Pharmaceuticals | Technology Licensing

Available Technologies by Category

Melting Microneedle Patches Extend Drug Delivery Applications, Simplify Manufacturing, and Reduce Costs Melting microneedles enable dispersion of both poorly soluble and water-soluble drugs, which eliminates the need for solvents for improved stabilization and broader applications. Melting microneedles shorten manufacturing and drying time, eliminate the need to maintain a cold chain for storage and transportation, and reduce the ultimate cost of the microneedle patch. The safe suppository bases are inexpensive and enable control of the drug release timing.	8904
Novel Nanocarriers Strengthen Therapeutic Delivery, Improves Efficacy Greater therapeutic effectiveness is due to the synergistic work of multiple therapeutic agents (hydrophobic/hydrophilic charged) that can be delivered via this dual-loaded biomaterial. The risk of immunotoxicity to a vaccine is reduced because an adjuvant, which can induce the body’s anti-inflammatory immune response, may be loaded and simultaneously delivered with the vaccine. The novel nanocarrier has broad market application since it can deliver vaccines, gene therapy, small molecule drugs, and even contrast agents.	8988
Automated Bioreactor Sampling System Can Eliminate Cross-Contamination of Samples Automated bioreactor sampling system maintains sample integrity by changing the syringe between samples In addition to savings related to reduced cross-contamination, automated sampling can further lower costs by reducing hands-on time and speeding sampling. Flexible platform can be used with any type of collected sample.	8886
patcherBotPHARMA Automated Intracellular Pharmacological Electrophysiology Robot Increased efficiency: Autonomous operation ensures accurate placement of components and creates high success rates for experiment completion. Decreased human effort: Performs typical ligand-gated ionotropic receptor experimentation protocols autonomously for up to a tenfold reduction in operator interaction time over the duration of the experiment Higher experiment yield: Rapidly replicates previous datasets, reducing the time to produce an 8-point concentration response curve from weeks of recording to ~13 hours of recording	8717
Simulated Synovial Fluid Offers Potential for Effective Treatment of Knee Osteoarthritis Osteoarthritis (OA)-simulated synovial fluid (simSF) provides the opportunity to evaluate how different cell therapies respond to an OA-like environment. By analyzing OA patient-derived synovial fluid (pdSF) and developing potency assays, researchers created a simSF comparable to pdSF that overcomes patient variability. The simSF allows for the investigation of OA biology with greater reproducibility of predictive outcomes and could advance effective treatment of knee OA.	8956
“Smart” Feedback-Controlled Bioreactor Platform Enables Consistent High-Yield and High-Quality MSC Products Scaled-down feedback-controlled hollow fiber-based bioreactor enables identifying the critical quality attributes and critical process parameters for high-quantity and high-quality hCT-MSCs for ideal cell growth and efficacy Provides the controls to maintain optimum conditions and improve expansion yield and cell viability System can be adapted and applied to industrial cell therapy manufacturing and can enable high-yield and high-quality products while minimizing variabilities	8887
Reducing Intraocular Pressure in Glaucoma Patients Without Drugs or Surgery via a Simple Hydrogel Injection Hydrogel injections alleviate elevated intraocular pressure (IOP) with fast results and extended impact. Surgery-free approach eliminates the risk of tissue damage caused by a surgical incision or laser application. Simplified and effective treatment process from standard daily drug intake to a brief office visit only once every 4-6 months.	8467
Synthetic Hydrogel for Satellite Cell Delivery in Dystrophic Skeletal Muscle Addresses the critical need for a viable treatment for deterioration of the diaphragm, which is a leading cause of respiratory failure and death in Duchenne Muscular Dystrophy patients Engineered hydrogels comprised of synthetic polymers and peptides are designed to enable successful muscle satellite cell (MuSC) transplantation to the diaphragm or other dystrophic skeletal muscle tissue Shown to support MuSC survival, proliferation, and differentiation, which can enable restoration of dystrophin – a protein absent in DMD and critical to strengthening and repairing muscle fibers	7841
