| Generative Causal Explanations for Black-Box Classifiers |
- Increased trust: Has the potential to improve the transparency and fairness of machine learning systems and increase the level of trust users place in their decisions
- Flexible explanation vocabulary: Provides a rich and flexible vocabulary for explanation that is more expressive than feature selection or saliency map–based methods
- Deeper insights: Offers visualizations that can be much more descriptive than saliency maps, particularly in vision applications, leading to better user understanding
|
8507 |
|
| Superior Supercapacitors |
- High performance: Achieves average energy densities as high as 90 Wh/Kg
- Scalable: Leverages a low-cost PAN fabrication process that dramatically increases surface area
- Widely applicable: Demonstrates potential for advances in a variety of energy storage and capacitive water desalination applications
|
6201 |
|
| Nanoparticle-Stabilized Carbon Molecular Sieve Membranes for Efficient, Large-Scale Gas Separation |
- Cost efficient: Eliminates the need for the time-consuming process of post-treating precursor fibers in a chemical modifying agent in order to prevent collapse
- Scalable: Increases available surface area for gas separation to accommodate large-scale applications
- Adaptable: Allows for selection of the nanoparticles’ concentration and type to meet a desired combination of gas permeance and selectivity
|
6723 |
|
| Smart Porous Hydrogels to Increase Cold Supply Chain Efficacy of Biologics and Pharmaceuticals |
- Preservation: With the ability to adjust the pore size of the SMH, researchers may be able to increase the rejection rate of bacteria, thereby protecting the medicine by slowing down biodegradation.
- Extended use: Preserving the potency of the transported and stored biologic or pharmaceutical should allow for an improved shelf-life (regardless of the cold supply chain) and an increase in the supply accessible to patients.
- Lower cost: Using Georgia Tech’s SMH for the storage and handling of biologics or pharmaceuticals should minimize the dependence on a cold supply chain, which utilizes freezers that cost between $10,000-$15,000.
|
8685 |
|
| Robotically Steerable Guidewire for Improved Vascular Intervention |
- Robotic: Provides operational improvement of guidewire navigation to facilitate catheter placement by employing robotics, while most other commercially available guidewires lack active steering capability
- Versatile: Controls the guidewire bending angle and also adjusts the bending length of the joint, increasing the capabilities of the guidewire and accommodating varied vasculature geometries
- Flexible: Can be extended to multiple bending sections and degrees of freedom, in stark contrast to passive guidewires that offer clinicians very limited degrees of freedom
|
8451 |
|
| Handheld Breath Collection Device for Detecting Disease Biomarkers |
- Improved diagnosis: Analyzes both the gas and liquid sampled from the patient’s breath for potentially more robust and multifaceted results
- Enhanced patient experience: Requires a shorter exhalation cycle to get a breath sample, making the test more comfortable for patients
- Small and portable: Optimizes and miniaturizes the collection process for easy point-of-care applications
|
8791 |
|
| Microscale High-Throughput Phenotypic Assay for Fibrosis |
- Powerful: Provides high-throughput image-based analysis of fibrotic processes as well as fibrinolysis
- Convenient: Combines label-free readouts for fibrin degradation, collagen synthesis, and cell contraction to evaluate fibrotic tissue remodeling
- Enabling: Opens new opportunities for understanding fibrosis pathogenesis and for evaluating anti-fibrotic therapeutics
|
8502 |
|
| A Chip-Scale Linear Ion Trap to Enable Portable Mass Spectrometers |
- Enabling: Can be used in the development of much smaller mass spectrometers than are currently available—from benchtop devices to handheld or even smaller instruments—which would extend their use to applications in which they are not currently cost effective
- High-performance: Provides better than unit-mass resolution and high detection efficiency, and operates at much higher pressures than larger mass analyzers, as shown during lab-based simulations
- Multi-modal: Allows for several different modes of operation and enables tandem(MS/MS or MS2) or multi-stage/sequential (MSn) mass spectrometry, greatly improving capability compared with other analyzers
|
8137 |
|
| Increasing Medium-Chain Fatty Acid (MCFA) Yield in Bacterial Host with Engineered Enzyme |
- High performance: Increases the yield of MCFAs during chemical and biopolymer synthesis
- Enabling: Improves the microbial production of chemicals that require the expression of heterologous enzymes
- Adaptable: Potentially applies to methods of engineering other heterologous enzymes to interact with endogenous proteins in order to produce molecules of interest in a bacterial host
|
7595 |
|
| Quasi-Melt Processing Technique for Stronger Single-Polymer Composites |
- Highly effective: Facilitates increased fabrication of SPCs using a variety of processing techniques
- Simpler: Eliminates the need to develop a textile preform, which is necessary during fiber hot compaction processing
- Flexible: Is compatible with standard high-throughput melt processes for polymers and plastics
|
5449 |
|
| A Biomimetic Nose with Machine Learning for Advanced Threat Detection |
- Enhanced chemical detection: Reduces proximity issues and enhances detection
- Functional in air and liquid mediums: Can detect single or multiple chemical agents even when the medium contains both a liquid and a gas. An attachment makes it possible to use the device in liquid with air monitoring sensors.
