| 3D Light-Field Endoscopy for High-Precision Microsurgery |
- Enhanced control and safety: Real time visual navigation enhances guidance and intervention in complex microenvironments, maintaining high spatial resolution while providing quantitative depth information
- Comfortable: System does not require 3D glasses that can cause physician dizziness or headaches after long periods of use
- Streamlined: Technique eliminates the need for other imaging procedures such as micro-CT or MRI to quantify the 3D morphology of tissue
|
8848 |
|
| Cluster-Wells: Isolating Aggressive Tumor Cell Clusters for Improved Cancer Diagnosis and Treatment |
- High performing: Demonstrates superior abilities to isolate CTCs without clogging the system or dissociating the clusters
- Low cost: Shows high potential for large-scale production because it uses simple equipment and a straightforward process
- Versatile: Isolates CTC clusters of any cancer type and uses hardware that can be modified to accommodate various devices
|
8203 |
|
| Fourier Light-Field Microscope (FLFM) for Fast, Volumetric, and High-Resolution Imaging of Entire Organoids |
- Cost-efficient and scalable: Is fully adaptable to epifluorescence protocols resulting in a system that is both cost-efficient and highly scalable
- Fast: Captures fast cellular and tissue dynamic processes in a simultaneous, volumetric manner (e.g., collective cellular responses at sub-second time scales across whole samples)
- Validated: Responses to extracellular physical cues such as osmotic and mechanical stresses have been recorded using human induced pluripotent stem cell-derived colon organoids (hCOs).
|
8844 |
|
| Reprocessing, Recycling, and Repairing Covalent Adaptable Network Polymers |
- Environmentally friendly: Recycles fibers and polymers without the use of supercritical chemicals (e.g., acids)
- Effective: Allows for pressure-free surface repair and welding
- Efficient: Reclaims fibers and polymer with the same mechanical properties as fresh material for use in new products
|
7348 |
|
| TabAccess: A Wireless Controller for Tablet Accessibility |
- Enabling: Provides an alternative interface to touchscreen-based devices for people with limited fine motor control, potentially enabling them to interact with applications that could improve their quality of life or even create employment opportunities
- Reconfigurable: Sensor modules can be interconnected as well as separated and mounted anywhere (e.g., on the human body or on a table, floor, wheelchair, etc.), enabling adaptation of the device based on the capability, range of access, and the individual’s range of motion.
- Adjustable: Uses an adjustable Velcro strap so one size fits the majority of forearms
|
5946 |
|
| Cell-free Biosensors to Detect Creatinine, Creatine, and Sarcosine |
- Portable: This technology demonstrates the potential to develop point-of-care screening and monitoring, which is essential to expanding access to care worldwide, including to low- and middle-income countries.
- Inexpensive: CFE-based biosensors can cost as little as a few cents per test and could provide a low-cost alternative to current renal function monitoring and diagnosis, which currently involves laboratory visits, trained phlebotomists, skilled technicians, and expensive, specialized equipment.
- Cell-free: The use of a cell-free expression system could enable easier-to-read quantitative output that is less susceptible to matrix effects.
|
8776 |
|
| Chip-Scale Atomic Beam System |
- Precision timekeeping (e.g., chip-scale atomic clocks primarily used in cell phone base stations)
- Navigation (e.g., interferometers used in underwater oil and gas exploration)
- Robotics
|
8896 |
|
| New Methods for Skin Tissue Engineering: Textile-Based Sandwich Scaffold and CNT-based Electrospun Polymer Composite Yarns |
- Biocompatible: Exhibits good biocompatibility of the yarns fabricated using a wet electrospinning technique (results shown within a limited range of CNT concentration in the bath)
- Purposeful: Mimics the strain-stiffening behavior of human tissue, unlike other scaffolds that exhibit strain-softening of their synthetic materials
- Demonstrated: Exhibits the ability to guide cell anisotropic arrangement as well as support cell proliferation and infiltration in in vitro biological tests
|
8751, 8752 |
|
| Versatile Retroreflective Metastructures for Enhanced Electromagnetic Response |
- Improved steep angle performance: Increases the angular range of reflectivity to greatly reduce the precision needed to produce a retroreflective response
- Increased bandwidth: Combines multiple periodic metasurfaces into a hybrid metastructure for greater bandwidth
- Versatile design: Can be designed for either single- or dual-polarized retroreflection, with metasurfaces of different periodicities combined for varying angles
|
8764 |
|
| Small Beamformer for Simultaneous Spatial and Channel Diversity Communications |
- Scalable: Improves capacity by increasing the number of arrays and increasing the gain of each interpenetrating array
- Small formfactor: Contains nine interpenetrating arrays in the same area as a single legacy array capable of carrying only one bandwidth
- Efficient: Demonstrates that each antenna array can spatially scan at least nine independent interpenetrating arrays simultaneously, each carrying its assigned information channel within the assigned bandwidth
|
8635 |
|
| Small Molecule Glycosylated Histone Deacetylase Inhibitors (HDACi) |
- Targeted: The compounds were particularly cytotoxic to liver or hepatocellular cancer cells (HCC) during in vivo murine model laboratory studies.
- Enhanced potency: The compounds’ hepatocellular carcinoma selectivity observed in laboratory studies potentially increases their efficacy on liver cancer and possibly other cancers.
