Biological | Technology Licensing

Available Technologies by Category

A Biological Computing Framework for Living Systems Innovative: Builds on probabilistic computing principles to construct analog biological bits, enabling an entirely new set of logic gates and algorithms and potentially allowing users to solve previously intractable problems Robust: Can sense every extracellular protease encoded in the human genome, for which there is a known peptide substrate, enabling a simple plug-and-play framework for communicating with a variety of biological activities and offering performance competitive with DNA-based computers but with increased processing speed Relevant: Provides a framework based on biological activity and constructed from biological materials, which enables a direct interface with and understanding of living materials and systems	8009
Adaptive Broadband Impedance Matching in Ultrasound Front-End Electronics High performance: Improves power transfer and acoustic reflectivity Flexible: Enables multimodal and tunable operation of CMUTs Efficient: Provides optimal matching for co-design of CMUT electronics	8342
Advancing Mass Spectrometry with Novel Interface Flexible: Allows for integration with a range of operational modes and analytical workflows for different ESI-MS techniques High performance: Offers enhanced sensitivity and a significantly improved limit of detection Robust and effective: Minimizes charged ion loss and enables sampling of the most analytically “valuable” droplets	4182
AFM Cantilevers for Operation in Air and Immersion Efficient — enables fast actuation with integrated electrostatic actuators Accuracy — accurate force measurements with nanoscale lateral resolution Improved speed — improvement for both speed of actuation and accuracy of detection	3629
Airy-beam Tomographic Microscopy for Biological Imaging Streamlined: Offers a scan-free method of obtaining 3D-resolution images Volumetric imaging: Generates and resolves images of tissues and cells in the 3D space High resolution and image depth: Provides 3D diffraction-limited resolution	8381
All-Electronic Immunophenotyping Device for Point-of-Care Testing Convenient: Provides an all-electronic immunophenotyping process with straightforward equipment and techniques Low cost: Performs sophisticated, multistep analyses in a system that is affordable enough for point-of-care settings Flexible: Allows for the easy immobilization of multiple antibodies in the device—a shortcoming of current systems	8045, 8047
Alveolar Breath Separation and Collection Device Simple: this device has fewer components than prior devices Inexpensive: this device is less expensive than previous devices due to its simpler design	4734
Biopolymer Fabricated Materials for Biomaterials Novelty – first technology that enables the formation of biopolymer brushes at interfaces of any thickness Incredibly biocompatible – hyaluronan has many salient features such as being non-fouling, non-immunogenic, and viscoelastic that make it a common polymer used in biomedical applications Potential for regenerative technology – further applied in regenerative interface technology research	7535
Block Resonator Biosensor with Annexed Platform Improved mass sensitivity High-quality in air Simplicity in fabrication	3255
Cancer Diagnosis Using Nanotechnology Can be used with a simple microscope More sensitive and cost-effective Non-toxic	3424
Carbon Nanotube Electrode Array for Neural Prosthetics Densely packed CNT arrays allow for better bio-incorporation, prevention of glial scarring, chronic inflammation, and neuronal cell loss Readily functionalized to promote neuronal growth and tissue-electrode adhesion, enhancing electrode performance and quality of read-out signals Inherent mechanical stiffness enhances the rigidity of adjacent CNTs preventing buckling as in other high-aspect probe systems.	4434
Cell-free Biosensors to Detect Creatinine, Creatine, and Sarcosine Portable: This technology demonstrates the potential to develop point-of-care screening and monitoring, which is essential to expanding access to care worldwide, including to low- and middle-income countries. Inexpensive: CFE-based biosensors can cost as little as a few cents per test and could provide a low-cost alternative to current renal function monitoring and diagnosis, which currently involves laboratory visits, trained phlebotomists, skilled technicians, and expensive, specialized equipment. Cell-free: The use of a cell-free expression system could enable easier-to-read quantitative output that is less susceptible to matrix effects.	8776