- Continuous improvement: Uses machine learning algorithms to continually improve agent characterization
|
7796 |
|
| Tissue-Selective Anticancer Agents |
- Tissue-targeted activity: Appended macrocyclic skeletons provide selective tissue distribution.
- Potent: HDAC inhibitors display stronger in vivo anticancer activity against solid tumors compared to current technology.
- Lower toxicity: Mice in preclinical experiments did not exhibit significant weight loss, pointing to potentially lower toxicity of these compounds.
|
4195 |
|
| Heat-Responsive Programmable T-Cells |
- Specific: The remote programmable nature of these T-cells allows them to be selectively activated only in the necessary locations.
- Protective: This focused, genetically engineered immunotherapy is intended to protect patients from the additional harm of the off-target cell death and unnecessary systemic damage that is more common with oncological therapeutics.
- Non-invasive: With NIR light’s ability to penetrate into multiple layers of biological tissue and be absorbed by AuNRs, this technology removes the need for a light source in the body to trigger the T-cells.
|
7422 |
|
| Self-Titrating Bacterial Protease-Activated Prodrug |
- Effective: Activates an internal dosing mechanism such that the magnitude of an infection locally determines the prodrug dose
- Robust: Increases the stability of the prodrug form by neutralizing the effective charge of the administered antimicrobial peptide
- Improves safety: Decreases the potential for off-target effects
|
8010 |
|
| Scalable, Low-Cost, Inversion-Free Method of Enabling Automated Underside Cell Seeding |
- Convenient: Eliminates the need for inversion procedures, which tend to be tedious, difficult to automate, and prone to failure—especially for 96-well inserts due to their limited culture area
- Generalizable: Developed for screenings that focus on the air-blood barrier, but can also be applied to gut, skin, oral mucosa, and other organ systems
- Scalable: Employs a simple method that is extensible to automated processes for high-throughput drug screenings and pharmacological tests
|
8677 |
|
| Rapid Development of SARS-CoV-2 Monoclonal Antibodies |
- Powerful: Demonstrates potential to recognize intact SARS-CoV-2 virions with high affinity
- Highly efficient: Enables researchers to select pairs of high-affinity antibodies that bind to different receptor sites, maximizing the efficiencies of sandwich-style rapid testing methods
- Enabling: Furthers the development of neutralizing antibodies that can be used as therapeutic agents, delivered either directly or via mRNA for in situ expression
|
8487 |
|
| Real-Time Mobilization of Computer Software Applications |
- Comprehensive: Overcomes speed, traffic, and interface limitations of basic remote computing
- Resourceful: Allows for seamless function without a high data usage burden
- Efficient: Applies unique transformation services to accelerate and enhance the user’s mobilized application experiences
|
5798 |
|
| AwareSite Proximity Safety Sensing System for Construction and Other Work Sites |
- Improved work safety and efficiency: Not only are accidents prevented when workers and equipment operators are alerted that they are crossing set safety boundaries, their proximity and movement data are also stored in the cloud and can be used to analyze work patterns that could improve safety, work process efficiency, and more.
- Low-cost and flexible hardware: The system uses inexpensive custom PPU devices but can also be paired with workers’ personal smartphones for connecting to the system.
- User friendly and reliable: System setup and operation is simple. Beacons use Bluetooth® low-energy technology and can last more than one year without changing batteries.
|
7970, 7971 |
|
| Advance Warning System for Improved Safety in Roadway Work Zones |
- Enhanced safety: Rather than relying on impact-activated devices, the system issues real-time warnings as soon as the perimeter is breached, providing more time for workers to react and get to safety.
- Portable and changeable: The system can be easily moved or adjusted to accommodate changes to the work zone during the day.
- Smart analytics: Analysis of intrusion data helps pinpoint areas within the work zone that are more susceptible to breaches, enabling more effective and efficient security.
|
7397 |
|
| Rapid Mobilization of Essential Enterprise Applications |
- Rapid: Significantly reduces time needed to mobilize an enterprise application as compared to conventional mobilization solutions
- Cost-efficient: Leverages a cloud-based, codeless platform that saves on both time and budget
- Flexible: Demonstrates potential to efficiently provide mobile functionality for a wide variety of applications necessary for business operations
|
5583 |
|
