| Systems and Methods for Flexible Sheath Locking with Integrated Shape Sensing |
- This technology aims to become a new steerable device to reduce the invasiveness of traditional methods for delivering drugs and diagnostic devices inside the body.
- There are no known existing methods of delivering radiotherapy without the potential of adversely affecting healthy cells.
- This device and method will enable drastic improvements in the quality of life of patients having to undergo radiotherapy treatment.
|
9264 |
|
| Back-Illuminated, Modified Silicon Photomultipliers with Largely Enhanced Efficiency for Multiple Applications |
- A novel photomultiplier device has been created that minimizes photon losses, and greatly enhances the efficiency of the device.
- The photomultiplier may improve the fill factor to 100% from 75% for the current SiPM and increases the usable wavelength range to cover the entire UV-Vis spectrum.
- The technology contains a texturized photoelectric surface and at least one coating layer and can be produced using standard manufacturing processes and low extinction coefficient materials.
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8965 |
|
| Enhanced Diversifying Base Editors for Directed Evolution in S. cerevisiae |
- This invention presents an optimized and integrated CRISPR diversifying base editor for use in yeast and demonstrate its ability to rapidly improve the affinity of an antibody through yeast display.
- The innovation has enhanced the base editor mutation rate up has been increased to 27-fold by characterizing an improved key variant and by optimizing the structure of the CRISPR guide RNAs.
- The technology has attained a rate roughly 10-fold higher than state-of-art systems and facilitates ultra-rapid antibody diversification.
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9111 |
|
| Novel Repressor Proteins for Gene Regulation and CRISPRi |
- The new CRISPRi platform uses novel fusion proteins to specifically inhibit target genes of interest and overcome the off-target issues with existing CRISPR platforms already on the market.
- The technology can be used as a life science tool and/or for diagnostics and therapeutics.
- The platform aims to limit off-target editing, circumvent incomplete gene knockdown sgRNA sequence-dependent repression activity, and variable performance across human cancer cell lines.
|
9106 |
|
| Tunable Membrane-Based Wastewater Treatment and Resource Recovery |
- Customizable membrane structure and surface properties provide selective removal of contaminants of emerging concerns (CEC) and recovery of valuable components.
- An enlarged membrane surface area, combined with a gutter effect from the interlayer, results in nearly double the water permeability of current filtration membranes.
- Achieves high-performance recovery of essential nutrients/fertilizers that are free of CECs.
|
8633 |
|
| A Brayton Electrochemical Refrigerator/Air-Conditioner |
- The Brayton Electrochemical Refrigerator/AC is a new, electrochemistry-based method of highly efficient cooling.
- Based on the Brayton cycle, the process provides continuous cooling while also providing near-zero global warming potential (GWP) refrigeration.
- This technology is highly efficient with a measured coefficient of performance that exceeds 8 as well as a non-flammable and non-toxic technology.
|
8711 |
|
| Enabling Rapid Detection of Label-Free RNA for Use in COVID-19 Testing |
- Earlier detection: Identifying the viral components themselves—rather than the body’s reaction to the viral presence (i.e., antibodies)—potentially improves early detection in asymptomatic subjects.
- Simpler process: Use of minimal reagents and fewer preparatory steps is designed to enable more efficient and facile sample preparation. Avoidance of “wash steps” aims to minimize target loss.
- Fewer disruptions: Avoiding the use of high-demand supplies (e.g., swabs) and reagents potentially reduces supply-chain and contamination issues.
|
8669 |
|
| Magnetohydrodynamic Pumped Liquid Metal Loops for Spacecraft Thermal Control |
- The absence of moving parts and low vapor pressure of the liquid result in enhanced reliability and minimum power consumption.
- The near-zero vapor pressure of the liquid metal reduces leaks and minimizes the pressure difference between the loop and the external environment, which reduces the mass of the pipes and enables the use of non-metallic lightweight fluid handling materials.
- With thermal conductivity values two orders of magnitude above standard refrigerants, the volume and mass of heat exchangers are reduced proportionally.
|
9251 |
|
| Messenger Ribonucleic Acid (mRNA)–Based Opsin Expression Enables New and Safer Optogenetic Studies |
- Opsin expression using messenger RNA (mRNA) provides an alternative to viral vectors for use in optogenetic studies involving neurons as well as drug testing with cardiomyocytes.
- Expression with mRNAs has lower toxicity and is usually detectable within 2–24 hours rather than 2–3 weeks.
- The controllable and temporary nature of mRNA offers improved expression regulation based on the transfection amount.
|
7534 |
|
| Microfluidic Device Enables Prediction of T-Cell Ability to Home and Engraft to Disease Tissues |
- Improve the homing capabilities of T cells to increase adoptive cell therapy treatment response and safety while decreasing off-target effects.
- Enhance tumor-infiltrating capabilities with engineered microfluidic devices that identify optimal subsets of cells.
