Available Technologies by Category
Low-Cost, Efficient Intracellular Delivery of Proteins and Nucleic Acids via Hydrophobic Ion Pairing
  • Safe and efficient approach of delivering therapeutics to disease by mixing cargo and charged hydrophobic ions with cells.
  • Applications in therapeutic/drug delivery, protein transduction reagent, and gene transduction reagent.
  • Enables efficacious delivery of a wide range of protein and nucleic acid therapeutics.
Low-Power Real-Time Ionizing Radiation Detector
  • Sensitive: Detects the charge generated from the interactions of ionizing radiation within matter with a high level of precision and discerns X-ray pulses of varying dose
  • Scalable: Covers a significantly larger detection area than other methods, ranging from 60,000 square micrometers to one square millimeter
  • Responsive: Responds within microseconds and proportionately with the overall radiation dose when exposed to X-rays of varying tube voltage (energy) and tube current (number of particles)
Low-Temperature Solution for Growth P-Typed Zinc Oxide Nanowires
  • Can be used to create p- and n-type homojuntion ZnO nanowires.
  • Nanowires as long as 340 µm were fabricated in a reproducible manner.
  • Fabrication technique employs low temperature conditions in an aqueous environment.
Low-Voltage Nanowire-Assisted Electroporation for Water Disinfection
  • Efficient: Achieves rapid and universal pathogen inactivation with low power consumption
  • Flexible: Features a configurable structure that can be placed easily into existing pipeline systems
  • Chemical-free: Permits disinfection without the addition of chemicals that generate harmful and carcinogenic byproducts
Lymphatic System-Specific Lipid Nanoparticles
  • This platform technology improves current targeting to lymphatic tissues and specifically lymphatic endothelial cells.
  • Provides superior tissue targeting and functional delivery of mRNA to lymphatics via loco-regional dermal or subcutaneous avenues.
  • mRNA-based platforms offer a transient and less immunogenic method of delivery compared to protein therapeutics or adeno-associated virus-based platforms.
Lymphoid Tissue System Harnesses Ex Vivo Immune Reactions for Rapid Antibody Production and Immune Response Prediction
  • This immunocompetent system uniquely accounts for the unexpected activation of various immune cells to allow proper immune cell differentiation, recapitulating an effective immune response.
  • The chemokine gradient is switchable, allowing the immune cell differentiation needed for an appropriate immune reaction.
  • An ex vivo system supports immune response creation in a controlled environment, allowing reproduction of immunologic events for developing improved therapeutics.
Machine Learning–Based Transportation Asset Inventory
  • The invention performs more intelligent segmentation using advanced computation methods with Artificial Intelligence.
  • Makes use of cost-efficient 2-dimensional images of roadways, making it easier to implement on a larger scale.
  • Can detect transportation assets and inventory them simultaneously.
Magnesium Composites for Biomedical Implant Applications
  • Biodegradable – Healing process is not compromised by a permanent implant device
  • High Strength – Mechanical properties match those of the natural skeletal structure
  • Reliable – Decreases failure during or after installation
Magnetohydrodynamic Drive for Gas Production in Microgravity
  • Novel technology using magnetohydrodynamic (MHD) forces for gas production and phase separation in microgravity environments.
  • Unifies gas generation and phase separation stages, eliminating the need for moving parts and enhancing reliability.
  • Versatile applications in space exploration, satellite propulsion, in-space manufacturing, and other areas, offering efficient and dependable gas production solutions.
Magnetohydrodynamic Pumped Liquid Metal Loops for Spacecraft Thermal Control
  • The absence of moving parts and low vapor pressure of the liquid result in enhanced reliability and minimum power consumption.
  • The near-zero vapor pressure of the liquid metal reduces leaks and minimizes the pressure difference between the loop and the external environment, which reduces the mass of the pipes and enables the use of non-metallic lightweight fluid handling materials.
