Available Technologies by Category
Universal Transcriptional Programming in a Bacteroides Consortium Creates a Foundation to Advance Living Therapeutics
  • Consortium-based, universal transcriptional programming framework is a biotic decision-making technology using genetic circuit compression in a Bacteroides community.
  • Compressed genetic circuit design shortens circuit-building time, offers a compact circuit footprint that allows more complexity, uses fewer resources, and reduces cell communication time. 
  • Has potential applications in living therapeutics, advanced biomanufacturing, and next-generation biosecurity.
9006
Fast, Effective Thrombolytic Agent for Arterial Blood Clots
  • The disulfide dimer of the amino acid cystine, has the potential to be a highly efficient thrombolytic agent for treating dangerous arterial blood clots.
  • During in vitro testing DiNAC dissolved thrombi in as quickly as 90 seconds and reduced the diameter and surface area of certain thrombi by 50–95 percent.
  • DiNAC has the potential to treat multiple conditions associated with arterial thrombus formation and to mitigate life-threatening side effects. 
8007
Thermoformed Polymeric Valved Conduits Offer a Biocompatible, Customizable Heart Valve Replacement Treatment
  • This biocompatible device may reduce adverse events resulting in a lower incidence of post-surgical adverse events for better long-term outcomes.
  • Customizable valve conduits allow patient-specific device creation for potentially easier surgical placement and optimal post-surgical valve function.
  • This unique device may offer a safer treatment option by providing a biocompatible, patient-specific intervention, resulting in fewer undesirable adverse events.
9003
Safe and Effective von Willebrand factor (VWF) Therapeutic to Prevent Arterial Thrombi
  • Using anti-von Willebrand factor (VWF) agent has the potential to be safer and much more effective for preventing the formation of arterial thrombi.
  • Low doses of N-acetylcysteine (NAC) have been shown to reduce the rate of platelet aggregation, while higher doses completely prevented platelet aggregation.
  • Uses the safe, Federal Drug Administration–approved drug NAC that has a known safety profile.
8975
AI Systems for Personalized Wearable Robotic Systems
  • The system generalizes to different users, varying terrain conditions and walking speeds.
  • The system is designed to transfer between different wearable robotics devices.
  • The system optimally estimates the physiological state of the user to provide the best assistance that the wearable robot can give the user allowing for optimal control across tasks.
8985
Single Cell Metabolomics Assay
  • The technology makes it possible to identify single cell resolution of lipids and other small molecules in complex tissue types, as well as metabolism mapping specific to different cell types.
  • The measurements found through this can be used to study metabolomic response to drug exposure.
  • The technology can achieve submicron resolution of lipids and other small molecules at anywhere from 200-1000 depth slices, using spatially resolved metabolic profiling.
9023
Measurement and Modeling System Using Cell Signaling Networks
  • The technology quickly identifies cell signaling pathways from a patient biopsy, allowing for personalized treatment approaches to be identified.
  • Measurements can be used to study potential tumor response to drug treatment, through the use of xenografted cells from the patient.
  • 30-100 potential protein pathways and interactions can be measured using a single sample through multiplexing of rapid immunofluorescence.
9022
Multi-Modal Deep Learning Training Model
  • Resource Efficient
  • Improved Modeling Method
9098
Fully Bioresorbable Heart Valve Scaffold Supports Native Neovalve Growth to Reduce Future Procedures
  • Replacing a stenotic fetal heart valve with a living autologous valve could possibly cure the complex cardiac anomalies that cause single ventricle physiology.
  • With this approach, the valve has the potential to accommodate patient growth and eliminate the need for multiple heart valve replacements during the patient’s lifetime.
  • The transcatheter nature of this valve deployment makes the procedure similar in risk to a traditional fetal valvuloplasty.
8868
Saliva-Based Multiplexed Assay with 25x Higher Sensitivity to SARS-CoV-2 and Influenza A and B
  • New lateral flow assay device achieves enhanced sensitivity with the same sample concentration, significantly reducing the risk of false negatives.
  • Tunable capillary flow allows sample/reagent to be concurrently delivered to multiple regions, enabling multiplexed and repetitive assays on a single device.
  • Transforms a variety of biological assays and tests performed at clinical laboratories into single-use, disposable dipstick tests to be used at the point of care or home.
9149
Patterned Implantable Devices for Improved Reconstruction of Tubular Tissue Passageway Defects
  • This innovation improves patterned airway stents for passageways or tubular tissues to potentially enable long-passageway reconstructions. 
  • Extrusion-based 3D bioprinting produces a patterned implantable device with higher mechanical strength without increasing the wall thickness of the device.
