Biotechnology | Technology Licensing

Available Technologies by Category

Melting Microneedle Patches Extend Drug Delivery Applications, Simplify Manufacturing, and Reduce Costs Melting microneedles enable dispersion of both poorly soluble and water-soluble drugs, which eliminates the need for solvents for improved stabilization and broader applications. Melting microneedles shorten manufacturing and drying time, eliminate the need to maintain a cold chain for storage and transportation, and reduce the ultimate cost of the microneedle patch. The safe suppository bases are inexpensive and enable control of the drug release timing.	8904
Novel Nanocarriers Strengthen Therapeutic Delivery, Improves Efficacy Greater therapeutic effectiveness is due to the synergistic work of multiple therapeutic agents (hydrophobic/hydrophilic charged) that can be delivered via this dual-loaded biomaterial. The risk of immunotoxicity to a vaccine is reduced because an adjuvant, which can induce the body’s anti-inflammatory immune response, may be loaded and simultaneously delivered with the vaccine. The novel nanocarrier has broad market application since it can deliver vaccines, gene therapy, small molecule drugs, and even contrast agents.	8988
Automated Bioreactor Sampling System Can Eliminate Cross-Contamination of Samples Automated bioreactor sampling system maintains sample integrity by changing the syringe between samples In addition to savings related to reduced cross-contamination, automated sampling can further lower costs by reducing hands-on time and speeding sampling. Flexible platform can be used with any type of collected sample.	8886
Efficiently Generating Complex Hydrogel Structures for Tissue/Organ-on-a-Chip Models Faster: Reduces preparation time from several hours to minutes Simplified: Generates complex patterns, including perfusable channels, using light-triggered polymerization of synthetic hydrogels and photomasks rather than current equipment-intensive methods that use laser-based patterning or ablation techniques Lowers regulatory burdens: Using synthetic rather than biological matrices simplifies regulatory hurdles, increases reproducibility from batch to batch, and increases tunability of the mechanical and biochemical properties of the matrix	8838, 8839
patcherBotPHARMA Automated Intracellular Pharmacological Electrophysiology Robot Increased efficiency: Autonomous operation ensures accurate placement of components and creates high success rates for experiment completion. Decreased human effort: Performs typical ligand-gated ionotropic receptor experimentation protocols autonomously for up to a tenfold reduction in operator interaction time over the duration of the experiment Higher experiment yield: Rapidly replicates previous datasets, reducing the time to produce an 8-point concentration response curve from weeks of recording to ~13 hours of recording	8717
Simulated Synovial Fluid Offers Potential for Effective Treatment of Knee Osteoarthritis Osteoarthritis (OA)-simulated synovial fluid (simSF) provides the opportunity to evaluate how different cell therapies respond to an OA-like environment. By analyzing OA patient-derived synovial fluid (pdSF) and developing potency assays, researchers created a simSF comparable to pdSF that overcomes patient variability. The simSF allows for the investigation of OA biology with greater reproducibility of predictive outcomes and could advance effective treatment of knee OA.	8956
“Smart” Feedback-Controlled Bioreactor Platform Enables Consistent High-Yield and High-Quality MSC Products Scaled-down feedback-controlled hollow fiber-based bioreactor enables identifying the critical quality attributes and critical process parameters for high-quantity and high-quality hCT-MSCs for ideal cell growth and efficacy Provides the controls to maintain optimum conditions and improve expansion yield and cell viability System can be adapted and applied to industrial cell therapy manufacturing and can enable high-yield and high-quality products while minimizing variabilities	8887
Reducing Intraocular Pressure in Glaucoma Patients Without Drugs or Surgery via a Simple Hydrogel Injection Hydrogel injections alleviate elevated intraocular pressure (IOP) with fast results and extended impact. Surgery-free approach eliminates the risk of tissue damage caused by a surgical incision or laser application. Simplified and effective treatment process from standard daily drug intake to a brief office visit only once every 4-6 months.	8467
Synthetic Hydrogel for Satellite Cell Delivery in Dystrophic Skeletal Muscle Addresses the critical need for a viable treatment for deterioration of the diaphragm, which is a leading cause of respiratory failure and death in Duchenne Muscular Dystrophy patients Engineered hydrogels comprised of synthetic polymers and peptides are designed to enable successful muscle satellite cell (MuSC) transplantation to the diaphragm or other dystrophic skeletal muscle tissue Shown to support MuSC survival, proliferation, and differentiation, which can enable restoration of dystrophin – a protein absent in DMD and critical to strengthening and repairing muscle fibers	7841
