Pharmaceuticals | Technology Licensing

Available Technologies by Category

Antibodies for Glaucoma Research Precise: Distinguishes between correctly folded and mutated forms from samples, allowing for more precise research and interventions Powerful: Enables a more complete and robust understanding of myocilin antibody targets and their applications in potential glaucoma treatments Enabling: Opens new opportunities for development of pharmaceuticals to treat or prevent damage to the eye caused by glaucoma	8489
Antibody Coated Nanoparticle Vaccines Enhance vaccine immunogenicity Prolong vaccine protection Reduce safety risks associated with pathogen-derived vaccine adjuvants	7403
Antifolate Compound as Multi-Drug Resistant Pathogens Novel structure with high binding affinity for DHFR Demonstrated growth inhibition of numerous pathogens Demonstrated antibacterial activity for mulit-drug resistant strains of E. coli, methicillin-resistant S. aureus (MRSA), vancomycin-resistant E. faecalis & antifungal activity against amphotericin–resistant Candida albicans	6296
Aptamer-Driven Gene Targeting Apatamers have unique secondary structure, allowing them to bind with high specificity and affinity to a specific target Utilizes intrinsic double stranded DNA break (DSB) and repair system, enabling targeted delivery of exogenous DNA in all eukaryotic cell types AGT development could lead to enhancement of gene editing technologies and ultimately disease-targeted therapy	6757
Assessment of Soluble Cancer Biomarkers for Focused Ultrasound Therapy Simple: Avoids reliance on magnetic resonance imaging (MRI)-based methods of monitoring and optimizing FUS therapy Safe: Relies on a small amount of fluid collected before/after FUS-targeted drug delivery Robust: Enables a range of new therapeutic interventions for cancerous tumors as well as both delivery and monitoring/optimizing of those therapies	8473
Automated Bioreactor Sampling System Can Eliminate Cross-Contamination of Samples Automated bioreactor sampling system maintains sample integrity by changing the syringe between samples In addition to savings related to reduced cross-contamination, automated sampling can further lower costs by reducing hands-on time and speeding sampling. Flexible platform can be used with any type of collected sample.	8886
Biomolecular Coating for Implants Simple, one-step surface modification without chemical cross-linking agents Modification at the time of surgery in the operation room Straight forward sterilization	3967
Carbon Nanotube Electrode Array for Neural Prosthetics Densely packed CNT arrays allow for better bio-incorporation, prevention of glial scarring, chronic inflammation, and neuronal cell loss Readily functionalized to promote neuronal growth and tissue-electrode adhesion, enhancing electrode performance and quality of read-out signals Inherent mechanical stiffness enhances the rigidity of adjacent CNTs preventing buckling as in other high-aspect probe systems.	4434
Cell-Free Biomaterial for Tissue Regeneration and Repair Simple — does not require difficult or extensive preparation Regenerative — provides unique molecular cues similar to early embryogenesis, enabling directing of cell differentiation and tissue morphogenesis Compatible and customizable — can be tailored for specific tissue applications by directing the differentiation of the ES cells prior to acellularization	3662
Constellation Diagrams to Model Biomolecules’ Electrostatic Properties Low computational cost – reduces algorithm run-time via reduction in complexity of computing molecular electrostatic properties Digitally encoded molecular electrostatic properties – utilizes orthogonal basis functions Visual toolsets- to analyze molecular electrostatic properties and generates 4D plots of molecular electrostatic properties	8245
Core-Shell Nanogel Cellular Delivery Vehicles Delivery of a broad range of various materials to cells Higher payloads and faster and more sustained RNA interference than non-targeted commercial siRNA delivery vehicle Less toxic than commercial liposomal formulations	4480
Developing Tumor Immune Microenvironments via Engineered Hydrogel Scalable: Enables increased tumor formation rate without sacrificing the dynamic complexity of an in vivo adaptive immune response Improved consistency: Demonstrates consistent induction of tumor growth, latency, and immune infiltration in early analyses of the technology Cost-effective: Eliminates the repetitive processes of conventional methods and leverages inexpensive hydrogel	8785
Devices, Systems, and Methods for Excavating Cancer Cells Tumors are able to migrate on manufactured fibers or films instead of healthy brain tissue Minimally invasive- the device can be deployed directly or using a catheter The device is size and shape variable- films can range from nano- to micron- scale	5057