Synthetic Hydrogels for Human Organoid (HO) Generation and Transplantation Synthetic hydrogel exhibits high cytocompatibility and minimal toxicity and inflammation in vivo for improved human organoid viability Injectable delivery vehicle supports localized HO engraftment in mucosal wounds to potentially enhance wound closure and repair Modular design and delivery via endoscopic techniques enables the translational potential of this delivery platform for regenerative medicine and overcomes limitations associated with the use of commercially available matrices for hPSC-based organoid technologies	7536
Hybrid Molecular Catalysts: A New Blueprint for Catalyst Design, Preparation, and Testing Attachment of molecular catalysts to solid supports can lead to new reactivity not seen under homogeneous conditions At an optimal atomic layer deposition (ALD) layer thickness, the molecular catalyst remains highly active while still being resistant to surface detachment and subsequent deactivation Catalyst separation and recovery achieved via a simple filtering and washing process rather than energy- and time-intensive distillation or re-crystallization processes In addition to the simple filter-and-wash process mentioned above, encapsulation requires only about 10 reaction cycles, making this process technologically and economically viable for large-scale manufacturing	8537
Hydrogels for Controlled Delivery of Lysostaphin to Treat Staphylococcus aureus Infections Injectable (or surgically applied) hydrogel formulation conforms and adheres to the fracture and surrounding tissue, ensuring efficient, local delivery of lysostaphin Localized treatments enable higher relative doses to be given at the site of infection, and enhanced stability from the hydrogel carrier may reduce the number of overall doses needed Tunable nature of the material provides control over the amount and time over which lysostaphin is delivered	7729
Innovative Polymeric Bipolar Membrane Design Provides Wide Industrial Applications This innovative bipolar membrane design dissociates water at a low voltage and provides a tunable membrane with a green method for large-scale manufacturing. Polyvinyl alcohol-based bipolar membrane designs reduce energy costs, maintenance, and toxic chemical usage. This polymeric bipolar membrane is widely applicable across industries, including fuel cells, hydrogen production, carbon capture/conversion, wastewater treatment, and battery-based technologies.	9044
Developing Tumor Immune Microenvironments via Engineered Hydrogel Scalable: Enables increased tumor formation rate without sacrificing the dynamic complexity of an in vivo adaptive immune response Improved consistency: Demonstrates consistent induction of tumor growth, latency, and immune infiltration in early analyses of the technology Cost-effective: Eliminates the repetitive processes of conventional methods and leverages inexpensive hydrogel	8785
TabAccess: A Wireless Controller for Tablet Accessibility Enabling: Provides an alternative interface to touchscreen-based devices for people with limited fine motor control, potentially enabling them to interact with applications that could improve their quality of life or even create employment opportunities Reconfigurable: Sensor modules can be interconnected as well as separated and mounted anywhere (e.g., on the human body or on a table, floor, wheelchair, etc.), enabling adaptation of the device based on the capability, range of access, and the individual’s range of motion. Adjustable: Uses an adjustable Velcro strap so one size fits the majority of forearms	5946
Small Molecule Glycosylated Histone Deacetylase Inhibitors (HDACi) Targeted: The compounds were particularly cytotoxic to liver or hepatocellular cancer cells (HCC) during in vivo murine model laboratory studies. Enhanced potency: The compounds’ hepatocellular carcinoma selectivity observed in laboratory studies potentially increases their efficacy on liver cancer and possibly other cancers. Many formulations: A number of formulation methods are potentially available, including tablets, beads, granules, microparticle, or nanoparticles that provide a variety of drug release profiles.	8373
Wearable Device for Evaluating Post-Injury Ankle Health During Ambulation Better decisions: Helps clinicians more easily determine the best course for ankle rehabilitation and improves compliance with physical therapy Faster recovery: Enables improved rehabilitation guidance based on collected telehealth data that may speed the time to recovery Fewer re-injuries: Supports clinicians in making better decisions regarding appropriate activity levels and readiness to return to activities to avoid re-injury	8513