Chemotaxis Bacterial Cell Separation and Preconcentration Ease-to-use – Sensor design is simple and device is self-powered Versatile – Allows detection of: NOx, SOx, H2S, CH4, CO, CO2, H2O, HCL, NH3, PH3, toluene, and mercaptons Reliable – Design allows analysis with low power consumption at high temperatures	6535
Detecting Change of Dielectric Constant Enables detection of materials based on changes to the effective dielectric constant of a circular resonator Measures the index of refraction to detect the change in optical wavelength that is occurring Able to detect the power of the electromagnetic wave in the circular resonator at resonance condition and/or during build-up stage	2839
DetectIV Offers Noninvasive Early IV Infiltration and Extravasation Detection DetectIV provides a continuous, noninvasive, and wireless IV infiltration and extravasation detection system. The sensor does not cover the IV site and works well with all skin types—significant improvements over existing detection devices. The device detects infiltrations on average 2 hours ahead of nursing standard of care making it an effective early detection system that prevents extended hospital stays.	7207
Disposable Cassette for Dialysis Efficient- designed to minimize human error and reduces set-up time of dialysis treatment Automated- enables automated dialysis mode selection using radio frequency identification Disposable- eliminates potential contamination in patient treatment	7111
Efficiently Generating Complex Hydrogel Structures for Tissue/Organ-on-a-Chip Models Faster: Reduces preparation time from several hours to minutes Simplified: Generates complex patterns, including perfusable channels, using light-triggered polymerization of synthetic hydrogels and photomasks rather than current equipment-intensive methods that use laser-based patterning or ablation techniques Lowers regulatory burdens: Using synthetic rather than biological matrices simplifies regulatory hurdles, increases reproducibility from batch to batch, and increases tunability of the mechanical and biochemical properties of the matrix	8838, 8839
Eliminating Phase Separation Issues Phase separation is eliminated Growth process is faster Processing temperatures are lower and over a wider range	5459
Embedded Wireless Temperature Sensor for Orthopedic Implants Utilizes temperature as indication of deep tissue infection Deep tissue measurement vs. only reaching skin surface Non-invasive monitoring	7682
Enabling Rapid Detection of Label-Free RNA for Use in COVID-19 Testing Earlier detection: Identifying the viral components themselves—rather than the body’s reaction to the viral presence (i.e., antibodies)—potentially improves early detection in asymptomatic subjects. Simpler process: Use of minimal reagents and fewer preparatory steps is designed to enable more efficient and facile sample preparation. Avoidance of “wash steps” aims to minimize target loss. Fewer disruptions: Avoiding the use of high-demand supplies (e.g., swabs) and reagents potentially reduces supply-chain and contamination issues.	8669
EnerCage: A Scalable Array of Wireless Sensor Modules Wireless Functional with small animals Scalable	4367
Facile Synthesis of Ultrathin Silver Nanowires Produces Ag nanowires less than 20 nm in diameter, with high aspect ratios (over 1000), and in high yield (>85%) One pot, quick (< 35 min) synthetic process that is performed under ambient pressure Great mechanical flexibility and can be bent at acute angles without breaking	6791
Facilitating Ultrasound Penetration of the Skull for Diagnosis and Treatment Portable: Designed to enable imaging of the brain via small, mobile ultrasound devices, which may offer greater convenience compared with MRI and CT machines Affordable: May be a lower cost modality compared with leading techniques, such as MRI, CT, or positron emission tomography (PET) Robust: Demonstrates energy transmission through the skull on par with that of an aqueous medium in preliminary testing	8340
Fast Evaporating Polymers and Copolymers Cross-linking Incorporation of small molecules that are capable of amplification Residue reduction Waste elimination	7472, 7645
Fast Microscale Actuators for Probe Microscopy Enables fast and parallel actuation with integrated electrostatic actuators and built-in optical displacement sensors Accurate force measurement with nanometer resolution in parallel single-molecule mechanics experiments Novel FIRAT structures for high speed AFM imaging in liquid environments	3916
Fluorescent Nanoprobes for Live-Cell RNA Imaging Sensitive — can image single molecules with multiple emission wavelengths Fast — probe is multivalent and bind to RNA in less than 10 minutes Low cost — the alternative dual-label probes are more expensive	4513
