Research Tools | Technology Licensing

Available Technologies by Category

Paper-Based Multi-Well Depletion Enzyme-Linked Immunosorbent Assay (ELISA) Enables Point-of-Care (POC) Testing Paper-based lateral flow assay automatically performs multi-well ELISA testing for POC titer measurements. Simplifies ELISA testing by eliminating the need for centralized laboratories staffed with trained personnel who perform multiple steps in a specific sequence to execute the assay workflow. Transforms a variety of ELISA-based tests into single-use, disposable dipstick tests to be used at the point of care or at home.	9124
Artificial Neural Network (ANN) with Unique Input Design That Significantly Reduces Computational Costs of Complex Engineering Systems Neural network’s novel input can utilize first-order schemes and local patches and allows for discontinuities to be reflected accurately and with greater resolution than existing products. This adaptable ANN can be adopted by commercial and scientific research as a stand-alone solution or in conjunction with existing software. Lower costs for running complex and repetitive computations can be achieved by implementing this neural network with an input system that processes low-cost numerical solution patches arising from two or more converging solutions.	8963
Automated Bioreactor Sampling System Can Eliminate Cross-Contamination of Samples Automated bioreactor sampling system maintains sample integrity by changing the syringe between samples In addition to savings related to reduced cross-contamination, automated sampling can further lower costs by reducing hands-on time and speeding sampling. Flexible platform can be used with any type of collected sample.	8886
Electronic Immunoassay Using Enzymatic Metallization on Microparticles Lower cost: Replacing fluorescent markers and readout methods with impedance detection has the potential to significantly decrease the cost of the assay. Transportable: Impedance measurements in microfluidics can be made transportable, which can potentially enable point-of-care applications, as electronic elements are more durable than optical elements. Practical: Identification of COVID-19 antibodies in COVID-positive serum samples has already been demonstrated.	8813
patcherBotPHARMA Automated Intracellular Pharmacological Electrophysiology Robot Increased efficiency: Autonomous operation ensures accurate placement of components and creates high success rates for experiment completion. Decreased human effort: Performs typical ligand-gated ionotropic receptor experimentation protocols autonomously for up to a tenfold reduction in operator interaction time over the duration of the experiment Higher experiment yield: Rapidly replicates previous datasets, reducing the time to produce an 8-point concentration response curve from weeks of recording to ~13 hours of recording	8717
Simulated Synovial Fluid Offers Potential for Effective Treatment of Knee Osteoarthritis Osteoarthritis (OA)-simulated synovial fluid (simSF) provides the opportunity to evaluate how different cell therapies respond to an OA-like environment. By analyzing OA patient-derived synovial fluid (pdSF) and developing potency assays, researchers created a simSF comparable to pdSF that overcomes patient variability. The simSF allows for the investigation of OA biology with greater reproducibility of predictive outcomes and could advance effective treatment of knee OA.	8956
“Smart” Feedback-Controlled Bioreactor Platform Enables Consistent High-Yield and High-Quality MSC Products Scaled-down feedback-controlled hollow fiber-based bioreactor enables identifying the critical quality attributes and critical process parameters for high-quantity and high-quality hCT-MSCs for ideal cell growth and efficacy Provides the controls to maintain optimum conditions and improve expansion yield and cell viability System can be adapted and applied to industrial cell therapy manufacturing and can enable high-yield and high-quality products while minimizing variabilities	8887
Biodegradable Shape Memory Polymer for 3D-Printed Tissue and Biomedical Devices New synthesis reaction produces novel biomaterials for soft tissue treatment combines shape memory and biodegradability with custom 3D printing for patient-specific, minimally invasive solutions Customizable to patient needs by varying the formulation and molecular architecture to alter the mechanical properties Improves safety and efficacy by providing a much-needed middle range to existing “too hard/too soft” tissue repair options, while also being biodegradable and bioresorbable	8655
Synthetic Hydrogel for Satellite Cell Delivery in Dystrophic Skeletal Muscle Addresses the critical need for a viable treatment for deterioration of the diaphragm, which is a leading cause of respiratory failure and death in Duchenne Muscular Dystrophy patients Engineered hydrogels comprised of synthetic polymers and peptides are designed to enable successful muscle satellite cell (MuSC) transplantation to the diaphragm or other dystrophic skeletal muscle tissue Shown to support MuSC survival, proliferation, and differentiation, which can enable restoration of dystrophin – a protein absent in DMD and critical to strengthening and repairing muscle fibers	7841
