• Convenient: Eliminates the need for inversion procedures, which tend to be tedious, difficult to automate, and prone to failure—especially for 96-well inserts due to their limited culture area
• Generalizable: Developed for screenings that focus on the air-blood barrier, but can also be  applied to gut, skin, oral mucosa, and other organ systems
• Scalable: Employs a simple method that is extensible to automated processes for high-throughput drug screenings and pharmacological tests

• Computationally efficient
• User-friendly
• Operator guidance — correction of errors

• Effective: Activates an internal dosing mechanism such that the magnitude of an infection locally determines the prodrug dose
• Robust: Increases the stability of the prodrug form by neutralizing the effective charge of the administered antimicrobial peptide
• Improves safety: Decreases the potential for off-target effects

• Osteoarthritis (OA)-simulated synovial fluid (simSF) provides the opportunity to evaluate how different cell therapies respond to an OA-like environment.
• By analyzing OA patient-derived synovial fluid (pdSF) and developing potency assays, researchers created a simSF comparable to pdSF that overcomes patient variability. 
• The simSF allows for the investigation of OA biology with greater reproducibility of predictive outcomes and could advance effective treatment of knee OA. 

• First discovery of small-molecules binding to the central catalytic domain of NGly1
• Could be used to treat the inherited genetic disorder resulting from NGly1 deficiency

• Large-scale throughput, real-time cellular monitoring, and re- usability with no contamination
• Easily and inexpensively replaced
• Modules can be designed for various functions

• Cost effective manufacturing approach
• Eco Friendly
• Light-weight

• Increased safety — eradicates RF induced heating while providing position of catheters in the body during iMRI procedures
• Simultaneous measurements — offers temperature measurements, orientation, and other parameters

• Automatically determines optimal radiation therapy treatment phase
• Enables higher, more effective radiation dosage amounts
• Minimizes unnecessary radiation to normal surrounding tissues

• Fast: Accommodates preloading of specimen collection tubes and completes absorption of analytical targets within a few minutes of fluid collection
• Low cost: Employs economical materials and eliminates the need for refrigeration of samples while also lowering the weight of samples for transport
• Easy to use: Avoids the need for filtration, centrifugation, or pipetting and the associated equipment for such tasks

• Cost and Energy efficient- requires shorter times of surface modification with a lower concentration of solvents
• Less hazardous- lower concentrations of solvents decrease the negative environmental impact
• Versatile- though primarily related to biotechnology, this method can be applied in any industry requiring surface modification

This technology can be used in the development of yeast-based syntheses of plant alkaloids, or any other biosynthetic pathway that uses 5-hydroxytryptohan or L-DOPA as precursors. It can be used for the synthesis of compound monoterpene indole alkaloids derived from strictosidine (e.g. quinine, camptothecin, ajmalicine, serpentine, vinblastine and vincristine) or benzylisoquinoline alkaloids derived from dopamine (e.g. berberine and morphine).

• Synthetic hydrogel exhibits high cytocompatibility and minimal toxicity and inflammation in vivo for improved human organoid viability 
• Injectable delivery vehicle supports localized HO engraftment in mucosal wounds to potentially enhance wound closure and repair
• Modular design and delivery via endoscopic techniques enables the translational potential of this delivery platform for regenerative medicine and overcomes limitations associated with the use of commercially available matrices for hPSC-based organoid technologies

• Provides superior retention and release of osteoinductive protein
• Reduces necessary dose of osteoinductive protein
• Reduced cost of procedure

• High-performance: Enables a powerful process for high-throughput 3D printing of micro- and nanoscale structures
• Efficient: Reduces defects during printing to improve yield and decrease excess printing commonly observed with FP-TPL
• Improved: Broadens the applicability of FP-TPL to printing of functional micro- and nanoscale structures

• Low cost and effective production method
• Maintains protein structure and enzymatic activity and maximizes the amount of protein to be delivered
• Preserves bioactivity

• Allows individuals with disabilities to experience active, independent, ad satisfying lives
• Allows wireless tracking of the voluntary tongue motion in the 3-D oral space, which can be utilized for command, control, and navigation applications
• Low-cost

• Reduced flow stasis: This mechanism displaces the native valve leaflets away from the THV stent frame, essentially removing its “cover” and allowing blood to move freely through the open stent cells. This can help to significantly reduce flow stasis in the neo-sinus region, thereby reducing thrombus initiation/progression.
• Prevention of coronary artery obstruction: Coronary artery obstruction following TAVR is a rare but often fatal complication. In rare cases in patients with unusually large native leaflets or small aortic roots, the large leaflets block the flow of blood to the coronary arteries as the new valve’s scaffolding opens. Georgia Tech’s design displaces the native valve leaflets away from the THV stent frame, which can help to reduce this risk.
• Optimized THV deployment: The innovation offers dual feedback to aid clinicians in determining optimal THV deployment height—a key factor in optimizing patient outcomes. As the device’s “arms” extend against the native vessel wall, they create both tactile feedback during THV positioning as well as visual feedback via fluoroscopy. In addition to deployment height, the multi-arm design supports axial alignment of the THV with respect to the native vessel wall—a factor shown to impact valve performance. 

• Integrative perspective imaging - topological and chemical imaging of complex biological samples and heterogeneous nanomaterial interfaces with sub-micrometric resolution
• Improved spatial resolution - system provides chemical imaging resolution of ~ 250 nm and electron microscopy topological resolution of ~ 50 nm.

• Accuracy in analytics - analysis at the level of a single cell or with subcellular resolution has been seen as a next frontier in innovative approaches to discovery