- Optimize development pipelines by reducing the number of laborious in vivo studies, while also helping cell therapy companies ensure their products reach the desired tissue.
|
9052 |
|
| mRNA Therapeutic Delivery System Offers Targeted, Sustained HIV Pre-Exposure Protection in the Female Reproductive Tract |
- This system delivers messenger RNA that encodes neutralizing antibodies, which anchor to the female reproductive tract ensuring adequate, sustained tissue concentration for HIV prophylaxis.
- This HIV prevention therapy targets the female reproductive tract and offers month-long protection to reduce office visit frequency and potentially lower medical costs.
- This safe, water-based technology offers ease of administration to enhance patient compliance and prevent systemic complications.
|
8324 |
|
| Predictive Maintenance System for Large-Scale Operations Offers Potential for Significant Cost Savings |
- Consistent workflow improvements: Offers repeatable and consistent enterprise-level improvements to the maintenance workflow.
- Proactive readiness: Improves maintenance scheduling, allowing for improved logistics, scheduling, virtual kitting, and part/component availability.
- Customizable: Customers can build and tailor their PMx solutions according to their needs, providing increased data control and an alternative to costly and limited solutions.
|
8793 |
|
| High-Accuracy, Low-Cost, Low-Power Wireless Tracking Tags |
- Low-cost, ultra-low power wireless tag for real-time asset tracking
- Passive wireless tag costs less than $1 to manufacture and can operate for several years with maintenance-free operation
- Compatible with off-the-shelf devices, making it ideal for efficient inventory control in multiple industries
|
8943 |
|
| Overvoltage Surge Protection System for Distributed Energy Resources |
- iMOV is a dynamic system capable of achieving voltage surge clamping within 20% of the system’s nominal voltage. This effectively provides protection for highly sensitive semiconductors present in DER-associated power converters.
- This system is built upon a metal oxide varistors (MOV) foundation, whose material composition inherently allows rapid device connection of 500 picoseconds for quicker response times.
- iMOV uses integrated microprocessors and sensors in a cloud-based architecture that provides protection against cyberattacks, reduces system cost, and allows system and power grid monitoring.
|
9190 |
|
| Bi-Channel Needle for Injection |
- The injection fluids are completely separated until the tip of the needle, preventing their mixing until they have reached the syringe’s distal tip.
- Since the specific volumes of each drug required will be added to the channels of the syringe, this device reduces the amount of fluid left in the syringe after injection.
- The needle allows the clinician to inject with syringes that are parallel to each other, as opposed to at some oblique angle.
- The length of the device is not limited to the current 1-inch syringe. It can be longer (even greater than 1 meter) for catheter-based procedures.
|
9028 |
|
| AI-Designed High Energy–Density High-Temperature Polymers |
- The present materials are capable of withstanding enormous electric fields at very high temperatures.
- The materials produced are extremely lightweight.
- Vehicles making use of these materials will be lightweight, and lighter vehicles consume less energy.
|
9101 |
|
| Microgeodes Enable Tunable Optical Response for Advanced Coatings/Paint |
- Microgeodes have a programmable structure of nanowires that allows their optical response to be engineered precisely over multiple spectral bands, from UV through mid-IR.
- Microgeodes combine the tunability and versatility of nanowires with the processability of microspheres to provide a photonic materials platform for a wide range of applications.
- Microgeode paints could reduce building surface temperatures by as much as 25°C, offering the potential for significant consumer savings while retaining aesthetically pleasing colors.
|
8866 |
|
| Monitor Vehicle Location and Maintain Vehicle Health During Long-Term Storage |
- Vehicle health and location monitoring system automatically establishes a mesh network for vehicle fleet monitoring by a human, drone, or mobile robot.
- Checks battery and other vehicle health status as well as determines locations of all connected vehicles in storage.
- When a vehicle is found with low battery levels, a mobile robot can safely provide a charge to the battery to get the vehicle running.
|
8938 |
|
| Variable Slope, Multi-Octave Radio Frequency Filters |
- Customizable: The combined signal may be applied to a standard low-pass, band pass, or high-pass optical filter. The filter can be implemented with any number of poles for a maximum defined-slope, and the choice of pass type may be made according to the desired slope direction.
- Variable: By moving the optical carrier up and down in frequency through the transition band, the slope of the RF signal can be continuously varied.
- Versatile: The technology can be used as is or it can augment existing RF lab equipment.
|
7680 |
|
| Lymphatic System-Specific Lipid Nanoparticles |
- This platform technology improves current targeting to lymphatic tissues and specifically lymphatic endothelial cells.
- Provides superior tissue targeting and functional delivery of mRNA to lymphatics via loco-regional dermal or subcutaneous avenues.
- mRNA-based platforms offer a transient and less immunogenic method of delivery compared to protein therapeutics or adeno-associated virus-based platforms.
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9056 |
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