Synthetic Hydrogels for Human Organoid (HO) Generation and Transplantation Synthetic hydrogel exhibits high cytocompatibility and minimal toxicity and inflammation in vivo for improved human organoid viability Injectable delivery vehicle supports localized HO engraftment in mucosal wounds to potentially enhance wound closure and repair Modular design and delivery via endoscopic techniques enables the translational potential of this delivery platform for regenerative medicine and overcomes limitations associated with the use of commercially available matrices for hPSC-based organoid technologies	7536
Quantitative, Multiplexed Electronic Detection of COVID-19 Biomarkers Direct electronic detection: This innovation provides direct detection of biomarkers as a simple electronic readout without the use of any intermediate optics. Multiplexed: The device can simultaneously detect multiple biomarkers (e.g., a four-plex chip to detect IgG and IgM antibodies against spike or nucleocapsid antigens). Portable: A handheld, cellphone-interfaced reader is designed to enable detection and monitoring of diseases in remote areas for sensitive yet inexpensive point-of-care use.	8814
Developing Tumor Immune Microenvironments via Engineered Hydrogel Scalable: Enables increased tumor formation rate without sacrificing the dynamic complexity of an in vivo adaptive immune response Improved consistency: Demonstrates consistent induction of tumor growth, latency, and immune infiltration in early analyses of the technology Cost-effective: Eliminates the repetitive processes of conventional methods and leverages inexpensive hydrogel	8785
Capillary Flow Control in Lateral Flow Assays (LFAs) via Delaminating Timers ASSURED: LFAs readily satisfy the majority of the ASSURED (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverable to end-users) criteria reported by the World Health Organization to establish capabilities of POC devices. Agile: The addition of timers to LFAs provides an opportunity to develop more complex multi-step testing, as well as additional benefits such as built-in signal amplification and POC DNA extraction and purification. Automated: The ability to sequentially deliver different reagents into a reaction via programmable timers imprinted on paper makes it possible to automate multi-step assays that otherwise could only be performed in laboratories or with manual intervention.	8462, 8634
Recirculation System for Aerosol Collectors Maximizes Particle Concentration for Improved Pathogen Detection Enhanced detection: Continuously recirculated collection buffer increases the concentration of targeted particles collected and improves detection of pathogens Increased sampled air volume: Recirculating the buffer enables running the system for longer periods of time and with larger volumes of air to improve pathogen detection in entire buildings Increased control: Users have active control of the volume of fluid introduced during collection via the system’s recharge pump	8903
3D Light-Field Endoscopy for High-Precision Microsurgery Enhanced control and safety: Real time visual navigation enhances guidance and intervention in complex microenvironments, maintaining high spatial resolution while providing quantitative depth information Comfortable: System does not require 3D glasses that can cause physician dizziness or headaches after long periods of use Streamlined: Technique eliminates the need for other imaging procedures such as micro-CT or MRI to quantify the 3D morphology of tissue	8848
Cluster-Wells: Isolating Aggressive Tumor Cell Clusters for Improved Cancer Diagnosis and Treatment High performing: Demonstrates superior abilities to isolate CTCs without clogging the system or dissociating the clusters Low cost: Shows high potential for large-scale production because it uses simple equipment and a straightforward process Versatile: Isolates CTC clusters of any cancer type and uses hardware that can be modified to accommodate various devices	8203
Fourier Light-Field Microscope (FLFM) for Fast, Volumetric, and High-Resolution Imaging of Entire Organoids Cost-efficient and scalable: Is fully adaptable to epifluorescence protocols resulting in a system that is both cost-efficient and highly scalable Fast: Captures fast cellular and tissue dynamic processes in a simultaneous, volumetric manner (e.g., collective cellular responses at sub-second time scales across whole samples) Validated: Responses to extracellular physical cues such as osmotic and mechanical stresses have been recorded using human induced pluripotent stem cell-derived colon organoids (hCOs).	8844
Bio-SIM-S1: An Automated Biological Sample Aliquoting Processing System Automated: Leverages robotics to eliminate the need for manual aliquoting of biological swab samples Non-contact: Sidesteps the need for human contact with biological samples during the aliquoting process, thereby reducing risk of sample carryover and cross-contamination Economical: Offers the potential to lower the costs associated with biological sample aliquoting and processing, especially for large quantities of samples	3357
