| Magnetohydrodynamic Pumped Liquid Metal Loops for Spacecraft Thermal Control |
- The absence of moving parts and low vapor pressure of the liquid result in enhanced reliability and minimum power consumption.
- The near-zero vapor pressure of the liquid metal reduces leaks and minimizes the pressure difference between the loop and the external environment, which reduces the mass of the pipes and enables the use of non-metallic lightweight fluid handling materials.
- With thermal conductivity values two orders of magnitude above standard refrigerants, the volume and mass of heat exchangers are reduced proportionally.
|
9251 |
|
| Messenger Ribonucleic Acid (mRNA)–Based Opsin Expression Enables New and Safer Optogenetic Studies |
- Opsin expression using messenger RNA (mRNA) provides an alternative to viral vectors for use in optogenetic studies involving neurons as well as drug testing with cardiomyocytes.
- Expression with mRNAs has lower toxicity and is usually detectable within 2–24 hours rather than 2–3 weeks.
- The controllable and temporary nature of mRNA offers improved expression regulation based on the transfection amount.
|
7534 |
|
| Microfluidic Device Enables Prediction of T-Cell Ability to Home and Engraft to Disease Tissues |
- Improve the homing capabilities of T cells to increase adoptive cell therapy treatment response and safety while decreasing off-target effects.
- Enhance tumor-infiltrating capabilities with engineered microfluidic devices that identify optimal subsets of cells.
- Optimize development pipelines by reducing the number of laborious in vivo studies, while also helping cell therapy companies ensure their products reach the desired tissue.
|
9052 |
|
| mRNA Therapeutic Delivery System Offers Targeted, Sustained HIV Pre-Exposure Protection in the Female Reproductive Tract |
- This system delivers messenger RNA that encodes neutralizing antibodies, which anchor to the female reproductive tract ensuring adequate, sustained tissue concentration for HIV prophylaxis.
- This HIV prevention therapy targets the female reproductive tract and offers month-long protection to reduce office visit frequency and potentially lower medical costs.
- This safe, water-based technology offers ease of administration to enhance patient compliance and prevent systemic complications.
|
8324 |
|
| Predictive Maintenance System for Large-Scale Operations Offers Potential for Significant Cost Savings |
- Consistent workflow improvements: Offers repeatable and consistent enterprise-level improvements to the maintenance workflow.
- Proactive readiness: Improves maintenance scheduling, allowing for improved logistics, scheduling, virtual kitting, and part/component availability.
- Customizable: Customers can build and tailor their PMx solutions according to their needs, providing increased data control and an alternative to costly and limited solutions.
|
8793 |
|
| High-Accuracy, Low-Cost, Low-Power Wireless Tracking Tags |
- Low-cost, ultra-low power wireless tag for real-time asset tracking
- Passive wireless tag costs less than $1 to manufacture and can operate for several years with maintenance-free operation
- Compatible with off-the-shelf devices, making it ideal for efficient inventory control in multiple industries
|
8943 |
|
| Overvoltage Surge Protection System for Distributed Energy Resources |
- iMOV is a dynamic system capable of achieving voltage surge clamping within 20% of the system’s nominal voltage. This effectively provides protection for highly sensitive semiconductors present in DER-associated power converters.
- This system is built upon a metal oxide varistors (MOV) foundation, whose material composition inherently allows rapid device connection of 500 picoseconds for quicker response times.
- iMOV uses integrated microprocessors and sensors in a cloud-based architecture that provides protection against cyberattacks, reduces system cost, and allows system and power grid monitoring.
|
9190 |
|
| Bi-Channel Needle for Injection |
- The injection fluids are completely separated until the tip of the needle, preventing their mixing until they have reached the syringe’s distal tip.
- Since the specific volumes of each drug required will be added to the channels of the syringe, this device reduces the amount of fluid left in the syringe after injection.
- The needle allows the clinician to inject with syringes that are parallel to each other, as opposed to at some oblique angle.
- The length of the device is not limited to the current 1-inch syringe. It can be longer (even greater than 1 meter) for catheter-based procedures.
|
9028 |
|
| AI-Designed High Energy–Density High-Temperature Polymers |
- The present materials are capable of withstanding enormous electric fields at very high temperatures.
- The materials produced are extremely lightweight.
- Vehicles making use of these materials will be lightweight, and lighter vehicles consume less energy.
|
9101 |
|
| Microgeodes Enable Tunable Optical Response for Advanced Coatings/Paint |
- Microgeodes have a programmable structure of nanowires that allows their optical response to be engineered precisely over multiple spectral bands, from UV through mid-IR.
- Microgeodes combine the tunability and versatility of nanowires with the processability of microspheres to provide a photonic materials platform for a wide range of applications.
- Microgeode paints could reduce building surface temperatures by as much as 25°C, offering the potential for significant consumer savings while retaining aesthetically pleasing colors.
|
8866 |
|
| Monitor Vehicle Location and Maintain Vehicle Health During Long-Term Storage |
- Vehicle health and location monitoring system automatically establishes a mesh network for vehicle fleet monitoring by a human, drone, or mobile robot.
