| Smart, Wireless, Bioelectronic Pacifier for Real-Time Continuous Salivary Electrolyte Monitoring in Infants |
- Smart pacifier offers wireless, real-time, continuous detection of sodium and potassium levels in infants.
- This totally non-invasive monitoring pacifier eliminates the need for blood draws, which can only be done three times each day, and is designed to provide non-invasive neonatal health monitoring.
- Microfluidic channels are designed to efficiently pump optimum quantities and concentration of viscous saliva to the sensor area for quick measurement and to eliminate the need to induce salivary stimulation.
|
8942 |
|
| Quantitative, Multiplexed Electronic Detection of COVID-19 Biomarkers |
- Direct electronic detection: This innovation provides direct detection of biomarkers as a simple electronic readout without the use of any intermediate optics.
- Multiplexed: The device can simultaneously detect multiple biomarkers (e.g., a four-plex chip to detect IgG and IgM antibodies against spike or nucleocapsid antigens).
- Portable: A handheld, cellphone-interfaced reader is designed to enable detection and monitoring of diseases in remote areas for sensitive yet inexpensive point-of-care use.
|
8814 |
|
| Intracellular Anticancer Delivery |
- Self-assembling: Forms an organized structure in water at room temperature
- Nano-scale: Approximately 35 nm, ideal for intracellular uptake
- Versatile: Can be used with any antibody
|
7174 |
|
| Developing Tumor Immune Microenvironments via Engineered Hydrogel |
- Scalable: Enables increased tumor formation rate without sacrificing the dynamic complexity of an in vivo adaptive immune response
- Improved consistency: Demonstrates consistent induction of tumor growth, latency, and immune infiltration in early analyses of the technology
- Cost-effective: Eliminates the repetitive processes of conventional methods and leverages inexpensive hydrogel
|
8785 |
|
| Biologically Inspired Connected Advanced Driver Assistance System |
- Cost-effective: Leverages existing vehicle infrastructure (e.g., sensors, lights) along with an affordable software upgrade to provide enhanced collision avoidance capabilities, typically for less than $500
- Safety-enhancing: Designed to help prevent up to 94% of automotive crashes by providing reduced lag time and enabling faster driver reaction rates
- Convenient: Aims to optimize vehicle travel speeds and reduce traffic congestion and travel times
|
8918 |
|
| Atomic Metal Catalysts |
- Innovative: Generates new isomers by changing the order in which atoms are added in a hetero-atomic cluster (can maximize available catalytic sites)
- Efficient: Creates and optimizes active isomers of atomic metals such as Au and Pd, increasing the catalytic efficiency of these high-demand metals (requires minimal precious catalytic metal)
- Scalable: Provides a scalable process resulting in theoretically predictable catalytic properties
|
6451, 5217 |
|
| Capillary Flow Control in Lateral Flow Assays (LFAs) via Delaminating Timers |
- ASSURED: LFAs readily satisfy the majority of the ASSURED (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverable to end-users) criteria reported by the World Health Organization to establish capabilities of POC devices.
- Agile: The addition of timers to LFAs provides an opportunity to develop more complex multi-step testing, as well as additional benefits such as built-in signal amplification and POC DNA extraction and purification.
- Automated: The ability to sequentially deliver different reagents into a reaction via programmable timers imprinted on paper makes it possible to automate multi-step assays that otherwise could only be performed in laboratories or with manual intervention.
|
8462, 8634 |
|
| Recirculation System for Aerosol Collectors Maximizes Particle Concentration for Improved Pathogen Detection |
- Enhanced detection: Continuously recirculated collection buffer increases the concentration of targeted particles collected and improves detection of pathogens
- Increased sampled air volume: Recirculating the buffer enables running the system for longer periods of time and with larger volumes of air to improve pathogen detection in entire buildings
- Increased control: Users have active control of the volume of fluid introduced during collection via the system’s recharge pump
|
8903 |
|
| 3D Light-Field Endoscopy for High-Precision Microsurgery |
- Enhanced control and safety: Real time visual navigation enhances guidance and intervention in complex microenvironments, maintaining high spatial resolution while providing quantitative depth information
- Comfortable: System does not require 3D glasses that can cause physician dizziness or headaches after long periods of use
- Streamlined: Technique eliminates the need for other imaging procedures such as micro-CT or MRI to quantify the 3D morphology of tissue
|
8848 |
|
| Cluster-Wells: Isolating Aggressive Tumor Cell Clusters for Improved Cancer Diagnosis and Treatment |
- High performing: Demonstrates superior abilities to isolate CTCs without clogging the system or dissociating the clusters
- Low cost: Shows high potential for large-scale production because it uses simple equipment and a straightforward process
- Versatile: Isolates CTC clusters of any cancer type and uses hardware that can be modified to accommodate various devices
|
8203 |
|
| Fourier Light-Field Microscope (FLFM) for Fast, Volumetric, and High-Resolution Imaging of Entire Organoids |
- Cost-efficient and scalable: Is fully adaptable to epifluorescence protocols resulting in a system that is both cost-efficient and highly scalable
- Fast: Captures fast cellular and tissue dynamic processes in a simultaneous, volumetric manner (e.g., collective cellular responses at sub-second time scales across whole samples)
- Validated: Responses to extracellular physical cues such as osmotic and mechanical stresses have been recorded using human induced pluripotent stem cell-derived colon organoids (hCOs).