Synthetic Hydrogels for Human Organoid (HO) Generation and Transplantation Synthetic hydrogel exhibits high cytocompatibility and minimal toxicity and inflammation in vivo for improved human organoid viability Injectable delivery vehicle supports localized HO engraftment in mucosal wounds to potentially enhance wound closure and repair Modular design and delivery via endoscopic techniques enables the translational potential of this delivery platform for regenerative medicine and overcomes limitations associated with the use of commercially available matrices for hPSC-based organoid technologies	7536
Hybrid Molecular Catalysts: A New Blueprint for Catalyst Design, Preparation, and Testing Attachment of molecular catalysts to solid supports can lead to new reactivity not seen under homogeneous conditions At an optimal atomic layer deposition (ALD) layer thickness, the molecular catalyst remains highly active while still being resistant to surface detachment and subsequent deactivation Catalyst separation and recovery achieved via a simple filtering and washing process rather than energy- and time-intensive distillation or re-crystallization processes In addition to the simple filter-and-wash process mentioned above, encapsulation requires only about 10 reaction cycles, making this process technologically and economically viable for large-scale manufacturing	8537
Advanced Manufacturing of Biodegradable Shape Memory Polymers Increases In Vivo Success Faster healing: Improvements catalyze the regeneration of tissue for a faster recovery Increased efficacy: Decreases the likelihood of rejection because the polymers are manufactured in such a way to increase tissue ingrowth and cell attachment Reduced healthcare resource utilization: When initial implantation is successful, it reduces the need for secondary procedures or advanced clinical care for infection	8658
Hydrogels for Controlled Delivery of Lysostaphin to Treat Staphylococcus aureus Infections Injectable (or surgically applied) hydrogel formulation conforms and adheres to the fracture and surrounding tissue, ensuring efficient, local delivery of lysostaphin Localized treatments enable higher relative doses to be given at the site of infection, and enhanced stability from the hydrogel carrier may reduce the number of overall doses needed Tunable nature of the material provides control over the amount and time over which lysostaphin is delivered	7729
Scalable Manufacturing Approach of Graded Polymer Thin Film Has Potential for Widespread Use Combines slot die coating with a custom roll-to-roll imaging system to allow for efficient, rapid, and scalable fabrication of high-quality gradient thin films. An improved manufacturing process over existing techniques because it uses broad material combinations and yields higher quality patterned thin films. Incorporates multiple materials to increase the application of patterned thin films across industries, including microelectronics, energy technologies, and environmental systems.	8994
New Methods for Skin Tissue Engineering: Textile-Based Sandwich Scaffold and CNT-based Electrospun Polymer Composite Yarns Biocompatible: Exhibits good biocompatibility of the yarns fabricated using a wet electrospinning technique (results shown within a limited range of CNT concentration in the bath) Purposeful: Mimics the strain-stiffening behavior of human tissue, unlike other scaffolds that exhibit strain-softening of their synthetic materials Demonstrated: Exhibits the ability to guide cell anisotropic arrangement as well as support cell proliferation and infiltration in in vitro biological tests	8751, 8752
A Biological Computing Framework for Living Systems Innovative: Builds on probabilistic computing principles to construct analog biological bits, enabling an entirely new set of logic gates and algorithms and potentially allowing users to solve previously intractable problems Robust: Can sense every extracellular protease encoded in the human genome, for which there is a known peptide substrate, enabling a simple plug-and-play framework for communicating with a variety of biological activities and offering performance competitive with DNA-based computers but with increased processing speed Relevant: Provides a framework based on biological activity and constructed from biological materials, which enables a direct interface with and understanding of living materials and systems	8009
Smart Porous Hydrogels to Increase Cold Supply Chain Efficacy of Biologics and Pharmaceuticals Preservation: With the ability to adjust the pore size of the SMH, researchers may be able to increase the rejection rate of bacteria, thereby protecting the medicine by slowing down biodegradation. Extended use: Preserving the potency of the transported and stored biologic or pharmaceutical should allow for an improved shelf-life (regardless of the cold supply chain) and an increase in the supply accessible to patients. Lower cost: Using Georgia Tech’s SMH for the storage and handling of biologics or pharmaceuticals should minimize the dependence on a cold supply chain, which utilizes freezers that cost between $10,000-$15,000.	8685
A Chip-Scale Linear Ion Trap to Enable Portable Mass Spectrometers Enabling: Can be used in the development of much smaller mass spectrometers than are currently available—from benchtop devices to handheld or even smaller instruments—which would extend their use to applications in which they are not currently cost effective High-performance: Provides better than unit-mass resolution and high detection efficiency, and operates at much higher pressures than larger mass analyzers, as shown during lab-based simulations Multi-modal: Allows for several different modes of operation and enables tandem(MS/MS or MS2) or multi-stage/sequential (MSn) mass spectrometry, greatly improving capability compared with other analyzers	8137
