Biological | Technology Licensing

Available Technologies by Category

Parametric Resonance Approach for Efficient, Versatile Acoustic Power Transfer for Implantable/Wearable Devices, Sensing, and Communications New class of transducers utilizes parametric resonance to convert acoustic energy from an ultrasonic source to a sustained electrical signal. Technology powers implantable biomedical devices, small wearable sensors, and other wireless charging applications. Simple yet robust generation of stable electromechanical frequency combs is also possible in both air and liquid environments using a capacitive micro-resonator array.	7635, 9075
Efficiently Generating Complex Hydrogel Structures for Tissue/Organ-on-a-Chip Models Faster: Reduces preparation time from several hours to minutes Simplified: Generates complex patterns, including perfusable channels, using light-triggered polymerization of synthetic hydrogels and photomasks rather than current equipment-intensive methods that use laser-based patterning or ablation techniques Lowers regulatory burdens: Using synthetic rather than biological matrices simplifies regulatory hurdles, increases reproducibility from batch to batch, and increases tunability of the mechanical and biochemical properties of the matrix	8838, 8839
patcherBotPHARMA Automated Intracellular Pharmacological Electrophysiology Robot Increased efficiency: Autonomous operation ensures accurate placement of components and creates high success rates for experiment completion. Decreased human effort: Performs typical ligand-gated ionotropic receptor experimentation protocols autonomously for up to a tenfold reduction in operator interaction time over the duration of the experiment Higher experiment yield: Rapidly replicates previous datasets, reducing the time to produce an 8-point concentration response curve from weeks of recording to ~13 hours of recording	8717
“Smart” Feedback-Controlled Bioreactor Platform Enables Consistent High-Yield and High-Quality MSC Products Scaled-down feedback-controlled hollow fiber-based bioreactor enables identifying the critical quality attributes and critical process parameters for high-quantity and high-quality hCT-MSCs for ideal cell growth and efficacy Provides the controls to maintain optimum conditions and improve expansion yield and cell viability System can be adapted and applied to industrial cell therapy manufacturing and can enable high-yield and high-quality products while minimizing variabilities	8887
DetectIV Offers Noninvasive Early IV Infiltration and Extravasation Detection DetectIV provides a continuous, noninvasive, and wireless IV infiltration and extravasation detection system. The sensor does not cover the IV site and works well with all skin types—significant improvements over existing detection devices. The device detects infiltrations on average 2 hours ahead of nursing standard of care making it an effective early detection system that prevents extended hospital stays.	7207
Microrobots for Neurosurgery Applications Minimally invasive: Significantly reduces invasiveness of procedures in comparison to current macroscale, neurosurgical robots Precise control: Uses 3D position data of the microrobots on the brain surface in a closed-loop system to adjust the magnetic field parameters (i.e., magnitude, frequency, phase, and direct current [DC] offset of each coil) as well as the forces the robots exert to the biopsy tissue Facilitates movement: Employs microfabricated shapes that dictate the microrobot's movements, limits their contact with the brain surface to reduce adhesion, and may also provide a means for the robot to propel itself in fluid	8749
Smart, Wireless, Bioelectronic Pacifier for Real-Time Continuous Salivary Electrolyte Monitoring in Infants Smart pacifier offers wireless, real-time, continuous detection of sodium and potassium levels in infants. This totally non-invasive monitoring pacifier eliminates the need for blood draws, which can only be done three times each day, and is designed to provide non-invasive neonatal health monitoring. Microfluidic channels are designed to efficiently pump optimum quantities and concentration of viscous saliva to the sensor area for quick measurement and to eliminate the need to induce salivary stimulation.	8942
Quantitative, Multiplexed Electronic Detection of COVID-19 Biomarkers Direct electronic detection: This innovation provides direct detection of biomarkers as a simple electronic readout without the use of any intermediate optics. Multiplexed: The device can simultaneously detect multiple biomarkers (e.g., a four-plex chip to detect IgG and IgM antibodies against spike or nucleocapsid antigens). Portable: A handheld, cellphone-interfaced reader is designed to enable detection and monitoring of diseases in remote areas for sensitive yet inexpensive point-of-care use.	8814