|
8844 |
|
| Airborne Acoustic Sensing System for “Ear in the Sky” Capabilities on Unmanned Aerial Vehicles (UAVs) |
- Optimizes speech clarity: Uses acquired empirical data and iteratively refines the processing capability until the optimal signal to noise ratio (SNR) is achieved
- Improves covert detection: Enables acquisition of a live voice signal from a person of interest without detection by using UAS platforms to remotely acquire acoustic signals and using digital signal processing algorithms to filter, enhance, and localize the speech signal of interest
- Enhances warfare tools: Provides increased situational awareness, enhanced ISR capabilities, and helps identify potential security threats to deployed assets
|
6985, 7223 |
|
| Reprocessing, Recycling, and Repairing Covalent Adaptable Network Polymers |
- Environmentally friendly: Recycles fibers and polymers without the use of supercritical chemicals (e.g., acids)
- Effective: Allows for pressure-free surface repair and welding
- Efficient: Reclaims fibers and polymer with the same mechanical properties as fresh material for use in new products
|
7348 |
|
| TabAccess: A Wireless Controller for Tablet Accessibility |
- Enabling: Provides an alternative interface to touchscreen-based devices for people with limited fine motor control, potentially enabling them to interact with applications that could improve their quality of life or even create employment opportunities
- Reconfigurable: Sensor modules can be interconnected as well as separated and mounted anywhere (e.g., on the human body or on a table, floor, wheelchair, etc.), enabling adaptation of the device based on the capability, range of access, and the individual’s range of motion.
- Adjustable: Uses an adjustable Velcro strap so one size fits the majority of forearms
|
5946 |
|
| Cell-free Biosensors to Detect Creatinine, Creatine, and Sarcosine |
- Portable: This technology demonstrates the potential to develop point-of-care screening and monitoring, which is essential to expanding access to care worldwide, including to low- and middle-income countries.
- Inexpensive: CFE-based biosensors can cost as little as a few cents per test and could provide a low-cost alternative to current renal function monitoring and diagnosis, which currently involves laboratory visits, trained phlebotomists, skilled technicians, and expensive, specialized equipment.
- Cell-free: The use of a cell-free expression system could enable easier-to-read quantitative output that is less susceptible to matrix effects.
|
8776 |
|
| Chip-Scale Atomic Beam System |
- Precision timekeeping (e.g., chip-scale atomic clocks primarily used in cell phone base stations)
- Navigation (e.g., interferometers used in underwater oil and gas exploration)
- Robotics
|
8896 |
|
| New Methods for Skin Tissue Engineering: Textile-Based Sandwich Scaffold and CNT-based Electrospun Polymer Composite Yarns |
- Biocompatible: Exhibits good biocompatibility of the yarns fabricated using a wet electrospinning technique (results shown within a limited range of CNT concentration in the bath)
- Purposeful: Mimics the strain-stiffening behavior of human tissue, unlike other scaffolds that exhibit strain-softening of their synthetic materials
- Demonstrated: Exhibits the ability to guide cell anisotropic arrangement as well as support cell proliferation and infiltration in in vitro biological tests
|
8751, 8752 |
|
| Versatile Retroreflective Metastructures for Enhanced Electromagnetic Response |
- Improved steep angle performance: Increases the angular range of reflectivity to greatly reduce the precision needed to produce a retroreflective response
- Increased bandwidth: Combines multiple periodic metasurfaces into a hybrid metastructure for greater bandwidth
- Versatile design: Can be designed for either single- or dual-polarized retroreflection, with metasurfaces of different periodicities combined for varying angles
|
8764 |
|
| Small Beamformer for Simultaneous Spatial and Channel Diversity Communications |
- Scalable: Improves capacity by increasing the number of arrays and increasing the gain of each interpenetrating array
- Small formfactor: Contains nine interpenetrating arrays in the same area as a single legacy array capable of carrying only one bandwidth
- Efficient: Demonstrates that each antenna array can spatially scan at least nine independent interpenetrating arrays simultaneously, each carrying its assigned information channel within the assigned bandwidth
|
8635 |
|
| Small Molecule Glycosylated Histone Deacetylase Inhibitors (HDACi) |
- Targeted: The compounds were particularly cytotoxic to liver or hepatocellular cancer cells (HCC) during in vivo murine model laboratory studies.
- Enhanced potency: The compounds’ hepatocellular carcinoma selectivity observed in laboratory studies potentially increases their efficacy on liver cancer and possibly other cancers.
- Many formulations: A number of formulation methods are potentially available, including tablets, beads, granules, microparticle, or nanoparticles that provide a variety of drug release profiles.
|
8373 |
|
