Available Technologies by Category
Superluminescent Light Projection (SLP) System Decreases Nanoscale Printing Costs by 10–50 Times
  • This superluminescent light projection (SLP) system decreases overall nanoscale printing costs by 10–50 times. 
  • A parallel writing mechanism supports higher throughput speeds: up to 100 times higher than existing metal printing methods and four times higher than existing polymer printing methods. 
  • SLP creates sharp-edged images with minimal speckling patterns, resulting in high-resolution images and structures on both polymer and metal-based films. 
9066
Versatile Continuum Robots with Variable Stiffness Control for Improved Positioning and Manipulation
  • Continuum robot design offers stiffness control continuously along the length of a guidewire or at variable discrete locations along the structure’s length. 
  • Versatile design is not restricted to one actuator type along the length of the guidewire, and elements can be placed along any section of the guidewire body.
  • With better control of the wire positioning within a patient’s anatomy, it may be possible to improve treatment outcomes.
9166
Metasurface Enables Rapid, Sensitive, and Low-Cost Permittivity Characterization of Dielectric Materials at Radio Frequencies
  • Characterize complex permittivity of dielectric materials at radio frequencies quickly and at lower cost than with existing techniques. 
  • The electronically reconfigurable system allows integration of active electronics for tunability and eliminates the need for several masks to achieve the needed bandwidth.
  • Measure individual frequencies by swapping out only the metasurfaces, which can be used on a wide range of sample thicknesses.
9078
Patient-Centered Biofeedback Headset Can Isolate, Monitor, and Analyze Vocal Output in Real Time for Optimal Voice Modulation in Patients with Parkinson’s Disease
  • Innovative headset offers real-time haptic feedback for vocal improvement and increased patient autonomy.
  • Device stores easily accessible data for therapist review and fine-tuning of preset therapeutic thresholds to continually improve vocal output.
  • Lightweight, low-profile, battery-powered headset are favorable for all-day wear and use omnidirectional microphones for optimal comfort.
9134
Microfluidic System Enables Scalable, High-Throughput Separation for High-Purity Human Induced Pluripotent Stem Cells (hiPSCs)
  • Simple, tunable high-throughput process separates hiPSCs quickly and efficiently according to the degree to which they adhere to a substrate inside the microfluidic device. 
  • Separation of intact cell colonies enables this simple system to avoid damaging and adversely affecting the pluripotency of the cells.
  • The approach is fast, does not rely on labeling technologies, supports greatly enriched cells, and results in a cell survival rate greater than 80%.
5685
Hydrogel-Based Artificial Ligaments Offer Substantial Improvements for ACL Reconstruction Therapies
  • This biocompatible hydrogel-based device is designed to reproduce natural ligament/tendon function to decrease the incidence of immune responses that lead to chronic inflammation.
  • An alternative to standard artificial ligaments and tendons, the device is designed to be placed via non-invasive techniques, making it a safer alternative to current, invasive surgical methods.
  • Non-biodegradable hydrogels are highly durable, potentially increasing the lifespan of the prostheses.
5386
Universal Transcriptional Programming in a Bacteroides Consortium Creates a Foundation to Advance Living Therapeutics
  • Consortium-based, universal transcriptional programming framework is a biotic decision-making technology using genetic circuit compression in a Bacteroides community.
  • Compressed genetic circuit design shortens circuit-building time, offers a compact circuit footprint that allows more complexity, uses fewer resources, and reduces cell communication time. 
  • Has potential applications in living therapeutics, advanced biomanufacturing, and next-generation biosecurity.
9006
Fast, Effective Thrombolytic Agent for Arterial Blood Clots
  • The disulfide dimer of the amino acid cystine, has the potential to be a highly efficient thrombolytic agent for treating dangerous arterial blood clots.
  • During in vitro testing DiNAC dissolved thrombi in as quickly as 90 seconds and reduced the diameter and surface area of certain thrombi by 50–95 percent.
  • DiNAC has the potential to treat multiple conditions associated with arterial thrombus formation and to mitigate life-threatening side effects. 
8007
Thermoformed Polymeric Valved Conduits Offer a Biocompatible, Customizable Heart Valve Replacement Treatment
  • This biocompatible device may reduce adverse events resulting in a lower incidence of post-surgical adverse events for better long-term outcomes.
  • Customizable valve conduits allow patient-specific device creation for potentially easier surgical placement and optimal post-surgical valve function.