Recirculation System for Aerosol Collectors Maximizes Particle Concentration for Improved Pathogen Detection Enhanced detection: Continuously recirculated collection buffer increases the concentration of targeted particles collected and improves detection of pathogens Increased sampled air volume: Recirculating the buffer enables running the system for longer periods of time and with larger volumes of air to improve pathogen detection in entire buildings Increased control: Users have active control of the volume of fluid introduced during collection via the system’s recharge pump	8903
Fourier Light-Field Microscope (FLFM) for Fast, Volumetric, and High-Resolution Imaging of Entire Organoids Cost-efficient and scalable: Is fully adaptable to epifluorescence protocols resulting in a system that is both cost-efficient and highly scalable Fast: Captures fast cellular and tissue dynamic processes in a simultaneous, volumetric manner (e.g., collective cellular responses at sub-second time scales across whole samples) Validated: Responses to extracellular physical cues such as osmotic and mechanical stresses have been recorded using human induced pluripotent stem cell-derived colon organoids (hCOs).	8844
Cell-free Biosensors to Detect Creatinine, Creatine, and Sarcosine Portable: This technology demonstrates the potential to develop point-of-care screening and monitoring, which is essential to expanding access to care worldwide, including to low- and middle-income countries. Inexpensive: CFE-based biosensors can cost as little as a few cents per test and could provide a low-cost alternative to current renal function monitoring and diagnosis, which currently involves laboratory visits, trained phlebotomists, skilled technicians, and expensive, specialized equipment. Cell-free: The use of a cell-free expression system could enable easier-to-read quantitative output that is less susceptible to matrix effects.	8776
Enabling Rapid Detection of Label-Free RNA for Use in COVID-19 Testing Earlier detection: Identifying the viral components themselves—rather than the body’s reaction to the viral presence (i.e., antibodies)—potentially improves early detection in asymptomatic subjects. Simpler process: Use of minimal reagents and fewer preparatory steps is designed to enable more efficient and facile sample preparation. Avoidance of “wash steps” aims to minimize target loss. Fewer disruptions: Avoiding the use of high-demand supplies (e.g., swabs) and reagents potentially reduces supply-chain and contamination issues.	8669
A Biological Computing Framework for Living Systems Innovative: Builds on probabilistic computing principles to construct analog biological bits, enabling an entirely new set of logic gates and algorithms and potentially allowing users to solve previously intractable problems Robust: Can sense every extracellular protease encoded in the human genome, for which there is a known peptide substrate, enabling a simple plug-and-play framework for communicating with a variety of biological activities and offering performance competitive with DNA-based computers but with increased processing speed Relevant: Provides a framework based on biological activity and constructed from biological materials, which enables a direct interface with and understanding of living materials and systems	8009
Wearable Health Monitoring Device Improves Data Quality and Accuracy High performance: Captures real-time, real-world data of multiple physiological signals with a significant reduction in MA interference Chest-mounted: Provides more accurate ECG, heart rate, respiratory rate, and activity detection than existing wrist-worn commercial monitors Comfortable: Adheres securely and discretely to the skin using a breathable soft membrane for continuous conformal contact, eliminating excessive sweating and skin irritation	8691
Handheld Breath Collection Device for Detecting Disease Biomarkers Improved diagnosis: Analyzes both the gas and liquid sampled from the patient’s breath for potentially more robust and multifaceted results Enhanced patient experience: Requires a shorter exhalation cycle to get a breath sample, making the test more comfortable for patients Small and portable: Optimizes and miniaturizes the collection process for easy point-of-care applications	8791
