Technologies | Office of Technology Licensing

Available Technologies by Category
Tissue-Selective Anticancer Agents	Tissue-targeted activity: Appended macrocyclic skeletons provide selective tissue distribution. Potent: HDAC inhibitors display stronger in vivo anticancer activity against solid tumors compared to current technology. Lower toxicity: Mice in preclinical experiments did not exhibit significant weight loss, pointing to potentially lower toxicity of these compounds.	4195
Heat-Responsive Programmable T-Cells	Specific: The remote programmable nature of these T-cells allows them to be selectively activated only in the necessary locations. Protective: This focused, genetically engineered immunotherapy is intended to protect patients from the additional harm of the off-target cell death and unnecessary systemic damage that is more common with oncological therapeutics. Non-invasive: With NIR light’s ability to penetrate into multiple layers of biological tissue and be absorbed by AuNRs, this technology removes the need for a light source in the body to trigger the T-cells.	7422
Self-Titrating Bacterial Protease-Activated Prodrug	Effective: Activates an internal dosing mechanism such that the magnitude of an infection locally determines the prodrug dose Robust: Increases the stability of the prodrug form by neutralizing the effective charge of the administered antimicrobial peptide Improves safety: Decreases the potential for off-target effects	8010
Scalable, Low-Cost, Inversion-Free Method of Enabling Automated Underside Cell Seeding	Convenient: Eliminates the need for inversion procedures, which tend to be tedious, difficult to automate, and prone to failure—especially for 96-well inserts due to their limited culture area Generalizable: Developed for screenings that focus on the air-blood barrier, but can also be applied to gut, skin, oral mucosa, and other organ systems Scalable: Employs a simple method that is extensible to automated processes for high-throughput drug screenings and pharmacological tests	8677
Rapid Development of SARS-CoV-2 Monoclonal Antibodies	Powerful: Demonstrates potential to recognize intact SARS-CoV-2 virions with high affinity Highly efficient: Enables researchers to select pairs of high-affinity antibodies that bind to different receptor sites, maximizing the efficiencies of sandwich-style rapid testing methods Enabling: Furthers the development of neutralizing antibodies that can be used as therapeutic agents, delivered either directly or via mRNA for in situ expression	8487
Real-Time Mobilization of Computer Software Applications	Comprehensive: Overcomes speed, traffic, and interface limitations of basic remote computing Resourceful: Allows for seamless function without a high data usage burden Efficient: Applies unique transformation services to accelerate and enhance the user’s mobilized application experiences	5798
AwareSite Proximity Safety Sensing System for Construction and Other Work Sites	Improved work safety and efficiency: Not only are accidents prevented when workers and equipment operators are alerted that they are crossing set safety boundaries, their proximity and movement data are also stored in the cloud and can be used to analyze work patterns that could improve safety, work process efficiency, and more. Low-cost and flexible hardware: The system uses inexpensive custom PPU devices but can also be paired with workers’ personal smartphones for connecting to the system. User friendly and reliable: System setup and operation is simple. Beacons use Bluetooth® low-energy technology and can last more than one year without changing batteries.	7970, 7971
Advance Warning System for Improved Safety in Roadway Work Zones	Enhanced safety: Rather than relying on impact-activated devices, the system issues real-time warnings as soon as the perimeter is breached, providing more time for workers to react and get to safety. Portable and changeable: The system can be easily moved or adjusted to accommodate changes to the work zone during the day. Smart analytics: Analysis of intrusion data helps pinpoint areas within the work zone that are more susceptible to breaches, enabling more effective and efficient security.	7397
Rapid Mobilization of Essential Enterprise Applications	Rapid: Significantly reduces time needed to mobilize an enterprise application as compared to conventional mobilization solutions Cost-efficient: Leverages a cloud-based, codeless platform that saves on both time and budget Flexible: Demonstrates potential to efficiently provide mobile functionality for a wide variety of applications necessary for business operations	5583