  • Incorporating auxetic-patterning creates an implantable splinting device for supporting passageway defects in growing patients, such as infants or children.
8831
D-Band Vector Modulator Phase Shifter (VMPS) Achieves Higher Bandwidth
  • Uses tapered delay lines at the input to generate differential quadrature signals that enable wider bandwidth and result in higher speed communications
  • Reaches a moderate gain of 1.5 decibels at a center frequency of 128 GHz, while simultaneously achieving higher bandwidth of 35 GHz than any other mmWave VMPS in silicon
  • Has low power consumption, using only 20.3 mW of average DC power from a 1.5 V supply
9180
Machine Learning–Based Transportation Asset Inventory
  • The invention performs more intelligent segmentation using advanced computation methods with Artificial Intelligence.
  • Makes use of cost-efficient 2-dimensional images of roadways, making it easier to implement on a larger scale.
  • Can detect transportation assets and inventory them simultaneously.
9109
Dynamic Neck Support for Extended Surgeries and Other Applications
  • This device alleviates neck pain caused by looking down for extended periods of time. 
  • The pulling force changes relative to the extent the head is bent, providing comfortable support both when the head is upright and when bent.
  • In mass production, the cost could be less than $10. 
9159
Novel Hydrogels for Encapsulation, Vascularization, and Transplantation of Cells
  • This hydrolytically degradable poly(ethylene glycol) (PEG) hydrogel leverages ester linkages combined at various ratios with non-degradable macromers to enable tunable degradation kinetics.
  • Potential applications include controlled release and delivery of drugs or proteins as well as cell encapsulation. It can also be used as a delivery vehicle and adhesive for cells in transplantation settings.
  • These innovative hydrogels allow for rapid hydrolytic cleavage in vivo but remain stable in vitro for weeks at neural pH 7 to support regenerative medicine techniques.
9019
High-Performance Analog Processor Offers Potential to Expand Capabilities of Radio Frequency (RF) Systems
  • TRAFFIC is the first generalized, high-performance analog finite impulse response processor technology that enables direct throughput processing of RF signals within the RF and microwave spectrums.
  • The device enables multiple-function RF capabilities and significantly reduces the size, weight, and power requirements of RF technologies.
  • TRAFFIC has unique performance benefits that allow it to operate reliably in extreme environments, including high performance across wide temperature ranges and radiation-intense applications.
8143
Quickly and Easily Generate Designer Photopatterned Hydrogel Matrices for Complex Microfluidic Tissue/Organ-on-a-Chip Devices
  • Offers better spatiotemporal control and customization of hydrogel crosslinking and cell patterning
  • Provides a viable alternative to PEG-MAL for culturing primary B cells ex vivo and studying their response to antigens
  • Reduces timing and compatibility issues and offers designer flexibility compared to natural matrices
8986
Foot Ankle Orthotic (FAO) Delivers Real-Time Portable, Discreet Haptic Feedback for Patients and Athletes
  • Providing patients with discreet notifications of real-time plantar pressure to improve rehabilitation of foot-ankle injuries between clinical visits can reduce risk of injury strain and minimize long-term damage.
  • Athletes from various sports (e.g., tennis, football, basketball) could prioritize injury prevention during practice and games because of the discreet haptic notifications that bring attention to foot planting techniques via pressure monitoring.
  • The benefits of measuring plantar pressure from the four zones of this device’s insole (heel, toes, medial, and lateral) extend beyond foot-ankle injuries and can be key to diabetic pressure wound prevention as well as knee osteoarthritis therapy.
8944
Portable, Reusable, Micropower Radiation Monitors Provide Real-Time Assessment of Radiation Risk
  • Innovative radiation detection system provides real-time, on-demand, micropower detection in a versatile design.
  • The device materials offer higher conductivity (mobility) than silicon, resulting in reduced power needs (i.e., requiring power only during read-out).
  • Selection and layering of channel and gate materials enables tuning devices for different radiation types.
8084
Plasma-Activated Catalytic Air Purifier Cleans Enclosed Spaces
  • This plasma-activated catalytic air purifier can be used to clean enclosed spaces, such as aircraft, hospitals, and classrooms, while mitigating hazardous gas-phase byproducts. 
  • The air purifier can be used synergistically with UV diode lasers and UV lamps, providing additional contaminant destruction pathways while lowering the potential for dielectric breakdown and plasma formation.
  • This comprehensive technology is effective for germicide and sterilization activities as well as for hydroxyl-radical production and ozone removal in a wide variety of indoor environments.
8536