Recombinant Antibodies for Exclusive Detection of Glaucoma-Associated Myocilin Exclusive detection: Unlike current myocilin-directed antibodies that do not differentiate among numerous disease-associated states of the protein (e.g., folded, cleaved, and misfolded myocilin), these reagents only detect folded myocilin Authentic and reproducible: Antibodies are produced using recombinant DNA technology, which enables robust precision sequencing of the reagent and maintains fidelity over time High affinity: Antibodies detect both mouse and human myocilin with well-characterized epitopes and high affinity	8055
Enabling Rapid Detection of Label-Free RNA for Use in COVID-19 Testing Earlier detection: Identifying the viral components themselves—rather than the body’s reaction to the viral presence (i.e., antibodies)—potentially improves early detection in asymptomatic subjects. Simpler process: Use of minimal reagents and fewer preparatory steps is designed to enable more efficient and facile sample preparation. Avoidance of “wash steps” aims to minimize target loss. Fewer disruptions: Avoiding the use of high-demand supplies (e.g., swabs) and reagents potentially reduces supply-chain and contamination issues.	8669
Antibodies for Glaucoma Research Precise: Distinguishes between correctly folded and mutated forms from samples, allowing for more precise research and interventions Powerful: Enables a more complete and robust understanding of myocilin antibody targets and their applications in potential glaucoma treatments Enabling: Opens new opportunities for development of pharmaceuticals to treat or prevent damage to the eye caused by glaucoma	8489
High-Throughput MSC Potency Assay to Bring Feasibility to Immune/Inflammatory Therapeutics Reproducibility: The well-defined cellular environment of the device enables a highly reproducible MSC response not observed in 2D cultures. Scalable: The assay’s simplistic design is amendable to cost-effective scale up. Economical: The low cost of the microfluidic chip and the ease of implementing the assay into existing cell therapy manufacturing practices provide for low costs to enter the market.	8722
Handheld Breath Collection Device for Detecting Disease Biomarkers Improved diagnosis: Analyzes both the gas and liquid sampled from the patient’s breath for potentially more robust and multifaceted results Enhanced patient experience: Requires a shorter exhalation cycle to get a breath sample, making the test more comfortable for patients Small and portable: Optimizes and miniaturizes the collection process for easy point-of-care applications	8791
Microscale High-Throughput Phenotypic Assay for Fibrosis Powerful: Provides high-throughput image-based analysis of fibrotic processes as well as fibrinolysis Convenient: Combines label-free readouts for fibrin degradation, collagen synthesis, and cell contraction to evaluate fibrotic tissue remodeling Enabling: Opens new opportunities for understanding fibrosis pathogenesis and for evaluating anti-fibrotic therapeutics	8502
A Biomimetic Nose with Machine Learning for Advanced Threat Detection Enhanced chemical detection: Reduces proximity issues and enhances detection Functional in air and liquid mediums: Can detect single or multiple chemical agents even when the medium contains both a liquid and a gas. An attachment makes it possible to use the device in liquid with air monitoring sensors. Continuous improvement: Uses machine learning algorithms to continually improve agent characterization	7796
Self-Titrating Bacterial Protease-Activated Prodrug Effective: Activates an internal dosing mechanism such that the magnitude of an infection locally determines the prodrug dose Robust: Increases the stability of the prodrug form by neutralizing the effective charge of the administered antimicrobial peptide Improves safety: Decreases the potential for off-target effects	8010
Scalable, Low-Cost, Inversion-Free Method of Enabling Automated Underside Cell Seeding Convenient: Eliminates the need for inversion procedures, which tend to be tedious, difficult to automate, and prone to failure—especially for 96-well inserts due to their limited culture area Generalizable: Developed for screenings that focus on the air-blood barrier, but can also be applied to gut, skin, oral mucosa, and other organ systems Scalable: Employs a simple method that is extensible to automated processes for high-throughput drug screenings and pharmacological tests	8677
Rapid Development of SARS-CoV-2 Monoclonal Antibodies Powerful: Demonstrates potential to recognize intact SARS-CoV-2 virions with high affinity Highly efficient: Enables researchers to select pairs of high-affinity antibodies that bind to different receptor sites, maximizing the efficiencies of sandwich-style rapid testing methods Enabling: Furthers the development of neutralizing antibodies that can be used as therapeutic agents, delivered either directly or via mRNA for in situ expression	8487
Skin-Conformal Wearable Stress Monitor Delivers Greater Precision and Continuous, Wireless Monitoring with Comfort and Flexibility All-in-one: The personal adhesive bandage-like single device platform offers wireless, multi-data sensing by simply mounting it on the skin. Disposable: This wearable device is fully disposable after the use and the measured data can be simply sent to the cloud via a tablet or smartphone app. Compact: The unique, thin design of this bioelectric device is one-sixth the volume of current market offerings—weighing less than 7 g, including its rechargeable battery.	8414