  • This unique device may offer a safer treatment option by providing a biocompatible, patient-specific intervention, resulting in fewer undesirable adverse events.
9003
Safe and Effective von Willebrand factor (VWF) Therapeutic to Prevent Arterial Thrombi
  • Using anti-von Willebrand factor (VWF) agent has the potential to be safer and much more effective for preventing the formation of arterial thrombi.
  • Low doses of N-acetylcysteine (NAC) have been shown to reduce the rate of platelet aggregation, while higher doses completely prevented platelet aggregation.
  • Uses the safe, Federal Drug Administration–approved drug NAC that has a known safety profile.
8975
AI Systems for Personalized Wearable Robotic Systems
  • The system generalizes to different users, varying terrain conditions and walking speeds.
  • The system is designed to transfer between different wearable robotics devices.
  • The system optimally estimates the physiological state of the user to provide the best assistance that the wearable robot can give the user allowing for optimal control across tasks.
8985
Single Cell Metabolomics Assay
  • The technology makes it possible to identify single cell resolution of lipids and other small molecules in complex tissue types, as well as metabolism mapping specific to different cell types.
  • The measurements found through this can be used to study metabolomic response to drug exposure.
  • The technology can achieve submicron resolution of lipids and other small molecules at anywhere from 200-1000 depth slices, using spatially resolved metabolic profiling.
9023
Measurement and Modeling System Using Cell Signaling Networks
  • The technology quickly identifies cell signaling pathways from a patient biopsy, allowing for personalized treatment approaches to be identified.
  • Measurements can be used to study potential tumor response to drug treatment, through the use of xenografted cells from the patient.
  • 30-100 potential protein pathways and interactions can be measured using a single sample through multiplexing of rapid immunofluorescence.
9022
Multi-Modal Deep Learning Training Model
  • Resource Efficient
  • Improved Modeling Method
9098
Fully Bioresorbable Heart Valve Scaffold Supports Native Neovalve Growth to Reduce Future Procedures
  • Replacing a stenotic fetal heart valve with a living autologous valve could possibly cure the complex cardiac anomalies that cause single ventricle physiology.
  • With this approach, the valve has the potential to accommodate patient growth and eliminate the need for multiple heart valve replacements during the patient’s lifetime.
  • The transcatheter nature of this valve deployment makes the procedure similar in risk to a traditional fetal valvuloplasty.
8868
Saliva-Based Multiplexed Assay with 25x Higher Sensitivity to SARS-CoV-2 and Influenza A and B
  • New lateral flow assay device achieves enhanced sensitivity with the same sample concentration, significantly reducing the risk of false negatives.
  • Tunable capillary flow allows sample/reagent to be concurrently delivered to multiple regions, enabling multiplexed and repetitive assays on a single device.
  • Transforms a variety of biological assays and tests performed at clinical laboratories into single-use, disposable dipstick tests to be used at the point of care or home.
9149
Patterned Implantable Devices for Improved Reconstruction of Tubular Tissue Passageway Defects
  • This innovation improves patterned airway stents for passageways or tubular tissues to potentially enable long-passageway reconstructions. 
  • Extrusion-based 3D bioprinting produces a patterned implantable device with higher mechanical strength without increasing the wall thickness of the device.
  • Incorporating auxetic-patterning creates an implantable splinting device for supporting passageway defects in growing patients, such as infants or children.
8831
D-Band Vector Modulator Phase Shifter (VMPS) Achieves Higher Bandwidth
  • Uses tapered delay lines at the input to generate differential quadrature signals that enable wider bandwidth and result in higher speed communications
  • Reaches a moderate gain of 1.5 decibels at a center frequency of 128 GHz, while simultaneously achieving higher bandwidth of 35 GHz than any other mmWave VMPS in silicon
  • Has low power consumption, using only 20.3 mW of average DC power from a 1.5 V supply
9180
Machine Learning–Based Transportation Asset Inventory
  • The invention performs more intelligent segmentation using advanced computation methods with Artificial Intelligence.
  • Makes use of cost-efficient 2-dimensional images of roadways, making it easier to implement on a larger scale.
  • Can detect transportation assets and inventory them simultaneously.
9109
Dynamic Neck Support for Extended Surgeries and Other Applications
  • This device alleviates neck pain caused by looking down for extended periods of time. 
  • The pulling force changes relative to the extent the head is bent, providing comfortable support both when the head is upright and when bent.
  • In mass production, the cost could be less than $10. 
9159