| Melting Microneedle Patches Extend Drug Delivery Applications, Simplify Manufacturing, and Reduce Costs Dissolving microneedle drug delivery applications are limited by drug/biomolecule solubility/instability |
8904 |
| Novel Nanocarriers Strengthen Therapeutic Delivery, Improves Efficacy Overcoming limited durability and variant response in vaccine development and delivery |
8988 |
| Automated Bioreactor Sampling System Can Eliminate Cross-Contamination of SamplesMany bioreactor sampling systems have cross-contamination |
8886 |
| patcherBotPHARMA Automated Intracellular Pharmacological Electrophysiology RobotProvides faster throughput and less hands-on time for complex pharmacological patch-clamp experiments |
8717 |
| Simulated Synovial Fluid Offers Potential for Effective Treatment of Knee OsteoarthritisKnee Osteoarthritis Difficult to Treat Despite High Prevalence |
8956 |
| “Smart” Feedback-Controlled Bioreactor Platform Enables Consistent High-Yield and High-Quality MSC ProductsLarge-scale reproduction of high-quality hCT-MSC clinical cultures needed |
8887 |
| Reducing Intraocular Pressure in Glaucoma Patients Without Drugs or Surgery via a Simple Hydrogel InjectionDrug-free and surgery-free management of intraocular pressure (IOP) may lower risks and increase patient adherence |
8467 |
| Synthetic Hydrogel for Satellite Cell Delivery in Dystrophic Skeletal Muscle Current clinical interventions do not regenerate muscle tissue due to aging, trauma, and dystrophic disease |
7841 |
| Synthetic Hydrogels for Human Organoid (HO) Generation and TransplantationCurrent HOs rely on tumor-derived extracellular matrices that limit their use in regenerative and translational medicine |
7536 |
| Hybrid Molecular Catalysts: A New Blueprint for Catalyst Design, Preparation, and Testing Homogeneous molecular catalysts cannot be easily scaled up due to complex product separation and catalyst recovery |
8537 |
| Hydrogels for Controlled Delivery of Lysostaphin to Treat Staphylococcus aureus InfectionsOrthopedic hardware infections lack effective treatment options |
7729 |
| Innovative Polymeric Bipolar Membrane Design Provides Wide Industrial ApplicationsCurrent Bipolar Membranes Lack Scalability |
9044 |
| Developing Tumor Immune Microenvironments via Engineered HydrogelA biomaterial-programmed method for preclinical in vivo cancer immunotherapy evaluation |
8785 |
| TabAccess: A Wireless Controller for Tablet AccessibilitySignificantly improves user capabilities for individuals with limited fine motor control |
5946 |
| Small Molecule Glycosylated Histone Deacetylase Inhibitors (HDACi) A targeted potential therapy for liver cancer |
8373 |
| Wearable Device for Evaluating Post-Injury Ankle Health During AmbulationFor improving rehabilitation, shortening recovery time, and reducing re-injury rates |
8513 |
| New Class of Tissue-Targeting Agents Inhibits Fibrosis, Inflammation, and Cancer GrowthA 1,000x more potent idiopathic pulmonary fibrosis (IPF) treatment than currently available |
8374 |
| Antibodies for Glaucoma ResearchDetecting glaucoma-associated myocilin with antibodies that bind to different conformational states |
8489 |
| High-Throughput MSC Potency Assay to Bring Feasibility to Immune/Inflammatory TherapeuticsBreaking barriers that have limited the approval of human mesenchymal stromal cells (MSC) as a therapeutic application by refining quality control (QC) measures |
8722 |
| Microscale High-Throughput Phenotypic Assay for FibrosisEnables applications in personalized medicine, diagnostics, and therapeutics |
8502 |
| Tissue-Selective Anticancer AgentsTargeted HDAC inhibitors that potently suppress hepatocellular solid tumor growth |
4195 |
| Heat-Responsive Programmable T-Cells Increasing oncological patients’ precision medicine with engineered T-cell therapies that contain heat-responsive biocircuitry |
7422 |
| Self-Titrating Bacterial Protease-Activated ProdrugA new strategy to reduce antibiotic-resistant bacteria |
8010 |
| Rapid Development of SARS-CoV-2 Monoclonal AntibodiesOffers potential for diagnostic, research, and therapeutic applications |
8487 |
| Novel, Non-Invasive Stimulation to Control Brain Inflammation and Boost Resilience to StressReaches deep brain regions quickly and precisely to decrease neuroinflammation and reduce susceptibility to neurodegenerative and neuropsychiatric disorders |
7773, 7832, 8745 |
| Scalable Microfluidic Device with Multiple Constriction Channels for High-Throughput MechanophenotypingA straightforward lab-on-a-chip system with parallel channels to minimize idle time |
8031 |
| Facilitating Ultrasound Penetration of the Skull for Diagnosis and TreatmentOpening the door to portable, lower cost alternatives to magnetic resonance imaging (MRI) and computed tomography (CT) for the brain |
8340 |
| Near-Real-Time Positioning for Instruments and Tools in Magnetic Resonance Elastography (MRE) and Imaging (MRI)An actuator-guided system that provides rapid and precise position control with significant advantages over static imaging |
8412 |
| Novel Crosslinked Hydrogel Improves Efficacy and Side Effects of Cancer Treatment An innovative immunotherapy method uses checkpoint inhibitors to advance current antitumor therapeutics |
8505 |
| Novel Pharmaceutical Compounds Based on Tumor-Selective KDM InhibitorsCan inhibit cell growth with dramatically enhanced cytotoxic potency for triple negative breast cancer |
7880 |
| Assessment of Soluble Cancer Biomarkers for Focused Ultrasound Therapy Addressing critical barriers in noninvasive delivery and monitoring of anticancer agents in tumors |
8473 |
| Novel Chemical Compounds Support Excess Copper Removal in Biological SystemsA preorganized phosphine sulfide-stabilized phosphine (PSP) framework that displays unique capabilities for binding with copper (Cu) and shows high potential for drug candidacy |
8151 |
| Precision Needle Positioning Robotic System for MRI Guided InjectionAn MRI compatible robotic needle positioning system |
8246 |
| Guided Injection of Charged Cargo for Intracellular DeliveryA system and method for precise delivery of cellular subcomponents with improved control and delivery. |
8275 |
| Constellation Diagrams to Model Biomolecules’ Electrostatic Properties A computationally efficient method that computes the multipole moments of molecules and visually represents them as constellation diagrams in a 4D plot. |
8245 |
| Storage Media for Determining Optimal Respiratory Treatment Systems, methods, and computer-readable media storing instructions for automatically determining optimal treatment phase for delivering radiation therapy based on respiration motion of a patient |
6926 |
| Self-Assembling Peptides for Cell and Notch-Ligand Delivery Self-assembling peptides that form hydrogels comprising peptide sequences for the activation of signaling pathways |
6480 |
| Method for Treatment of PathologiesA antiviral method that uses mRNA acting as a targeted RNA cleaving enzyme from various bacterial species |
7878 |
| Fibrin "Knob" TherapeuticsA rapid and simple method for the in vitro production of biological reagents |
4021 |
| Biomolecular Coating for ImplantsBiological protein ligands that recapitulate the structure of natural proteins and convey integrin receptor specificity |
3967 |
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