  • With thermal conductivity values two orders of magnitude above standard refrigerants, the volume and mass of heat exchangers are reduced proportionally.
MANTIS: Wireless YouTube Load-Shifting
  • Shorter download times- videos are downloaded during non-peak hours
  • Decreases data usage-  due to less online traffic during download
  • Less cost- due to less bandwidth required
Manually Powered Laboratory Mixing Device
  • This manually operated laboratory device mixes and separates solution components at performance levels comparable to existing powered vortexes and centrifuges.
  • The device operates with no external power source, providing labs without access to consistent electrical infrastructure a reliable solution to mixing and separating solution components.
  • This multiuse device is compatible with containers and sample tubes of various sizes and solution amounts.
Measurement and Modeling System Using Cell Signaling Networks
  • The technology quickly identifies cell signaling pathways from a patient biopsy, allowing for personalized treatment approaches to be identified.
  • Measurements can be used to study potential tumor response to drug treatment, through the use of xenografted cells from the patient.
  • 30-100 potential protein pathways and interactions can be measured using a single sample through multiplexing of rapid immunofluorescence.
Measuring Surface Antigen Expression via Microflow Cytometry
  • Portable: This innovation uses a disposable, handheld device without bulky or costly equipment, which is expected to be especially useful in low-resource settings.
  • Simple: It is designed to achieve results similar to those from a commercial flow cytometer but without requiring initial purification.
  • Recoverable samples: Unlike commercial systems, the analyzed sample can be recovered for further tests at the end of the analysis.
7913, 8048
Mechanocatalytic Depolymerization of Plastics
  • A new process for recycling plastics has been created where plastics are broken down simultaneously by mechanical and catalytical forces.
  • This chemical recycling has less economic costs, produces less wastes, and allows for an increase in the number of different types of plastics that can be recycled.
  • The process also provides a convenient solution as it is highly scalable, requires less volumes of catalysts, and can be fueled by electronic and renewable energies.
Medical Tubing Solution for Bacteria Prevention
  • Prevent various infections currently impacting patients due to bacteria formation on medical tubes.
  • Solution that can be utilized with existing medical tubes.
  • Does not leach any materials from the tubing surface.
Melting Microneedle Patches Extend Drug Delivery Applications, Simplify Manufacturing, and Reduce Costs
  • Melting microneedles enable dispersion of both poorly soluble and water-soluble drugs, which eliminates the need for solvents for improved stabilization and broader applications.
  • Melting microneedles shorten manufacturing and drying time, eliminate the need to maintain a cold chain for storage and transportation, and reduce the ultimate cost of the microneedle patch.
  • The safe suppository bases are inexpensive and enable control of the drug release timing.
Messenger Ribonucleic Acid (mRNA)–Based Opsin Expression Enables New and Safer Optogenetic Studies
  • Opsin expression using messenger RNA (mRNA) provides an alternative to viral vectors for use in optogenetic studies involving neurons as well as drug testing with cardiomyocytes.
  • Expression with mRNAs has lower toxicity and is usually detectable within 2–24 hours rather than 2–3 weeks.
  • The controllable and temporary nature of mRNA offers improved expression regulation based on the transfection amount.
Messenger RNA–Based Expression of Cardiomyocyte Phenotype Sensors and Differentiating Genes for In Vitro Correction of Cardiac Disorders
  • This invention uses a gene therapy as a direct treatment for symptomatic bradyarrhythmia and removes the needs for implantation of electronic pacemakers.
  • The innovation does not lead to spillover to the liver, spleen and lungs; allows for mRNA gene transfer to stay focal to the injection site; and does not have danger of integration into the host’s DNA.
  • The new gene therapy could be used as first-line treatment of arrhythmias and consequent ailments and to circumvent the need for major surgical interventions.
Metal Compounds for Use in Electronics
  • Potential for strong intermolecular overlap
  • Low reorganization energies
  • Tunability of redox potential