| Recombinant Antibodies for Exclusive Detection of Glaucoma-Associated Myocilin |
- Exclusive detection: Unlike current myocilin-directed antibodies that do not differentiate among numerous disease-associated states of the protein (e.g., folded, cleaved, and misfolded myocilin), these reagents only detect folded myocilin
- Authentic and reproducible: Antibodies are produced using recombinant DNA technology, which enables robust precision sequencing of the reagent and maintains fidelity over time
- High affinity: Antibodies detect both mouse and human myocilin with well-characterized epitopes and high affinity
|
8055 |
|
| Air-Breathing Plasma Jet Engine |
- Sustainable: This invention has the potential to replace costly hydrocarbon fuel with a sustainable and cost-effective alternative.
- Adaptable: Depending on the application, the plasma can be created and coupled by various means, including direct current electric arcs, radio frequency plasma, and microwave plasma.
- Cost-saving: This invention has the potential to replace costly hydrocarbon fuel with a sustainable and cost-effective alternative.
|
8788 |
|
| Transcatheter Heart Valve with Multi-Arm Mechanism |
- Reduced flow stasis: This mechanism displaces the native valve leaflets away from the THV stent frame, essentially removing its “cover” and allowing blood to move freely through the open stent cells. This can help to significantly reduce flow stasis in the neo-sinus region, thereby reducing thrombus initiation/progression.
- Prevention of coronary artery obstruction: Coronary artery obstruction following TAVR is a rare but often fatal complication. In rare cases in patients with unusually large native leaflets or small aortic roots, the large leaflets block the flow of blood to the coronary arteries as the new valve’s scaffolding opens. Georgia Tech’s design displaces the native valve leaflets away from the THV stent frame, which can help to reduce this risk.
- Optimized THV deployment: The innovation offers dual feedback to aid clinicians in determining optimal THV deployment height—a key factor in optimizing patient outcomes. As the device’s “arms” extend against the native vessel wall, they create both tactile feedback during THV positioning as well as visual feedback via fluoroscopy. In addition to deployment height, the multi-arm design supports axial alignment of the THV with respect to the native vessel wall—a factor shown to impact valve performance.
|
8140 |
|
| Reinvented Toilet Technologies |
- Self-contained: Requires no plumbing or sewerage
- Ecological: Reduces the use of clean drinking water in sewerage processes, as well as the energy and infrastructure required for modern wastewater treatment and disposal
- Forward-looking: Could provide non-sewered locations with a much-needed sanitation solution, while potentially addressing ecological threats (water use, air and waterborne pathogens, etc.)
|
8592, 8593, 8594, 8595, 8596, 8597, 8917, 8996 |
|
| Low-Power Real-Time Ionizing Radiation Detector |
- Sensitive: Detects the charge generated from the interactions of ionizing radiation within matter with a high level of precision and discerns X-ray pulses of varying dose
- Scalable: Covers a significantly larger detection area than other methods, ranging from 60,000 square micrometers to one square millimeter
- Responsive: Responds within microseconds and proportionately with the overall radiation dose when exposed to X-rays of varying tube voltage (energy) and tube current (number of particles)
|
8780 |
|
| Self-Powered Highly Stretchable Sensing Interface for Gesture Recognition |
- Self-contained: Includes a signal processing pipeline, providing gesture recognition for an extensive range of input modalities without the need for external power or sensing equipment
- Assistive: Enables eyes-free, unobtrusive, and ergonomic interaction with computing devices embedded in wearables
- Versatile: Demonstrates far-reaching potential for applications beyond gesture recognition including in actuation and data acquisition
|
7987 |
|
| Integrated Alkali Dispenser Collimator |
- Precise: Reducing the “spread” of vapor via collimation can reduce potential signal-to-noise ratio degradation and avoid contamination of nearby electronic components.
- Simple: Generating a directed atomic beam from the dispenser can be achieved via integrated packaging.
- Cooler: Placing a spacer material between the dispenser and collimator creates a sealed gap that not only prevents leakage, but also allows the vapor to cool (via rapid thermalization with the collimator plate).
|
8872 |
|
| Flexible Power Generation with Negative Carbon Emissions |
- Energy security: This system enables the continued use of low-cost domestic fuel (i.e., natural gas) for electricity generation and increases the reliability of U.S. electricity production.
- Environmental protection: Flexible carbon capture and storage (CCS) systems can achieve high CO2 capture rates from flue gas. For example, with this system a power generator could shift the times it exports electricity to the grid, allowing the power generator and CCS plant to operate under steady-state conditions and with reduced emissions.
- Reduced costs: The cost of a net-zero carbon electricity system is lowered by providing dispatchable power to a high-VRE grid.
|
8834 |
|
| Salinity Exchange Process for Low-Cost, High-Quality Potable Water |
- Increases water supply: This process takes advantage of abundantly available wastewater to produce clean drinking water.
- Requires significantly less energy: Salinity exchange uses much less energy than conventional desalination technologies for which energy consumption is still a major obstacle. Georgia Tech’s bench scale prototype has demonstrated energy consumption of less than one-third of conventional reverse osmosis.