Increasing Medium-Chain Fatty Acid (MCFA) Yield in Bacterial Host with Engineered Enzyme High performance: Increases the yield of MCFAs during chemical and biopolymer synthesis Enabling: Improves the microbial production of chemicals that require the expression of heterologous enzymes Adaptable: Potentially applies to methods of engineering other heterologous enzymes to interact with endogenous proteins in order to produce molecules of interest in a bacterial host	7595
Scalable, Low-Cost, Inversion-Free Method of Enabling Automated Underside Cell Seeding Convenient: Eliminates the need for inversion procedures, which tend to be tedious, difficult to automate, and prone to failure—especially for 96-well inserts due to their limited culture area Generalizable: Developed for screenings that focus on the air-blood barrier, but can also be applied to gut, skin, oral mucosa, and other organ systems Scalable: Employs a simple method that is extensible to automated processes for high-throughput drug screenings and pharmacological tests	8677
Advancing Mass Spectrometry with Novel Interface Flexible: Allows for integration with a range of operational modes and analytical workflows for different ESI-MS techniques High performance: Offers enhanced sensitivity and a significantly improved limit of detection Robust and effective: Minimizes charged ion loss and enables sampling of the most analytically “valuable” droplets	4182
2D Array Device Simple – does not require microstructure fabrication or periphery equipment, such as pressure-driven pumps to operate Unique – loading method enables rapid sample loading and high-percentage sample isolation simultaneously Cheaper – improvements in efficiency and robustness reduce complexity and overhead expenses	8253
Disposable Impedance Biosensor for Cell Manufacturing Multi-point measurements- provide tempo-spatial profiles of culture attributes and can print a wide range of conductive and insulating materials on both rigid and flexible substrates with non-planar surfaces Wireless - collects the signal wirelessly via printed antennas to simplify the integration to different types of existing bioreactor technologies Safe - system does not apply contact, and minimizes any chance of harm or contamination to affect the cell culture	8270
A Technique for Integrating Photographs for Medical Imaging Examinations Prevents the application of incorrect patient identification at the time of medical image generation Allows the correlation of serial imaging studies by ensuring that all studies are from the same patient Avoids the generation of incorrect reports	6402
Microfluidic Platform for Phase Separation of Aqueous Solutions Efficient workflow- sample removal and analysis can be performed without manual oversight Smaller sample size- less sample volume required alleviating dilution of low concentration solutions that is common in alternative sample preparation workflows Faster process- thermoelectric cooling can induce separation in a matter of seconds with precision and tunability	8247
Method for Treatment of Pathologies Fast - activity is immediate (within 2 hours) Easy to use - applied to nasal sprays or skin patches Safe – less immunogenic	7878
Organ Transplant Decision Aid Simple – easy-to-use interface for entering patient and donor characteristics Flexible – separate survival models use different variables which enhance the performance of each model Multifaceted – calculates survival probabilities for multiple organs where current technologies only determine survival probability for kidneys	8001
Pterin-Based Hydroxylation of Aromatic Monomers Could provide substantial high value intermediates Enzymatic catalysis is more energy efficient, yields less (industrial type) waste than chemically based methods Higher level of precision than most chemical reactions	6943
GPCR-Based Biosensors for Medium-Chain Fatty Acids Innovative – first medium-chain fatty acid biosensor Cost Saving – enables more rapid production Diverse applications – applications that require different dynamic and linear ranges	6767
Method for Making Thermally Conductive Materials Property tuning capability Improved surface wettability and electrical conductivity which improved alignment of polymer chains Increased thermal capability	6725
A Method for Exhaustive CRISPR Off-Target Analysis Provides exhaustive genomic searches for off-target sites due to mismatches, deletions, and insertions Provides primers for experimental validation of predicted off-target sites Facilitates experimental testing using assays or deep sequencing of potential off-target sites given in the output	6478
Surface Nanomodification by Microwave Hydrothermal Treatments Cost and Energy efficient- requires shorter times of surface modification with a lower concentration of solvents Less hazardous- lower concentrations of solvents decrease the negative environmental impact Versatile- though primarily related to biotechnology, this method can be applied in any industry requiring surface modification	5784
Polymer Wrapping of Single Wall Carbon Nanotubes Scalable – process can be easily scaled up to enable commercial applications Flexible – PMMA wrap can be applied through a variety of processing conditions Removable – helical wrap allows PMMA to be removed without damaging nanotube	7213

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