |
- Vastly improves comfort and protection while bringing peace of mind to wearers through a custom fit and continuous monitoring
- Reduces pressure injuries caused by extended RPD use through both a customized fit and alerts to the wearer when the RPD should be adjusted or removed
- Minimizes exposures to workplace hazards by immediately detecting leakage during RPD use and alerting the wearer to adjust the device
|
8876, 9089, 9090, 9091 |
|
| Deployable Critical Active Learning (DECAL) System Offers Better Characterization for Improved Diagnostics and Imaging |
- The deployable critical active learning (DECAL) system’s bi-modal interface enables better characterization with large training sets that generate more accurate output for higher precision.
- The algorithm used during the initialization period creates a framework that can be expanded and generalized to any data method and application.
- The DECAL algorithm samples uniquely important, unlabeled data to aid existing active learning systems in generalizing more quickly, providing faster diagnosis statistics.
|
9099 |
|
| Sustained Lymphatic Drug Delivery System Potentially Improves Efficacy and Safety of Immunotherapy and Targeted Therapies |
- This sustained lymphatic drug delivery system guides therapeutics and imaging agents to the injection site, lymphatic vessels, and lymph nodes.
- Sustained lymphatic delivery enables lower dosing and fewer administrations to potentially improve therapeutic response while reducing adverse effects and costs.
- The simplicity of a vaccine-like, sustained drug release injection allows use at less expensive community health centers.
|
8637 |
|
| “Smart” Feedback-Controlled Bioreactor Platform Enables Consistent High-Yield and High-Quality MSC Products |
- Scaled-down feedback-controlled hollow fiber-based bioreactor enables identifying the critical quality attributes and critical process parameters for high-quantity and high-quality hCT-MSCs for ideal cell growth and efficacy
- Provides the controls to maintain optimum conditions and improve expansion yield and cell viability
- System can be adapted and applied to industrial cell therapy manufacturing and can enable high-yield and high-quality products while minimizing variabilities
|
8887 |
|
| Manually Powered Laboratory Mixing Device |
- This manually operated laboratory device mixes and separates solution components at performance levels comparable to existing powered vortexes and centrifuges.
- The device operates with no external power source, providing labs without access to consistent electrical infrastructure a reliable solution to mixing and separating solution components.
- This multiuse device is compatible with containers and sample tubes of various sizes and solution amounts.
|
9096 |
|
| Novel Silicon Radiation Detector Enabled By Tunnel Oxide Passivating Contact |
- The technology passivates the bottom surface well and suppresses electron recombination near the bottom contact, resulting in low leakage current.
- Passivating the silicon surface and decreasing hole recombination near the front contact leads to low recombination current density at the surface and low effective contact resistivity.
- An extremely low J0 for the tunnel oxide passivating contact on both sides yields a higher energy resolution and lower noise level.
|
9227 |
|
| High-Precision, Hands-Free Remote Control of Complex Robotic Systems Via Eye Movements |
- This two-camera eye-tracking system (TCES) integrates a commercial eye tracker with machine-learning technology for continuous real-time classification of gaze and eye directions for robotic arm control.
- The system provides highly accurate classification for four directions of eye movement and has achieved 99.99% accuracy in studies.
- Using simple eye movement, the TCES offers low-cost, high-precision control of external devices/hardware for people with disabilities, surgery robots, warehouse systems, construction tools, and more.
|
9184 |
|
| Customized 3D-Printed Bioresorbable Heart Valves |
- Resorbable, patient-specific heart valves offer great flexibility for treating a wider range of conditions and patients than traditionally manufactured heart valves.
- Customizable valves potentially decrease complications due to poor fit and the need for reinterventions.
- Selecting materials for optimal mechanical properties, thermodynamic properties, chemical properties, and surface chemistry and morphology reduces mismatch between device and tissue, potentially improving performance and patient outcomes.
|
8893 |
|
| Paper-Based Multi-Well Depletion Enzyme-Linked Immunosorbent Assay (ELISA) Enables Point-of-Care (POC) Testing |
- Paper-based lateral flow assay automatically performs multi-well ELISA testing for POC titer measurements.
- Simplifies ELISA testing by eliminating the need for centralized laboratories staffed with trained personnel who perform multiple steps in a specific sequence to execute the assay workflow.
- Transforms a variety of ELISA-based tests into single-use, disposable dipstick tests to be used at the point of care or at home.
|
9124 |
|
| Streamlined Combination Analysis by FORECAST Accurately Predicts and Identifies Pending Malware Attacks |
- Automating the combined techniques of memory forensics and symbolic analysis accelerates how fast an enterprise or government becomes aware of the true extent of malware’s capabilities.
- When countering cyberattacks, FORECAST provides improved accuracy (94%, overall) with its automated analysis, which is crucial to helping cybersecurity efforts to efficiently focus on high-impact solutions.
- FORECAST has the flexibility to be a valuable incidence response tool, even when malware is fileless since it uses the software’s memory image to accurately predict the program’s capabilities.
|
8581 |
|
| Electric Field Treatment Creates Safe, Effective Antimicrobial Surfaces |
- Creates safe, effective antimicrobial surfaces via bacteria inactivation without the use of chemicals
- Targets cell membranes or capsid, is less likely to induce antimicrobial resistance, and should be effective for antibiotic-resistant bacteria
- Requires very short electrical pulses to achieve effective bacteria inactivation, potentially leading to better antifouling performance
|
9130 |
|
| Parametric Resonance Approach for Efficient, Versatile Acoustic Power Transfer for Implantable/Wearable Devices, Sensing, and Communications |
- New class of transducers utilizes parametric resonance to convert acoustic energy from an ultrasonic source to a sustained electrical signal.
- Technology powers implantable biomedical devices, small wearable sensors, and other wireless charging applications.
- Simple yet robust generation of stable electromechanical frequency combs is also possible in both air and liquid environments using a capacitive micro-resonator array.
|
7635, 9075 |
|
| Customizable Smart Charging Solution for Electric Vehicles in Residential Areas |
- This customizable smart charger uses algorithms and a hardware prototype to control electric vehicle charging and optimize benefits to consumers and power grid operators.
- Consumers can charge according to their preference (e.g., minimize cost, maximize carbon-free energy usage, minimize charging time, or minimize battery degradation).
- The smart charger selects charging profiles that delay charging to avoid excessive loads on the power grid.
|
8980 |
|
| Chemically Modified Reduced Graphene Oxides (rGOs) Improve Strength and Qualities of Polymer Composites |
- Chemically modifying rGO creates improved dispersibility and miscibility that can be used in polymer processes as a composite reinforcement or coating material.
- Easily scalable solution chemistry and purification/filtration makes the process economically feasible, resulting in a commercially viable material for many applications.
- Melt lamination results in a robust conductive coating that is more durable than comparable polymer-based coatings and enables many electronically active device designs.
|
8297 |
|