New Class of Tissue-Targeting Agents Inhibits Fibrosis, Inflammation, and Cancer Growth Potent: Candidates among these agents are 1,000 times more potent than pirfenidone, the standard treatment of IPF. Specific: The compounds may potentially exhibit tissue-targeting properties for sustained levels at disease sites. Minimal toxicity: Enhanced tissue specificity inhibits inflammation and growth of targeted cancer cells while minimizing off-target effects and toxicity.	8374
Antibodies for Glaucoma Research Precise: Distinguishes between correctly folded and mutated forms from samples, allowing for more precise research and interventions Powerful: Enables a more complete and robust understanding of myocilin antibody targets and their applications in potential glaucoma treatments Enabling: Opens new opportunities for development of pharmaceuticals to treat or prevent damage to the eye caused by glaucoma	8489
High-Throughput MSC Potency Assay to Bring Feasibility to Immune/Inflammatory Therapeutics Reproducibility: The well-defined cellular environment of the device enables a highly reproducible MSC response not observed in 2D cultures. Scalable: The assay’s simplistic design is amendable to cost-effective scale up. Economical: The low cost of the microfluidic chip and the ease of implementing the assay into existing cell therapy manufacturing practices provide for low costs to enter the market.	8722
Microscale High-Throughput Phenotypic Assay for Fibrosis Powerful: Provides high-throughput image-based analysis of fibrotic processes as well as fibrinolysis Convenient: Combines label-free readouts for fibrin degradation, collagen synthesis, and cell contraction to evaluate fibrotic tissue remodeling Enabling: Opens new opportunities for understanding fibrosis pathogenesis and for evaluating anti-fibrotic therapeutics	8502
Tissue-Selective Anticancer Agents Tissue-targeted activity: Appended macrocyclic skeletons provide selective tissue distribution. Potent: HDAC inhibitors display stronger in vivo anticancer activity against solid tumors compared to current technology. Lower toxicity: Mice in preclinical experiments did not exhibit significant weight loss, pointing to potentially lower toxicity of these compounds.	4195
Heat-Responsive Programmable T-Cells Specific: The remote programmable nature of these T-cells allows them to be selectively activated only in the necessary locations. Protective: This focused, genetically engineered immunotherapy is intended to protect patients from the additional harm of the off-target cell death and unnecessary systemic damage that is more common with oncological therapeutics. Non-invasive: With NIR light’s ability to penetrate into multiple layers of biological tissue and be absorbed by AuNRs, this technology removes the need for a light source in the body to trigger the T-cells.	7422
Self-Titrating Bacterial Protease-Activated Prodrug Effective: Activates an internal dosing mechanism such that the magnitude of an infection locally determines the prodrug dose Robust: Increases the stability of the prodrug form by neutralizing the effective charge of the administered antimicrobial peptide Improves safety: Decreases the potential for off-target effects	8010
Rapid Development of SARS-CoV-2 Monoclonal Antibodies Powerful: Demonstrates potential to recognize intact SARS-CoV-2 virions with high affinity Highly efficient: Enables researchers to select pairs of high-affinity antibodies that bind to different receptor sites, maximizing the efficiencies of sandwich-style rapid testing methods Enabling: Furthers the development of neutralizing antibodies that can be used as therapeutic agents, delivered either directly or via mRNA for in situ expression	8487
Novel, Non-Invasive Stimulation to Control Brain Inflammation and Boost Resilience to Stress Reaches deep brain regions: Drives rhythmic neural activity in deep brain regions that are unreachable by most non-invasive stimulation technology Non-invasive: Uses only lights and sound with precise timing and control Fast response: Effects are seen in 5 to 30 minutes rather than hours	7773, 7832, 8745
Scalable Microfluidic Device with Multiple Constriction Channels for High-Throughput Mechanophenotyping High throughput: Addresses the low-throughput challenges of other similar technologies by handling a sample volume near that of a Coulter counter Low cost: Eliminates the need for costly equipment, highly trained personnel, and long processing times that come with other measuring processes Scalable: Uses a frequency division scheme so that multiple copies of the system can operate concurrently	8031