Increasing Medium-Chain Fatty Acid (MCFA) Yield in Bacterial Host with Engineered Enzyme High performance: Increases the yield of MCFAs during chemical and biopolymer synthesis Enabling: Improves the microbial production of chemicals that require the expression of heterologous enzymes Adaptable: Potentially applies to methods of engineering other heterologous enzymes to interact with endogenous proteins in order to produce molecules of interest in a bacterial host	7595
Skin-Conformal Wearable Stress Monitor Delivers Greater Precision and Continuous, Wireless Monitoring with Comfort and Flexibility All-in-one: The personal adhesive bandage-like single device platform offers wireless, multi-data sensing by simply mounting it on the skin. Disposable: This wearable device is fully disposable after the use and the measured data can be simply sent to the cloud via a tablet or smartphone app. Compact: The unique, thin design of this bioelectric device is one-sixth the volume of current market offerings—weighing less than 7 g, including its rechargeable battery.	8414
Adaptive Broadband Impedance Matching in Ultrasound Front-End Electronics High performance: Improves power transfer and acoustic reflectivity Flexible: Enables multimodal and tunable operation of CMUTs Efficient: Provides optimal matching for co-design of CMUT electronics	8342
Miniaturized Modular-Array Fluorescence Microscopy Powerful: Offers high fluorescence sensitivity, efficiency, and spatiotemporal resolution (~3 µm and up to 60 Hz) Configurable: Offers compatibility with conventional cell culture assays and physiological imaging, providing accessibility to upright physiological imaging and integration with biochemical sensors under the cell platform Efficient: Provides effective parallelization of multi-site data acquisition	8580
Advancing Mass Spectrometry with Novel Interface Flexible: Allows for integration with a range of operational modes and analytical workflows for different ESI-MS techniques High performance: Offers enhanced sensitivity and a significantly improved limit of detection Robust and effective: Minimizes charged ion loss and enables sampling of the most analytically “valuable” droplets	4182
All-Electronic Immunophenotyping Device for Point-of-Care Testing Convenient: Provides an all-electronic immunophenotyping process with straightforward equipment and techniques Low cost: Performs sophisticated, multistep analyses in a system that is affordable enough for point-of-care settings Flexible: Allows for the easy immobilization of multiple antibodies in the device—a shortcoming of current systems	8045, 8047
Scalable Microfluidic Device with Multiple Constriction Channels for High-Throughput Mechanophenotyping High throughput: Addresses the low-throughput challenges of other similar technologies by handling a sample volume near that of a Coulter counter Low cost: Eliminates the need for costly equipment, highly trained personnel, and long processing times that come with other measuring processes Scalable: Uses a frequency division scheme so that multiple copies of the system can operate concurrently	8031
Measuring Surface Antigen Expression via Microflow Cytometry Portable: This innovation uses a disposable, handheld device without bulky or costly equipment, which is expected to be especially useful in low-resource settings. Simple: It is designed to achieve results similar to those from a commercial flow cytometer but without requiring initial purification. Recoverable samples: Unlike commercial systems, the analyzed sample can be recovered for further tests at the end of the analysis.	7913, 8048
Facilitating Ultrasound Penetration of the Skull for Diagnosis and Treatment Portable: Designed to enable imaging of the brain via small, mobile ultrasound devices, which may offer greater convenience compared with MRI and CT machines Affordable: May be a lower cost modality compared with leading techniques, such as MRI, CT, or positron emission tomography (PET) Robust: Demonstrates energy transmission through the skull on par with that of an aqueous medium in preliminary testing	8340
Portable Multi-Parameter Cancer Diagnostic Tool Powerful: Simultaneously measures multiple tissue parameters to determine electro-thermo-mechanical properties Disposable: Uses single-use biochip components to eliminate cross-contamination Versatile: Uses a variety of other micromotion-capable actuators and extends to other manufacturing techniques and different length scales	7619