Skin-Conformal Wearable Stress Monitor Delivers Greater Precision and Continuous, Wireless Monitoring with Comfort and Flexibility	All-in-one: The personal adhesive bandage-like single device platform offers wireless, multi-data sensing by simply mounting it on the skin. Disposable: This wearable device is fully disposable after the use and the measured data can be simply sent to the cloud via a tablet or smartphone app. Compact: The unique, thin design of this bioelectric device is one-sixth the volume of current market offerings—weighing less than 7 g, including its rechargeable battery.	8414
Using Smart Macros to Optimize User Actions on Smartphones	Improves user experience: Provides near-desktop level experience for the mobile phone environment Easy to use: Reduces user burden by presenting programmable macros in a simple and user-friendly manner Causes minimum overhead: Does not contain any process that degrades the remote desktop performance because of high requirements for the central processing unit (CPU) or memory	5501
Super Aggregation: Multihoming for Wireless Devices	Performance-improving: Improves the aggregate performance of multiple heterogeneous wireless interfaces used simultaneously compared to the performance each could achieve on its own Proven: Indicates TCP acceleration achieved in wireless data networks when tested on two mobile platforms, including a laptop computer and an Android™ mobile phone Impactful: Addresses the performance improvement needs of ubiquitous, widely used mobile technologies	4712
Fully Passive, Long-Range Radio-Frequency Identification (RFID) via 5G	Large coverage: Provides a unique combination of large angular coverage and turn-on sensitivity in both planar and bent configurations Long range: Demonstrates the potential for RFIDs with practical reading ranges over 1.8 km Scalable: Scales in size to a precise degree, enabling selection of the optimal tradeoff between size and harvested power/reading range	8141, 8439
Smart Webcam Shield Protects Users from Unknown External Digital Intrusion	Secure: Offers visual obstruction of the webcam even when remote software attempts to record without triggering the computer’s LED indicator Reliable: Automates the webcam safeguard for ongoing protection without reliance on user engagement Flexible: Enables two different actuators via the same sensor	8610
Adaptive Broadband Impedance Matching in Ultrasound Front-End Electronics	High performance: Improves power transfer and acoustic reflectivity Flexible: Enables multimodal and tunable operation of CMUTs Efficient: Provides optimal matching for co-design of CMUT electronics	8342
Purely Passive Radio-Frequency Identification	Powerful: Projected to support energy harvesting sensors at distances over 100 meters from readers and/or radio transmission sources Efficient: Enables conversion of RF energy at higher efficiency and at higher output voltages than current electronic energy harvesting methods Widely applicable: May advance RFID applications in a wide range of fields including computing, sensing, and communication	7194
IMUTube: Converting Videos of Human Activity into Virtual IMU Data Streams	Automated: Automates wearable sensor data collection, which can in turn be used to train HAR models by simply giving them access to large-scale video repositories Accurate: Demonstrated recognition accuracy in some cases comparable to models trained only with non-virtual (“real”) sensor data in benchmark studies Superior: Outperformed models using real sensor data alone by adding only small amounts of real sensor data to the virtual sensor dataset in benchmark studies	8538
Miniaturized Modular-Array Fluorescence Microscopy	Powerful: Offers high fluorescence sensitivity, efficiency, and spatiotemporal resolution (~3 µm and up to 60 Hz) Configurable: Offers compatibility with conventional cell culture assays and physiological imaging, providing accessibility to upright physiological imaging and integration with biochemical sensors under the cell platform Efficient: Provides effective parallelization of multi-site data acquisition	8580
Post-Processing Side Chain Cleavage to Enhance Conjugated Polymers	Advanced: Can increase electrical conductivity of doped polymer films by tenfold while decreasing the Seebeck coefficient from 46 μV/K to 18 μV/K, resulting in a doubling in thermoelectric power factor Robust: Demonstrates an increase in both in-plane and through-plane thermal conductivity upon hydrolysis Best-in-Class: Surpasses the S/cm value of any currently reported oligoether/glycol-based CP system	8702
Sustainable Combination Technology Delivers a Long-Lasting Self-Powered Battery	Continuous: Regulates power harvested in the presence of constant mechanical motion to store excess energy while pushing a constant voltage to the external load Eco-friendly: Reduces the need for consumers and technology developers to utilize supply-limited traditional batteries that are thrown away after a short use and could leak harmful chemicals into the environment Sustainable: Eliminates the need to mine an additional power supply by harvesting energy from underutilized electrostatic induction found in naturally occurring mechanical motion	6418