Facilitating Ultrasound Penetration of the Skull for Diagnosis and Treatment Portable: Designed to enable imaging of the brain via small, mobile ultrasound devices, which may offer greater convenience compared with MRI and CT machines Affordable: May be a lower cost modality compared with leading techniques, such as MRI, CT, or positron emission tomography (PET) Robust: Demonstrates energy transmission through the skull on par with that of an aqueous medium in preliminary testing	8340
Near-Real-Time Positioning for Instruments and Tools in Magnetic Resonance Elastography (MRE) and Imaging (MRI) Precise: Extremely precise positioning mechanism enables orientation and control capable of sub-millimeter motions within the MR environment Rapid: Significantly speeds up procedure time over standard MRI and offers wavefield images in near real time High resolution: Uses high-frequency actuation to enable imaging of small, geometrically difficult targets	8412
Novel Crosslinked Hydrogel Improves Efficacy and Side Effects of Cancer Treatment Versatile: Can integrate with all types of immune checkpoint blockade antibodies and respond to various types of cancers Improved tolerability via local delivery: Limits side effects on nonmalignant tissues and organs—a challenge of other immunotherapies Innovative: Leverages the body’s natural immune response to reduce the likelihood of cancer recurrence	8505
Novel Pharmaceutical Compounds Based on Tumor-Selective KDM Inhibitors Selective: Can be used to target specific types of tumors Proven efficacy in vitro: Can be used to inhibit proliferation of cells (e.g., cancer or tumor cells), reducing tumor burden, inhibiting tumor growth, or both Enhanced potency: Displayed a 65-fold increase in cytotoxic potency against tested triple negative breast cancer cell lines	7880
Assessment of Soluble Cancer Biomarkers for Focused Ultrasound Therapy Simple: Avoids reliance on magnetic resonance imaging (MRI)-based methods of monitoring and optimizing FUS therapy Safe: Relies on a small amount of fluid collected before/after FUS-targeted drug delivery Robust: Enables a range of new therapeutic interventions for cancerous tumors as well as both delivery and monitoring/optimizing of those therapies	8473
Novel Chemical Compounds Support Excess Copper Removal in Biological Systems Powerful: Displays an affinity for copper that is unprecedented among synthetic ligands, with a complex stability constant of logK = 20.0 Specific: Functions without interference by other metals in the body Effective: Possesses a strong copper coordinating ability, even in the complex chemical environments of different biological systems	8151
Precision Needle Positioning Robotic System for MRI Guided Injection Increased accuracy — robot capable of less than 100 micron accuracy Increased speed — faster targeting of injection locations	8246
Guided Injection of Charged Cargo for Intracellular Delivery Novelty – use of an electrically-charged liquid beam of electrospray Improved control – control of action on the scale of single cell/single pores Diversity – arbitrary diverse set of cargo	8275
Constellation Diagrams to Model Biomolecules’ Electrostatic Properties Low computational cost – reduces algorithm run-time via reduction in complexity of computing molecular electrostatic properties Digitally encoded molecular electrostatic properties – utilizes orthogonal basis functions Visual toolsets- to analyze molecular electrostatic properties and generates 4D plots of molecular electrostatic properties	8245
Storage Media for Determining Optimal Respiratory Treatment Automatically determines optimal radiation therapy treatment phase Enables higher, more effective radiation dosage amounts Minimizes unnecessary radiation to normal surrounding tissues	6926
Self-Assembling Peptides for Cell and Notch-Ligand Delivery Hydrogels are biocompatible, easy to modify and biodegradable Could be applied in a more platform-like manner by incorporating other peptides to repair cardiac or other tissues The peptide sequence activates signaling of pathways improving the growth or replication of tissue or cells	6480
Method for Treatment of Pathologies Fast - activity is immediate (within 2 hours) Easy to use - applied to nasal sprays or skin patches Safe – less immunogenic	7878
Fibrin "Knob" Therapeutics Simple method Robust production Innate therapeutic potential	4021
Biomolecular Coating for Implants Simple, one-step surface modification without chemical cross-linking agents Modification at the time of surgery in the operation room Straight forward sterilization	3967

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