Facilitating Ultrasound Penetration of the Skull for Diagnosis and Treatment Portable: Designed to enable imaging of the brain via small, mobile ultrasound devices, which may offer greater convenience compared with MRI and CT machines Affordable: May be a lower cost modality compared with leading techniques, such as MRI, CT, or positron emission tomography (PET) Robust: Demonstrates energy transmission through the skull on par with that of an aqueous medium in preliminary testing	8340
Fibrin "Knob" Therapeutics Simple method Robust production Innate therapeutic potential	4021
Guided Injection of Charged Cargo for Intracellular Delivery Novelty – use of an electrically-charged liquid beam of electrospray Improved control – control of action on the scale of single cell/single pores Diversity – arbitrary diverse set of cargo	8275
Heat-Responsive Programmable T-Cells Specific: The remote programmable nature of these T-cells allows them to be selectively activated only in the necessary locations. Protective: This focused, genetically engineered immunotherapy is intended to protect patients from the additional harm of the off-target cell death and unnecessary systemic damage that is more common with oncological therapeutics. Non-invasive: With NIR light’s ability to penetrate into multiple layers of biological tissue and be absorbed by AuNRs, this technology removes the need for a light source in the body to trigger the T-cells.	7422
High-Throughput MSC Potency Assay to Bring Feasibility to Immune/Inflammatory Therapeutics Reproducibility: The well-defined cellular environment of the device enables a highly reproducible MSC response not observed in 2D cultures. Scalable: The assay’s simplistic design is amendable to cost-effective scale up. Economical: The low cost of the microfluidic chip and the ease of implementing the assay into existing cell therapy manufacturing practices provide for low costs to enter the market.	8722
Hybrid Molecular Catalysts: A New Blueprint for Catalyst Design, Preparation, and Testing Attachment of molecular catalysts to solid supports can lead to new reactivity not seen under homogeneous conditions At an optimal atomic layer deposition (ALD) layer thickness, the molecular catalyst remains highly active while still being resistant to surface detachment and subsequent deactivation Catalyst separation and recovery achieved via a simple filtering and washing process rather than energy- and time-intensive distillation or re-crystallization processes In addition to the simple filter-and-wash process mentioned above, encapsulation requires only about 10 reaction cycles, making this process technologically and economically viable for large-scale manufacturing	8537
Hydrogels for Controlled Delivery of Lysostaphin to Treat Staphylococcus aureus Infections Injectable (or surgically applied) hydrogel formulation conforms and adheres to the fracture and surrounding tissue, ensuring efficient, local delivery of lysostaphin Localized treatments enable higher relative doses to be given at the site of infection, and enhanced stability from the hydrogel carrier may reduce the number of overall doses needed Tunable nature of the material provides control over the amount and time over which lysostaphin is delivered	7729
Improved AZA-peptide Epoxides Versatile: able to treat multiple diseases Can be administered with or without other protease inhibitors	3738
Innovative Polymeric Bipolar Membrane Design Provides Wide Industrial Applications This innovative bipolar membrane design dissociates water at a low voltage and provides a tunable membrane with a green method for large-scale manufacturing. Polyvinyl alcohol-based bipolar membrane designs reduce energy costs, maintenance, and toxic chemical usage. This polymeric bipolar membrane is widely applicable across industries, including fuel cells, hydrogen production, carbon capture/conversion, wastewater treatment, and battery-based technologies.	9044
Interfering RNA Production and Delivery Using Virus-Like Particles Inexpensive, rapid, adaptable, and reliable in vivo system for sequestering and packaging of iRNAs Flexible, for long or short, single-stranded or double-stranded iRNA of any sequence Efficiently delivers iRNA to biological targets; VLP-iRNAs are readily taken up by many cell types	6427
Intracellular Anticancer Delivery Self-assembling – Forms an organized structure in water at room temperature Nano-scale – Approximately 35 nm, ideal for intracellular uptake Versatile – Can be used with any antibody	7174
Medical Tubing Solution for Bacteria Prevention Prevent various infections currently impacting patients due to bacteria formation on medical tubes. Solution that can be utilized with existing medical tubes. Does not leach any materials from the tubing surface.	7274
Melting Microneedle Patches Extend Drug Delivery Applications, Simplify Manufacturing, and Reduce Costs Melting microneedles enable dispersion of both poorly soluble and water-soluble drugs, which eliminates the need for solvents for improved stabilization and broader applications. Melting microneedles shorten manufacturing and drying time, eliminate the need to maintain a cold chain for storage and transportation, and reduce the ultimate cost of the microneedle patch. The safe suppository bases are inexpensive and enable control of the drug release timing.	8904