- Many formulations: A number of formulation methods are potentially available, including tablets, beads, granules, microparticle, or nanoparticles that provide a variety of drug release profiles.
|
8373 |
|
| Wearable Device for Evaluating Post-Injury Ankle Health During Ambulation |
- Better decisions: Helps clinicians more easily determine the best course for ankle rehabilitation and improves compliance with physical therapy
- Faster recovery: Enables improved rehabilitation guidance based on collected telehealth data that may speed the time to recovery
- Fewer re-injuries: Supports clinicians in making better decisions regarding appropriate activity levels and readiness to return to activities to avoid re-injury
|
8513 |
|
| New Class of Tissue-Targeting Agents Inhibits Fibrosis, Inflammation, and Cancer Growth |
- Potent: Candidates among these agents are 1,000 times more potent than pirfenidone, the standard treatment of IPF.
- Specific: The compounds may potentially exhibit tissue-targeting properties for sustained levels at disease sites.
- Minimal toxicity: Enhanced tissue specificity inhibits inflammation and growth of targeted cancer cells while minimizing off-target effects and toxicity.
|
8374 |
|
| Raised Cosine (RC) Pulse Shaping for Next Generation Multi-Mode Fiber (MMF) Links |
- Small design: Uses direct modulation and detection with VCSEL-based MMF links for small form factor
- High speeds with low cost and power: Achieves speeds of 100 Gbps and higher while maintaining low cost and low power consumption with VCSEL MMF-based links and other direct-modulated lasers
- Low bandwidth requirements: Minimizes intersymbol interference and reduces the required electrical bandwidth to enable use with commercially packaged VCSELs that have bandwidth in the low 20 GHz range
|
7398 |
|
| Passive Learning via Wearable Haptic Stimuli System |
- Fast: This technology significantly reduces the time needed to learn Braille. In only four hours, eight test subjects were taught to type the entire Braille alphabet as well as read Braille (with >90% accuracy), while simultaneously focusing on another task.
- Simplifies learning: A lack of certified Braille teachers, few learning centers, and a steep learning curve make teaching Braille difficult. This technology greatly simplifies the learning process.
- Passive: Because it doesn’t require the user’s attention on the stimuli, this technology allows them to focus on other tasks while still learning.
|
6678 |
|
| More Efficient Method for Electrochemical Reduction of Carbon Dioxide |
- Efficient CO2 recycling: Allows for robust recycling of unreacted CO2 from an electrochemical cell
- Increased overall CO2 conversion: Features efficient use of recycling, enabling 100% theoretical atom conversion for this reaction with an intrinsically low CO2 conversion
- Customized deployment: Integrates with a wide variety of product streams
|
8875 |
|
| Recombinant Antibodies for Exclusive Detection of Glaucoma-Associated Myocilin |
- Exclusive detection: Unlike current myocilin-directed antibodies that do not differentiate among numerous disease-associated states of the protein (e.g., folded, cleaved, and misfolded myocilin), these reagents only detect folded myocilin
- Authentic and reproducible: Antibodies are produced using recombinant DNA technology, which enables robust precision sequencing of the reagent and maintains fidelity over time
- High affinity: Antibodies detect both mouse and human myocilin with well-characterized epitopes and high affinity
|
8055 |
|
| Air-Breathing Plasma Jet Engine |
- Sustainable: This invention has the potential to replace costly hydrocarbon fuel with a sustainable and cost-effective alternative.
- Adaptable: Depending on the application, the plasma can be created and coupled by various means, including direct current electric arcs, radio frequency plasma, and microwave plasma.
- Cost-saving: This invention has the potential to replace costly hydrocarbon fuel with a sustainable and cost-effective alternative.
|
8788 |
|
| Transcatheter Heart Valve with Multi-Arm Mechanism |
- Reduced flow stasis: This mechanism displaces the native valve leaflets away from the THV stent frame, essentially removing its “cover” and allowing blood to move freely through the open stent cells. This can help to significantly reduce flow stasis in the neo-sinus region, thereby reducing thrombus initiation/progression.
- Prevention of coronary artery obstruction: Coronary artery obstruction following TAVR is a rare but often fatal complication. In rare cases in patients with unusually large native leaflets or small aortic roots, the large leaflets block the flow of blood to the coronary arteries as the new valve’s scaffolding opens. Georgia Tech’s design displaces the native valve leaflets away from the THV stent frame, which can help to reduce this risk.
- Optimized THV deployment: The innovation offers dual feedback to aid clinicians in determining optimal THV deployment height—a key factor in optimizing patient outcomes. As the device’s “arms” extend against the native vessel wall, they create both tactile feedback during THV positioning as well as visual feedback via fluoroscopy. In addition to deployment height, the multi-arm design supports axial alignment of the THV with respect to the native vessel wall—a factor shown to impact valve performance.
|
8140 |
|
| Reinvented Toilet Technologies |
- Self-contained: Requires no plumbing or sewerage
- Ecological: Reduces the use of clean drinking water in sewerage processes, as well as the energy and infrastructure required for modern wastewater treatment and disposal
- Forward-looking: Could provide non-sewered locations with a much-needed sanitation solution, while potentially addressing ecological threats (water use, air and waterborne pathogens, etc.)
|
8592, 8593, 8594, 8595, 8596, 8597, 8917, 8996 |
|
