Interactions between different cell types can now be studied without the need for labor-intensive manipulations. This technology, developed by researchers at Georgia Tech, is a microfluidic device that automatically traps microscale particles, such as cells, in chambers where they can then be imaged using light or fluorescent microscopy. Due to its unique design, this device allows controllable pairing of different ratios of cells. This device and method enable interactions between defined numbers of each cell type to be observed in real time.
This technology provides the ability to study cell-cell interactions, which is of particular interest in the field of cellular therapies for cancer treatments. Beyond studying cells, the technology can also be adapted for assessing other microscale objects of interest such as embryos, worms, or microparticles.
- Simple: Requires no valving or active components
- Adaptable: Can be modified to study any number or type of cells
- Precise: Provides the ability to pair cells with exact ratios in a deterministic manner
- Analytical tool for commercial manufacturing of chimeric antigen receptor T-cell (CAR T-cell) therapy and other cell therapies for treating cancer and other diseases
- Biomedical Research tool
- Other indication fields
- Diagnostic tool
Used to observe cells and their interactions, current microfluidic technologies pair only one cell of one type with one cell of a second type, or pair higher numbers of cells but cannot do so in a controlled and reproducible manner. Current non-microfluidic technologies also do not provide the ability to precisely pair two or more cells and cell types and observe those cells and their interactions at a single cell level and with exact ratios in a deterministic manner. This Georgia Tech innovation addresses those limitations.