Technologies | Office of Technology Licensing

Available Technologies by Category
Novel Hydrogels for Encapsulation, Vascularization, and Transplantation of Cells	This hydrolytically degradable poly(ethylene glycol) (PEG) hydrogel leverages ester linkages combined at various ratios with non-degradable macromers to enable tunable degradation kinetics. Potential applications include controlled release and delivery of drugs or proteins as well as cell encapsulation. It can also be used as a delivery vehicle and adhesive for cells in transplantation settings. These innovative hydrogels allow for rapid hydrolytic cleavage in vivo but remain stable in vitro for weeks at neural pH 7 to support regenerative medicine techniques.	9019
Novel Crosslinked Hydrogel Improves Efficacy and Side Effects of Cancer Treatment	Versatile: Can integrate with all types of immune checkpoint blockade antibodies and respond to various types of cancers Improved tolerability via local delivery: Limits side effects on nonmalignant tissues and organs—a challenge of other immunotherapies Innovative: Leverages the body’s natural immune response to reduce the likelihood of cancer recurrence	8505
Novel Chemical Compounds Support Excess Copper Removal in Biological Systems	Powerful: Displays an affinity for copper that is unprecedented among synthetic ligands, with a complex stability constant of logK = 20.0 Specific: Functions without interference by other metals in the body Effective: Possesses a strong copper coordinating ability, even in the complex chemical environments of different biological systems	8151
Noncoding RNA Targets for RNA Interference	Novel group of RNA interference targets with utility in basic research and practical applications Non-coding interference RNAs (nciRNAs) offer an efficient mechanism of mortality in eukaryotic cells Highly specific targeting of pests or pathogens	6432
Non-Destructive Quality Control of Automated Weld Processes	Eliminates cut checks: Provides a nondestructive method for evaluating weld quality Real-time inspections: Allows for automation of welding operations Goes long: Uses Lamb waves to test welds over a larger area than is possible using higher frequency ultrasound waves	5680
Non-contact vital sign detection	Automatically adjusts the feedback signals to suppress the noise when the measurement environment changes Improves SNR by 50% at 50 cm when compared to an unlocked system Detects heartbeat at 250 cm, more than twice the distance of the unlocked system	7064
Non-Aqueous 2D Material-Based Hydrogen Isotope Separation	Increased efficiency - reduction of mechanical issues found in existing proton conductors Increased performance - solid state proton conductor is rigid eliminating concern of flexibility of polymer membranes in existing devices	8043
Next-Generation Flow Battery for Large-Scale Energy Storage at One-Tenth the Cost	Higher power density: This design has achieved ultra-high power densities of 630 W/Ldevice (charge) and 170 W/Ldevice (discharge), compared to existing flow battery designs that achieve only 500 W/Ldevice (charge) and 90 W/Ldevice (discharge). Ultra-high current density: The design has achieved current densities of >300 mA/cm3 per device. Dramatically lower cost: The elimination of parts reduces fabrication costs by 90%. Cost is ~$330 rather than ~$4,400.	8284, 8571
Next-Generation Custom-Fit Reusable Mask for Respiratory Protection	Aims to eliminate fit-testing: Designed to remove the expensive and time-consuming federal (i.e., OSHA) mandate for annual fit-testing for workplace use Improved fit: Adapts to fit specific facial features, increasing comfort and enhancing efficacy and potentially eliminating face-seal leakage to enhance performance Reusable: Withstands cleaning and decontamination	6635
New Methods of Fabrication for Biosensor Arrays	Low manufacturing and operating cost Compatible with multiple standard electrochemical techniques Can be used with CMOS detection chips with multiple chemical detection and/or actuation channels or sites	4231
New Methods for Skin Tissue Engineering: Textile-Based Sandwich Scaffold and CNT-based Electrospun Polymer Composite Yarns	Biocompatible: Exhibits good biocompatibility of the yarns fabricated using a wet electrospinning technique (results shown within a limited range of CNT concentration in the bath) Purposeful: Mimics the strain-stiffening behavior of human tissue, unlike other scaffolds that exhibit strain-softening of their synthetic materials Demonstrated: Exhibits the ability to guide cell anisotropic arrangement as well as support cell proliferation and infiltration in in vitro biological tests	8751, 8752
New Imaging Tool to Compare Healthy and Diseased Cells	Discrimination between healthy & diseased cell biology Personalized medicine – specific treatment for an individual Diagnosis of a disease prior to symptoms	6458
New Class of Tissue-Targeting Agents Inhibits Fibrosis, Inflammation, and Cancer Growth	Potent: Candidates among these agents are 1,000 times more potent than pirfenidone, the standard treatment of IPF. Specific: The compounds may potentially exhibit tissue-targeting properties for sustained levels at disease sites. Minimal toxicity: Enhanced tissue specificity inhibits inflammation and growth of targeted cancer cells while minimizing off-target effects and toxicity.	8374
Neuromodulation of Vagal Stimulation	Enhances anti-inflammatory effects of vagus nerve stimulation Pairs electrical stimulation with kilohertz electrical stimulation nerve block to achieve directional stimulation Quick, reliable anti-inflammatory clinical effects	7275
Needle-like Nanostructures to Deliver Multi-scale Biomolecules to Non-activated Immune Cells	This functionalized nanowire platform delivers multiple genetic materials to naïve T and B cells without pre-activation, enhancing their efficacy in adoptive cell therapy. The prototype improves gene delivery efficiency while preserving the naïve state of immune cells, increasing cell viability and immune response modulation. It offers superior protection against intracellular pathogens and serves as a research tool for immune cell manipulation across various species, ages, and subtypes.	9341
Near-Real-Time Positioning for Instruments and Tools in Magnetic Resonance Elastography (MRE) and Imaging (MRI)	Precise: Extremely precise positioning mechanism enables orientation and control capable of sub-millimeter motions within the MR environment Rapid: Significantly speeds up procedure time over standard MRI and offers wavefield images in near real time High resolution: Uses high-frequency actuation to enable imaging of small, geometrically difficult targets	8412
Nanoparticle-Stabilized Carbon Molecular Sieve Membranes for Efficient, Large-Scale Gas Separation	Cost efficient: Eliminates the need for the time-consuming process of post-treating precursor fibers in a chemical modifying agent in order to prevent collapse Scalable: Increases available surface area for gas separation to accommodate large-scale applications Adaptable: Allows for selection of the nanoparticles’ concentration and type to meet a desired combination of gas permeance and selectivity	6723
Nanoparticle Modulation of Thrombus Formation	Selective: Operates only in high shear blood flow as in a stenosis Improved Safety: Reduces the risk of bleeding complications from slow bleeds	7466
Nanogenerator for Harvesting Energy	Compact – Easily used for small electronics Energy saving – Harnesses energy from human body and water wave motions	6668
Nanocomposite Film for Volatile Organic Compound Sensing	The invention is a new type of chemoresistor capable of sensing volatile organic compounds (VOCs). The chemoresistor is comprised of a conductive nanoparticle surrounded by a polymer matrix which allows for the chemoresistor’s resistance, sensitivity, and target VOC to be adjusted. The nanocomposite can be placed on electrodes through drop casting, dip coating, and painting, which provides a cheap, simple and sensitive sensor ideal for fieldwork.	8695