Miniaturized Modular-Array Fluorescence Microscopy Powerful: Offers high fluorescence sensitivity, efficiency, and spatiotemporal resolution (~3 µm and up to 60 Hz) Configurable: Offers compatibility with conventional cell culture assays and physiological imaging, providing accessibility to upright physiological imaging and integration with biochemical sensors under the cell platform Efficient: Provides effective parallelization of multi-site data acquisition	8580
Novel, Non-Invasive Stimulation to Control Brain Inflammation and Boost Resilience to Stress Reaches deep brain regions: Drives rhythmic neural activity in deep brain regions that are unreachable by most non-invasive stimulation technology Non-invasive: Uses only lights and sound with precise timing and control Fast response: Effects are seen in 5 to 30 minutes rather than hours	7773, 7832, 8745
Integrating Electrical Sensors into Soft-Lithography Microfluidic Devices Sophisticated: Advances the integration of electrical sensors on microfluidic devices with a simple, approachable solution Sensitive: Demonstrates a higher signal sensitivity than electrodes in a typical coplanar arrangement Adaptable: Allows for greater layout flexibility because of its straightforward fabrication process	7769
Microfluidic CODES with Innovative Machine-Learning Analysis Scalable: Set-up allows for the integration of multiple microfluidic devices to increase throughput volume. Versatile: Machine learning analysis can be applied to other microfluidic devices integrated with the same Coulter sensor network. Pragmatic: This innovation improves the capabilities of lab-on-a-chip systems to provide an affordable solution for low-resource settings.	7107, 8032
Utilizing Impedance Spectroscopy for Advanced Characterization of Particles Comprehensive: Simultaneously measures both spatial and dielectric properties of particles Streamlined: Helps resolve signal interference from coincident cells—a challenge of other assessment techniques Precise: Offers complex impedance as a new level of particle feature assessment, integrating it with other measurements such as elasticity and size for more predictive analyses	8049
All-Electronic Immunophenotyping Device for Point-of-Care Testing Convenient: Provides an all-electronic immunophenotyping process with straightforward equipment and techniques Low cost: Performs sophisticated, multistep analyses in a system that is affordable enough for point-of-care settings Flexible: Allows for the easy immobilization of multiple antibodies in the device—a shortcoming of current systems	8045, 8047
Scalable Microfluidic Device with Multiple Constriction Channels for High-Throughput Mechanophenotyping High throughput: Addresses the low-throughput challenges of other similar technologies by handling a sample volume near that of a Coulter counter Low cost: Eliminates the need for costly equipment, highly trained personnel, and long processing times that come with other measuring processes Scalable: Uses a frequency division scheme so that multiple copies of the system can operate concurrently	8031
Measuring Surface Antigen Expression via Microflow Cytometry Portable: This innovation uses a disposable, handheld device without bulky or costly equipment, which is expected to be especially useful in low-resource settings. Simple: It is designed to achieve results similar to those from a commercial flow cytometer but without requiring initial purification. Recoverable samples: Unlike commercial systems, the analyzed sample can be recovered for further tests at the end of the analysis.	7913, 8048
Innovative Ion Mobility Spectrometry with Open-Air Assembly Protective: Potentially helps protect the technician against contact with ionic hazards Rapid: Separates ions through fast detection of differences in their mass, charge, and cross-section Convenient: Leverages an open-air arrangement that significantly reduces time for experiment setup and sample preparation	4885
High-Tech Infant Suit for Earlier Detection of Cerebral Palsy Advanced: May allow for earlier detection of motor dysfunctions in order to begin therapeutic interventions as soon as possible Robust: Collects data from three limb segments on the leg for a multifaceted assessment Long-lasting: Uses one power source with regulated voltage in order to prolong the use of the device	7949
A Partial-Hand Prosthesis Simulator Specific: Designed to maintain limb length by placing artificial fingers in positions similar to where they would be in an intact hand performing grasping actions (rather than extending the length of the limb as many prostheses do) User friendly: Features rubber-capped fingertips that may provide a more lifelike representation of grasp and enhance usability Nuanced: Designed to limit tactile sensation and feedback from immobilized fingers, which may allow better evaluation of how the device is functioning for the patient in comparison to an actual prosthesis	8534

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