- Checks battery and other vehicle health status as well as determines locations of all connected vehicles in storage.
- When a vehicle is found with low battery levels, a mobile robot can safely provide a charge to the battery to get the vehicle running.
|
8938 |
|
| Variable Slope, Multi-Octave Radio Frequency Filters |
- Customizable: The combined signal may be applied to a standard low-pass, band pass, or high-pass optical filter. The filter can be implemented with any number of poles for a maximum defined-slope, and the choice of pass type may be made according to the desired slope direction.
- Variable: By moving the optical carrier up and down in frequency through the transition band, the slope of the RF signal can be continuously varied.
- Versatile: The technology can be used as is or it can augment existing RF lab equipment.
|
7680 |
|
| Lymphatic System-Specific Lipid Nanoparticles |
- This platform technology improves current targeting to lymphatic tissues and specifically lymphatic endothelial cells.
- Provides superior tissue targeting and functional delivery of mRNA to lymphatics via loco-regional dermal or subcutaneous avenues.
- mRNA-based platforms offer a transient and less immunogenic method of delivery compared to protein therapeutics or adeno-associated virus-based platforms.
|
9056 |
|
| Soft Wireless Sternal Patch for Detecting Systemic Vasoconstriction Using Photoplethysmography |
- A wireless, soft sternal patch includes integrated skin-like, photolithographically patterned electronics specifically tuned to continuously measure vasoconstriction from the sternum.
- In overnight trials, the device detected sleep apnea and hypopnea with 95% precision and 100% sensitivity compared to data professionally scored by licensed clinicians.
- Use of this patch on the chest could improve detection of key markers of numerous harmful health conditions.
|
9170 |
|
| Intelligent Eye-Tracking System Offers Next-Gen Technology for Virtual and Augmented Reality (VR/AR) Applications |
- This system uses an AI accelerator chip with 4X higher throughput to achieve over 300 FPS, greatly improving processing speed without loss of accuracy.
- EyeCoD achieves faster communication time by using a lens-less camera that reduces distance between the camera and the accelerator chip.
- Using a “predict-then-focus” model, this system creates highly accurate images as well as improves visual privacy.
|
9202 |
|
| Targeted Single Cell Electroporation for Gene and Cell Therapy |
- The technology enables high efficiency delivery and high post-electroporation cell viability compared to current commercial electroporation systems.
- The technology performs in-flow single cell measurements integrated with electroporation unlike current commercial electroporation systems which have no single cell measurement capabilities.
- The technology enables automatic feedback control and real-time optimization of electroporation parameters at the single-cell level unlike current commercial electroporation systems which apply the same parameters to all cells in a batch at a bulk scale.
- The technology enables selected or targeted electroporation and delivery to selected cells or cell types from a mixture of cells unlike current commercial electroporation systems which require upstream or downstream cell sorting steps.
|
9086 |
|
| Lymphoid Tissue System Harnesses Ex Vivo Immune Reactions for Rapid Antibody Production and Immune Response Prediction |
- This immunocompetent system uniquely accounts for the unexpected activation of various immune cells to allow proper immune cell differentiation, recapitulating an effective immune response.
- The chemokine gradient is switchable, allowing the immune cell differentiation needed for an appropriate immune reaction.
- An ex vivo system supports immune response creation in a controlled environment, allowing reproduction of immunologic events for developing improved therapeutics.
|
9196 |
|
| Expandable Back Drive–Resistant Wedge Improves Payload Support and Security in Satellite and Other Limited-Access Applications |
- This expandable wedge designed to resist back drive creates a more predictable load path for limited-access payloads, such as small satellite installations.
- The design reduces the likelihood of payload damage caused by sudden shock loading that can occur due to the higher stresses of cantilevered loads.
- Two offset, spring-activated pawls make the cartridge resistant to vibration by holding the wedge in place once proper contact has been established.
|
9002 |
|
| Solar Cell Manufacturing Technique Increases Efficiency and Lowers Costs |
- This double-side polysilicon/silicon oxide TOPCon (tunnel oxide passivated contact) solar cell concept provides a simple and low-cost way to passivate front and back surfaces of silicon wafers to enhance efficiency.
- Provides current and voltage comparable to full-area double-side TOPCon but with no appreciable absorption in front polysilicon and without compromising short circuit current density
- Includes a novel and fast way to pattern polysilicon using laser-induced selective oxidation
|
8888 |
|
| Bioabsorbable, Permeable, and Flexible 3D Auxetic Implants Offer Large-Volume Soft Tissue Reconstruction |
- A novel 3D auxetic architecture offers enhanced compressive flexibility, permeability, and nonlinear mechanical behavior.
- This high-performance technology has the potential to generate implants with soft tissue-mimetic biomechanical properties and high mass transfer capacity.
- Implants can be customized for patients by adjusting the strut width and intervals and by fitting the complex anatomic geometry of the defect based on patient medical data.
|
8821 |
|