Fourier Light-Field Microscope (FLFM) for Fast, Volumetric, and High-Resolution Imaging of Entire Organoids Cost-efficient and scalable: Is fully adaptable to epifluorescence protocols resulting in a system that is both cost-efficient and highly scalable Fast: Captures fast cellular and tissue dynamic processes in a simultaneous, volumetric manner (e.g., collective cellular responses at sub-second time scales across whole samples) Validated: Responses to extracellular physical cues such as osmotic and mechanical stresses have been recorded using human induced pluripotent stem cell-derived colon organoids (hCOs).	8844
Glucose Regulation Via Electrical Stimulation Of Nerves Needle-free blood glucose control. Potential to either eliminate or decrease use of blood glucose control medications. First demonstrated use of electrical stimulation to inhibit nerve activity to cause a decrease in measured blood glucose levels	6745
GPCR-Based Biosensors for Medium-Chain Fatty Acids Innovative – first medium-chain fatty acid biosensor Cost Saving – enables more rapid production Diverse applications – applications that require different dynamic and linear ranges	6767
Handheld Breath Collection Device for Detecting Disease Biomarkers Improved diagnosis: Analyzes both the gas and liquid sampled from the patient’s breath for potentially more robust and multifaceted results Enhanced patient experience: Requires a shorter exhalation cycle to get a breath sample, making the test more comfortable for patients Small and portable: Optimizes and miniaturizes the collection process for easy point-of-care applications	8791
High Throughput Spectrometer Low cost – decrease in the number of components decreases cost Compact – decrease in the number of components decreases size High resolution – improvements in hologram recording maintain high resolutions	3548
High-Precision Microphone for Body-Worn Devices Wearable small form-factor (micro-chip technology) Increased sensitivity (micro-gravity sensitivity) Large bandwidth (DC to 10kHz) and wide dynamic range (120dB)	7891
Hybrid Meta-Surfaces for Active, Non-Volatile Light Manipulation Fast: Enables highly dense pixels with fast (nanosecond) switching capability Scalable: Can be fabricated with features down to nanometer sizes; the overall device can incorporate several meta-surfaces with different features over a large-size wafer Agile: Offers high switching robustness (up to 1012 cycles)	8530
Increasing Medium-Chain Fatty Acid (MCFA) Yield in Bacterial Host with Engineered Enzyme High performance: Increases the yield of MCFAs during chemical and biopolymer synthesis Enabling: Improves the microbial production of chemicals that require the expression of heterologous enzymes Adaptable: Potentially applies to methods of engineering other heterologous enzymes to interact with endogenous proteins in order to produce molecules of interest in a bacterial host	7595
Integrated Force Sensing for Probe Microscopy Optimization of the optical detection sensitivity in air or liquid Mini AFM configuration able to form images in very small volumes Multi-tip nanosensors with simultaneous, multifunctional capabilities	3527
Integrated Force Sensor Fabrication Process Fast actuation Allows for integration of sensor cantilevers	3536
Intravascular and Intracardiac Ultrasound Imaging Probes Simple - significantly reduces the complexity and area requirement Increased rate - allows the collection of a reduced number of data from the available dataset to get faster data collection and enough frame rates Powerful - generates high voltage transmit pulses and low noise amplification of the CMUT output current	5194
Lab-on-a-Headset Ocular Monitoring Device Low cost Monitor both eyes simultaneously Can be remotely configured	7814
Measuring Surface Antigen Expression via Microflow Cytometry Portable: This innovation uses a disposable, handheld device without bulky or costly equipment, which is expected to be especially useful in low-resource settings. Simple: It is designed to achieve results similar to those from a commercial flow cytometer but without requiring initial purification. Recoverable samples: Unlike commercial systems, the analyzed sample can be recovered for further tests at the end of the analysis.	7913, 8048
Measuring Visual Attention Deficits in Mammals Simultaneously studies circuit activity and cognitive dysfunction in genetically defined models of human neurological disease Enables high-resolution study of neural circuit basis of attentional deficits found in many devastating neurological conditions Enables precise and repeatable measurement of the effects of pharmacological interventions on attentional effects on behavior	7983

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