Optical Architecture Enables High-Performance Chips High performance: Provides efficient, practical, and manufacturable optical computing solutions for a variety of platforms Efficient: Permits a new way of designing high-performance computing and decision-making tasks using manufacturable solutions with high-speed processing, despite fabrication imperfections Flexible: Offers photonic chips in a variety of material platforms (i.e., silicon, silicon nitride) and meta-surface arrays implemented in hybrid platforms that combine dielectrics and nonlinear/reconfigurable materials	8437
Hybrid Meta-Surfaces for Active, Non-Volatile Light Manipulation Fast: Enables highly dense pixels with fast (nanosecond) switching capability Scalable: Can be fabricated with features down to nanometer sizes; the overall device can incorporate several meta-surfaces with different features over a large-size wafer Agile: Offers high switching robustness (up to 1012 cycles)	8530
Powered Bilateral Knee Exoskeleton for Rehabilitation of Children and Adults Lightweight: Uses one of the lightest available electromechanical actuators—just 0.5 kg—along with a mere 1.5 kg for the exoskeleton assembly Back-drivable: Lowers the mechanical effort involved in back driving with a single-stage actuator Efficient: Reduces battery consumption compared with existing systems	8369
Multi-Functional Sparse Phased Arrays for Guiding Focused Ultrasound Therapies Robust: Provides sensitivity of detection down to a single microbubble for FUS-induced microbubble activity Precise: Offers broadband B-mode imaging capabilities to improve workflow and efficacy of FUS-based therapies Scalable: Enables the formation of large CMUT arrays and subarrays with appropriate element spacing	8493
Streamlined Hematology Analysis for Point-of-Care Settings Streamlined: Enables testing in point-of-care settings without complex procedures and specially trained personnel Highly accurate: Offers a spatial resolution higher than current methods due to the shorter wavelength of UV light Cost-effective: Saves on reagents, complex equipment costs, and time-intensive processes without compromising diagnostic quality	8303
Airy-beam Tomographic Microscopy for Biological Imaging Streamlined: Offers a scan-free method of obtaining 3D-resolution images Volumetric imaging: Generates and resolves images of tissues and cells in the 3D space High resolution and image depth: Provides 3D diffraction-limited resolution	8381
Wireless Neurovascular Monitoring System Minimally invasive: minimal impact on hemodynamics (dynamics of blood flow) Flexible and stretchable: able to conform to complex vessel geometry Longer range: improved wireless detection range	7908
Switchable Solvents and Methods of Use Thereof Lowers cost - eliminates the need to add and remove multiple solvents for each reaction step Lower pollution - eliminates the need to remove and capture solvents Easier separation of product - ideal for separation of vegetables such as soybean oil	3776
Detecting Change of Dielectric Constant Enables detection of materials based on changes to the effective dielectric constant of a circular resonator Measures the index of refraction to detect the change in optical wavelength that is occurring Able to detect the power of the electromagnetic wave in the circular resonator at resonance condition and/or during build-up stage	2839
Nanocrystalline Glass Ceramic Scintillators Cheaper – Can be easily fabricated on a large scale Efficient – High luminescence efficiency and light output Compact – Greater portability	5509
Fast Microscale Actuators for Probe Microscopy Enables fast and parallel actuation with integrated electrostatic actuators and built-in optical displacement sensors Accurate force measurement with nanometer resolution in parallel single-molecule mechanics experiments Novel FIRAT structures for high speed AFM imaging in liquid environments	3916
New Methods of Fabrication for Biosensor Arrays Low manufacturing and operating cost Compatible with multiple standard electrochemical techniques Can be used with CMOS detection chips with multiple chemical detection and/or actuation channels or sites	4231
Piezoelectric Nanowire Based Hearing Aids Smaller size More power efficient	4222
Eliminating Phase Separation Issues Phase separation is eliminated Growth process is faster Processing temperatures are lower and over a wider range	5459
Alveolar Breath Separation and Collection Device Simple: this device has fewer components than prior devices Inexpensive: this device is less expensive than previous devices due to its simpler design	4734

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