- Publicly acceptable: Drinking desalinated seawater and brackish water is much more cognitively appealing than direct potable reuse of treated wastewater, overcoming public perception obstacles to water treatment.
|
8797 |
|
| Antibodies for Glaucoma Research |
- Precise: Distinguishes between correctly folded and mutated forms from samples, allowing for more precise research and interventions
- Powerful: Enables a more complete and robust understanding of myocilin antibody targets and their applications in potential glaucoma treatments
- Enabling: Opens new opportunities for development of pharmaceuticals to treat or prevent damage to the eye caused by glaucoma
|
8489 |
|
| Anti-Resonance System Enables Variable Speed Rotors |
- High performance: Enables variable rotor speeds by significantly reducing resonance loads during transition from one rotor speed to another
- Agile: Reduces vibration by completely removing resonance points within the rotor operating range
- Energy efficient: Decreases power consumption by optimizing rotor speeds for different flight conditions
|
8857 |
|
| Scalable Polymers of Intrinsic Microporosity for Chemical Separations |
- Scalable: Uses simple chemistry and eliminates production steps to enable large scale polymer manufacturing
- Solution-processable: Permits the development of a variety of membrane morphologies including dense flat sheets, thin film composites, and hollow fibers
- High chemical stability: Results in stable structures able to withstand exposure to solvents and other chemicals, enabling stable separation performance and industrial application
|
8113 |
|
| A Mechanical Topological Insulator-Based Multiplexer/Demultiplexer |
- Novel: Offers the first known design of its kind, addressing the signal loss challenges of applying acoustic wave technologies to mechanical applications
- Practical: Enables potential development of a single mechanical platform to accomplish both filtering and channeling using inexpensive components that avoid high battery usage
- Signal-protecting: Guides waves from input(s) to output(s) with minimal signal loss and topological protection from backscattering
|
8802 |
|
| Two-Phase Thermal Management System for Integrated Motor Cooling |
- High-performance: Utilizes three-dimensional silicon carbide packaging and novel drive topologies with reduced switching losses, leading to increased power density and lower motor system size and weight
- Embedded: Integrates with the motor and drive electronics rather than requiring an externally attached heat exchanger system
- Efficient: Dramatically increases volumetric heat removal rates in electric motor systems by employing a wick structure designed to assist liquid delivery to enable evaporative cooling
|
8280 |
|
| RobocallGuardPlus |
- Advanced: Uses a unique smart virtual assistant with a voice interaction model that generates natural conversation to filter out robocalls
- Robust: Blocks robocalls that other methods may miss, such as those that evade call block lists through caller ID spoofing
- Unique: Provides the first known system to block mass, evasive, and targeted robocalls using natural, interactive conversation methods rather than relying solely on caller ID and block lists
|
8817 |
|
| A Method for Creating a Protective Cap Layer for Semiconductor Wafers |
- Protective: Provides a thin protective layer or “cap” after the first layer is deposited, protecting the underlying structure from atmospheric contaminants
- Robust: Enables realization of the advantages of hybrid growth processes by eliminating performance-degrading contaminants and resulting defects
- Advanced: Offers superior protection against contamination compared with simple chemical cleaning methods utilized in other systems, especially against impurity species such as oxides
|
8435 |
|
| A Biological Computing Framework for Living Systems |
- Innovative: Builds on probabilistic computing principles to construct analog biological bits, enabling an entirely new set of logic gates and algorithms and potentially allowing users to solve previously intractable problems
- Robust: Can sense every extracellular protease encoded in the human genome, for which there is a known peptide substrate, enabling a simple plug-and-play framework for communicating with a variety of biological activities and offering performance competitive with DNA-based computers but with increased processing speed
- Relevant: Provides a framework based on biological activity and constructed from biological materials, which enables a direct interface with and understanding of living materials and systems
|
8009 |
|
| High-Throughput MSC Potency Assay to Bring Feasibility to Immune/Inflammatory Therapeutics |
- Reproducibility: The well-defined cellular environment of the device enables a highly reproducible MSC response not observed in 2D cultures.
- Scalable: The assay’s simplistic design is amendable to cost-effective scale up.
- Economical: The low cost of the microfluidic chip and the ease of implementing the assay into existing cell therapy manufacturing practices provide for low costs to enter the market.
|
8722 |
|
| Fluid Interface–Supported Printing Process for Stereolithography 3D Printing |
- Reduced costs: Lowers costs by using less resin and requiring less user effort for support removal and post-processing
- Faster printing: Produces parts more quickly and easily
- Enhanced creation of complex geometries: Enhances the ability to create more detailed and complex structures using SLA 3D printing
|
8774 |
|
| Steerable and Flexible Robotic Endoscopic Tool with Instrument-Changing System |
- Flexible: Offers multiple tendon-driven degrees of freedom and is designed to enable the surgeon to avoid obstacles within the workspace
- Simplifies instrument changes: Includes three instrument stations with a motorized shaft to allow insertion into or retraction from the working channel(s) without leaving the surgical field
- Reduces procedure time: Demonstrates potential to improve procedure efficiency and patient safety by reducing procedure time
|
8118 |
|