Method for Clinical T-Cell Expansion Higher cell densities Protection from high shear production environments Reduced initial and operating cost	7434
Method for Treatment of Pathologies Fast - activity is immediate (within 2 hours) Easy to use - applied to nasal sprays or skin patches Safe – less immunogenic	7878
Methods for Generating Functional Therapeutic Cells Novel – No present technology exists Versatile – Can be adapted to suit a variety of diseases, human and animal Targeted – Antigen-binding qualities within the B cell allow for highly specific therapies	7080
Microfluidic Droplet for Drug Delivery and Therapeutic Applications Viable, cellular micro-environments requiring precise control are achieved using hydrogel microspheres with diameter sizes ranging from 10-1000 micrometers A protective, semi-permeable capsule encases the cells and biomolecules Release rates of encapsulated biomolecules or drugs are controlled by adjusting the polymer parameters used to fabricate hydrogel microspheres	6467
Microneedle Coating Alternative method for hypodermic needles Coating uniformity Spatial control on coating length	3526
Microscale High-Throughput Phenotypic Assay for Fibrosis Powerful: Provides high-throughput image-based analysis of fibrotic processes as well as fibrinolysis Convenient: Combines label-free readouts for fibrin degradation, collagen synthesis, and cell contraction to evaluate fibrotic tissue remodeling Enabling: Opens new opportunities for understanding fibrosis pathogenesis and for evaluating anti-fibrotic therapeutics	8502
Nanoparticle Modulation of Thrombus Formation Selective: Operates only in high shear blood flow as in a stenosis Improved Safety: Reduces the risk of bleeding complications from slow bleeds	7466
Near-Real-Time Positioning for Instruments and Tools in Magnetic Resonance Elastography (MRE) and Imaging (MRI) Precise: Extremely precise positioning mechanism enables orientation and control capable of sub-millimeter motions within the MR environment Rapid: Significantly speeds up procedure time over standard MRI and offers wavefield images in near real time High resolution: Uses high-frequency actuation to enable imaging of small, geometrically difficult targets	8412
New Class of Tissue-Targeting Agents Inhibits Fibrosis, Inflammation, and Cancer Growth Potent: Candidates among these agents are 1,000 times more potent than pirfenidone, the standard treatment of IPF. Specific: The compounds may potentially exhibit tissue-targeting properties for sustained levels at disease sites. Minimal toxicity: Enhanced tissue specificity inhibits inflammation and growth of targeted cancer cells while minimizing off-target effects and toxicity.	8374
Noncoding RNA Targets for RNA Interference Novel group of RNA interference targets with utility in basic research and practical applications Non-coding interference RNAs (nciRNAs) offer an efficient mechanism of mortality in eukaryotic cells Highly specific targeting of pests or pathogens	6432
Novel Chemical Compounds Support Excess Copper Removal in Biological Systems Powerful: Displays an affinity for copper that is unprecedented among synthetic ligands, with a complex stability constant of logK = 20.0 Specific: Functions without interference by other metals in the body Effective: Possesses a strong copper coordinating ability, even in the complex chemical environments of different biological systems	8151
Novel Crosslinked Hydrogel Improves Efficacy and Side Effects of Cancer Treatment Versatile: Can integrate with all types of immune checkpoint blockade antibodies and respond to various types of cancers Improved tolerability via local delivery: Limits side effects on nonmalignant tissues and organs—a challenge of other immunotherapies Innovative: Leverages the body’s natural immune response to reduce the likelihood of cancer recurrence	8505
Novel Nanocarriers Strengthen Therapeutic Delivery, Improves Efficacy Greater therapeutic effectiveness is due to the synergistic work of multiple therapeutic agents (hydrophobic/hydrophilic charged) that can be delivered via this dual-loaded biomaterial. The risk of immunotoxicity to a vaccine is reduced because an adjuvant, which can induce the body’s anti-inflammatory immune response, may be loaded and simultaneously delivered with the vaccine. The novel nanocarrier has broad market application since it can deliver vaccines, gene therapy, small molecule drugs, and even contrast agents.	8988
Novel Pharmaceutical Compounds Based on Tumor-Selective KDM Inhibitors Selective: Can be used to target specific types of tumors Proven efficacy in vitro: Can be used to inhibit proliferation of cells (e.g., cancer or tumor cells), reducing tumor burden, inhibiting tumor growth, or both Enhanced potency: Displayed a 65-fold increase in cytotoxic potency against tested triple negative breast cancer cell lines	7880

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