Technologies | Office of Technology Licensing

Available Technologies by Category
Microrobots for Neurosurgery Applications	Minimally invasive: Significantly reduces invasiveness of procedures in comparison to current macroscale, neurosurgical robots Precise control: Uses 3D position data of the microrobots on the brain surface in a closed-loop system to adjust the magnetic field parameters (i.e., magnitude, frequency, phase, and direct current [DC] offset of each coil) as well as the forces the robots exert to the biopsy tissue Facilitates movement: Employs microfabricated shapes that dictate the microrobot's movements, limits their contact with the brain surface to reduce adhesion, and may also provide a means for the robot to propel itself in fluid	8749
Microneedle Coating	Alternative method for hypodermic needles Coating uniformity Spatial control on coating length	3526
Microgeodes Enable Tunable Optical Response for Advanced Coatings/Paint	Microgeodes have a programmable structure of nanowires that allows their optical response to be engineered precisely over multiple spectral bands, from UV through mid-IR. Microgeodes combine the tunability and versatility of nanowires with the processability of microspheres to provide a photonic materials platform for a wide range of applications. Microgeode paints could reduce building surface temperatures by as much as 25°C, offering the potential for significant consumer savings while retaining aesthetically pleasing colors.	8866
Microfluidic System Enables Scalable, High-Throughput Separation for High-Purity Human Induced Pluripotent Stem Cells (hiPSCs)	Simple, tunable high-throughput process separates hiPSCs quickly and efficiently according to the degree to which they adhere to a substrate inside the microfluidic device. Separation of intact cell colonies enables this simple system to avoid damaging and adversely affecting the pluripotency of the cells. The approach is fast, does not rely on labeling technologies, supports greatly enriched cells, and results in a cell survival rate greater than 80%.	5685
Microfluidic Platform for Phase Separation of Aqueous Solutions	Efficient workflow- sample removal and analysis can be performed without manual oversight Smaller sample size- less sample volume required alleviating dilution of low concentration solutions that is common in alternative sample preparation workflows Faster process- thermoelectric cooling can induce separation in a matter of seconds with precision and tunability	8247
Microfluidic Platform for High-Density Cell Delivery	Allows for hundreds of cells to be immobilized on a very small footprint- including non-adherent cells Can analyze cell response at a single-cell resolution Can simultaneously observe cell response and generate chemical cues- allows for observation of immediate cell response	5691
Microfluidic Droplet for Drug Delivery and Therapeutic Applications	Viable, cellular micro-environments requiring precise control are achieved using hydrogel microspheres with diameter sizes ranging from 10-1000 micrometers A protective, semi-permeable capsule encases the cells and biomolecules Release rates of encapsulated biomolecules or drugs are controlled by adjusting the polymer parameters used to fabricate hydrogel microspheres	6467
Microfluidic Device for Cell Aggregates	Control - Precise control over the cell culture environment High content assays – Multiple types of imaging-based assays can be done on the same sample, both during live culture and at end-point High throughput – Greater number of experiments	7720
Microfluidic Device Enables Prediction of T-Cell Ability to Home and Engraft to Disease Tissues	Improve the homing capabilities of T cells to increase adoptive cell therapy treatment response and safety while decreasing off-target effects. Enhance tumor-infiltrating capabilities with engineered microfluidic devices that identify optimal subsets of cells. Optimize development pipelines by reducing the number of laborious in vivo studies, while also helping cell therapy companies ensure their products reach the desired tissue.	9052
Microfluidic CODES with Innovative Machine-Learning Analysis	Scalable: Set-up allows for the integration of multiple microfluidic devices to increase throughput volume. Versatile: Machine learning analysis can be applied to other microfluidic devices integrated with the same Coulter sensor network. Pragmatic: This innovation improves the capabilities of lab-on-a-chip systems to provide an affordable solution for low-resource settings.	7107, 8032
Micro-scale Fuel Processor for Hydrogen Fuels	Scalability — processor can be configured for a variety of processes Ease of operation — simple and robust Compact — overall design can be only a few millimeters to a few centimeters in size	3667
Methods to Impart Color and Patterns on Metal	Long Lasting: Does not wear off or fade Stream-lined: Eliminates the need for paint touch-ups and repairs Cost Effective: Prevents costly repair of material damage caused by paint	7327
Methods of Recycling and Replacing Lithium Ion Batteries	Low cost – low energy use compared to other methods Environmentally friendly – low emissions High purity – accurate separation of high value metals from other components	7892, 7941
Methods for Sensing Wearouts of Electronic Circuits	Circuit details are taken into account in estimating lifetime Wearout methods can be used to determine “timing closure” at 10 years lifetime Methods serve as foundation for a new electronic design automation tool for “timing closure”	7145
Methods for Generating Palladium-Rhodium Hetero-Nanostructures	Improved performance: Core-frame structure enhances shape stability and catalytic activity at high temperatures. Cost effective: Less rhodium is used than with other crystal growth methods. Simple: Crystals are formed in a scalable solution-based process.	6252
Methods for Generating Functional Therapeutic Cells	Novel – No present technology exists Versatile – Can be adapted to suit a variety of diseases, human and animal Targeted – Antigen-binding qualities within the B cell allow for highly specific therapies	7080
Methods for Dynamic Modeling and Closed-Loop Control of Inflammation	Dynamic Adjustments: can make dynamic adjustments to obtain control over the response Predict Stimuli: will predict when pro- and anti-inflammatory stimuli should be applied to generate the appropriate temporal profile of cellular response	8026
Method to modify the Conductivity of Graphene	Does not require the application of a dielectric layer to the graphene Graphene does not need to be chemically modified Maintains quality of graphene	5042
Method to Enrich Glyco-Peptides & Proteins for Analysis	More effective - enrichment of glycoproteins and glycopeptides in complex biological samples, especially low-abundance ones Reversible binding - for intact glycoprotein and glycopeptide analysis	7139
Method to Control the Annular Septal-Lateral Diameter of a Valve	Minimally invasive- tools for SLAC deployed endovascularly, percutaneously, or thorocoscopically through a catheter Effective- reduces the septal-lateral diameter on the mitral valve Biocompatible- provides an anchoring system for anchoring a minimally invasively deployed annuloplasty ring	3690